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Articleid 50029313

Compile data set for download or QSAR
Found 134 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Type-1 angiotensin II receptor A/B


(RAT)		BDBM50283305
PNG
(3'-Fluoro-4'-[6-(3-isopropyl-ureido)-4-oxo-2-propy...)
Show SMILES CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)c1ccc(CC)cc1F
Show InChI InChI=1S/C37H37F2N5O5S/c1-5-9-34-42-32-17-15-26(41-37(47)40-22(3)4)20-29(32)36(46)44(34)21-25-14-13-24(19-30(25)38)27-10-7-8-11-33(27)50(48,49)43-35(45)28-16-12-23(6-2)18-31(28)39/h7-8,10-20,22H,5-6,9,21H2,1-4H3,(H,43,45)(H2,40,41,47)
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n/an/a 0.110n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rat adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(RABBIT)		BDBM50283319
PNG
(2-Butyl-3-(3-fluoro-2'-(2-cyclopropylethyloxycarbo...)
Show SMILES CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC1CC1
Show InChI InChI=1S/C36H42FN5O6S/c1-5-6-11-33-39-31-17-16-27(38-35(44)41(4)23(2)3)21-29(31)34(43)42(33)22-26-15-14-25(20-30(26)37)28-9-7-8-10-32(28)49(46,47)40-36(45)48-19-18-24-12-13-24/h7-10,14-17,20-21,23-24H,5-6,11-13,18-19,22H2,1-4H3,(H,38,44)(H,40,45)
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TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of rabbit aorta membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor A/B


(RAT)		BDBM50283317
PNG
(2-Propyl-3-(3-fluoro-2'-(3-methylbutyloxycarbonyla...)
Show SMILES CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C35H40FN5O7S/c1-4-7-32-38-30-13-12-26(37-34(43)40-15-18-47-19-16-40)21-28(30)33(42)41(32)22-25-11-10-24(20-29(25)36)27-8-5-6-9-31(27)49(45,46)39-35(44)48-17-14-23(2)3/h5-6,8-13,20-21,23H,4,7,14-19,22H2,1-3H3,(H,37,43)(H,39,44)
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TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II, type 2 of rat midbrain membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor A/B


(RAT)		BDBM50283312
PNG
(4'-[2-Ethyl-6-(3-isopropyl-ureido)-4-oxo-4H-quinaz...)
Show SMILES CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1
Show InChI InChI=1S/C36H35F2N5O5S/c1-5-22-11-15-27(30(38)17-22)34(44)42-49(47,48)32-10-8-7-9-26(32)23-12-13-24(29(37)18-23)20-43-33(6-2)41-31-16-14-25(19-28(31)35(43)45)40-36(46)39-21(3)4/h7-19,21H,5-6,20H2,1-4H3,(H,42,44)(H2,39,40,46)
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TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against AT2 receptor of rat adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor A/B


(RAT)		BDBM50283310
PNG
(4'-[2-Ethyl-6-(3-isopropyl-3-methyl-ureido)-4-oxo-...)
Show SMILES CCc1ccc(cc1)C(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1
Show InChI InChI=1S/C37H38FN5O5S/c1-6-24-12-14-25(15-13-24)35(44)41-49(47,48)33-11-9-8-10-29(33)26-16-17-27(31(38)20-26)22-43-34(7-2)40-32-19-18-28(21-30(32)36(43)45)39-37(46)42(5)23(3)4/h8-21,23H,6-7,22H2,1-5H3,(H,39,46)(H,41,44)
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TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II, type 2 of rat midbrain membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor A/B


(RAT)		BDBM50283300
PNG
(2-Butyl-3-(3-fluoro-2'-(3-methylbutyloxycarbonylam...)
Show SMILES CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C36H44FN5O6S/c1-7-8-13-33-39-31-17-16-27(38-35(44)41(6)24(4)5)21-29(31)34(43)42(33)22-26-15-14-25(20-30(26)37)28-11-9-10-12-32(28)49(46,47)40-36(45)48-19-18-23(2)3/h9-12,14-17,20-21,23-24H,7-8,13,18-19,22H2,1-6H3,(H,38,44)(H,40,45)
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TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II, type 2 of rat midbrain membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor A/B


