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PubMed code 32305182

Compile data set for download or QSAR
Found 48 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))		BDBM50026612
PNG
(BIBF-1120 | Nintedanib | US10981896, Compound Nint...)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,38)/b29-28-
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n/an/a 3.80n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-fused human PDGFRbeta cytoplasmic domain (557 to 1106 (end) residues) expressed in baculovirus expression system using F...

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2020.115486
BindingDB Entry DOI: 10.7270/Q21N84QK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50026612
PNG
(BIBF-1120 | Nintedanib | US10981896, Compound Nint...)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,38)/b29-28-
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n/an/a 4.70n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST fused human VEGFR2 cytoplasmic domain (790 to 1356 (end) residues) expressed in baculovirus expression system using FAM-...

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2020.115486
BindingDB Entry DOI: 10.7270/Q21N84QK
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50543578
PNG
(CHEMBL4644718)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)-n3c(C)ccc3CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C34H35N5O3/c1-23-9-13-28(22-38-19-17-37(2)18-20-38)39(23)27-14-11-26(12-15-27)35-32(24-7-5-4-6-8-24)31-29-16-10-25(34(41)42-3)21-30(29)36-33(31)40/h4-16,21,35H,17-20,22H2,1-3H3,(H,36,40)/b32-31-
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n/an/a 6.5n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST fused human VEGFR2 cytoplasmic domain (790 to 1356 (end) residues) expressed in baculovirus expression system using FAM-...

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2020.115486
BindingDB Entry DOI: 10.7270/Q21N84QK
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))		BDBM50543578
PNG
(CHEMBL4644718)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)-n3c(C)ccc3CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C34H35N5O3/c1-23-9-13-28(22-38-19-17-37(2)18-20-38)39(23)27-14-11-26(12-15-27)35-32(24-7-5-4-6-8-24)31-29-16-10-25(34(41)42-3)21-30(29)36-33(31)40/h4-16,21,35H,17-20,22H2,1-3H3,(H,36,40)/b32-31-
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n/an/a 9.90n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-fused human PDGFRbeta cytoplasmic domain (557 to 1106 (end) residues) expressed in baculovirus expression system using F...

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2020.115486
BindingDB Entry DOI: 10.7270/Q21N84QK
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))		BDBM50230972
PNG
(CHEMBL4069394)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)-n3cccc3CN(C)C)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C30H28N4O3/c1-33(2)19-24-10-7-17-34(24)23-14-12-22(13-15-23)31-28(20-8-5-4-6-9-20)27-25-16-11-21(30(36)37-3)18-26(25)32-29(27)35/h4-18,31H,19H2,1-3H3,(H,32,35)/b28-27-
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n/an/a 11n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-fused human PDGFRbeta cytoplasmic domain (557 to 1106 (end) residues) expressed in baculovirus expression system using F...

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2020.115486
BindingDB Entry DOI: 10.7270/Q21N84QK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50543583
PNG
(CHEMBL4639712)
Show SMILES CN1CCN(Cc2ccc(C)n2-c2ccc(N\C(=C3/C(=O)Nc4cc(ccc34)C(O)=O)c3ccccc3)cc2)CC1
Show InChI InChI=1S/C33H33N5O3/c1-22-8-12-27(21-37-18-16-36(2)17-19-37)38(22)26-13-10-25(11-14-26)34-31(23-6-4-3-5-7-23)30-28-15-9-24(33(40)41)20-29(28)35-32(30)39/h3-15,20,34H,16-19,21H2,1-2H3,(H,35,39)(H,40,41)/b31-30-
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n/an/a 14n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST fused human VEGFR2 cytoplasmic domain (790 to 1356 (end) residues) expressed in baculovirus expression system using FAM-...

