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PubMed code 27161876

Compile data set for download or QSAR
Found 41 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glucagon receptor


(Homo sapiens (Human))		BDBM50168081
PNG
(CHEMBL3799802 | MK 0893)
Show SMILES COc1ccc2cc(ccc2c1)-c1cc(nn1C(C)c1ccc(cc1)C(=O)NCCC(O)=O)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C32H27Cl2N3O4/c1-19(20-3-5-21(6-4-20)32(40)35-12-11-31(38)39)37-30(18-29(36-37)25-14-26(33)17-27(34)15-25)24-8-7-23-16-28(41-2)10-9-22(23)13-24/h3-10,13-19H,11-12H2,1-2H3,(H,35,40)(H,38,39)
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n/an/a 100n/an/an/an/an/an/a



Shanghai Institute of Materia Medica

Curated by ChEMBL


Assay Description
Antagonist activity at wild type human glucagon receptor expressed in HEK293T cells assessed as inhibition of glucagon-induced cAMP accumulation incu...

Bioorg Med Chem 24: 2852-63 (2016)


Article DOI: 10.1016/j.bmc.2016.04.053
BindingDB Entry DOI: 10.7270/Q27P919J
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Glucagon receptor


(Homo sapiens (Human))		BDBM50168081
PNG
(CHEMBL3799802 | MK 0893)
Show SMILES COc1ccc2cc(ccc2c1)-c1cc(nn1C(C)c1ccc(cc1)C(=O)NCCC(O)=O)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C32H27Cl2N3O4/c1-19(20-3-5-21(6-4-20)32(40)35-12-11-31(38)39)37-30(18-29(36-37)25-14-26(33)17-27(34)15-25)24-8-7-23-16-28(41-2)10-9-22(23)13-24/h3-10,13-19H,11-12H2,1-2H3,(H,35,40)(H,38,39)
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n/an/a 600n/an/an/an/an/an/a



Shanghai Institute of Materia Medica

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from wild type human glucagon receptor expressed in CHO-K1 cells after 3 hrs by scintillation counting method

Bioorg Med Chem 24: 2852-63 (2016)


Article DOI: 10.1016/j.bmc.2016.04.053
BindingDB Entry DOI: 10.7270/Q27P919J
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Glucagon receptor


(Homo sapiens (Human))		BDBM50168091
PNG
(CHEMBL3800525)
Show SMILES OC(=O)CCNC(=O)c1ccc2C(CCc2c1)n1nc(cc1-c1ccc2ccccc2c1)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C32H25Cl2N3O3/c33-25-15-24(16-26(34)17-25)28-18-30(22-6-5-19-3-1-2-4-20(19)13-22)37(36-28)29-10-8-21-14-23(7-9-27(21)29)32(40)35-12-11-31(38)39/h1-7,9,13-18,29H,8,10-12H2,(H,35,40)(H,38,39)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Shanghai Institute of Materia Medica

Curated by ChEMBL


Assay Description
Antagonist activity at wild type human glucagon receptor expressed in HEK293T cells assessed as inhibition of glucagon-induced cAMP accumulation incu...

Bioorg Med Chem 24: 2852-63 (2016)


Article DOI: 10.1016/j.bmc.2016.04.053
BindingDB Entry DOI: 10.7270/Q27P919J
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50168080
PNG
(CHEMBL3799439)
Show SMILES COc1cc(OC)cc(c1)-c1cc(nn1C1CCc2cc(ccc12)C(=O)NCCC(O)=O)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C30H27Cl2N3O5/c1-39-23-12-20(13-24(15-23)40-2)28-16-26(19-10-21(31)14-22(32)11-19)34-35(28)27-6-4-17-9-18(3-5-25(17)27)30(38)33-8-7-29(36)37/h3,5,9-16,27H,4,6-8H2,1-2H3,(H,33,38)(H,36,37)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Shanghai Institute of Materia Medica

Curated by ChEMBL


Assay Description
Antagonist activity at wild type human glucagon receptor expressed in HEK293T cells assessed as inhibition of glucagon-induced cAMP accumulation incu...

Bioorg Med Chem 24: 2852-63 (2016)


Article DOI: 10.1016/j.bmc.2016.04.053
BindingDB Entry DOI: 10.7270/Q27P919J
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50168096
PNG
(CHEMBL3800473)
Show SMILES OC(=O)CCNC(=O)c1ccc2C(CCc2c1)n1nc(cc1-c1ccc(Cl)cc1)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C28H22Cl3N3O3/c29-20-5-1-16(2-6-20)26-15-24(19-12-21(30)14-22(31)13-19)33-34(26)25-8-4-17-11-18(3-7-23(17)25)28(37)32-10-9-27(35)36/h1-3,5-7,11-15,25H,4,8-10H2,(H,32,37)(H,35,36)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Shanghai Institute of Materia Medica

Curated by ChEMBL


Assay Description
Antagonist activity at wild type human glucagon receptor expressed in HEK293T cells assessed as inhibition of glucagon-induced cAMP accumulation incu...

