Affinity Data by PubMed id=29271657

PubMed code 29271657

Found 7 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Beta-lactamase TEM (Escherichia coli)	BDBM50247467 (CHEMBL4083640) Show SMILES OC(=O)c1ccc(cc1CS)-c1cccc(Cl)c1Cl Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Leeds Curated by ChEMBL					Assay Description Inhibition of recombinant N-terminal His-tagged bacterial Escherichia coli TEM-1 (24 to 286 residues) expressed in Escherichia coli BL21 (DE3) cells ...				J Med Chem 61: 1255-1260 (2018) Article DOI: 10.1021/acs.jmedchem.7b01728 BindingDB Entry DOI: 10.7270/Q2GQ716Z
University of Leeds Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-lactamase TEM (Escherichia coli)	BDBM50247459 (CHEMBL4065946) Show SMILES OC(=O)c1ccc(cc1CS)-c1ccc(F)cc1 Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.28E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Leeds Curated by ChEMBL					Assay Description Inhibition of recombinant N-terminal His-tagged bacterial Escherichia coli TEM-1 (24 to 286 residues) expressed in Escherichia coli BL21 (DE3) cells ...				J Med Chem 61: 1255-1260 (2018) Article DOI: 10.1021/acs.jmedchem.7b01728 BindingDB Entry DOI: 10.7270/Q2GQ716Z
University of Leeds Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-lactamase OXA-10 (Pseudomonas aeruginosa)	BDBM50247467 (CHEMBL4083640) Show SMILES OC(=O)c1ccc(cc1CS)-c1cccc(Cl)c1Cl Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.73E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Leeds Curated by ChEMBL					Assay Description Inhibition of recombinant Pseudomonas aeruginosa OXA-10 expressed in Escherichia coli BL21 (DE3) cells using FC5 as substrate preincubated up to 360 ...				J Med Chem 61: 1255-1260 (2018) Article DOI: 10.1021/acs.jmedchem.7b01728 BindingDB Entry DOI: 10.7270/Q2GQ716Z
University of Leeds Curated by ChEMBL					More data for this Ligand-Target Pair
5' exonuclease Apollo (Homo sapiens)	BDBM50247468 (CHEMBL4076158) Show SMILES OC(=O)c1ccc(cc1CS)-c1ccccc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.49E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Leeds Curated by ChEMBL					Assay Description Inhibition of human DCLRE1B				J Med Chem 61: 1255-1260 (2018) Article DOI: 10.1021/acs.jmedchem.7b01728 BindingDB Entry DOI: 10.7270/Q2GQ716Z
University of Leeds Curated by ChEMBL					More data for this Ligand-Target Pair
5' exonuclease Apollo (Homo sapiens)	BDBM50247470 (CHEMBL4088063) Show SMILES OC(=O)c1ccc(cc1CS)-c1cccc(F)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.85E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Leeds Curated by ChEMBL					Assay Description Inhibition of human DCLRE1B				J Med Chem 61: 1255-1260 (2018) Article DOI: 10.1021/acs.jmedchem.7b01728 BindingDB Entry DOI: 10.7270/Q2GQ716Z
University of Leeds Curated by ChEMBL					More data for this Ligand-Target Pair
DNA cross-link repair 1A protein (Homo sapiens)	BDBM50247468 (CHEMBL4076158) Show SMILES OC(=O)c1ccc(cc1CS)-c1ccccc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.47E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Leeds Curated by ChEMBL					Assay Description Inhibition of human DCLRE1A				J Med Chem 61: 1255-1260 (2018) Article DOI: 10.1021/acs.jmedchem.7b01728 BindingDB Entry DOI: 10.7270/Q2GQ716Z
University of Leeds Curated by ChEMBL					More data for this Ligand-Target Pair
5' exonuclease Apollo (Homo sapiens)	BDBM50247469 (CHEMBL4092378) Show SMILES OC(=O)c1ccc(cc1CS)-c1cccc(Cl)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.68E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Leeds Curated by ChEMBL					Assay Description Inhibition of human DCLRE1B				J Med Chem 61: 1255-1260 (2018) Article DOI: 10.1021/acs.jmedchem.7b01728 BindingDB Entry DOI: 10.7270/Q2GQ716Z
University of Leeds Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%