(RAT)		BDBM50283316
PNG
(3'-Fluoro-4'-[6-(3-isopropyl-ureido)-4-oxo-2-propy...)
Show SMILES CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)COCC(C)C
Show InChI InChI=1S/C34H40FN5O6S/c1-6-9-31-38-29-15-14-25(37-34(43)36-22(4)5)17-27(29)33(42)40(31)18-24-13-12-23(16-28(24)35)26-10-7-8-11-30(26)47(44,45)39-32(41)20-46-19-21(2)3/h7-8,10-17,21-22H,6,9,18-20H2,1-5H3,(H,39,41)(H2,36,37,43)
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TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II, type 2 of rat midbrain membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(RABBIT)		BDBM50283312
PNG
(4'-[2-Ethyl-6-(3-isopropyl-ureido)-4-oxo-4H-quinaz...)
Show SMILES CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1
Show InChI InChI=1S/C36H35F2N5O5S/c1-5-22-11-15-27(30(38)17-22)34(44)42-49(47,48)32-10-8-7-9-26(32)23-12-13-24(29(37)18-23)20-43-33(6-2)41-31-16-14-25(19-28(31)35(43)45)40-36(46)39-21(3)4/h7-19,21H,5-6,20H2,1-4H3,(H,42,44)(H2,39,40,46)
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TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of rabbit aorta membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(RABBIT)		BDBM50283318
PNG
(2-Butyl-3-(3-fluoro-2'-(butyloxycarbonylaminosulph...)
Show SMILES CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1
Show InChI InChI=1S/C35H42FN5O6S/c1-6-8-14-32-38-30-18-17-26(37-34(43)40(5)23(3)4)21-28(30)33(42)41(32)22-25-16-15-24(20-29(25)36)27-12-10-11-13-31(27)48(45,46)39-35(44)47-19-9-7-2/h10-13,15-18,20-21,23H,6-9,14,19,22H2,1-5H3,(H,37,43)(H,39,44)
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TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of rabbit aorta membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(RABBIT)		BDBM50283305
PNG
(3'-Fluoro-4'-[6-(3-isopropyl-ureido)-4-oxo-2-propy...)
Show SMILES CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)c1ccc(CC)cc1F
Show InChI InChI=1S/C37H37F2N5O5S/c1-5-9-34-42-32-17-15-26(41-37(47)40-22(3)4)20-29(32)36(46)44(34)21-25-14-13-24(19-30(25)38)27-10-7-8-11-33(27)50(48,49)43-35(45)28-16-12-23(6-2)18-31(28)39/h7-8,10-20,22H,5-6,9,21H2,1-4H3,(H,43,45)(H2,40,41,47)
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TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of rabbit aorta membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(RAT)		BDBM50283302
PNG
(2-ethyl-3-(3-fluoro-2'-(3-methyl-butyloxycarbonyla...)
Show SMILES CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C34H40FN5O6S/c1-7-31-37-29-15-14-25(36-33(42)39(6)22(4)5)19-27(29)32(41)40(31)20-24-13-12-23(18-28(24)35)26-10-8-9-11-30(26)47(44,45)38-34(43)46-17-16-21(2)3/h8-15,18-19,21-22H,7,16-17,20H2,1-6H3,(H,36,42)(H,38,43)
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TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II, type 2 of rat midbrain membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(RAT)		BDBM50283300
PNG
(2-Butyl-3-(3-fluoro-2'-(3-methylbutyloxycarbonylam...)
Show SMILES CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C36H44FN5O6S/c1-7-8-13-33-39-31-17-16-27(38-35(44)41(6)24(4)5)21-29(31)34(43)42(33)22-26-15-14-25(20-30(26)37)28-11-9-10-12-32(28)49(46,47)40-36(45)48-19-18-23(2)3/h9-12,14-17,20-21,23-24H,7-8,13,18-19,22H2,1-6H3,(H,38,44)(H,40,45)
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TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II, type 2 of rat midbrain membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(RAT)		BDBM50283307
PNG
(4'-[2-Ethyl-6-(3-isopropyl-3-methyl-ureido)-4-oxo-...)
Show SMILES CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)COCC(C)C
Show InChI InChI=1S/C34H40FN5O6S/c1-7-31-37-29-15-14-25(36-34(43)39(6)22(4)5)17-27(29)33(42)40(31)18-24-13-12-23(16-28(24)35)26-10-8-9-11-30(26)47(44,45)38-32(41)20-46-19-21(2)3/h8-17,21-22H,7,18-20H2,1-6H3,(H,36,43)(H,38,41)
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TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II, type 2 of rat midbrain membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(RAT)		BDBM50283305
PNG
(3'-Fluoro-4'-[6-(3-isopropyl-ureido)-4-oxo-2-propy...)
Show SMILES CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)c1ccc(CC)cc1F
Show InChI InChI=1S/C37H37F2N5O5S/c1-5-9-34-42-32-17-15-26(41-37(47)40-22(3)4)20-29(32)36(46)44(34)21-25-14-13-24(19-30(25)38)27-10-7-8-11-33(27)50(48,49)43-35(45)28-16-12-23(6-2)18-31(28)39/h7-8,10-20,22H,5-6,9,21H2,1-4H3,(H,43,45)(H2,40,41,47)
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TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against AT2 receptor of rat adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(RAT)		BDBM50283300
PNG
(2-Butyl-3-(3-fluoro-2'-(3-methylbutyloxycarbonylam...)
Show SMILES CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C36H44FN5O6S/c1-7-8-13-33-39-31-17-16-27(38-35(44)41(6)24(4)5)21-29(31)34(43)42(33)22-26-15-14-25(20-30(26)37)28-11-9-10-12-32(28)49(46,47)40-36(45)48-19-18-23(2)3/h9-12,14-17,20-21,23-24H,7-8,13,18-19,22H2,1-6H3,(H,38,44)(H,40,45)
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TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against AT2 receptor of rat adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(RABBIT)		BDBM50283300
PNG
(2-Butyl-3-(3-fluoro-2'-(3-methylbutyloxycarbonylam...)
Show SMILES CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C36H44FN5O6S/c1-7-8-13-33-39-31-17-16-27(38-35(44)41(6)24(4)5)21-29(31)34(43)42(33)22-26-15-14-25(20-30(26)37)28-11-9-10-12-32(28)49(46,47)40-36(45)48-19-18-23(2)3/h9-12,14-17,20-21,23-24H,7-8,13,18-19,22H2,1-6H3,(H,38,44)(H,40,45)
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TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of rabbit aorta membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor A/B


(RAT)		BDBM50283319
PNG
(2-Butyl-3-(3-fluoro-2'-(2-cyclopropylethyloxycarbo...)
Show SMILES CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC1CC1
Show InChI InChI=1S/C36H42FN5O6S/c1-5-6-11-33-39-31-17-16-27(38-35(44)41(4)23(2)3)21-29(31)34(43)42(33)22-26-15-14-25(20-30(26)37)28-9-7-8-10-32(28)49(46,47)40-36(45)48-19-18-24-12-13-24/h7-10,14-17,20-21,23-24H,5-6,11-13,18-19,22H2,1-4H3,(H,38,44)(H,40,45)
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n/an/a 0.230n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rat adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(RABBIT)		BDBM50049181
PNG
(2-Butyl-3-(2'-(butyloxycarbonylaminosulphonyl)-bip...)
Show SMILES CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1
Show InChI InChI=1S/C35H43N5O6S/c1-6-8-14-32-37-30-20-19-27(36-34(42)39(5)24(3)4)22-29(30)33(41)40(32)23-25-15-17-26(18-16-25)28-12-10-11-13-31(28)47(44,45)38-35(43)46-21-9-7-2/h10-13,15-20,22,24H,6-9,14,21,23H2,1-5H3,(H,36,42)(H,38,43)
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n/an/a 0.240n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of rabbit aorta membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(RABBIT)		BDBM50283317
PNG
(2-Propyl-3-(3-fluoro-2'-(3-methylbutyloxycarbonyla...)
Show SMILES CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C35H40FN5O7S/c1-4-7-32-38-30-13-12-26(37-34(43)40-15-18-47-19-16-40)21-28(30)33(42)41(32)22-25-11-10-24(20-29(25)36)27-8-5-6-9-31(27)49(45,46)39-35(44)48-17-14-23(2)3/h5-6,8-13,20-21,23H,4,7,14-19,22H2,1-3H3,(H,37,43)(H,39,44)
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n/an/a 0.240n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of rabbit aorta membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor A/B


(RAT)		BDBM50283318
PNG
(2-Butyl-3-(3-fluoro-2'-(butyloxycarbonylaminosulph...)
Show SMILES CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1
Show InChI InChI=1S/C35H42FN5O6S/c1-6-8-14-32-38-30-18-17-26(37-34(43)40(5)23(3)4)21-28(30)33(42)41(32)22-25-16-15-24(20-29(25)36)27-12-10-11-13-31(27)48(45,46)39-35(44)47-19-9-7-2/h10-13,15-18,20-21,23H,6-9,14,19,22H2,1-5H3,(H,37,43)(H,39,44)
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n/an/a 0.25n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rat adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(RAT)		BDBM50283310
PNG
(4'-[2-Ethyl-6-(3-isopropyl-3-methyl-ureido)-4-oxo-...)
Show SMILES CCc1ccc(cc1)C(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1
Show InChI InChI=1S/C37H38FN5O5S/c1-6-24-12-14-25(15-13-24)35(44)41-49(47,48)33-11-9-8-10-29(33)26-16-17-27(31(38)20-26)22-43-34(7-2)40-32-19-18-28(21-30(32)36(43)45)39-37(46)42(5)23(3)4/h8-21,23H,6-7,22H2,1-5H3,(H,39,46)(H,41,44)
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n/an/a 0.25n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II, type 2 of rat midbrain membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(RAT)		BDBM50283312
PNG
(4'-[2-Ethyl-6-(3-isopropyl-ureido)-4-oxo-4H-quinaz...)
Show SMILES CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1
Show InChI InChI=1S/C36H35F2N5O5S/c1-5-22-11-15-27(30(38)17-22)34(44)42-49(47,48)32-10-8-7-9-26(32)23-12-13-24(29(37)18-23)20-43-33(6-2)41-31-16-14-25(19-28(31)35(43)45)40-36(46)39-21(3)4/h7-19,21H,5-6,20H2,1-4H3,(H,42,44)(H2,39,40,46)
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n/an/a 0.25n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II, type 2 of rat midbrain membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(RAT)		BDBM50283305
PNG
(3'-Fluoro-4'-[6-(3-isopropyl-ureido)-4-oxo-2-propy...)
Show SMILES CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)c1ccc(CC)cc1F
Show InChI InChI=1S/C37H37F2N5O5S/c1-5-9-34-42-32-17-15-26(41-37(47)40-22(3)4)20-29(32)36(46)44(34)21-25-14-13-24(19-30(25)38)27-10-7-8-11-33(27)50(48,49)43-35(45)28-16-12-23(6-2)18-31(28)39/h7-8,10-20,22H,5-6,9,21H2,1-4H3,(H,43,45)(H2,40,41,47)
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n/an/a 0.280n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(RAT)		BDBM50283319
PNG
(2-Butyl-3-(3-fluoro-2'-(2-cyclopropylethyloxycarbo...)
Show SMILES CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC1CC1
Show InChI InChI=1S/C36H42FN5O6S/c1-5-6-11-33-39-31-17-16-27(38-35(44)41(4)23(2)3)21-29(31)34(43)42(33)22-26-15-14-25(20-30(26)37)28-9-7-8-10-32(28)49(46,47)40-36(45)48-19-18-24-12-13-24/h7-10,14-17,20-21,23-24H,5-6,11-13,18-19,22H2,1-4H3,(H,38,44)(H,40,45)
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n/an/a 0.290n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against AT2 receptor of rat adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(RAT)		BDBM50283302
PNG
(2-ethyl-3-(3-fluoro-2'-(3-methyl-butyloxycarbonyla...)
Show SMILES CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C34H40FN5O6S/c1-7-31-37-29-15-14-25(36-33(42)39(6)22(4)5)19-27(29)32(41)40(31)20-24-13-12-23(18-28(24)35)26-10-8-9-11-30(26)47(44,45)38-34(43)46-17-16-21(2)3/h8-15,18-19,21-22H,7,16-17,20H2,1-6H3,(H,36,42)(H,38,43)
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n/an/a 0.300n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II, type 2 of rat midbrain membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor A/B