Bioorg Med Chem 24: 2852-63 (2016)


Article DOI: 10.1016/j.bmc.2016.04.053
BindingDB Entry DOI: 10.7270/Q27P919J
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50168097
PNG
(CHEMBL3798135)
Show SMILES OC(=O)CCNC(=O)c1ccc2C(CCc2c1)n1nc(cc1-c1ccc(F)cc1)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C28H22Cl2FN3O3/c29-20-12-19(13-21(30)14-20)24-15-26(16-1-5-22(31)6-2-16)34(33-24)25-8-4-17-11-18(3-7-23(17)25)28(37)32-10-9-27(35)36/h1-3,5-7,11-15,25H,4,8-10H2,(H,32,37)(H,35,36)
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Shanghai Institute of Materia Medica

Curated by ChEMBL


Assay Description
Antagonist activity at wild type human glucagon receptor expressed in HEK293T cells assessed as inhibition of glucagon-induced cAMP accumulation incu...

Bioorg Med Chem 24: 2852-63 (2016)


Article DOI: 10.1016/j.bmc.2016.04.053
BindingDB Entry DOI: 10.7270/Q27P919J
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50168090
PNG
(CHEMBL3799468)
Show SMILES COc1ccc2cc(ccc2c1)-c1cc(nn1C1CCc2cc(ccc12)C(=O)NCCC(O)=O)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C33H27Cl2N3O4/c1-42-27-7-4-19-12-22(3-2-20(19)16-27)31-18-29(24-14-25(34)17-26(35)15-24)37-38(31)30-9-6-21-13-23(5-8-28(21)30)33(41)36-11-10-32(39)40/h2-5,7-8,12-18,30H,6,9-11H2,1H3,(H,36,41)(H,39,40)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Shanghai Institute of Materia Medica

Curated by ChEMBL


Assay Description
Antagonist activity at wild type human glucagon receptor expressed in HEK293T cells assessed as inhibition of glucagon-induced cAMP accumulation incu...

Bioorg Med Chem 24: 2852-63 (2016)


Article DOI: 10.1016/j.bmc.2016.04.053
BindingDB Entry DOI: 10.7270/Q27P919J
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50168085
PNG
(CHEMBL3799017)
Show SMILES COc1ccc2cc(ccc2c1)-c1cc(nn1C(C)c1ccc(cc1)C(=O)NCC(C)C(O)=O)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C33H29Cl2N3O4/c1-19(33(40)41)18-36-32(39)22-6-4-21(5-7-22)20(2)38-31(17-30(37-38)26-13-27(34)16-28(35)14-26)25-9-8-24-15-29(42-3)11-10-23(24)12-25/h4-17,19-20H,18H2,1-3H3,(H,36,39)(H,40,41)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Shanghai Institute of Materia Medica

Curated by ChEMBL


Assay Description
Antagonist activity at wild type human glucagon receptor expressed in HEK293T cells assessed as inhibition of glucagon-induced cAMP accumulation incu...

Bioorg Med Chem 24: 2852-63 (2016)


Article DOI: 10.1016/j.bmc.2016.04.053
BindingDB Entry DOI: 10.7270/Q27P919J
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50168087
PNG
(CHEMBL3797757)
Show SMILES COc1ccc2cc(ccc2c1)-c1cc(nn1C(C)c1ccc(cc1)C(=O)NC(C)CC(O)=O)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C33H29Cl2N3O4/c1-19(12-32(39)40)36-33(41)22-6-4-21(5-7-22)20(2)38-31(18-30(37-38)26-14-27(34)17-28(35)15-26)25-9-8-24-16-29(42-3)11-10-23(24)13-25/h4-11,13-20H,12H2,1-3H3,(H,36,41)(H,39,40)
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n/an/a 1.90E+3n/an/an/an/an/an/a



Shanghai Institute of Materia Medica

Curated by ChEMBL


Assay Description
Antagonist activity at wild type human glucagon receptor expressed in HEK293T cells assessed as inhibition of glucagon-induced cAMP accumulation incu...

Bioorg Med Chem 24: 2852-63 (2016)


Article DOI: 10.1016/j.bmc.2016.04.053
BindingDB Entry DOI: 10.7270/Q27P919J
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50168092
PNG
(CHEMBL3797782)
Show SMILES OC(=O)CCNC(=O)c1ccc2C(CCc2c1)n1nc(cc1-c1cccc2ccccc12)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C32H25Cl2N3O3/c33-23-15-22(16-24(34)17-23)28-18-30(27-7-3-5-19-4-1-2-6-25(19)27)37(36-28)29-11-9-20-14-21(8-10-26(20)29)32(40)35-13-12-31(38)39/h1-8,10,14-18,29H,9,11-13H2,(H,35,40)(H,38,39)
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n/an/a 2.10E+3n/an/an/an/an/an/a



Shanghai Institute of Materia Medica

Curated by ChEMBL


Assay Description
Antagonist activity at wild type human glucagon receptor expressed in HEK293T cells assessed as inhibition of glucagon-induced cAMP accumulation incu...

