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PubMed code 28792219

Compile data set for download or QSAR
Found 61 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Cannabinoid receptor 1


(Homo sapiens (Human))		BDBM50258769
PNG
(CHEMBL4096928)
Show SMILES Fc1ccc(c(F)c1)-c1cccc(NC(=O)Nc2ccc(Cl)cc2)c1
Show InChI InChI=1S/C19H13ClF2N2O/c20-13-4-7-15(8-5-13)23-19(25)24-16-3-1-2-12(10-16)17-9-6-14(21)11-18(17)22/h1-11H,(H2,23,24,25)
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n/an/a 18n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Allosteric modulation of human CB1 receptor expressed in CHO cells co-expressing Galpha16 assessed as inhibition of CP55,940-induced calcium mobiliza...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))		BDBM50258826
PNG
(CHEMBL4067016)
Show SMILES Clc1ccc(NC(=O)Nc2cccc(c2)-c2cc(Cl)cc(Cl)c2)cc1
Show InChI InChI=1S/C19H13Cl3N2O/c20-14-4-6-17(7-5-14)23-19(25)24-18-3-1-2-12(10-18)13-8-15(21)11-16(22)9-13/h1-11H,(H2,23,24,25)
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n/an/a 22n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Allosteric modulation of human CB1 receptor expressed in CHO cells co-expressing Galpha16 assessed as inhibition of CP55,940-induced calcium mobiliza...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))		BDBM50258768
PNG
(CHEMBL4078901)
Show SMILES Fc1ccc(cc1)-c1cccc(NC(=O)Nc2ccc(Cl)cc2)c1
Show InChI InChI=1S/C19H14ClFN2O/c20-15-6-10-17(11-7-15)22-19(24)23-18-3-1-2-14(12-18)13-4-8-16(21)9-5-13/h1-12H,(H2,22,23,24)
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n/an/a 23n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Allosteric modulation of human CB1 receptor expressed in CHO cells co-expressing Galpha16 assessed as inhibition of CP55,940-induced calcium mobiliza...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))		BDBM50258766
PNG
(CHEMBL4077975)
Show SMILES [O-][N+](=O)c1cccc(c1)-c1cccc(NC(=O)Nc2ccc(Cl)cc2)c1
Show InChI InChI=1S/C19H14ClN3O3/c20-15-7-9-16(10-8-15)21-19(24)22-17-5-1-3-13(11-17)14-4-2-6-18(12-14)23(25)26/h1-12H,(H2,21,22,24)
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n/an/a 27n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Allosteric modulation of human CB1 receptor expressed in CHO cells co-expressing Galpha16 assessed as inhibition of CP55,940-induced calcium mobiliza...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))		BDBM50258767
PNG
(CHEMBL4086756)
Show SMILES Clc1ccc(NC(=O)Nc2cccc(c2)-c2ccc(Cl)c(Cl)c2)cc1
Show InChI InChI=1S/C19H13Cl3N2O/c20-14-5-7-15(8-6-14)23-19(25)24-16-3-1-2-12(10-16)13-4-9-17(21)18(22)11-13/h1-11H,(H2,23,24,25)
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n/an/a 30n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Allosteric modulation of human CB1 receptor expressed in CHO cells co-expressing Galpha16 assessed as inhibition of CP55,940-induced calcium mobiliza...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))		BDBM50258738
PNG
(CHEMBL4070648)
Show SMILES Clc1ccc(NC(=O)Nc2cccc(c2)-c2ccccc2)cc1
Show InChI InChI=1S/C19H15ClN2O/c20-16-9-11-17(12-10-16)21-19(23)22-18-8-4-7-15(13-18)14-5-2-1-3-6-14/h1-13H,(H2,21,22,23)
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n/an/a 32n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Allosteric modulation of human CB1 receptor expressed in CHO cells co-expressing Galpha16 assessed as inhibition of CP55,940-induced calcium mobiliza...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))		BDBM50023629
PNG
(CHEMBL3341861)
Show SMILES Clc1ccc(NC(=O)Nc2cccc(c2)-c2cccc(n2)N2CCCC2)cc1
Show InChI InChI=1S/C22H21ClN4O/c23-17-9-11-18(12-10-17)24-22(28)25-19-6-3-5-16(15-19)20-7-4-8-21(26-20)27-13-1-2-14-27/h3-12,15H,1-2,13-14H2,(H2,24,25,28)
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n/an/a 33n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Allosteric modulation of human CB1 receptor expressed in CHO cells co-expressing Galpha16 assessed as inhibition of CP55,940-induced calcium mobiliza...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50023629
PNG
(CHEMBL3341861)
Show SMILES Clc1ccc(NC(=O)Nc2cccc(c2)-c2cccc(n2)N2CCCC2)cc1