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2020.115486
BindingDB Entry DOI: 10.7270/Q21N84QK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lyn


(Homo sapiens (Human))		BDBM50543578
PNG
(CHEMBL4644718)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)-n3c(C)ccc3CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C34H35N5O3/c1-23-9-13-28(22-38-19-17-37(2)18-20-38)39(23)27-14-11-26(12-15-27)35-32(24-7-5-4-6-8-24)31-29-16-10-25(34(41)42-3)21-30(29)36-33(31)40/h4-16,21,35H,17-20,22H2,1-3H3,(H,36,40)/b32-31-
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n/an/a 16n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of LYN (unknown origin) using FAM-labeled peptide and ATP as substrate preincubated for 10 mins followed by substrate addition measured af...

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2020.115486
BindingDB Entry DOI: 10.7270/Q21N84QK
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM50026612
PNG
(BIBF-1120 | Nintedanib | US10981896, Compound Nint...)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,38)/b29-28-
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n/an/a 16n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of SRC (unknown origin) using FAM-labeled peptide and ATP as substrate preincubated for 10 mins followed by substrate addition measured af...

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2020.115486
BindingDB Entry DOI: 10.7270/Q21N84QK
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM50543578
PNG
(CHEMBL4644718)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)-n3c(C)ccc3CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C34H35N5O3/c1-23-9-13-28(22-38-19-17-37(2)18-20-38)39(23)27-14-11-26(12-15-27)35-32(24-7-5-4-6-8-24)31-29-16-10-25(34(41)42-3)21-30(29)36-33(31)40/h4-16,21,35H,17-20,22H2,1-3H3,(H,36,40)/b32-31-
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n/an/a 17n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of c-Kit (unknown origin) using FAM-labeled peptide and ATP as substrate preincubated for 10 mins followed by substrate addition measured ...

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2020.115486
BindingDB Entry DOI: 10.7270/Q21N84QK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))		BDBM50026612
PNG
(BIBF-1120 | Nintedanib | US10981896, Compound Nint...)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,38)/b29-28-
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n/an/a 23n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human recombinant VEGFR1 cytoplasmic domain (781 to 1338 residues) expressed in baculovirus expression system using FAM-labe...

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2020.115486
BindingDB Entry DOI: 10.7270/Q21N84QK
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM50543578
PNG
(CHEMBL4644718)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)-n3c(C)ccc3CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C34H35N5O3/c1-23-9-13-28(22-38-19-17-37(2)18-20-38)39(23)27-14-11-26(12-15-27)35-32(24-7-5-4-6-8-24)31-29-16-10-25(34(41)42-3)21-30(29)36-33(31)40/h4-16,21,35H,17-20,22H2,1-3H3,(H,36,40)/b32-31-
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n/an/a 23n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST fused human recombinant FGFR1 cytoplasmic domain (398 to 822 (end) residues) expressed in baculovirus expression system ...

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2020.115486
BindingDB Entry DOI: 10.7270/Q21N84QK
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))		BDBM50543579
PNG
(CHEMBL4634687)
Show SMILES CCN(CC)Cc1ccc(C)n1-c1ccc(N\C(=C2/C(=O)Nc3cc(ccc23)C(=O)OC)c2ccccc2)cc1
Show InChI InChI=1S/C33H34N4O3/c1-5-36(6-2)21-27-16-12-22(3)37(27)26-17-14-25(15-18-26)34-31(23-10-8-7-9-11-23)30-28-19-13-24(33(39)40-4)20-29(28)35-32(30)38/h7-20,34H,5-6,21H2,1-4H3,(H,35,38)/b31-30-
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n/an/a 24n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-fused human PDGFRbeta cytoplasmic domain (557 to 1106 (end) residues) expressed in baculovirus expression system using F...

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2020.115486
BindingDB Entry DOI: 10.7270/Q21N84QK
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))		BDBM50543573
PNG
(CHEMBL4647154)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(nc3)-n3cccc3CN(C)C)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C29H27N5O3/c1-33(2)18-22-10-7-15-34(22)25-14-12-21(17-30-25)31-27(19-8-5-4-6-9-19)26-23-13-11-20(29(36)37-3)16-24(23)32-28(26)35/h4-17,31H,18H2,1-3H3,(H,32,35)/b27-26-
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n/an/a 26n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-fused human PDGFRbeta cytoplasmic domain (557 to 1106 (end) residues) expressed in baculovirus expression system using F...