Bioorg Med Chem 24: 2852-63 (2016)


Article DOI: 10.1016/j.bmc.2016.04.053
BindingDB Entry DOI: 10.7270/Q27P919J
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50168093
PNG
(CHEMBL3798581)
Show SMILES OC(=O)CCNC(=O)c1ccc2C(CCc2c1)n1nc(cc1-c1ccc(cc1)-c1ccccc1)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C34H27Cl2N3O3/c35-27-17-26(18-28(36)19-27)30-20-32(23-8-6-22(7-9-23)21-4-2-1-3-5-21)39(38-30)31-13-11-24-16-25(10-12-29(24)31)34(42)37-15-14-33(40)41/h1-10,12,16-20,31H,11,13-15H2,(H,37,42)(H,40,41)
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n/an/a 2.60E+3n/an/an/an/an/an/a



Shanghai Institute of Materia Medica

Curated by ChEMBL


Assay Description
Antagonist activity at wild type human glucagon receptor expressed in HEK293T cells assessed as inhibition of glucagon-induced cAMP accumulation incu...

Bioorg Med Chem 24: 2852-63 (2016)


Article DOI: 10.1016/j.bmc.2016.04.053
BindingDB Entry DOI: 10.7270/Q27P919J
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50168078
PNG
(CHEMBL3799820)
Show SMILES OC(=O)CCNC(=O)c1ccc2C(CCc2c1)n1nc(cc1-c1ccccc1)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C28H23Cl2N3O3/c29-21-13-20(14-22(30)15-21)24-16-26(17-4-2-1-3-5-17)33(32-24)25-9-7-18-12-19(6-8-23(18)25)28(36)31-11-10-27(34)35/h1-6,8,12-16,25H,7,9-11H2,(H,31,36)(H,34,35)
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n/an/a 3.50E+3n/an/an/an/an/an/a



Shanghai Institute of Materia Medica

Curated by ChEMBL


Assay Description
Antagonist activity at wild type human glucagon receptor expressed in HEK293T cells assessed as inhibition of glucagon-induced cAMP accumulation incu...

Bioorg Med Chem 24: 2852-63 (2016)


Article DOI: 10.1016/j.bmc.2016.04.053
BindingDB Entry DOI: 10.7270/Q27P919J
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50168091
PNG
(CHEMBL3800525)
Show SMILES OC(=O)CCNC(=O)c1ccc2C(CCc2c1)n1nc(cc1-c1ccc2ccccc2c1)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C32H25Cl2N3O3/c33-25-15-24(16-26(34)17-25)28-18-30(22-6-5-19-3-1-2-4-20(19)13-22)37(36-28)29-10-8-21-14-23(7-9-27(21)29)32(40)35-12-11-31(38)39/h1-7,9,13-18,29H,8,10-12H2,(H,35,40)(H,38,39)
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n/an/a 3.60E+3n/an/an/an/an/an/a



Shanghai Institute of Materia Medica

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from wild type human glucagon receptor expressed in CHO-K1 cells after 3 hrs by scintillation counting method

Bioorg Med Chem 24: 2852-63 (2016)


Article DOI: 10.1016/j.bmc.2016.04.053
BindingDB Entry DOI: 10.7270/Q27P919J
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50168096
PNG
(CHEMBL3800473)
Show SMILES OC(=O)CCNC(=O)c1ccc2C(CCc2c1)n1nc(cc1-c1ccc(Cl)cc1)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C28H22Cl3N3O3/c29-20-5-1-16(2-6-20)26-15-24(19-12-21(30)14-22(31)13-19)33-34(26)25-8-4-17-11-18(3-7-23(17)25)28(37)32-10-9-27(35)36/h1-3,5-7,11-15,25H,4,8-10H2,(H,32,37)(H,35,36)
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n/an/a 3.90E+3n/an/an/an/an/an/a



Shanghai Institute of Materia Medica

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from wild type human glucagon receptor expressed in CHO-K1 cells after 3 hrs by scintillation counting method

Bioorg Med Chem 24: 2852-63 (2016)


Article DOI: 10.1016/j.bmc.2016.04.053
BindingDB Entry DOI: 10.7270/Q27P919J
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50168082
PNG
(CHEMBL3799556)
Show SMILES COc1ccc2cc(ccc2c1)-c1cc(nn1C(C)c1ccc(cc1)C(=O)N1CCC(CC1)C(O)=O)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C35H31Cl2N3O4/c1-21(22-3-5-23(6-4-22)34(41)39-13-11-24(12-14-39)35(42)43)40-33(20-32(38-40)28-16-29(36)19-30(37)17-28)27-8-7-26-18-31(44-2)10-9-25(26)15-27/h3-10,15-21,24H,11-14H2,1-2H3,(H,42,43)
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n/an/a 4.50E+3n/an/an/an/an/an/a



Shanghai Institute of Materia Medica

Curated by ChEMBL


Assay Description
Antagonist activity at wild type human glucagon receptor expressed in HEK293T cells assessed as inhibition of glucagon-induced cAMP accumulation incu...