Show InChI InChI=1S/C22H21ClN4O/c23-17-9-11-18(12-10-17)24-22(28)25-19-6-3-5-16(15-19)20-7-4-8-21(26-20)27-13-1-2-14-27/h3-12,15H,1-2,13-14H2,(H2,24,25,28)
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n/an/a 42n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Allosteric modulation of CB1 receptor in rat cerebellar membranes assessed as inhibition of CP55,940-induced [35S]GTPgammaS binding

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))		BDBM50258802
PNG
(CHEMBL4089126)
Show SMILES Clc1ccc(NC(=O)Nc2cccc(c2)-c2ccccn2)cc1
Show InChI InChI=1S/C18H14ClN3O/c19-14-7-9-15(10-8-14)21-18(23)22-16-5-3-4-13(12-16)17-6-1-2-11-20-17/h1-12H,(H2,21,22,23)
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n/an/a 47n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Allosteric modulation of human CB1 receptor expressed in CHO cells co-expressing Galpha16 assessed as inhibition of CP55,940-induced calcium mobiliza...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))		BDBM50023629
PNG
(CHEMBL3341861)
Show SMILES Clc1ccc(NC(=O)Nc2cccc(c2)-c2cccc(n2)N2CCCC2)cc1
Show InChI InChI=1S/C22H21ClN4O/c23-17-9-11-18(12-10-17)24-22(28)25-19-6-3-5-16(15-19)20-7-4-8-21(26-20)27-13-1-2-14-27/h3-12,15H,1-2,13-14H2,(H2,24,25,28)
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n/an/a 50n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Allosteric modulation of CB1 receptor in HEK293 cell membranes assessed as inhibition of CP55,940-induced [35S]GTPgammaS binding

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))		BDBM50258739
PNG
(CHEMBL4064299)
Show SMILES Clc1ccc(NC(=O)Nc2cccc(c2)-c2ccc3OCOc3c2)cc1
Show InChI InChI=1S/C20H15ClN2O3/c21-15-5-7-16(8-6-15)22-20(24)23-17-3-1-2-13(10-17)14-4-9-18-19(11-14)26-12-25-18/h1-11H,12H2,(H2,22,23,24)
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n/an/a 70n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Allosteric modulation of human CB1 receptor expressed in CHO cells co-expressing Galpha16 assessed as inhibition of CP55,940-induced calcium mobiliza...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))		BDBM50258740
PNG
(CHEMBL4085844)
Show SMILES Cc1cccc(c1)-c1cccc(NC(=O)Nc2ccc(Cl)cc2)c1
Show InChI InChI=1S/C20H17ClN2O/c1-14-4-2-5-15(12-14)16-6-3-7-19(13-16)23-20(24)22-18-10-8-17(21)9-11-18/h2-13H,1H3,(H2,22,23,24)
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n/an/a 74n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Allosteric modulation of human CB1 receptor expressed in CHO cells co-expressing Galpha16 assessed as inhibition of CP55,940-induced calcium mobiliza...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))		BDBM50258866
PNG
(CHEMBL4097779)
Show SMILES COc1cccc(c1)-c1cccc(NC(=O)Nc2ccc(Cl)cc2)c1
Show InChI InChI=1S/C20H17ClN2O2/c1-25-19-7-3-5-15(13-19)14-4-2-6-18(12-14)23-20(24)22-17-10-8-16(21)9-11-17/h2-13H,1H3,(H2,22,23,24)
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n/an/a 81n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Allosteric modulation of human CB1 receptor expressed in CHO cells co-expressing Galpha16 assessed as inhibition of CP55,940-induced calcium mobiliza...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(MOUSE)		BDBM50023629
PNG
(CHEMBL3341861)
Show SMILES Clc1ccc(NC(=O)Nc2cccc(c2)-c2cccc(n2)N2CCCC2)cc1
Show InChI InChI=1S/C22H21ClN4O/c23-17-9-11-18(12-10-17)24-22(28)25-19-6-3-5-16(15-19)20-7-4-8-21(26-20)27-13-1-2-14-27/h3-12,15H,1-2,13-14H2,(H2,24,25,28)
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n/an/a 89n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Allosteric modulation of CB1 receptor in CD-1 mouse cerebellar membranes assessed as inhibition of CP55,940-induced [35S]GTPgammaS binding after 60 m...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))		BDBM50258867
PNG
(CHEMBL4094495)
Show SMILES Clc1ccc(NC(=O)Nc2cccc(c2)-c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C19H14Cl2N2O/c20-15-6-4-13(5-7-15)14-2-1-3-18(12-14)23-19(24)22-17-10-8-16(21)9-11-17/h1-12H,(H2,22,23,24)
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n/an/a 95n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Allosteric modulation of human CB1 receptor expressed in CHO cells co-expressing Galpha16 assessed as inhibition of CP55,940-induced calcium mobiliza...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))		BDBM50258772