(RAT)		BDBM50283302
PNG
(2-ethyl-3-(3-fluoro-2'-(3-methyl-butyloxycarbonyla...)
Show SMILES CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C34H40FN5O6S/c1-7-31-37-29-15-14-25(36-33(42)39(6)22(4)5)19-27(29)32(41)40(31)20-24-13-12-23(18-28(24)35)26-10-8-9-11-30(26)47(44,45)38-34(43)46-17-16-21(2)3/h8-15,18-19,21-22H,7,16-17,20H2,1-6H3,(H,36,42)(H,38,43)
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n/an/a 0.300n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II, type 2 of rat midbrain membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(RAT)		BDBM50283314
PNG
(2-ethyl-3-(3-fluoro-2'-(3-methyl-butyloxycarbonyla...)
Show SMILES CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C34H38FN5O7S/c1-4-31-37-29-12-11-25(36-33(42)39-14-17-46-18-15-39)20-27(29)32(41)40(31)21-24-10-9-23(19-28(24)35)26-7-5-6-8-30(26)48(44,45)38-34(43)47-16-13-22(2)3/h5-12,19-20,22H,4,13-18,21H2,1-3H3,(H,36,42)(H,38,43)
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n/an/a 0.310n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II, type 2 of rat midbrain membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(RAT)		BDBM50283312
PNG
(4'-[2-Ethyl-6-(3-isopropyl-ureido)-4-oxo-4H-quinaz...)
Show SMILES CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1
Show InChI InChI=1S/C36H35F2N5O5S/c1-5-22-11-15-27(30(38)17-22)34(44)42-49(47,48)32-10-8-7-9-26(32)23-12-13-24(29(37)18-23)20-43-33(6-2)41-31-16-14-25(19-28(31)35(43)45)40-36(46)39-21(3)4/h7-19,21H,5-6,20H2,1-4H3,(H,42,44)(H2,39,40,46)
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n/an/a 0.340n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against AT2 receptor of rat adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(RAT)		BDBM50283319
PNG
(2-Butyl-3-(3-fluoro-2'-(2-cyclopropylethyloxycarbo...)
Show SMILES CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC1CC1
Show InChI InChI=1S/C36H42FN5O6S/c1-5-6-11-33-39-31-17-16-27(38-35(44)41(4)23(2)3)21-29(31)34(43)42(33)22-26-15-14-25(20-30(26)37)28-9-7-8-10-32(28)49(46,47)40-36(45)48-19-18-24-12-13-24/h7-10,14-17,20-21,23-24H,5-6,11-13,18-19,22H2,1-4H3,(H,38,44)(H,40,45)
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n/an/a 0.360n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against AT2 receptor of rat adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(RAT)		BDBM50283316
PNG
(3'-Fluoro-4'-[6-(3-isopropyl-ureido)-4-oxo-2-propy...)
Show SMILES CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)COCC(C)C
Show InChI InChI=1S/C34H40FN5O6S/c1-6-9-31-38-29-15-14-25(37-34(43)36-22(4)5)17-27(29)33(42)40(31)18-24-13-12-23(16-28(24)35)26-10-7-8-11-30(26)47(44,45)39-32(41)20-46-19-21(2)3/h7-8,10-17,21-22H,6,9,18-20H2,1-5H3,(H,39,41)(H2,36,37,43)
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n/an/a 0.380n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against AT2 receptor of rat adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor A/B


(RAT)		BDBM50283308
PNG
(2-ethyl-3-(3-fluoro-2'-(3-methyl-but-2-enyloxycarb...)
Show SMILES [#6]-[#6]-c1nc2ccc(-[#7]-[#6](=O)-[#7](-[#6])-[#6](-[#6])-[#6])cc2c(=O)n1-[#6]-c1ccc(cc1F)-c1ccccc1S(=O)(=O)[#7]-[#6](=O)-[#8]-[#6]\[#6]=[#6](\[#6])-[#6]
Show InChI InChI=1S/C34H38FN5O6S/c1-7-31-37-29-15-14-25(36-33(42)39(6)22(4)5)19-27(29)32(41)40(31)20-24-13-12-23(18-28(24)35)26-10-8-9-11-30(26)47(44,45)38-34(43)46-17-16-21(2)3/h8-16,18-19,22H,7,17,20H2,1-6H3,(H,36,42)(H,38,43)
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n/an/a 0.390n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rat adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(RAT)		BDBM50049204
PNG
(2-ethyl-3-(3-fluoro-2'-(2-cyclopropylethyloxycarbo...)
Show SMILES CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC1CC1
Show InChI InChI=1S/C34H38FN5O6S/c1-5-31-37-29-15-14-25(36-33(42)39(4)21(2)3)19-27(29)32(41)40(31)20-24-13-12-23(18-28(24)35)26-8-6-7-9-30(26)47(44,45)38-34(43)46-17-16-22-10-11-22/h6-9,12-15,18-19,21-22H,5,10-11,16-17,20H2,1-4H3,(H,36,42)(H,38,43)
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n/an/a 0.390n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(RAT)		BDBM50283318
PNG
(2-Butyl-3-(3-fluoro-2'-(butyloxycarbonylaminosulph...)
Show SMILES CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1
Show InChI InChI=1S/C35H42FN5O6S/c1-6-8-14-32-38-30-18-17-26(37-34(43)40(5)23(3)4)21-28(30)33(42)41(32)22-25-16-15-24(20-29(25)36)27-12-10-11-13-31(27)48(45,46)39-35(44)47-19-9-7-2/h10-13,15-18,20-21,23H,6-9,14,19,22H2,1-5H3,(H,37,43)(H,39,44)
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n/an/a 0.440n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(RAT)		BDBM50283317
PNG
(2-Propyl-3-(3-fluoro-2'-(3-methylbutyloxycarbonyla...)
Show SMILES CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C35H40FN5O7S/c1-4-7-32-38-30-13-12-26(37-34(43)40-15-18-47-19-16-40)21-28(30)33(42)41(32)22-25-11-10-24(20-29(25)36)27-8-5-6-9-31(27)49(45,46)39-35(44)48-17-14-23(2)3/h5-6,8-13,20-21,23H,4,7,14-19,22H2,1-3H3,(H,37,43)(H,39,44)
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n/an/a 0.480n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II, type 2 of rat midbrain membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor A/B