Bioorg Med Chem 24: 2852-63 (2016)


Article DOI: 10.1016/j.bmc.2016.04.053
BindingDB Entry DOI: 10.7270/Q27P919J
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50168090
PNG
(CHEMBL3799468)
Show SMILES COc1ccc2cc(ccc2c1)-c1cc(nn1C1CCc2cc(ccc12)C(=O)NCCC(O)=O)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C33H27Cl2N3O4/c1-42-27-7-4-19-12-22(3-2-20(19)16-27)31-18-29(24-14-25(34)17-26(35)15-24)37-38(31)30-9-6-21-13-23(5-8-28(21)30)33(41)36-11-10-32(39)40/h2-5,7-8,12-18,30H,6,9-11H2,1H3,(H,36,41)(H,39,40)
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n/an/a 4.70E+3n/an/an/an/an/an/a



Shanghai Institute of Materia Medica

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from wild type human glucagon receptor expressed in CHO-K1 cells after 3 hrs by scintillation counting method

Bioorg Med Chem 24: 2852-63 (2016)


Article DOI: 10.1016/j.bmc.2016.04.053
BindingDB Entry DOI: 10.7270/Q27P919J
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50168094
PNG
(CHEMBL3800146)
Show SMILES OC(=O)CCNC(=O)c1ccc2C(CCc2c1)n1nc(cc1-c1cccs1)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C26H21Cl2N3O3S/c27-18-11-17(12-19(28)13-18)21-14-23(24-2-1-9-35-24)31(30-21)22-6-4-15-10-16(3-5-20(15)22)26(34)29-8-7-25(32)33/h1-3,5,9-14,22H,4,6-8H2,(H,29,34)(H,32,33)
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n/an/a 5.30E+3n/an/an/an/an/an/a



Shanghai Institute of Materia Medica

Curated by ChEMBL


Assay Description
Antagonist activity at wild type human glucagon receptor expressed in HEK293T cells assessed as inhibition of glucagon-induced cAMP accumulation incu...

Bioorg Med Chem 24: 2852-63 (2016)


Article DOI: 10.1016/j.bmc.2016.04.053
BindingDB Entry DOI: 10.7270/Q27P919J
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50168080
PNG
(CHEMBL3799439)
Show SMILES COc1cc(OC)cc(c1)-c1cc(nn1C1CCc2cc(ccc12)C(=O)NCCC(O)=O)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C30H27Cl2N3O5/c1-39-23-12-20(13-24(15-23)40-2)28-16-26(19-10-21(31)14-22(32)11-19)34-35(28)27-6-4-17-9-18(3-5-25(17)27)30(38)33-8-7-29(36)37/h3,5,9-16,27H,4,6-8H2,1-2H3,(H,33,38)(H,36,37)
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n/an/a 5.70E+3n/an/an/an/an/an/a



Shanghai Institute of Materia Medica

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from wild type human glucagon receptor expressed in CHO-K1 cells after 3 hrs by scintillation counting method

Bioorg Med Chem 24: 2852-63 (2016)


Article DOI: 10.1016/j.bmc.2016.04.053
BindingDB Entry DOI: 10.7270/Q27P919J
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50168092
PNG
(CHEMBL3797782)
Show SMILES OC(=O)CCNC(=O)c1ccc2C(CCc2c1)n1nc(cc1-c1cccc2ccccc12)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C32H25Cl2N3O3/c33-23-15-22(16-24(34)17-23)28-18-30(27-7-3-5-19-4-1-2-6-25(19)27)37(36-28)29-11-9-20-14-21(8-10-26(20)29)32(40)35-13-12-31(38)39/h1-8,10,14-18,29H,9,11-13H2,(H,35,40)(H,38,39)
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n/an/a 5.90E+3n/an/an/an/an/an/a



Shanghai Institute of Materia Medica

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from wild type human glucagon receptor expressed in CHO-K1 cells after 3 hrs by scintillation counting method

Bioorg Med Chem 24: 2852-63 (2016)


Article DOI: 10.1016/j.bmc.2016.04.053
BindingDB Entry DOI: 10.7270/Q27P919J
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50168089
PNG
(CHEMBL3798761)
Show SMILES CC(CC(O)=O)NC(=O)c1ccc(cc1)C(C)n1nc(cc1-c1ccc(cc1)C(C)(C)C)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C32H33Cl2N3O3/c1-19(14-30(38)39)35-31(40)23-8-6-21(7-9-23)20(2)37-29(22-10-12-25(13-11-22)32(3,4)5)18-28(36-37)24-15-26(33)17-27(34)16-24/h6-13,15-20H,14H2,1-5H3,(H,35,40)(H,38,39)
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n/an/a 6.30E+3n/an/an/an/an/an/a



Shanghai Institute of Materia Medica

Curated by ChEMBL


Assay Description
Antagonist activity at wild type human glucagon receptor expressed in HEK293T cells assessed as inhibition of glucagon-induced cAMP accumulation incu...