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2020.115486
BindingDB Entry DOI: 10.7270/Q21N84QK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))		BDBM50543578
PNG
(CHEMBL4644718)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)-n3c(C)ccc3CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C34H35N5O3/c1-23-9-13-28(22-38-19-17-37(2)18-20-38)39(23)27-14-11-26(12-15-27)35-32(24-7-5-4-6-8-24)31-29-16-10-25(34(41)42-3)21-30(29)36-33(31)40/h4-16,21,35H,17-20,22H2,1-3H3,(H,36,40)/b32-31-
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n/an/a 31n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human recombinant VEGFR1 cytoplasmic domain (781 to 1338 residues) expressed in baculovirus expression system using FAM-labe...

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2020.115486
BindingDB Entry DOI: 10.7270/Q21N84QK
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))		BDBM50543571
PNG
(CHEMBL4642920)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(c(C)c3)-n3cccc3CN(C)C)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C31H30N4O3/c1-20-17-23(13-15-27(20)35-16-8-11-24(35)19-34(2)3)32-29(21-9-6-5-7-10-21)28-25-14-12-22(31(37)38-4)18-26(25)33-30(28)36/h5-18,32H,19H2,1-4H3,(H,33,36)/b29-28-
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n/an/a 31n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-fused human PDGFRbeta cytoplasmic domain (557 to 1106 (end) residues) expressed in baculovirus expression system using F...

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2020.115486
BindingDB Entry DOI: 10.7270/Q21N84QK
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))		BDBM50543581
PNG
(CHEMBL4638817)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(nc3)-n3c(C)ccc3CN(C)C)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C30H29N5O3/c1-19-10-13-23(18-34(2)3)35(19)26-15-12-22(17-31-26)32-28(20-8-6-5-7-9-20)27-24-14-11-21(30(37)38-4)16-25(24)33-29(27)36/h5-17,32H,18H2,1-4H3,(H,33,36)/b28-27-
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n/an/a 32n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-fused human PDGFRbeta cytoplasmic domain (557 to 1106 (end) residues) expressed in baculovirus expression system using F...

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2020.115486
BindingDB Entry DOI: 10.7270/Q21N84QK
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))		BDBM50543580
PNG
(CHEMBL4649259)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)-n3c(C)ccc3CN3CCOCC3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C33H32N4O4/c1-22-8-12-27(21-36-16-18-41-19-17-36)37(22)26-13-10-25(11-14-26)34-31(23-6-4-3-5-7-23)30-28-15-9-24(33(39)40-2)20-29(28)35-32(30)38/h3-15,20,34H,16-19,21H2,1-2H3,(H,35,38)/b31-30-
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Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-fused human PDGFRbeta cytoplasmic domain (557 to 1106 (end) residues) expressed in baculovirus expression system using F...

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2020.115486
BindingDB Entry DOI: 10.7270/Q21N84QK
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))		BDBM50543577
PNG
(CHEMBL4640617)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)-n3c(C)ccc3CN(C)C)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C31H30N4O3/c1-20-10-14-25(19-34(2)3)35(20)24-15-12-23(13-16-24)32-29(21-8-6-5-7-9-21)28-26-17-11-22(31(37)38-4)18-27(26)33-30(28)36/h5-18,32H,19H2,1-4H3,(H,33,36)/b29-28-
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Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-fused human PDGFRbeta cytoplasmic domain (557 to 1106 (end) residues) expressed in baculovirus expression system using F...