(RAT)		BDBM50283306
PNG
(2-methyl-3-(3-fluoro-2'-(3-methyl-butyloxycarbonyl...)
Show SMILES CC(C)CCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(C)nc3ccc(NC(=O)NC(C)C)cc3c2=O)c(F)c1
Show InChI InChI=1S/C32H36FN5O6S/c1-19(2)14-15-44-32(41)37-45(42,43)29-9-7-6-8-25(29)22-10-11-23(27(33)16-22)18-38-21(5)35-28-13-12-24(17-26(28)30(38)39)36-31(40)34-20(3)4/h6-13,16-17,19-20H,14-15,18H2,1-5H3,(H,37,41)(H2,34,36,40)
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TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rat adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor A/B


(RAT)		BDBM50049204
PNG
(2-ethyl-3-(3-fluoro-2'-(2-cyclopropylethyloxycarbo...)
Show SMILES CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC1CC1
Show InChI InChI=1S/C34H38FN5O6S/c1-5-31-37-29-15-14-25(36-33(42)39(4)21(2)3)19-27(29)32(41)40(31)20-24-13-12-23(18-28(24)35)26-8-6-7-9-30(26)47(44,45)38-34(43)46-17-16-22-10-11-22/h6-9,12-15,18-19,21-22H,5,10-11,16-17,20H2,1-4H3,(H,36,42)(H,38,43)
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TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rat adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(RAT)		BDBM50283317
PNG
(2-Propyl-3-(3-fluoro-2'-(3-methylbutyloxycarbonyla...)
Show SMILES CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C35H40FN5O7S/c1-4-7-32-38-30-13-12-26(37-34(43)40-15-18-47-19-16-40)21-28(30)33(42)41(32)22-25-11-10-24(20-29(25)36)27-8-5-6-9-31(27)49(45,46)39-35(44)48-17-14-23(2)3/h5-6,8-13,20-21,23H,4,7,14-19,22H2,1-3H3,(H,37,43)(H,39,44)
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TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II, type 2 of rat midbrain membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(RABBIT)		BDBM50283316
PNG
(3'-Fluoro-4'-[6-(3-isopropyl-ureido)-4-oxo-2-propy...)
Show SMILES CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)COCC(C)C
Show InChI InChI=1S/C34H40FN5O6S/c1-6-9-31-38-29-15-14-25(37-34(43)36-22(4)5)17-27(29)33(42)40(31)18-24-13-12-23(16-28(24)35)26-10-7-8-11-30(26)47(44,45)39-32(41)20-46-19-21(2)3/h7-8,10-17,21-22H,6,9,18-20H2,1-5H3,(H,39,41)(H2,36,37,43)
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n/an/a 0.520n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of rabbit aorta membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(RABBIT)		BDBM50283310
PNG
(4'-[2-Ethyl-6-(3-isopropyl-3-methyl-ureido)-4-oxo-...)
Show SMILES CCc1ccc(cc1)C(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1
Show InChI InChI=1S/C37H38FN5O5S/c1-6-24-12-14-25(15-13-24)35(44)41-49(47,48)33-11-9-8-10-29(33)26-16-17-27(31(38)20-26)22-43-34(7-2)40-32-19-18-28(21-30(32)36(43)45)39-37(46)42(5)23(3)4/h8-21,23H,6-7,22H2,1-5H3,(H,39,46)(H,41,44)
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n/an/a 0.540n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of rabbit aorta membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(RAT)		BDBM50283315
PNG
(2-Ethyl-3-(3-fluoro-2'-(2-cyclopropylethyloxycarbo...)
Show SMILES CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(cc3F)-c3ccccc3S(=O)(=O)NC(=O)OCCC3CC3)c(=O)c2c1
Show InChI InChI=1S/C32H34FN5O6S/c1-3-29-36-27-14-13-23(35-31(40)34-4-2)18-25(27)30(39)38(29)19-22-12-11-21(17-26(22)33)24-7-5-6-8-28(24)45(42,43)37-32(41)44-16-15-20-9-10-20/h5-8,11-14,17-18,20H,3-4,9-10,15-16,19H2,1-2H3,(H,37,41)(H2,34,35,40)
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n/an/a 0.560n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(RAT)		BDBM50283309
PNG
(2-ethyl-3-(3-fluoro-2'-(2-cyclopropylethyloxycarbo...)
Show SMILES CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC1CC1
Show InChI InChI=1S/C33H36FN5O6S/c1-4-30-37-28-14-13-24(36-32(41)35-20(2)3)18-26(28)31(40)39(30)19-23-12-11-22(17-27(23)34)25-7-5-6-8-29(25)46(43,44)38-33(42)45-16-15-21-9-10-21/h5-8,11-14,17-18,20-21H,4,9-10,15-16,19H2,1-3H3,(H,38,42)(H2,35,36,41)
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n/an/a 0.560n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II, type 2 of rat midbrain membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(RABBIT)		BDBM50049204
PNG
(2-ethyl-3-(3-fluoro-2'-(2-cyclopropylethyloxycarbo...)
Show SMILES CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC1CC1
Show InChI InChI=1S/C34H38FN5O6S/c1-5-31-37-29-15-14-25(36-33(42)39(4)21(2)3)19-27(29)32(41)40(31)20-24-13-12-23(18-28(24)35)26-8-6-7-9-30(26)47(44,45)38-34(43)46-17-16-22-10-11-22/h6-9,12-15,18-19,21-22H,5,10-11,16-17,20H2,1-4H3,(H,36,42)(H,38,43)
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n/an/a 0.570n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of rabbit aorta membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor A/B