Bioorg Med Chem 24: 2852-63 (2016)


Article DOI: 10.1016/j.bmc.2016.04.053
BindingDB Entry DOI: 10.7270/Q27P919J
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50168079
PNG
(CHEMBL3798231)
Show SMILES OC(=O)CCNC(=O)c1ccc2C(CCc2c1)n1nc(cc1-c1ccc2OCCOc2c1)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C30H25Cl2N3O5/c31-21-12-20(13-22(32)15-21)24-16-26(18-3-6-27-28(14-18)40-10-9-39-27)35(34-24)25-5-2-17-11-19(1-4-23(17)25)30(38)33-8-7-29(36)37/h1,3-4,6,11-16,25H,2,5,7-10H2,(H,33,38)(H,36,37)
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n/an/a 6.30E+3n/an/an/an/an/an/a



Shanghai Institute of Materia Medica

Curated by ChEMBL


Assay Description
Antagonist activity at wild type human glucagon receptor expressed in HEK293T cells assessed as inhibition of glucagon-induced cAMP accumulation incu...

Bioorg Med Chem 24: 2852-63 (2016)


Article DOI: 10.1016/j.bmc.2016.04.053
BindingDB Entry DOI: 10.7270/Q27P919J
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50168098
PNG
(CHEMBL3799499)
Show SMILES Cc1ccccc1-c1cc(nn1C1CCc2cc(ccc12)C(=O)NCCC(O)=O)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C29H25Cl2N3O3/c1-17-4-2-3-5-23(17)27-16-25(20-13-21(30)15-22(31)14-20)33-34(27)26-9-7-18-12-19(6-8-24(18)26)29(37)32-11-10-28(35)36/h2-6,8,12-16,26H,7,9-11H2,1H3,(H,32,37)(H,35,36)
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n/an/a 6.90E+3n/an/an/an/an/an/a



Shanghai Institute of Materia Medica

Curated by ChEMBL


Assay Description
Antagonist activity at wild type human glucagon receptor expressed in HEK293T cells assessed as inhibition of glucagon-induced cAMP accumulation incu...

Bioorg Med Chem 24: 2852-63 (2016)


Article DOI: 10.1016/j.bmc.2016.04.053
BindingDB Entry DOI: 10.7270/Q27P919J
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50168084
PNG
(CHEMBL3798548)
Show SMILES COc1ccc2cc(ccc2c1)-c1cc(nn1C(C)c1ccc(cc1)C(=O)N1CCC(C1)C(O)=O)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C34H29Cl2N3O4/c1-20(21-3-5-22(6-4-21)33(40)38-12-11-26(19-38)34(41)42)39-32(18-31(37-39)27-14-28(35)17-29(36)15-27)25-8-7-24-16-30(43-2)10-9-23(24)13-25/h3-10,13-18,20,26H,11-12,19H2,1-2H3,(H,41,42)
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n/an/a 6.90E+3n/an/an/an/an/an/a



Shanghai Institute of Materia Medica

Curated by ChEMBL


Assay Description
Antagonist activity at wild type human glucagon receptor expressed in HEK293T cells assessed as inhibition of glucagon-induced cAMP accumulation incu...

Bioorg Med Chem 24: 2852-63 (2016)


Article DOI: 10.1016/j.bmc.2016.04.053
BindingDB Entry DOI: 10.7270/Q27P919J
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50168085
PNG
(CHEMBL3799017)
Show SMILES COc1ccc2cc(ccc2c1)-c1cc(nn1C(C)c1ccc(cc1)C(=O)NCC(C)C(O)=O)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C33H29Cl2N3O4/c1-19(33(40)41)18-36-32(39)22-6-4-21(5-7-22)20(2)38-31(17-30(37-38)26-13-27(34)16-28(35)14-26)25-9-8-24-15-29(42-3)11-10-23(24)12-25/h4-17,19-20H,18H2,1-3H3,(H,36,39)(H,40,41)
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n/an/a 8.40E+3n/an/an/an/an/an/a



Shanghai Institute of Materia Medica

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from wild type human glucagon receptor expressed in CHO-K1 cells after 3 hrs by scintillation counting method

Bioorg Med Chem 24: 2852-63 (2016)


Article DOI: 10.1016/j.bmc.2016.04.053
BindingDB Entry DOI: 10.7270/Q27P919J
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50168097
PNG
(CHEMBL3798135)
Show SMILES OC(=O)CCNC(=O)c1ccc2C(CCc2c1)n1nc(cc1-c1ccc(F)cc1)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C28H22Cl2FN3O3/c29-20-12-19(13-21(30)14-20)24-15-26(16-1-5-22(31)6-2-16)34(33-24)25-8-4-17-11-18(3-7-23(17)25)28(37)32-10-9-27(35)36/h1-3,5-7,11-15,25H,4,8-10H2,(H,32,37)(H,35,36)
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n/an/a 8.90E+3n/an/an/an/an/an/a



Shanghai Institute of Materia Medica

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from wild type human glucagon receptor expressed in CHO-K1 cells after 3 hrs by scintillation counting method

Bioorg Med Chem 24: 2852-63 (2016)


Article DOI: 10.1016/j.bmc.2016.04.053
BindingDB Entry DOI: 10.7270/Q27P919J
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50168095
PNG
(CHEMBL3799656)
Show SMILES OC(=O)CCNC(=O)c1ccc2C(CCc2c1)n1nc(cc1-c1ccco1)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C26H21Cl2N3O4/c27-18-11-17(12-19(28)13-18)21-14-23(24-2-1-9-35-24)31(30-21)22-6-4-15-10-16(3-5-20(15)22)26(34)29-8-7-25(32)33/h1-3,5,9-14,22H,4,6-8H2,(H,29,34)(H,32,33)
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n/an/a 1.08E+4n/an/an/an/an/an/a



Shanghai Institute of Materia Medica

Curated by ChEMBL


Assay Description
Antagonist activity at wild type human glucagon receptor expressed in HEK293T cells assessed as inhibition of glucagon-induced cAMP accumulation incu...