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2020.115486
BindingDB Entry DOI: 10.7270/Q21N84QK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lyn


(Homo sapiens (Human))		BDBM50026612
PNG
(BIBF-1120 | Nintedanib | US10981896, Compound Nint...)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,38)/b29-28-
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n/an/a 55n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of LYN (unknown origin) using FAM-labeled peptide and ATP as substrate preincubated for 10 mins followed by substrate addition measured af...

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2020.115486
BindingDB Entry DOI: 10.7270/Q21N84QK
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))		BDBM50230976
PNG
(CHEMBL4079087)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)-n3cccc3CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C33H33N5O3/c1-36-17-19-37(20-18-36)22-27-9-6-16-38(27)26-13-11-25(12-14-26)34-31(23-7-4-3-5-8-23)30-28-15-10-24(33(40)41-2)21-29(28)35-32(30)39/h3-16,21,34H,17-20,22H2,1-2H3,(H,35,39)/b31-30-
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n/an/a 55n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-fused human PDGFRbeta cytoplasmic domain (557 to 1106 (end) residues) expressed in baculovirus expression system using F...

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2020.115486
BindingDB Entry DOI: 10.7270/Q21N84QK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50230976
PNG
(CHEMBL4079087)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)-n3cccc3CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C33H33N5O3/c1-36-17-19-37(20-18-36)22-27-9-6-16-38(27)26-13-11-25(12-14-26)34-31(23-7-4-3-5-8-23)30-28-15-10-24(33(40)41-2)21-29(28)35-32(30)39/h3-16,21,34H,17-20,22H2,1-2H3,(H,35,39)/b31-30-
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n/an/a 58n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST fused human VEGFR2 cytoplasmic domain (790 to 1356 (end) residues) expressed in baculovirus expression system using FAM-...

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2020.115486
BindingDB Entry DOI: 10.7270/Q21N84QK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50543585
PNG
(CHEMBL4643300)
Show SMILES CN(C)C(=O)c1ccc2\C(=C(\Nc3ccc(cc3)-n3c(C)ccc3CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C35H38N6O2/c1-24-10-14-29(23-40-20-18-39(4)19-21-40)41(24)28-15-12-27(13-16-28)36-33(25-8-6-5-7-9-25)32-30-17-11-26(35(43)38(2)3)22-31(30)37-34(32)42/h5-17,22,36H,18-21,23H2,1-4H3,(H,37,42)/b33-32-
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n/an/a 65n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST fused human VEGFR2 cytoplasmic domain (790 to 1356 (end) residues) expressed in baculovirus expression system using FAM-...

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2020.115486
BindingDB Entry DOI: 10.7270/Q21N84QK
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))		BDBM50543575
PNG
(CHEMBL4647153)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3cnc(c(C)c3)-n3cccc3CN(C)C)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C30H29N5O3/c1-19-15-22(17-31-28(19)35-14-8-11-23(35)18-34(2)3)32-27(20-9-6-5-7-10-20)26-24-13-12-21(30(37)38-4)16-25(24)33-29(26)36/h5-17,32H,18H2,1-4H3,(H,33,36)/b27-26-
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n/an/a 71n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-fused human PDGFRbeta cytoplasmic domain (557 to 1106 (end) residues) expressed in baculovirus expression system using F...

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2020.115486
BindingDB Entry DOI: 10.7270/Q21N84QK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50230972
PNG
(CHEMBL4069394)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)-n3cccc3CN(C)C)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C30H28N4O3/c1-33(2)19-24-10-7-17-34(24)23-14-12-22(13-15-23)31-28(20-8-5-4-6-9-20)27-25-16-11-21(30(36)37-3)18-26(25)32-29(27)35/h4-18,31H,19H2,1-3H3,(H,32,35)/b28-27-
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n/an/a 82n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST fused human VEGFR2 cytoplasmic domain (790 to 1356 (end) residues) expressed in baculovirus expression system using FAM-...