PNG
(CHEMBL4091847)
Show SMILES Clc1ccc(NC(=O)Nc2cccc(c2)-c2ccc3ccccc3c2)cc1
Show InChI InChI=1S/C23H17ClN2O/c24-20-10-12-21(13-11-20)25-23(27)26-22-7-3-6-18(15-22)19-9-8-16-4-1-2-5-17(16)14-19/h1-15H,(H2,25,26,27)
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n/an/a 132n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Allosteric modulation of human CB1 receptor expressed in CHO cells co-expressing Galpha16 assessed as inhibition of CP55,940-induced calcium mobiliza...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))		BDBM50258726
PNG
(CHEMBL4078811)
Show SMILES COc1cc(ccn1)-c1cccc(NC(=O)Nc2ccc(Cl)cc2)c1
Show InChI InChI=1S/C19H16ClN3O2/c1-25-18-12-14(9-10-21-18)13-3-2-4-17(11-13)23-19(24)22-16-7-5-15(20)6-8-16/h2-12H,1H3,(H2,22,23,24)
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n/an/a 133n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Allosteric modulation of human CB1 receptor expressed in CHO cells co-expressing Galpha16 assessed as inhibition of CP55,940-induced calcium mobiliza...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))		BDBM50258771
PNG
(CHEMBL4062376)
Show SMILES Clc1ccc(NC(=O)Nc2cccc(c2)-c2ccc3occc3c2)cc1
Show InChI InChI=1S/C21H15ClN2O2/c22-17-5-7-18(8-6-17)23-21(25)24-19-3-1-2-14(13-19)15-4-9-20-16(12-15)10-11-26-20/h1-13H,(H2,23,24,25)
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n/an/a 134n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Allosteric modulation of human CB1 receptor expressed in CHO cells co-expressing Galpha16 assessed as inhibition of CP55,940-induced calcium mobiliza...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))		BDBM50258818
PNG
(CHEMBL4064182)
Show SMILES CC(C)Oc1cccc(c1)-c1cccc(NC(=O)Nc2ccc(Cl)cc2)c1
Show InChI InChI=1S/C22H21ClN2O2/c1-15(2)27-21-8-4-6-17(14-21)16-5-3-7-20(13-16)25-22(26)24-19-11-9-18(23)10-12-19/h3-15H,1-2H3,(H2,24,25,26)
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n/an/a 141n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Allosteric modulation of human CB1 receptor expressed in CHO cells co-expressing Galpha16 assessed as inhibition of CP55,940-induced calcium mobiliza...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(MOUSE)		BDBM50258768
PNG
(CHEMBL4078901)
Show SMILES Fc1ccc(cc1)-c1cccc(NC(=O)Nc2ccc(Cl)cc2)c1
Show InChI InChI=1S/C19H14ClFN2O/c20-15-6-10-17(11-7-15)22-19(24)23-18-3-1-2-14(12-18)13-4-8-16(21)9-5-13/h1-12H,(H2,22,23,24)
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n/an/a 151n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Allosteric modulation of CB1 receptor in CD-1 mouse cerebellar membranes assessed as inhibition of CP55,940-induced [35S]GTPgammaS binding after 60 m...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))		BDBM50258727
PNG
(CHEMBL4081259)
Show SMILES Clc1ccc(NC(=O)Nc2cccc(c2)-c2ccncc2)cc1
Show InChI InChI=1S/C18H14ClN3O/c19-15-4-6-16(7-5-15)21-18(23)22-17-3-1-2-14(12-17)13-8-10-20-11-9-13/h1-12H,(H2,21,22,23)
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n/an/a 178n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Allosteric modulation of human CB1 receptor expressed in CHO cells co-expressing Galpha16 assessed as inhibition of CP55,940-induced calcium mobiliza...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))		BDBM50258785
PNG
(CHEMBL4102237)
Show SMILES Cc1ccccc1-c1cccc(NC(=O)Nc2ccc(Cl)cc2)c1
Show InChI InChI=1S/C20H17ClN2O/c1-14-5-2-3-8-19(14)15-6-4-7-18(13-15)23-20(24)22-17-11-9-16(21)10-12-17/h2-13H,1H3,(H2,22,23,24)
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n/an/a 190n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Allosteric modulation of human CB1 receptor expressed in CHO cells co-expressing Galpha16 assessed as inhibition of CP55,940-induced calcium mobiliza...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))		BDBM50258868
PNG
(CHEMBL4073727)
Show SMILES Clc1ccc(NC(=O)Nc2cccc(c2)-c2cccc(c2)-c2ccccc2)cc1
Show InChI InChI=1S/C25H19ClN2O/c26-22-12-14-23(15-13-22)27-25(29)28-24-11-5-10-21(17-24)20-9-4-8-19(16-20)18-6-2-1-3-7-18/h1-17H,(H2,27,28,29)