(RAT)		BDBM50283304
PNG
(2-methyl-3-(3-fluoro-2'-(3-methyl-butyloxycarbonyl...)
Show SMILES CC(C)CCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(C)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1
Show InChI InChI=1S/C33H38FN5O6S/c1-20(2)15-16-45-33(42)37-46(43,44)30-10-8-7-9-26(30)23-11-12-24(28(34)17-23)19-39-22(5)35-29-14-13-25(18-27(29)31(39)40)36-32(41)38(6)21(3)4/h7-14,17-18,20-21H,15-16,19H2,1-6H3,(H,36,41)(H,37,42)
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n/an/a 0.580n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rat adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(RAT)		BDBM50283307
PNG
(4'-[2-Ethyl-6-(3-isopropyl-3-methyl-ureido)-4-oxo-...)
Show SMILES CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)COCC(C)C
Show InChI InChI=1S/C34H40FN5O6S/c1-7-31-37-29-15-14-25(36-34(43)39(6)22(4)5)17-27(29)33(42)40(31)18-24-13-12-23(16-28(24)35)26-10-8-9-11-30(26)47(44,45)38-32(41)20-46-19-21(2)3/h8-17,21-22H,7,18-20H2,1-6H3,(H,36,43)(H,38,41)
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n/an/a 0.610n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against AT2 receptor of rat adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(RABBIT)		BDBM50283302
PNG
(2-ethyl-3-(3-fluoro-2'-(3-methyl-butyloxycarbonyla...)
Show SMILES CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C34H40FN5O6S/c1-7-31-37-29-15-14-25(36-33(42)39(6)22(4)5)19-27(29)32(41)40(31)20-24-13-12-23(18-28(24)35)26-10-8-9-11-30(26)47(44,45)38-34(43)46-17-16-21(2)3/h8-15,18-19,21-22H,7,16-17,20H2,1-6H3,(H,36,42)(H,38,43)
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n/an/a 0.620n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of rabbit aorta membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(RAT)		BDBM50283311
PNG
(2-ethyl-3-(3-fluoro-2'-(3-methyl-butyloxycarbonyla...)
Show SMILES CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C35H34FN5O6S/c1-4-32-39-29-15-14-25(38-33(42)30-10-7-8-17-37-30)20-27(29)34(43)41(32)21-24-13-12-23(19-28(24)36)26-9-5-6-11-31(26)48(45,46)40-35(44)47-18-16-22(2)3/h5-15,17,19-20,22H,4,16,18,21H2,1-3H3,(H,38,42)(H,40,44)
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n/an/a 0.630n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against AT2 receptor of rat adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(RAT)		BDBM50283306
PNG
(2-methyl-3-(3-fluoro-2'-(3-methyl-butyloxycarbonyl...)
Show SMILES CC(C)CCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(C)nc3ccc(NC(=O)NC(C)C)cc3c2=O)c(F)c1
Show InChI InChI=1S/C32H36FN5O6S/c1-19(2)14-15-44-32(41)37-45(42,43)29-9-7-6-8-25(29)22-10-11-23(27(33)16-22)18-38-21(5)35-28-13-12-24(17-26(28)30(38)39)36-31(40)34-20(3)4/h6-13,16-17,19-20H,14-15,18H2,1-5H3,(H,37,41)(H2,34,36,40)
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TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against AT2 receptor of rat adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor A/B


(RAT)		BDBM50283315
PNG
(2-Ethyl-3-(3-fluoro-2'-(2-cyclopropylethyloxycarbo...)
Show SMILES CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(cc3F)-c3ccccc3S(=O)(=O)NC(=O)OCCC3CC3)c(=O)c2c1
Show InChI InChI=1S/C32H34FN5O6S/c1-3-29-36-27-14-13-23(35-31(40)34-4-2)18-25(27)30(39)38(29)19-22-12-11-21(17-26(22)33)24-7-5-6-8-28(24)45(42,43)37-32(41)44-16-15-20-9-10-20/h5-8,11-14,17-18,20H,3-4,9-10,15-16,19H2,1-2H3,(H,37,41)(H2,34,35,40)
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n/an/a 0.640n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II, type 2 of rat midbrain membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor A/B


(RAT)		BDBM50283309
PNG
(2-ethyl-3-(3-fluoro-2'-(2-cyclopropylethyloxycarbo...)
Show SMILES CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC1CC1
Show InChI InChI=1S/C33H36FN5O6S/c1-4-30-37-28-14-13-24(36-32(41)35-20(2)3)18-26(28)31(40)39(30)19-23-12-11-22(17-27(23)34)25-7-5-6-8-29(25)46(43,44)38-33(42)45-16-15-21-9-10-21/h5-8,11-14,17-18,20-21H,4,9-10,15-16,19H2,1-3H3,(H,38,42)(H2,35,36,41)
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n/an/a 0.640n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rat adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor A/B