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2020.115486
BindingDB Entry DOI: 10.7270/Q21N84QK
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))		BDBM50026612
PNG
(BIBF-1120 | Nintedanib | US10981896, Compound Nint...)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,38)/b29-28-
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n/an/a 99n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST fused human recombinant FGFR1 cytoplasmic domain (398 to 822 (end) residues) expressed in baculovirus expression system ...

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2020.115486
BindingDB Entry DOI: 10.7270/Q21N84QK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50543579
PNG
(CHEMBL4634687)
Show SMILES CCN(CC)Cc1ccc(C)n1-c1ccc(N\C(=C2/C(=O)Nc3cc(ccc23)C(=O)OC)c2ccccc2)cc1
Show InChI InChI=1S/C33H34N4O3/c1-5-36(6-2)21-27-16-12-22(3)37(27)26-17-14-25(15-18-26)34-31(23-10-8-7-9-11-23)30-28-19-13-24(33(39)40-4)20-29(28)35-32(30)38/h7-20,34H,5-6,21H2,1-4H3,(H,35,38)/b31-30-
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n/an/a 101n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST fused human VEGFR2 cytoplasmic domain (790 to 1356 (end) residues) expressed in baculovirus expression system using FAM-...

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2020.115486
BindingDB Entry DOI: 10.7270/Q21N84QK
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))		BDBM50543574
PNG
(CHEMBL4639539)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(nc3)-n3cccc3CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C32H32N6O3/c1-36-15-17-37(18-16-36)21-25-9-6-14-38(25)28-13-11-24(20-33-28)34-30(22-7-4-3-5-8-22)29-26-12-10-23(32(40)41-2)19-27(26)35-31(29)39/h3-14,19-20,34H,15-18,21H2,1-2H3,(H,35,39)/b30-29-
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n/an/a 114n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-fused human PDGFRbeta cytoplasmic domain (557 to 1106 (end) residues) expressed in baculovirus expression system using F...

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2020.115486
BindingDB Entry DOI: 10.7270/Q21N84QK
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))		BDBM50543582
PNG
(CHEMBL4640302)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(nc3)-n3c(C)ccc3CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C33H34N6O3/c1-22-9-12-26(21-38-17-15-37(2)16-18-38)39(22)29-14-11-25(20-34-29)35-31(23-7-5-4-6-8-23)30-27-13-10-24(33(41)42-3)19-28(27)36-32(30)40/h4-14,19-20,35H,15-18,21H2,1-3H3,(H,36,40)/b31-30-
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n/an/a 123n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-fused human PDGFRbeta cytoplasmic domain (557 to 1106 (end) residues) expressed in baculovirus expression system using F...

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2020.115486
BindingDB Entry DOI: 10.7270/Q21N84QK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50543577
PNG
(CHEMBL4640617)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)-n3c(C)ccc3CN(C)C)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C31H30N4O3/c1-20-10-14-25(19-34(2)3)35(20)24-15-12-23(13-16-24)32-29(21-8-6-5-7-9-21)28-26-17-11-22(31(37)38-4)18-27(26)33-30(28)36/h5-18,32H,19H2,1-4H3,(H,33,36)/b29-28-
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n/an/a 148n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST fused human VEGFR2 cytoplasmic domain (790 to 1356 (end) residues) expressed in baculovirus expression system using FAM-...

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2020.115486
BindingDB Entry DOI: 10.7270/Q21N84QK
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM50543578
PNG
(CHEMBL4644718)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)-n3c(C)ccc3CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C34H35N5O3/c1-23-9-13-28(22-38-19-17-37(2)18-20-38)39(23)27-14-11-26(12-15-27)35-32(24-7-5-4-6-8-24)31-29-16-10-25(34(41)42-3)21-30(29)36-33(31)40/h4-16,21,35H,17-20,22H2,1-3H3,(H,36,40)/b32-31-
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n/an/a 178n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of SRC (unknown origin) using FAM-labeled peptide and ATP as substrate preincubated for 10 mins followed by substrate addition measured af...