Bioorg Med Chem 24: 2852-63 (2016)


Article DOI: 10.1016/j.bmc.2016.04.053
BindingDB Entry DOI: 10.7270/Q27P919J
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50168078
PNG
(CHEMBL3799820)
Show SMILES OC(=O)CCNC(=O)c1ccc2C(CCc2c1)n1nc(cc1-c1ccccc1)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C28H23Cl2N3O3/c29-21-13-20(14-22(30)15-21)24-16-26(17-4-2-1-3-5-17)33(32-24)25-9-7-18-12-19(6-8-23(18)25)28(36)31-11-10-27(34)35/h1-6,8,12-16,25H,7,9-11H2,(H,31,36)(H,34,35)
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n/an/a 1.11E+4n/an/an/an/an/an/a



Shanghai Institute of Materia Medica

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from wild type human glucagon receptor expressed in CHO-K1 cells after 3 hrs by scintillation counting method

Bioorg Med Chem 24: 2852-63 (2016)


Article DOI: 10.1016/j.bmc.2016.04.053
BindingDB Entry DOI: 10.7270/Q27P919J
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50168093
PNG
(CHEMBL3798581)
Show SMILES OC(=O)CCNC(=O)c1ccc2C(CCc2c1)n1nc(cc1-c1ccc(cc1)-c1ccccc1)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C34H27Cl2N3O3/c35-27-17-26(18-28(36)19-27)30-20-32(23-8-6-22(7-9-23)21-4-2-1-3-5-21)39(38-30)31-13-11-24-16-25(10-12-29(24)31)34(42)37-15-14-33(40)41/h1-10,12,16-20,31H,11,13-15H2,(H,37,42)(H,40,41)
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n/an/a 1.27E+4n/an/an/an/an/an/a



Shanghai Institute of Materia Medica

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from wild type human glucagon receptor expressed in CHO-K1 cells after 3 hrs by scintillation counting method

Bioorg Med Chem 24: 2852-63 (2016)


Article DOI: 10.1016/j.bmc.2016.04.053
BindingDB Entry DOI: 10.7270/Q27P919J
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50168088
PNG
(CHEMBL3797325)
Show SMILES CC(CC(O)=O)NC(=O)c1ccc(cc1)C(C)n1nc(cc1-c1ccc2OCCc2c1)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C30H27Cl2N3O4/c1-17(11-29(36)37)33-30(38)20-5-3-19(4-6-20)18(2)35-27(21-7-8-28-22(12-21)9-10-39-28)16-26(34-35)23-13-24(31)15-25(32)14-23/h3-8,12-18H,9-11H2,1-2H3,(H,33,38)(H,36,37)
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n/an/a 1.30E+4n/an/an/an/an/an/a



Shanghai Institute of Materia Medica

Curated by ChEMBL


Assay Description
Antagonist activity at wild type human glucagon receptor expressed in HEK293T cells assessed as inhibition of glucagon-induced cAMP accumulation incu...

Bioorg Med Chem 24: 2852-63 (2016)


Article DOI: 10.1016/j.bmc.2016.04.053
BindingDB Entry DOI: 10.7270/Q27P919J
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50168098
PNG
(CHEMBL3799499)
Show SMILES Cc1ccccc1-c1cc(nn1C1CCc2cc(ccc12)C(=O)NCCC(O)=O)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C29H25Cl2N3O3/c1-17-4-2-3-5-23(17)27-16-25(20-13-21(30)15-22(31)14-20)33-34(27)26-9-7-18-12-19(6-8-24(18)26)29(37)32-11-10-28(35)36/h2-6,8,12-16,26H,7,9-11H2,1H3,(H,32,37)(H,35,36)
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n/an/a 1.45E+4n/an/an/an/an/an/a



Shanghai Institute of Materia Medica

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from wild type human glucagon receptor expressed in CHO-K1 cells after 3 hrs by scintillation counting method

Bioorg Med Chem 24: 2852-63 (2016)


Article DOI: 10.1016/j.bmc.2016.04.053
BindingDB Entry DOI: 10.7270/Q27P919J
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50168094
PNG
(CHEMBL3800146)
Show SMILES OC(=O)CCNC(=O)c1ccc2C(CCc2c1)n1nc(cc1-c1cccs1)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C26H21Cl2N3O3S/c27-18-11-17(12-19(28)13-18)21-14-23(24-2-1-9-35-24)31(30-21)22-6-4-15-10-16(3-5-20(15)22)26(34)29-8-7-25(32)33/h1-3,5,9-14,22H,4,6-8H2,(H,29,34)(H,32,33)
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n/an/a 1.45E+4n/an/an/an/an/an/a