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n/an/a 195n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Allosteric modulation of human CB1 receptor expressed in CHO cells co-expressing Galpha16 assessed as inhibition of CP55,940-induced calcium mobiliza...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))		BDBM50258786
PNG
(CHEMBL4093478)
Show SMILES COc1cccc(n1)-c1cccc(NC(=O)Nc2ccc(Cl)cc2)c1
Show InChI InChI=1S/C19H16ClN3O2/c1-25-18-7-3-6-17(23-18)13-4-2-5-16(12-13)22-19(24)21-15-10-8-14(20)9-11-15/h2-12H,1H3,(H2,21,22,24)
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n/an/a 231n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Allosteric modulation of human CB1 receptor expressed in CHO cells co-expressing Galpha16 assessed as inhibition of CP55,940-induced calcium mobiliza...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))		BDBM50258865
PNG
(CHEMBL4067924)
Show SMILES Clc1ccc(NC(=O)Nc2cccc(c2)-c2cccnc2)cc1
Show InChI InChI=1S/C18H14ClN3O/c19-15-6-8-16(9-7-15)21-18(23)22-17-5-1-3-13(11-17)14-4-2-10-20-12-14/h1-12H,(H2,21,22,23)
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n/an/a 244n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Allosteric modulation of human CB1 receptor expressed in CHO cells co-expressing Galpha16 assessed as inhibition of CP55,940-induced calcium mobiliza...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(MOUSE)		BDBM50258771
PNG
(CHEMBL4062376)
Show SMILES Clc1ccc(NC(=O)Nc2cccc(c2)-c2ccc3occc3c2)cc1
Show InChI InChI=1S/C21H15ClN2O2/c22-17-5-7-18(8-6-17)23-21(25)24-19-3-1-2-14(13-19)15-4-9-20-16(12-15)10-11-26-20/h1-13H,(H2,23,24,25)
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n/an/a 265n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Allosteric modulation of CB1 receptor in CD-1 mouse cerebellar membranes assessed as inhibition of CP55,940-induced [35S]GTPgammaS binding after 60 m...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))		BDBM50258784
PNG
(CHEMBL4105512)
Show SMILES Clc1ccc(NC(=O)Nc2cccc(c2)-c2cncnc2)cc1
Show InChI InChI=1S/C17H13ClN4O/c18-14-4-6-15(7-5-14)21-17(23)22-16-3-1-2-12(8-16)13-9-19-11-20-10-13/h1-11H,(H2,21,22,23)
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n/an/a 290n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Allosteric modulation of human CB1 receptor expressed in CHO cells co-expressing Galpha16 assessed as inhibition of CP55,940-induced calcium mobiliza...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(MOUSE)		BDBM50258826
PNG
(CHEMBL4067016)
Show SMILES Clc1ccc(NC(=O)Nc2cccc(c2)-c2cc(Cl)cc(Cl)c2)cc1
Show InChI InChI=1S/C19H13Cl3N2O/c20-14-4-6-17(7-5-14)23-19(25)24-18-3-1-2-12(10-18)13-8-15(21)11-16(22)9-13/h1-11H,(H2,23,24,25)
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n/an/a 299n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Allosteric modulation of CB1 receptor in CD-1 mouse cerebellar membranes assessed as inhibition of CP55,940-induced [35S]GTPgammaS binding after 60 m...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))		BDBM50258782
PNG
(CHEMBL4071010)
Show SMILES Clc1ccc(NC(=O)Nc2cccc(c2)-c2ccc3ccccc3n2)cc1
Show InChI InChI=1S/C22H16ClN3O/c23-17-9-11-18(12-10-17)24-22(27)25-19-6-3-5-16(14-19)21-13-8-15-4-1-2-7-20(15)26-21/h1-14H,(H2,24,25,27)
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n/an/a 334n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Allosteric modulation of human CB1 receptor expressed in CHO cells co-expressing Galpha16 assessed as inhibition of CP55,940-induced calcium mobiliza...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))		BDBM50258834
PNG
(CHEMBL4104660)
Show SMILES Clc1ccc(NC(=O)Nc2cccc(c2)-c2c(Cl)cccc2Cl)cc1
Show InChI InChI=1S/C19H13Cl3N2O/c20-13-7-9-14(10-8-13)23-19(25)24-15-4-1-3-12(11-15)18-16(21)5-2-6-17(18)22/h1-11H,(H2,23,24,25)
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n/an/a 338n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Allosteric modulation of human CB1 receptor expressed in CHO cells co-expressing Galpha16 assessed as inhibition of CP55,940-induced calcium mobiliza...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(MOUSE)		BDBM50258769
PNG
(CHEMBL4096928)
Show SMILES Fc1ccc(c(F)c1)-c1cccc(NC(=O)Nc2ccc(Cl)cc2)c1
Show InChI InChI=1S/C19H13ClF2N2O/c20-13-4-7-15(8-5-13)23-19(25)24-16-3-1-2-12(10-16)17-9-6-14(21)11-18(17)22/h1-11H,(H2,23,24,25)