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2020.115486
BindingDB Entry DOI: 10.7270/Q21N84QK
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))		BDBM50543572
PNG
(CHEMBL4641639)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(c(C)c3)-n3cccc3CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C34H35N5O3/c1-23-20-26(12-14-30(23)39-15-7-10-27(39)22-38-18-16-37(2)17-19-38)35-32(24-8-5-4-6-9-24)31-28-13-11-25(34(41)42-3)21-29(28)36-33(31)40/h4-15,20-21,35H,16-19,22H2,1-3H3,(H,36,40)/b32-31-
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Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-fused human PDGFRbeta cytoplasmic domain (557 to 1106 (end) residues) expressed in baculovirus expression system using F...

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2020.115486
BindingDB Entry DOI: 10.7270/Q21N84QK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50543580
PNG
(CHEMBL4649259)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)-n3c(C)ccc3CN3CCOCC3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C33H32N4O4/c1-22-8-12-27(21-36-16-18-41-19-17-36)37(22)26-13-10-25(11-14-26)34-31(23-6-4-3-5-7-23)30-28-15-9-24(33(39)40-2)20-29(28)35-32(30)38/h3-15,20,34H,16-19,21H2,1-2H3,(H,35,38)/b31-30-
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Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST fused human VEGFR2 cytoplasmic domain (790 to 1356 (end) residues) expressed in baculovirus expression system using FAM-...

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2020.115486
BindingDB Entry DOI: 10.7270/Q21N84QK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50543572
PNG
(CHEMBL4641639)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(c(C)c3)-n3cccc3CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C34H35N5O3/c1-23-20-26(12-14-30(23)39-15-7-10-27(39)22-38-18-16-37(2)17-19-38)35-32(24-8-5-4-6-9-24)31-28-13-11-25(34(41)42-3)21-29(28)36-33(31)40/h4-15,20-21,35H,16-19,22H2,1-3H3,(H,36,40)/b32-31-
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n/an/a 248n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST fused human VEGFR2 cytoplasmic domain (790 to 1356 (end) residues) expressed in baculovirus expression system using FAM-...

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2020.115486
BindingDB Entry DOI: 10.7270/Q21N84QK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50543582
PNG
(CHEMBL4640302)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(nc3)-n3c(C)ccc3CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C33H34N6O3/c1-22-9-12-26(21-38-17-15-37(2)16-18-38)39(22)29-14-11-25(20-34-29)35-31(23-7-5-4-6-8-23)30-27-13-10-24(33(41)42-3)19-28(27)36-32(30)40/h4-14,19-20,35H,15-18,21H2,1-3H3,(H,36,40)/b31-30-
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Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST fused human VEGFR2 cytoplasmic domain (790 to 1356 (end) residues) expressed in baculovirus expression system using FAM-...

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2020.115486
BindingDB Entry DOI: 10.7270/Q21N84QK
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))		BDBM50543576
PNG
(CHEMBL4641415)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3cnc(c(C)c3)-n3cccc3CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C33H34N6O3/c1-22-18-25(20-34-31(22)39-13-7-10-26(39)21-38-16-14-37(2)15-17-38)35-30(23-8-5-4-6-9-23)29-27-12-11-24(33(41)42-3)19-28(27)36-32(29)40/h4-13,18-20,35H,14-17,21H2,1-3H3,(H,36,40)/b30-29-
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n/an/a>300n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-fused human PDGFRbeta cytoplasmic domain (557 to 1106 (end) residues) expressed in baculovirus expression system using F...

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2020.115486
BindingDB Entry DOI: 10.7270/Q21N84QK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50543573
PNG
(CHEMBL4647154)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(nc3)-n3cccc3CN(C)C)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C29H27N5O3/c1-33(2)18-22-10-7-15-34(22)25-14-12-21(17-30-25)31-27(19-8-5-4-6-9-19)26-23-13-11-20(29(36)37-3)16-24(23)32-28(26)35/h4-17,31H,18H2,1-3H3,(H,32,35)/b27-26-
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Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST fused human VEGFR2 cytoplasmic domain (790 to 1356 (end) residues) expressed in baculovirus expression system using FAM-...