Shanghai Institute of Materia Medica

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from wild type human glucagon receptor expressed in CHO-K1 cells after 3 hrs by scintillation counting method

Bioorg Med Chem 24: 2852-63 (2016)


Article DOI: 10.1016/j.bmc.2016.04.053
BindingDB Entry DOI: 10.7270/Q27P919J
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50168088
PNG
(CHEMBL3797325)
Show SMILES CC(CC(O)=O)NC(=O)c1ccc(cc1)C(C)n1nc(cc1-c1ccc2OCCc2c1)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C30H27Cl2N3O4/c1-17(11-29(36)37)33-30(38)20-5-3-19(4-6-20)18(2)35-27(21-7-8-28-22(12-21)9-10-39-28)16-26(34-35)23-13-24(31)15-25(32)14-23/h3-8,12-18H,9-11H2,1-2H3,(H,33,38)(H,36,37)
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n/an/a 1.81E+4n/an/an/an/an/an/a



Shanghai Institute of Materia Medica

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from wild type human glucagon receptor expressed in CHO-K1 cells after 3 hrs by scintillation counting method

Bioorg Med Chem 24: 2852-63 (2016)


Article DOI: 10.1016/j.bmc.2016.04.053
BindingDB Entry DOI: 10.7270/Q27P919J
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50168087
PNG
(CHEMBL3797757)
Show SMILES COc1ccc2cc(ccc2c1)-c1cc(nn1C(C)c1ccc(cc1)C(=O)NC(C)CC(O)=O)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C33H29Cl2N3O4/c1-19(12-32(39)40)36-33(41)22-6-4-21(5-7-22)20(2)38-31(18-30(37-38)26-14-27(34)17-28(35)15-26)25-9-8-24-16-29(42-3)11-10-23(24)13-25/h4-11,13-20H,12H2,1-3H3,(H,36,41)(H,39,40)
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n/an/a 2.02E+4n/an/an/an/an/an/a



Shanghai Institute of Materia Medica

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from wild type human glucagon receptor expressed in CHO-K1 cells after 3 hrs by scintillation counting method

Bioorg Med Chem 24: 2852-63 (2016)


Article DOI: 10.1016/j.bmc.2016.04.053
BindingDB Entry DOI: 10.7270/Q27P919J
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50168086
PNG
(CHEMBL3798798)
Show SMILES COc1ccc2cc(ccc2c1)-c1cc(nn1C(C)c1ccc(cc1)C(=O)NC(CC(O)=O)c1ccccc1)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C38H31Cl2N3O4/c1-23(24-8-10-26(11-9-24)38(46)41-34(22-37(44)45)25-6-4-3-5-7-25)43-36(21-35(42-43)30-17-31(39)20-32(40)18-30)29-13-12-28-19-33(47-2)15-14-27(28)16-29/h3-21,23,34H,22H2,1-2H3,(H,41,46)(H,44,45)
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n/an/a 2.08E+4n/an/an/an/an/an/a



Shanghai Institute of Materia Medica

Curated by ChEMBL


Assay Description
Antagonist activity at wild type human glucagon receptor expressed in HEK293T cells assessed as inhibition of glucagon-induced cAMP accumulation incu...

Bioorg Med Chem 24: 2852-63 (2016)


Article DOI: 10.1016/j.bmc.2016.04.053
BindingDB Entry DOI: 10.7270/Q27P919J
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50168083
PNG
(CHEMBL3798731)
Show SMILES COc1ccc2cc(ccc2c1)-c1cc(nn1C(C)c1ccc(cc1)C(=O)N1CCCC(C1)C(O)=O)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C35H31Cl2N3O4/c1-21(22-5-7-23(8-6-22)34(41)39-13-3-4-27(20-39)35(42)43)40-33(19-32(38-40)28-15-29(36)18-30(37)16-28)26-10-9-25-17-31(44-2)12-11-24(25)14-26/h5-12,14-19,21,27H,3-4,13,20H2,1-2H3,(H,42,43)
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n/an/a 2.65E+4n/an/an/an/an/an/a



Shanghai Institute of Materia Medica

Curated by ChEMBL


Assay Description
Antagonist activity at wild type human glucagon receptor expressed in HEK293T cells assessed as inhibition of glucagon-induced cAMP accumulation incu...

Bioorg Med Chem 24: 2852-63 (2016)


Article DOI: 10.1016/j.bmc.2016.04.053
BindingDB Entry DOI: 10.7270/Q27P919J
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50168079
PNG
(CHEMBL3798231)
Show SMILES OC(=O)CCNC(=O)c1ccc2C(CCc2c1)n1nc(cc1-c1ccc2OCCOc2c1)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C30H25Cl2N3O5/c31-21-12-20(13-22(32)15-21)24-16-26(18-3-6-27-28(14-18)40-10-9-39-27)35(34-24)25-5-2-17-11-19(1-4-23(17)25)30(38)33-8-7-29(36)37/h1,3-4,6,11-16,25H,2,5,7-10H2,(H,33,38)(H,36,37)
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n/an/a 3.19E+4n/an/an/an/an/an/a