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n/an/a 353n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Allosteric modulation of CB1 receptor in CD-1 mouse cerebellar membranes assessed as inhibition of CP55,940-induced [35S]GTPgammaS binding after 60 m...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(MOUSE)		BDBM50258727
PNG
(CHEMBL4081259)
Show SMILES Clc1ccc(NC(=O)Nc2cccc(c2)-c2ccncc2)cc1
Show InChI InChI=1S/C18H14ClN3O/c19-15-4-6-16(7-5-15)21-18(23)22-17-3-1-2-14(12-17)13-8-10-20-11-9-13/h1-12H,(H2,21,22,23)
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n/an/a 405n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Allosteric modulation of CB1 receptor in CD-1 mouse cerebellar membranes assessed as inhibition of CP55,940-induced [35S]GTPgammaS binding after 60 m...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(MOUSE)		BDBM50258738
PNG
(CHEMBL4070648)
Show SMILES Clc1ccc(NC(=O)Nc2cccc(c2)-c2ccccc2)cc1
Show InChI InChI=1S/C19H15ClN2O/c20-16-9-11-17(12-10-16)21-19(23)22-18-8-4-7-15(13-18)14-5-2-1-3-6-14/h1-13H,(H2,21,22,23)
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n/an/a 439n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Allosteric modulation of CB1 receptor in CD-1 mouse cerebellar membranes assessed as inhibition of CP55,940-induced [35S]GTPgammaS binding after 60 m...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(MOUSE)		BDBM50258766
PNG
(CHEMBL4077975)
Show SMILES [O-][N+](=O)c1cccc(c1)-c1cccc(NC(=O)Nc2ccc(Cl)cc2)c1
Show InChI InChI=1S/C19H14ClN3O3/c20-15-7-9-16(10-8-15)21-19(24)22-17-5-1-3-13(11-17)14-4-2-6-18(12-14)23(25)26/h1-12H,(H2,21,22,24)
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n/an/a 452n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Allosteric modulation of CB1 receptor in CD-1 mouse cerebellar membranes assessed as inhibition of CP55,940-induced [35S]GTPgammaS binding after 60 m...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(MOUSE)		BDBM50258740
PNG
(CHEMBL4085844)
Show SMILES Cc1cccc(c1)-c1cccc(NC(=O)Nc2ccc(Cl)cc2)c1
Show InChI InChI=1S/C20H17ClN2O/c1-14-4-2-5-15(12-14)16-6-3-7-19(13-16)23-20(24)22-18-10-8-17(21)9-11-18/h2-13H,1H3,(H2,22,23,24)
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n/an/a 459n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Allosteric modulation of CB1 receptor in CD-1 mouse cerebellar membranes assessed as inhibition of CP55,940-induced [35S]GTPgammaS binding after 60 m...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))		BDBM50258836
PNG
(CHEMBL4092811)
Show SMILES CC(C)(C)c1cc(cc(c1)C(C)(C)C)-c1cccc(NC(=O)Nc2ccc(Cl)cc2)c1
Show InChI InChI=1S/C27H31ClN2O/c1-26(2,3)20-14-19(15-21(17-20)27(4,5)6)18-8-7-9-24(16-18)30-25(31)29-23-12-10-22(28)11-13-23/h7-17H,1-6H3,(H2,29,30,31)
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n/an/a 460n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Allosteric modulation of human CB1 receptor expressed in CHO cells co-expressing Galpha16 assessed as inhibition of CP55,940-induced calcium mobiliza...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(MOUSE)		BDBM50258767
PNG
(CHEMBL4086756)
Show SMILES Clc1ccc(NC(=O)Nc2cccc(c2)-c2ccc(Cl)c(Cl)c2)cc1
Show InChI InChI=1S/C19H13Cl3N2O/c20-14-5-7-15(8-6-14)23-19(25)24-16-3-1-2-12(10-16)13-4-9-17(21)18(22)11-13/h1-11H,(H2,23,24,25)
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n/an/a 464n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Allosteric modulation of CB1 receptor in CD-1 mouse cerebellar membranes assessed as inhibition of CP55,940-induced [35S]GTPgammaS binding after 60 m...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))		BDBM50258781
PNG
(CHEMBL4099590)
Show SMILES Clc1ccc(NC(=O)Nc2cccc(c2)-c2cnc3ccccc3c2)cc1
Show InChI InChI=1S/C22H16ClN3O/c23-18-8-10-19(11-9-18)25-22(27)26-20-6-3-5-15(13-20)17-12-16-4-1-2-7-21(16)24-14-17/h1-14H,(H2,25,26,27)
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n/an/a 516n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Allosteric modulation of human CB1 receptor expressed in CHO cells co-expressing Galpha16 assessed as inhibition of CP55,940-induced calcium mobiliza...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(MOUSE)		BDBM50258868