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2020.115486
BindingDB Entry DOI: 10.7270/Q21N84QK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50543584
PNG
(CHEMBL4648781)
Show SMILES CNC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)-n3c(C)ccc3CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C34H36N6O2/c1-23-9-13-28(22-39-19-17-38(3)18-20-39)40(23)27-14-11-26(12-15-27)36-32(24-7-5-4-6-8-24)31-29-16-10-25(33(41)35-2)21-30(29)37-34(31)42/h4-16,21,36H,17-20,22H2,1-3H3,(H,35,41)(H,37,42)/b32-31-
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Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST fused human VEGFR2 cytoplasmic domain (790 to 1356 (end) residues) expressed in baculovirus expression system using FAM-...

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2020.115486
BindingDB Entry DOI: 10.7270/Q21N84QK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50543571
PNG
(CHEMBL4642920)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(c(C)c3)-n3cccc3CN(C)C)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C31H30N4O3/c1-20-17-23(13-15-27(20)35-16-8-11-24(35)19-34(2)3)32-29(21-9-6-5-7-10-21)28-25-14-12-22(31(37)38-4)18-26(25)33-30(28)36/h5-18,32H,19H2,1-4H3,(H,33,36)/b29-28-
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Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST fused human VEGFR2 cytoplasmic domain (790 to 1356 (end) residues) expressed in baculovirus expression system using FAM-...

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2020.115486
BindingDB Entry DOI: 10.7270/Q21N84QK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50543574
PNG
(CHEMBL4639539)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(nc3)-n3cccc3CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C32H32N6O3/c1-36-15-17-37(18-16-36)21-25-9-6-14-38(25)28-13-11-24(20-33-28)34-30(22-7-4-3-5-8-22)29-26-12-10-23(32(40)41-2)19-27(26)35-31(29)39/h3-14,19-20,34H,15-18,21H2,1-2H3,(H,35,39)/b30-29-
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Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST fused human VEGFR2 cytoplasmic domain (790 to 1356 (end) residues) expressed in baculovirus expression system using FAM-...

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2020.115486
BindingDB Entry DOI: 10.7270/Q21N84QK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50543581
PNG
(CHEMBL4638817)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(nc3)-n3c(C)ccc3CN(C)C)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C30H29N5O3/c1-19-10-13-23(18-34(2)3)35(19)26-15-12-22(17-31-26)32-28(20-8-6-5-7-9-20)27-24-14-11-21(30(37)38-4)16-25(24)33-29(27)36/h5-17,32H,18H2,1-4H3,(H,33,36)/b28-27-
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Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST fused human VEGFR2 cytoplasmic domain (790 to 1356 (end) residues) expressed in baculovirus expression system using FAM-...

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2020.115486
BindingDB Entry DOI: 10.7270/Q21N84QK
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM50026612
PNG
(BIBF-1120 | Nintedanib | US10981896, Compound Nint...)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,38)/b29-28-
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n/an/a>1.00E+3n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of CHK (unknown origin) using FAM-labeled peptide and ATP as substrate preincubated for 10 mins followed by substrate addition measured af...

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2020.115486
BindingDB Entry DOI: 10.7270/Q21N84QK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50543576
PNG
(CHEMBL4641415)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3cnc(c(C)c3)-n3cccc3CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C33H34N6O3/c1-22-18-25(20-34-31(22)39-13-7-10-26(39)21-38-16-14-37(2)15-17-38)35-30(23-8-5-4-6-9-23)29-27-12-11-24(33(41)42-3)19-28(27)36-32(29)40/h4-13,18-20,35H,14-17,21H2,1-3H3,(H,36,40)/b30-29-
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Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST fused human VEGFR2 cytoplasmic domain (790 to 1356 (end) residues) expressed in baculovirus expression system using FAM-...