(RAT)		BDBM50283314
PNG
(2-ethyl-3-(3-fluoro-2'-(3-methyl-butyloxycarbonyla...)
Show SMILES CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C34H38FN5O7S/c1-4-31-37-29-12-11-25(36-33(42)39-14-17-46-18-15-39)20-27(29)32(41)40(31)21-24-10-9-23(19-28(24)35)26-7-5-6-8-30(26)48(44,45)38-34(43)47-16-13-22(2)3/h5-12,19-20,22H,4,13-18,21H2,1-3H3,(H,36,42)(H,38,43)
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n/an/a 0.660n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against AT2 receptor of rat adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(RAT)		BDBM82433
PNG
(CHEMBL302102 | L-159,689 | L-159689 | N-Pentyl-N-[...)
Show SMILES CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(cc3)-c3ccccc3-c3nnn[nH]3)c(=O)c2c1
Show InChI InChI=1S/C37H37N7O2/c1-3-5-11-23-43(36(45)28-13-7-6-8-14-28)29-21-22-33-32(24-29)37(46)44(34(38-33)12-4-2)25-26-17-19-27(20-18-26)30-15-9-10-16-31(30)35-39-41-42-40-35/h6-10,13-22,24H,3-5,11-12,23,25H2,1-2H3,(H,39,40,41,42)
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n/an/a 0.700n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II, type 2 of rat midbrain membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(RAT)		BDBM50283306
PNG
(2-methyl-3-(3-fluoro-2'-(3-methyl-butyloxycarbonyl...)
Show SMILES CC(C)CCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(C)nc3ccc(NC(=O)NC(C)C)cc3c2=O)c(F)c1
Show InChI InChI=1S/C32H36FN5O6S/c1-19(2)14-15-44-32(41)37-45(42,43)29-9-7-6-8-25(29)22-10-11-23(27(33)16-22)18-38-21(5)35-28-13-12-24(17-26(28)30(38)39)36-31(40)34-20(3)4/h6-13,16-17,19-20H,14-15,18H2,1-5H3,(H,37,41)(H2,34,36,40)
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n/an/a 0.700n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(Homo sapiens (Human))		BDBM50283317
PNG
(2-Propyl-3-(3-fluoro-2'-(3-methylbutyloxycarbonyla...)
Show SMILES CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C35H40FN5O7S/c1-4-7-32-38-30-13-12-26(37-34(43)40-15-18-47-19-16-40)21-28(30)33(42)41(32)22-25-11-10-24(20-29(25)36)27-8-5-6-9-31(27)49(45,46)39-35(44)48-17-14-23(2)3/h5-6,8-13,20-21,23H,4,7,14-19,22H2,1-3H3,(H,37,43)(H,39,44)
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n/an/a 0.710n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of human adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(RAT)		BDBM50283304
PNG
(2-methyl-3-(3-fluoro-2'-(3-methyl-butyloxycarbonyl...)
Show SMILES CC(C)CCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(C)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1
Show InChI InChI=1S/C33H38FN5O6S/c1-20(2)15-16-45-33(42)37-46(43,44)30-10-8-7-9-26(30)23-11-12-24(28(34)17-23)19-39-22(5)35-29-14-13-25(18-27(29)31(39)40)36-32(41)38(6)21(3)4/h7-14,17-18,20-21H,15-16,19H2,1-6H3,(H,36,41)(H,37,42)
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n/an/a 0.720n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against AT2 receptor of rat adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(RABBIT)		BDBM50283315
PNG
(2-Ethyl-3-(3-fluoro-2'-(2-cyclopropylethyloxycarbo...)
Show SMILES CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(cc3F)-c3ccccc3S(=O)(=O)NC(=O)OCCC3CC3)c(=O)c2c1
Show InChI InChI=1S/C32H34FN5O6S/c1-3-29-36-27-14-13-23(35-31(40)34-4-2)18-25(27)30(39)38(29)19-22-12-11-21(17-26(22)33)24-7-5-6-8-28(24)45(42,43)37-32(41)44-16-15-20-9-10-20/h5-8,11-14,17-18,20H,3-4,9-10,15-16,19H2,1-2H3,(H,37,41)(H2,34,35,40)
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n/an/a 0.730n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of rabbit aorta membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(RAT)		BDBM50283308
PNG
(2-ethyl-3-(3-fluoro-2'-(3-methyl-but-2-enyloxycarb...)
Show SMILES [#6]-[#6]-c1nc2ccc(-[#7]-[#6](=O)-[#7](-[#6])-[#6](-[#6])-[#6])cc2c(=O)n1-[#6]-c1ccc(cc1F)-c1ccccc1S(=O)(=O)[#7]-[#6](=O)-[#8]-[#6]\[#6]=[#6](\[#6])-[#6]
Show InChI InChI=1S/C34H38FN5O6S/c1-7-31-37-29-15-14-25(36-33(42)39(6)22(4)5)19-27(29)32(41)40(31)20-24-13-12-23(18-28(24)35)26-10-8-9-11-30(26)47(44,45)38-34(43)46-17-16-21(2)3/h8-16,18-19,22H,7,17,20H2,1-6H3,(H,36,42)(H,38,43)
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n/an/a 0.75n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(RAT)		BDBM50049204
PNG
(2-ethyl-3-(3-fluoro-2'-(2-cyclopropylethyloxycarbo...)
Show SMILES CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC1CC1
Show InChI InChI=1S/C34H38FN5O6S/c1-5-31-37-29-15-14-25(36-33(42)39(4)21(2)3)19-27(29)32(41)40(31)20-24-13-12-23(18-28(24)35)26-8-6-7-9-30(26)47(44,45)38-34(43)46-17-16-22-10-11-22/h6-9,12-15,18-19,21-22H,5,10-11,16-17,20H2,1-4H3,(H,36,42)(H,38,43)
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n/an/a 0.770n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against AT2 receptor of rat adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(RABBIT)		BDBM50283308
PNG
(2-ethyl-3-(3-fluoro-2'-(3-methyl-but-2-enyloxycarb...)
Show SMILES [#6]-[#6]-c1nc2ccc(-[#7]-[#6](=O)-[#7](-[#6])-[#6](-[#6])-[#6])cc2c(=O)n1-[#6]-c1ccc(cc1F)-c1ccccc1S(=O)(=O)[#7]-[#6](=O)-[#8]-[#6]\[#6]=[#6](\[#6])-[#6]
Show InChI InChI=1S/C34H38FN5O6S/c1-7-31-37-29-15-14-25(36-33(42)39(6)22(4)5)19-27(29)32(41)40(31)20-24-13-12-23(18-28(24)35)26-10-8-9-11-30(26)47(44,45)38-34(43)46-17-16-21(2)3/h8-16,18-19,22H,7,17,20H2,1-6H3,(H,36,42)(H,38,43)
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n/an/a 0.770n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of rabbit aorta membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(RAT)		BDBM50283318
PNG
(2-Butyl-3-(3-fluoro-2'-(butyloxycarbonylaminosulph...)
Show SMILES CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1
Show InChI InChI=1S/C35H42FN5O6S/c1-6-8-14-32-38-30-18-17-26(37-34(43)40(5)23(3)4)21-28(30)33(42)41(32)22-25-16-15-24(20-29(25)36)27-12-10-11-13-31(27)48(45,46)39-35(44)47-19-9-7-2/h10-13,15-18,20-21,23H,6-9,14,19,22H2,1-5H3,(H,37,43)(H,39,44)
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n/an/a 0.770n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against AT2 receptor of rat adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(RAT)		BDBM50283315
PNG
(2-Ethyl-3-(3-fluoro-2'-(2-cyclopropylethyloxycarbo...)
Show SMILES CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(cc3F)-c3ccccc3S(=O)(=O)NC(=O)OCCC3CC3)c(=O)c2c1
Show InChI InChI=1S/C32H34FN5O6S/c1-3-29-36-27-14-13-23(35-31(40)34-4-2)18-25(27)30(39)38(29)19-22-12-11-21(17-26(22)33)24-7-5-6-8-28(24)45(42,43)37-32(41)44-16-15-20-9-10-20/h5-8,11-14,17-18,20H,3-4,9-10,15-16,19H2,1-2H3,(H,37,41)(H2,34,35,40)
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n/an/a 0.800n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against AT2 receptor of rat adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(RAT)		BDBM50283309
PNG
(2-ethyl-3-(3-fluoro-2'-(2-cyclopropylethyloxycarbo...)
Show SMILES CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC1CC1