Shanghai Institute of Materia Medica

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from wild type human glucagon receptor expressed in CHO-K1 cells after 3 hrs by scintillation counting method

Bioorg Med Chem 24: 2852-63 (2016)


Article DOI: 10.1016/j.bmc.2016.04.053
BindingDB Entry DOI: 10.7270/Q27P919J
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50168089
PNG
(CHEMBL3798761)
Show SMILES CC(CC(O)=O)NC(=O)c1ccc(cc1)C(C)n1nc(cc1-c1ccc(cc1)C(C)(C)C)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C32H33Cl2N3O3/c1-19(14-30(38)39)35-31(40)23-8-6-21(7-9-23)20(2)37-29(22-10-12-25(13-11-22)32(3,4)5)18-28(36-37)24-15-26(33)17-27(34)16-24/h6-13,15-20H,14H2,1-5H3,(H,35,40)(H,38,39)
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n/an/a 4.10E+4n/an/an/an/an/an/a



Shanghai Institute of Materia Medica

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from wild type human glucagon receptor expressed in CHO-K1 cells after 3 hrs by scintillation counting method

Bioorg Med Chem 24: 2852-63 (2016)


Article DOI: 10.1016/j.bmc.2016.04.053
BindingDB Entry DOI: 10.7270/Q27P919J
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50168082
PNG
(CHEMBL3799556)
Show SMILES COc1ccc2cc(ccc2c1)-c1cc(nn1C(C)c1ccc(cc1)C(=O)N1CCC(CC1)C(O)=O)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C35H31Cl2N3O4/c1-21(22-3-5-23(6-4-22)34(41)39-13-11-24(12-14-39)35(42)43)40-33(20-32(38-40)28-16-29(36)19-30(37)17-28)27-8-7-26-18-31(44-2)10-9-25(26)15-27/h3-10,15-21,24H,11-14H2,1-2H3,(H,42,43)
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n/an/a 4.17E+4n/an/an/an/an/an/a



Shanghai Institute of Materia Medica

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from wild type human glucagon receptor expressed in CHO-K1 cells after 3 hrs by scintillation counting method

Bioorg Med Chem 24: 2852-63 (2016)


Article DOI: 10.1016/j.bmc.2016.04.053
BindingDB Entry DOI: 10.7270/Q27P919J
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50168095
PNG
(CHEMBL3799656)
Show SMILES OC(=O)CCNC(=O)c1ccc2C(CCc2c1)n1nc(cc1-c1ccco1)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C26H21Cl2N3O4/c27-18-11-17(12-19(28)13-18)21-14-23(24-2-1-9-35-24)31(30-21)22-6-4-15-10-16(3-5-20(15)22)26(34)29-8-7-25(32)33/h1-3,5,9-14,22H,4,6-8H2,(H,29,34)(H,32,33)
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n/an/a 7.18E+4n/an/an/an/an/an/a



Shanghai Institute of Materia Medica

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from wild type human glucagon receptor expressed in CHO-K1 cells after 3 hrs by scintillation counting method

Bioorg Med Chem 24: 2852-63 (2016)


Article DOI: 10.1016/j.bmc.2016.04.053
BindingDB Entry DOI: 10.7270/Q27P919J
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50168083
PNG
(CHEMBL3798731)
Show SMILES COc1ccc2cc(ccc2c1)-c1cc(nn1C(C)c1ccc(cc1)C(=O)N1CCCC(C1)C(O)=O)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C35H31Cl2N3O4/c1-21(22-5-7-23(8-6-22)34(41)39-13-3-4-27(20-39)35(42)43)40-33(19-32(38-40)28-15-29(36)18-30(37)16-28)26-10-9-25-17-31(44-2)12-11-24(25)14-26/h5-12,14-19,21,27H,3-4,13,20H2,1-2H3,(H,42,43)
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n/an/a 1.12E+5n/an/an/an/an/an/a



Shanghai Institute of Materia Medica

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from wild type human glucagon receptor expressed in CHO-K1 cells after 3 hrs by scintillation counting method

Bioorg Med Chem 24: 2852-63 (2016)


Article DOI: 10.1016/j.bmc.2016.04.053
BindingDB Entry DOI: 10.7270/Q27P919J
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50168084
PNG
(CHEMBL3798548)
Show SMILES COc1ccc2cc(ccc2c1)-c1cc(nn1C(C)c1ccc(cc1)C(=O)N1CCC(C1)C(O)=O)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C34H29Cl2N3O4/c1-20(21-3-5-22(6-4-21)33(40)38-12-11-26(19-38)34(41)42)39-32(18-31(37-39)27-14-28(35)17-29(36)15-27)25-8-7-24-16-30(43-2)10-9-23(24)13-25/h3-10,13-18,20,26H,11-12,19H2,1-2H3,(H,41,42)
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n/an/a 1.31E+5n/an/an/an/an/an/a



Shanghai Institute of Materia Medica

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from wild type human glucagon receptor expressed in CHO-K1 cells after 3 hrs by scintillation counting method

Bioorg Med Chem 24: 2852-63 (2016)


Article DOI: 10.1016/j.bmc.2016.04.053
BindingDB Entry DOI: 10.7270/Q27P919J
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%