PNG
(CHEMBL4073727)
Show SMILES Clc1ccc(NC(=O)Nc2cccc(c2)-c2cccc(c2)-c2ccccc2)cc1
Show InChI InChI=1S/C25H19ClN2O/c26-22-12-14-23(15-13-22)27-25(29)28-24-11-5-10-21(17-24)20-9-4-8-19(16-20)18-6-2-1-3-7-18/h1-17H,(H2,27,28,29)
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n/an/a 559n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Allosteric modulation of CB1 receptor in CD-1 mouse cerebellar membranes assessed as inhibition of CP55,940-induced [35S]GTPgammaS binding after 60 m...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))		BDBM50258835
PNG
(CHEMBL4065139)
Show SMILES CC(C)(C)c1ccc(cc1)-c1cccc(NC(=O)Nc2ccc(Cl)cc2)c1
Show InChI InChI=1S/C23H23ClN2O/c1-23(2,3)18-9-7-16(8-10-18)17-5-4-6-21(15-17)26-22(27)25-20-13-11-19(24)12-14-20/h4-15H,1-3H3,(H2,25,26,27)
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n/an/a 591n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Allosteric modulation of human CB1 receptor expressed in CHO cells co-expressing Galpha16 assessed as inhibition of CP55,940-induced calcium mobiliza...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(MOUSE)		BDBM50258739
PNG
(CHEMBL4064299)
Show SMILES Clc1ccc(NC(=O)Nc2cccc(c2)-c2ccc3OCOc3c2)cc1
Show InChI InChI=1S/C20H15ClN2O3/c21-15-5-7-16(8-6-15)22-20(24)23-17-3-1-2-13(10-17)14-4-9-18-19(11-14)26-12-25-18/h1-11H,12H2,(H2,22,23,24)
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n/an/a 619n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Allosteric modulation of CB1 receptor in CD-1 mouse cerebellar membranes assessed as inhibition of CP55,940-induced [35S]GTPgammaS binding after 60 m...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(MOUSE)		BDBM50258781
PNG
(CHEMBL4099590)
Show SMILES Clc1ccc(NC(=O)Nc2cccc(c2)-c2cnc3ccccc3c2)cc1
Show InChI InChI=1S/C22H16ClN3O/c23-18-8-10-19(11-9-18)25-22(27)26-20-6-3-5-15(13-20)17-12-16-4-1-2-7-21(16)24-14-17/h1-14H,(H2,25,26,27)
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n/an/a 651n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Allosteric modulation of CB1 receptor in CD-1 mouse cerebellar membranes assessed as inhibition of CP55,940-induced [35S]GTPgammaS binding after 60 m...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(MOUSE)		BDBM50258866
PNG
(CHEMBL4097779)
Show SMILES COc1cccc(c1)-c1cccc(NC(=O)Nc2ccc(Cl)cc2)c1
Show InChI InChI=1S/C20H17ClN2O2/c1-25-19-7-3-5-15(13-19)14-4-2-6-18(12-14)23-20(24)22-17-10-8-16(21)9-11-17/h2-13H,1H3,(H2,22,23,24)
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n/an/a 827n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Allosteric modulation of CB1 receptor in CD-1 mouse cerebellar membranes assessed as inhibition of CP55,940-induced [35S]GTPgammaS binding after 60 m...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))		BDBM50258807
PNG
(CHEMBL4085745)
Show SMILES Oc1cccc(c1)-c1cccc(NC(=O)Nc2ccc(Cl)cc2)c1
Show InChI InChI=1S/C19H15ClN2O2/c20-15-7-9-16(10-8-15)21-19(24)22-17-5-1-3-13(11-17)14-4-2-6-18(23)12-14/h1-12,23H,(H2,21,22,24)
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n/an/a 840n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Allosteric modulation of human CB1 receptor expressed in CHO cells co-expressing Galpha16 assessed as inhibition of CP55,940-induced calcium mobiliza...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))		BDBM50258783
PNG
(CHEMBL4081586)
Show SMILES Clc1ccc(NC(=O)Nc2cccc(c2)-c2ccc-3c(Cc4ccccc-34)c2)cc1
Show InChI InChI=1S/C26H19ClN2O/c27-21-9-11-22(12-10-21)28-26(30)29-23-6-3-5-17(16-23)18-8-13-25-20(14-18)15-19-4-1-2-7-24(19)25/h1-14,16H,15H2,(H2,28,29,30)
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n/an/a 1.26E+3n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Allosteric modulation of human CB1 receptor expressed in CHO cells co-expressing Galpha16 assessed as inhibition of CP55,940-induced calcium mobiliza...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))		BDBM50258864
PNG
(CHEMBL4096828)
Show SMILES Cc1ccnc(c1)-c1cccc(NC(=O)Nc2ccc(Cl)cc2)c1
Show InChI InChI=1S/C19H16ClN3O/c1-13-9-10-21-18(11-13)14-3-2-4-17(12-14)23-19(24)22-16-7-5-15(20)6-8-16/h2-12H,1H3,(H2,22,23,24)