Show InChI InChI=1S/C33H36FN5O6S/c1-4-30-37-28-14-13-24(36-32(41)35-20(2)3)18-26(28)31(40)39(30)19-23-12-11-22(17-27(23)34)25-7-5-6-8-29(25)46(43,44)38-33(42)45-16-15-21-9-10-21/h5-8,11-14,17-18,20-21H,4,9-10,15-16,19H2,1-3H3,(H,38,42)(H2,35,36,41)
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n/an/a 0.800n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against AT2 receptor of rat adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(Homo sapiens (Human))		BDBM50283305
PNG
(3'-Fluoro-4'-[6-(3-isopropyl-ureido)-4-oxo-2-propy...)
Show SMILES CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)c1ccc(CC)cc1F
Show InChI InChI=1S/C37H37F2N5O5S/c1-5-9-34-42-32-17-15-26(41-37(47)40-22(3)4)20-29(32)36(46)44(34)21-25-14-13-24(19-30(25)38)27-10-7-8-11-33(27)50(48,49)43-35(45)28-16-12-23(6-2)18-31(28)39/h7-8,10-20,22H,5-6,9,21H2,1-4H3,(H,43,45)(H2,40,41,47)
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n/an/a 0.840n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of human adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(Homo sapiens (Human))		BDBM50283318
PNG
(2-Butyl-3-(3-fluoro-2'-(butyloxycarbonylaminosulph...)
Show SMILES CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1
Show InChI InChI=1S/C35H42FN5O6S/c1-6-8-14-32-38-30-18-17-26(37-34(43)40(5)23(3)4)21-28(30)33(42)41(32)22-25-16-15-24(20-29(25)36)27-12-10-11-13-31(27)48(45,46)39-35(44)47-19-9-7-2/h10-13,15-18,20-21,23H,6-9,14,19,22H2,1-5H3,(H,37,43)(H,39,44)
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n/an/a 0.890n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of human adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(RABBIT)		BDBM50283309
PNG
(2-ethyl-3-(3-fluoro-2'-(2-cyclopropylethyloxycarbo...)
Show SMILES CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC1CC1
Show InChI InChI=1S/C33H36FN5O6S/c1-4-30-37-28-14-13-24(36-32(41)35-20(2)3)18-26(28)31(40)39(30)19-23-12-11-22(17-27(23)34)25-7-5-6-8-29(25)46(43,44)38-33(42)45-16-15-21-9-10-21/h5-8,11-14,17-18,20-21H,4,9-10,15-16,19H2,1-3H3,(H,38,42)(H2,35,36,41)
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n/an/a 0.920n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of rabbit aorta membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(RAT)		BDBM50283310
PNG
(4'-[2-Ethyl-6-(3-isopropyl-3-methyl-ureido)-4-oxo-...)
Show SMILES CCc1ccc(cc1)C(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1
Show InChI InChI=1S/C37H38FN5O5S/c1-6-24-12-14-25(15-13-24)35(44)41-49(47,48)33-11-9-8-10-29(33)26-16-17-27(31(38)20-26)22-43-34(7-2)40-32-19-18-28(21-30(32)36(43)45)39-37(46)42(5)23(3)4/h8-21,23H,6-7,22H2,1-5H3,(H,39,46)(H,41,44)
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n/an/a 0.930n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against AT2 receptor of rat adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(RAT)		BDBM50283314
PNG
(2-ethyl-3-(3-fluoro-2'-(3-methyl-butyloxycarbonyla...)
Show SMILES CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C34H38FN5O7S/c1-4-31-37-29-12-11-25(36-33(42)39-14-17-46-18-15-39)20-27(29)32(41)40(31)21-24-10-9-23(19-28(24)35)26-7-5-6-8-30(26)48(44,45)38-34(43)47-16-13-22(2)3/h5-12,19-20,22H,4,13-18,21H2,1-3H3,(H,36,42)(H,38,43)
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n/an/a 0.950n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II, type 2 of rat midbrain membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(RAT)		BDBM50283316
PNG
(3'-Fluoro-4'-[6-(3-isopropyl-ureido)-4-oxo-2-propy...)
Show SMILES CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)COCC(C)C
Show InChI InChI=1S/C34H40FN5O6S/c1-6-9-31-38-29-15-14-25(37-34(43)36-22(4)5)17-27(29)33(42)40(31)18-24-13-12-23(16-28(24)35)26-10-7-8-11-30(26)47(44,45)39-32(41)20-46-19-21(2)3/h7-8,10-17,21-22H,6,9,18-20H2,1-5H3,(H,39,41)(H2,36,37,43)
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n/an/a 1n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against AT2 receptor of rat adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(RAT)		BDBM50283308
PNG
(2-ethyl-3-(3-fluoro-2'-(3-methyl-but-2-enyloxycarb...)
Show SMILES [#6]-[#6]-c1nc2ccc(-[#7]-[#6](=O)-[#7](-[#6])-[#6](-[#6])-[#6])cc2c(=O)n1-[#6]-c1ccc(cc1F)-c1ccccc1S(=O)(=O)[#7]-[#6](=O)-[#8]-[#6]\[#6]=[#6](\[#6])-[#6]
Show InChI InChI=1S/C34H38FN5O6S/c1-7-31-37-29-15-14-25(36-33(42)39(6)22(4)5)19-27(29)32(41)40(31)20-24-13-12-23(18-28(24)35)26-10-8-9-11-30(26)47(44,45)38-34(43)46-17-16-21(2)3/h8-16,18-19,22H,7,17,20H2,1-6H3,(H,36,42)(H,38,43)
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n/an/a 1n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against AT2 receptor of rat adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(RAT)		BDBM50283304
PNG
(2-methyl-3-(3-fluoro-2'-(3-methyl-butyloxycarbonyl...)
Show SMILES CC(C)CCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(C)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1
Show InChI InChI=1S/C33H38FN5O6S/c1-20(2)15-16-45-33(42)37-46(43,44)30-10-8-7-9-26(30)23-11-12-24(28(34)17-23)19-39-22(5)35-29-14-13-25(18-27(29)31(39)40)36-32(41)38(6)21(3)4/h7-14,17-18,20-21H,15-16,19H2,1-6H3,(H,36,41)(H,37,42)
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n/an/a 1.10n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(RABBIT)		BDBM50283306
PNG
(2-methyl-3-(3-fluoro-2'-(3-methyl-butyloxycarbonyl...)
Show SMILES CC(C)CCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(C)nc3ccc(NC(=O)NC(C)C)cc3c2=O)c(F)c1
Show InChI InChI=1S/C32H36FN5O6S/c1-19(2)14-15-44-32(41)37-45(42,43)29-9-7-6-8-25(29)22-10-11-23(27(33)16-22)18-38-21(5)35-28-13-12-24(17-26(28)30(38)39)36-31(40)34-20(3)4/h6-13,16-17,19-20H,14-15,18H2,1-5H3,(H,37,41)(H2,34,36,40)
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n/an/a 1.20n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of rabbit aorta membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(Homo sapiens (Human))		BDBM50283319
PNG
(2-Butyl-3-(3-fluoro-2'-(2-cyclopropylethyloxycarbo...)
Show SMILES CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC1CC1
Show InChI InChI=1S/C36H42FN5O6S/c1-5-6-11-33-39-31-17-16-27(38-35(44)41(4)23(2)3)21-29(31)34(43)42(33)22-26-15-14-25(20-30(26)37)28-9-7-8-10-32(28)49(46,47)40-36(45)48-19-18-24-12-13-24/h7-10,14-17,20-21,23-24H,5-6,11-13,18-19,22H2,1-4H3,(H,38,44)(H,40,45)
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n/an/a 1.20n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of human adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(RAT)		BDBM50283301
PNG
(2-ethyl-3-(3-fluoro-2'-(butyloxycarbonylaminosulph...)
Show SMILES CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1
Show InChI InChI=1S/C33H36FN5O7S/c1-3-5-16-46-33(42)37-47(43,44)29-9-7-6-8-25(29)22-10-11-23(27(34)19-22)21-39-30(4-2)36-28-13-12-24(20-26(28)31(39)40)35-32(41)38-14-17-45-18-15-38/h6-13,19-20H,3-5,14-18,21H2,1-2H3,(H,35,41)(H,37,42)
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n/an/a 1.30n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor A/B