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2020.115486
BindingDB Entry DOI: 10.7270/Q21N84QK
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase B-raf


(Homo sapiens (Human))		BDBM50543578
PNG
(CHEMBL4644718)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)-n3c(C)ccc3CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C34H35N5O3/c1-23-9-13-28(22-38-19-17-37(2)18-20-38)39(23)27-14-11-26(12-15-27)35-32(24-7-5-4-6-8-24)31-29-16-10-25(34(41)42-3)21-30(29)36-33(31)40/h4-16,21,35H,17-20,22H2,1-3H3,(H,36,40)/b32-31-
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Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of B-Raf (unknown origin) using FAM-labeled peptide and ATP as substrate preincubated for 10 mins followed by substrate addition measured ...

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2020.115486
BindingDB Entry DOI: 10.7270/Q21N84QK
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))		BDBM50543578
PNG
(CHEMBL4644718)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)-n3c(C)ccc3CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C34H35N5O3/c1-23-9-13-28(22-38-19-17-37(2)18-20-38)39(23)27-14-11-26(12-15-27)35-32(24-7-5-4-6-8-24)31-29-16-10-25(34(41)42-3)21-30(29)36-33(31)40/h4-16,21,35H,17-20,22H2,1-3H3,(H,36,40)/b32-31-
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Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of CDK2 (unknown origin) using FAM-labeled peptide and ATP as substrate preincubated for 10 mins followed by substrate addition measured a...

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2020.115486
BindingDB Entry DOI: 10.7270/Q21N84QK
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))		BDBM50543578
PNG
(CHEMBL4644718)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)-n3c(C)ccc3CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C34H35N5O3/c1-23-9-13-28(22-38-19-17-37(2)18-20-38)39(23)27-14-11-26(12-15-27)35-32(24-7-5-4-6-8-24)31-29-16-10-25(34(41)42-3)21-30(29)36-33(31)40/h4-16,21,35H,17-20,22H2,1-3H3,(H,36,40)/b32-31-
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Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of CHK (unknown origin) using FAM-labeled peptide and ATP as substrate preincubated for 10 mins followed by substrate addition measured af...

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2020.115486
BindingDB Entry DOI: 10.7270/Q21N84QK
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))		BDBM50026612
PNG
(BIBF-1120 | Nintedanib | US10981896, Compound Nint...)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,38)/b29-28-
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Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of CDK2 (unknown origin) using FAM-labeled peptide and ATP as substrate preincubated for 10 mins followed by substrate addition measured a...

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2020.115486
BindingDB Entry DOI: 10.7270/Q21N84QK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50543575
PNG
(CHEMBL4647153)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3cnc(c(C)c3)-n3cccc3CN(C)C)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C30H29N5O3/c1-19-15-22(17-31-28(19)35-14-8-11-23(35)18-34(2)3)32-27(20-9-6-5-7-10-20)26-24-13-12-21(30(37)38-4)16-25(24)33-29(26)36/h5-17,32H,18H2,1-4H3,(H,33,36)/b27-26-
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Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST fused human VEGFR2 cytoplasmic domain (790 to 1356 (end) residues) expressed in baculovirus expression system using FAM-...

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2020.115486
BindingDB Entry DOI: 10.7270/Q21N84QK
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (Human))		BDBM50543578
PNG
(CHEMBL4644718)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)-n3c(C)ccc3CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C34H35N5O3/c1-23-9-13-28(22-38-19-17-37(2)18-20-38)39(23)27-14-11-26(12-15-27)35-32(24-7-5-4-6-8-24)31-29-16-10-25(34(41)42-3)21-30(29)36-33(31)40/h4-16,21,35H,17-20,22H2,1-3H3,(H,36,40)/b32-31-
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Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of CDK4 (unknown origin) using FAM-labeled peptide and ATP as substrate preincubated for 10 mins followed by substrate addition measured a...

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2020.115486
BindingDB Entry DOI: 10.7270/Q21N84QK
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%