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n/an/a 1.31E+3n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Allosteric modulation of human CB1 receptor expressed in CHO cells co-expressing Galpha16 assessed as inhibition of CP55,940-induced calcium mobiliza...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(MOUSE)		BDBM50258726
PNG
(CHEMBL4078811)
Show SMILES COc1cc(ccn1)-c1cccc(NC(=O)Nc2ccc(Cl)cc2)c1
Show InChI InChI=1S/C19H16ClN3O2/c1-25-18-12-14(9-10-21-18)13-3-2-4-17(11-13)23-19(24)22-16-7-5-15(20)6-8-16/h2-12H,1H3,(H2,22,23,24)
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n/an/a 1.32E+3n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Allosteric modulation of CB1 receptor in CD-1 mouse cerebellar membranes assessed as inhibition of CP55,940-induced [35S]GTPgammaS binding after 60 m...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))		BDBM50258770
PNG
(CHEMBL4100542)
Show SMILES Clc1ccc(NC(=O)Nc2cccc(c2)-c2ccc(cc2)-c2ccccc2)cc1
Show InChI InChI=1S/C25H19ClN2O/c26-22-13-15-23(16-14-22)27-25(29)28-24-8-4-7-21(17-24)20-11-9-19(10-12-20)18-5-2-1-3-6-18/h1-17H,(H2,27,28,29)
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n/an/a 1.34E+3n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Allosteric modulation of human CB1 receptor expressed in CHO cells co-expressing Galpha16 assessed as inhibition of CP55,940-induced calcium mobiliza...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(MOUSE)		BDBM50258772
PNG
(CHEMBL4091847)
Show SMILES Clc1ccc(NC(=O)Nc2cccc(c2)-c2ccc3ccccc3c2)cc1
Show InChI InChI=1S/C23H17ClN2O/c24-20-10-12-21(13-11-20)25-23(27)26-22-7-3-6-18(15-22)19-9-8-16-4-1-2-5-17(16)14-19/h1-15H,(H2,25,26,27)
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n/an/a 1.52E+3n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Allosteric modulation of CB1 receptor in CD-1 mouse cerebellar membranes assessed as inhibition of CP55,940-induced [35S]GTPgammaS binding after 60 m...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))		BDBM50258863
PNG
(CHEMBL4084091)
Show SMILES Clc1ccc(NC(=O)Nc2cccc(c2)-c2ccc(cc2)C(=O)c2ccccc2)cc1
Show InChI InChI=1S/C26H19ClN2O2/c27-22-13-15-23(16-14-22)28-26(31)29-24-8-4-7-21(17-24)18-9-11-20(12-10-18)25(30)19-5-2-1-3-6-19/h1-17H,(H2,28,29,31)
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n/an/a 1.57E+3n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Allosteric modulation of human CB1 receptor expressed in CHO cells co-expressing Galpha16 assessed as inhibition of CP55,940-induced calcium mobiliza...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(MOUSE)		BDBM50258782
PNG
(CHEMBL4071010)
Show SMILES Clc1ccc(NC(=O)Nc2cccc(c2)-c2ccc3ccccc3n2)cc1
Show InChI InChI=1S/C22H16ClN3O/c23-17-9-11-18(12-10-17)24-22(27)25-19-6-3-5-16(14-19)21-13-8-15-4-1-2-7-20(15)26-21/h1-14H,(H2,24,25,27)
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n/an/a 1.89E+3n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Allosteric modulation of CB1 receptor in CD-1 mouse cerebellar membranes assessed as inhibition of CP55,940-induced [35S]GTPgammaS binding after 60 m...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(MOUSE)		BDBM50258802
PNG
(CHEMBL4089126)
Show SMILES Clc1ccc(NC(=O)Nc2cccc(c2)-c2ccccn2)cc1
Show InChI InChI=1S/C18H14ClN3O/c19-14-7-9-15(10-8-14)21-18(23)22-16-5-3-4-13(12-16)17-6-1-2-11-20-17/h1-12H,(H2,21,22,23)
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n/an/a 2.65E+3n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Allosteric modulation of CB1 receptor in CD-1 mouse cerebellar membranes assessed as inhibition of CP55,940-induced [35S]GTPgammaS binding after 60 m...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM50258784
PNG
(CHEMBL4105512)
Show SMILES Clc1ccc(NC(=O)Nc2cccc(c2)-c2cncnc2)cc1
Show InChI InChI=1S/C17H13ClN4O/c18-14-4-6-15(7-5-14)21-17(23)22-16-3-1-2-12(8-16)13-9-19-11-20-10-13/h1-11H,(H2,21,22,23)
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n/an/a 3.40E+3n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Antagonist activity at human CB2 receptor expressed in CHO cells co-expressing Galpha16 assessed as inhibition of CP55,940-induced calcium mobilizati...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM50258781
PNG
(CHEMBL4099590)
Show SMILES Clc1ccc(NC(=O)Nc2cccc(c2)-c2cnc3ccccc3c2)cc1
Show InChI InChI=1S/C22H16ClN3O/c23-18-8-10-19(11-9-18)25-22(27)26-20-6-3-5-15(13-20)17-12-16-4-1-2-7-21(16)24-14-17/h1-14H,(H2,25,26,27)
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n/an/a 4.10E+3n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Antagonist activity at human CB2 receptor expressed in CHO cells co-expressing Galpha16 assessed as inhibition of CP55,940-induced calcium mobilizati...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM50258785
PNG
(CHEMBL4102237)
Show SMILES Cc1ccccc1-c1cccc(NC(=O)Nc2ccc(Cl)cc2)c1
Show InChI InChI=1S/C20H17ClN2O/c1-14-5-2-3-8-19(14)15-6-4-7-18(13-15)23-20(24)22-17-11-9-16(21)10-12-17/h2-13H,1H3,(H2,22,23,24)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Antagonist activity at human CB2 receptor expressed in CHO cells co-expressing Galpha16 assessed as inhibition of CP55,940-induced calcium mobilizati...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM50023629
PNG
(CHEMBL3341861)
Show SMILES Clc1ccc(NC(=O)Nc2cccc(c2)-c2cccc(n2)N2CCCC2)cc1
Show InChI InChI=1S/C22H21ClN4O/c23-17-9-11-18(12-10-17)24-22(28)25-19-6-3-5-16(15-19)20-7-4-8-21(26-20)27-13-1-2-14-27/h3-12,15H,1-2,13-14H2,(H2,24,25,28)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Antagonist activity at human CB2 receptor expressed in CHO cells co-expressing Galpha16 assessed as inhibition of CP55,940-induced calcium mobilizati...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM50258767
PNG
(CHEMBL4086756)
Show SMILES Clc1ccc(NC(=O)Nc2cccc(c2)-c2ccc(Cl)c(Cl)c2)cc1
Show InChI InChI=1S/C19H13Cl3N2O/c20-14-5-7-15(8-6-14)23-19(25)24-16-3-1-2-12(10-16)13-4-9-17(21)18(22)11-13/h1-11H,(H2,23,24,25)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Antagonist activity at human CB2 receptor expressed in CHO cells co-expressing Galpha16 assessed as inhibition of CP55,940-induced calcium mobilizati...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM50258766
PNG
(CHEMBL4077975)
Show SMILES [O-][N+](=O)c1cccc(c1)-c1cccc(NC(=O)Nc2ccc(Cl)cc2)c1
Show InChI InChI=1S/C19H14ClN3O3/c20-15-7-9-16(10-8-15)21-19(24)22-17-5-1-3-13(11-17)14-4-2-6-18(12-14)23(25)26/h1-12H,(H2,21,22,24)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Antagonist activity at human CB2 receptor expressed in CHO cells co-expressing Galpha16 assessed as inhibition of CP55,940-induced calcium mobilizati...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(MOUSE)		BDBM50258770
PNG
(CHEMBL4100542)
Show SMILES Clc1ccc(NC(=O)Nc2cccc(c2)-c2ccc(cc2)-c2ccccc2)cc1
Show InChI InChI=1S/C25H19ClN2O/c26-22-13-15-23(16-14-22)27-25(29)28-24-8-4-7-21(17-24)20-11-9-19(10-12-20)18-5-2-1-3-6-18/h1-17H,(H2,27,28,29)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Allosteric modulation of CB1 receptor in CD-1 mouse cerebellar membranes assessed as inhibition of CP55,940-induced [35S]GTPgammaS binding after 60 m...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM50258768
PNG
(CHEMBL4078901)
Show SMILES Fc1ccc(cc1)-c1cccc(NC(=O)Nc2ccc(Cl)cc2)c1
Show InChI InChI=1S/C19H14ClFN2O/c20-15-6-10-17(11-7-15)22-19(24)23-18-3-1-2-14(12-18)13-4-8-16(21)9-5-13/h1-12H,(H2,22,23,24)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
Antagonist activity at human CB2 receptor expressed in CHO cells co-expressing Galpha16 assessed as inhibition of CP55,940-induced calcium mobilizati...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(MOUSE)		BDBM50258768
PNG
(CHEMBL4078901)
Show SMILES Fc1ccc(cc1)-c1cccc(NC(=O)Nc2ccc(Cl)cc2)c1
Show InChI InChI=1S/C19H14ClFN2O/c20-15-6-10-17(11-7-15)22-19(24)23-18-3-1-2-14(12-18)13-4-8-16(21)9-5-13/h1-12H,(H2,22,23,24)
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Article
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n/an/an/an/a 790n/an/an/an/a



Research Triangle Institute , Research Triangle Park, North Carolina 27709, United States.

Curated by ChEMBL


Assay Description
PAM antagonist activity at CB1 receptor in CD-1 mouse cerebellar membranes assessed as increase in [3H]CP55,940 binding after 90 mins relative to con...

J Med Chem 60: 7410-7424 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00707
BindingDB Entry DOI: 10.7270/Q2XK8J0H
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%