(RAT)		BDBM50283301
PNG
(2-ethyl-3-(3-fluoro-2'-(butyloxycarbonylaminosulph...)
Show SMILES CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1
Show InChI InChI=1S/C33H36FN5O7S/c1-3-5-16-46-33(42)37-47(43,44)29-9-7-6-8-25(29)22-10-11-23(27(34)19-22)21-39-30(4-2)36-28-13-12-24(20-26(28)31(39)40)35-32(41)38-14-17-45-18-15-38/h6-13,19-20H,3-5,14-18,21H2,1-2H3,(H,35,41)(H,37,42)
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n/an/a 1.30n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rat adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor A/B


(RAT)		BDBM50283311
PNG
(2-ethyl-3-(3-fluoro-2'-(3-methyl-butyloxycarbonyla...)
Show SMILES CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C35H34FN5O6S/c1-4-32-39-29-15-14-25(38-33(42)30-10-7-8-17-37-30)20-27(29)34(43)41(32)21-24-13-12-23(19-28(24)36)26-9-5-6-11-31(26)48(45,46)40-35(44)47-18-16-22(2)3/h5-15,17,19-20,22H,4,16,18,21H2,1-3H3,(H,38,42)(H,40,44)
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n/an/a 1.30n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rat adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(Homo sapiens (Human))		BDBM50283316
PNG
(3'-Fluoro-4'-[6-(3-isopropyl-ureido)-4-oxo-2-propy...)
Show SMILES CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)COCC(C)C
Show InChI InChI=1S/C34H40FN5O6S/c1-6-9-31-38-29-15-14-25(37-34(43)36-22(4)5)17-27(29)33(42)40(31)18-24-13-12-23(16-28(24)35)26-10-7-8-11-30(26)47(44,45)39-32(41)20-46-19-21(2)3/h7-8,10-17,21-22H,6,9,18-20H2,1-5H3,(H,39,41)(H2,36,37,43)
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n/an/a 1.5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of human adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(RABBIT)		BDBM82433
PNG
(CHEMBL302102 | L-159,689 | L-159689 | N-Pentyl-N-[...)
Show SMILES CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(cc3)-c3ccccc3-c3nnn[nH]3)c(=O)c2c1
Show InChI InChI=1S/C37H37N7O2/c1-3-5-11-23-43(36(45)28-13-7-6-8-14-28)29-21-22-33-32(24-29)37(46)44(34(38-33)12-4-2)25-26-17-19-27(20-18-26)30-15-9-10-16-31(30)35-39-41-42-40-35/h6-10,13-22,24H,3-5,11-12,23,25H2,1-2H3,(H,39,40,41,42)
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n/an/a 1.5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of rabbit aorta membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(Homo sapiens (Human))		BDBM50283312
PNG
(4'-[2-Ethyl-6-(3-isopropyl-ureido)-4-oxo-4H-quinaz...)
Show SMILES CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1
Show InChI InChI=1S/C36H35F2N5O5S/c1-5-22-11-15-27(30(38)17-22)34(44)42-49(47,48)32-10-8-7-9-26(32)23-12-13-24(29(37)18-23)20-43-33(6-2)41-31-16-14-25(19-28(31)35(43)45)40-36(46)39-21(3)4/h7-19,21H,5-6,20H2,1-4H3,(H,42,44)(H2,39,40,46)
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n/an/a 1.60n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of human adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(RAT)		BDBM50283313
PNG
(4'-[2-Ethyl-6-(3-ethyl-ureido)-4-oxo-4H-quinazolin...)
Show SMILES CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(cc3F)-c3ccccc3S(=O)(=O)NC(=O)c3ccccc3F)c(=O)c2c1
Show InChI InChI=1S/C33H29F2N5O5S/c1-3-30-38-28-16-15-22(37-33(43)36-4-2)18-25(28)32(42)40(30)19-21-14-13-20(17-27(21)35)23-9-6-8-12-29(23)46(44,45)39-31(41)24-10-5-7-11-26(24)34/h5-18H,3-4,19H2,1-2H3,(H,39,41)(H2,36,37,43)
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n/an/a 1.60n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II, type 2 of rat midbrain membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(RAT)		BDBM50283311
PNG
(2-ethyl-3-(3-fluoro-2'-(3-methyl-butyloxycarbonyla...)
Show SMILES CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C35H34FN5O6S/c1-4-32-39-29-15-14-25(38-33(42)30-10-7-8-17-37-30)20-27(29)34(43)41(32)21-24-13-12-23(19-28(24)36)26-9-5-6-11-31(26)48(45,46)40-35(44)47-18-16-22(2)3/h5-15,17,19-20,22H,4,16,18,21H2,1-3H3,(H,38,42)(H,40,44)
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n/an/a 1.80n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(Homo sapiens (Human))		BDBM50283300
PNG
(2-Butyl-3-(3-fluoro-2'-(3-methylbutyloxycarbonylam...)
Show SMILES CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C36H44FN5O6S/c1-7-8-13-33-39-31-17-16-27(38-35(44)41(6)24(4)5)21-29(31)34(43)42(33)22-26-15-14-25(20-30(26)37)28-11-9-10-12-32(28)49(46,47)40-36(45)48-19-18-23(2)3/h9-12,14-17,20-21,23-24H,7-8,13,18-19,22H2,1-6H3,(H,38,44)(H,40,45)
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n/an/a 1.90n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of human adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor A/B


(RAT)		BDBM50283307
PNG
(4'-[2-Ethyl-6-(3-isopropyl-3-methyl-ureido)-4-oxo-...)
Show SMILES CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)COCC(C)C
Show InChI InChI=1S/C34H40FN5O6S/c1-7-31-37-29-15-14-25(36-34(43)39(6)22(4)5)17-27(29)33(42)40(31)18-24-13-12-23(16-28(24)35)26-10-8-9-11-30(26)47(44,45)38-32(41)20-46-19-21(2)3/h8-17,21-22H,7,18-20H2,1-6H3,(H,36,43)(H,38,41)
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n/an/a 2n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II, type 2 of rat midbrain membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(RABBIT)		BDBM50283314
PNG
(2-ethyl-3-(3-fluoro-2'-(3-methyl-butyloxycarbonyla...)
Show SMILES CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C34H38FN5O7S/c1-4-31-37-29-12-11-25(36-33(42)39-14-17-46-18-15-39)20-27(29)32(41)40(31)21-24-10-9-23(19-28(24)35)26-7-5-6-8-30(26)48(44,45)38-34(43)47-16-13-22(2)3/h5-12,19-20,22H,4,13-18,21H2,1-3H3,(H,36,42)(H,38,43)
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TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of rabbit aorta membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(RABBIT)		BDBM50283307
PNG
(4'-[2-Ethyl-6-(3-isopropyl-3-methyl-ureido)-4-oxo-...)
Show SMILES CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)COCC(C)C
Show InChI InChI=1S/C34H40FN5O6S/c1-7-31-37-29-15-14-25(36-34(43)39(6)22(4)5)17-27(29)33(42)40(31)18-24-13-12-23(16-28(24)35)26-10-8-9-11-30(26)47(44,45)38-32(41)20-46-19-21(2)3/h8-17,21-22H,7,18-20H2,1-6H3,(H,36,43)(H,38,41)
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n/an/a 2.20n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of rabbit aorta membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(RABBIT)		BDBM50283304
PNG
(2-methyl-3-(3-fluoro-2'-(3-methyl-butyloxycarbonyl...)
Show SMILES CC(C)CCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(C)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1
Show InChI InChI=1S/C33H38FN5O6S/c1-20(2)15-16-45-33(42)37-46(43,44)30-10-8-7-9-26(30)23-11-12-24(28(34)17-23)19-39-22(5)35-29-14-13-25(18-27(29)31(39)40)36-32(41)38(6)21(3)4/h7-14,17-18,20-21H,15-16,19H2,1-6H3,(H,36,41)(H,37,42)
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n/an/a 2.30n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of rabbit aorta membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(RABBIT)		BDBM50283311
PNG
(2-ethyl-3-(3-fluoro-2'-(3-methyl-butyloxycarbonyla...)
Show SMILES CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C35H34FN5O6S/c1-4-32-39-29-15-14-25(38-33(42)30-10-7-8-17-37-30)20-27(29)34(43)41(32)21-24-13-12-23(19-28(24)36)26-9-5-6-11-31(26)48(45,46)40-35(44)47-18-16-22(2)3/h5-15,17,19-20,22H,4,16,18,21H2,1-3H3,(H,38,42)(H,40,44)
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n/an/a 2.30n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of rabbit aorta membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor A/B


(RAT)		BDBM50283303
PNG
(2-methyl-3-(3-fluoro-2'-(2-cyclopropylethyloxycarb...)
Show SMILES CN(C)C(=O)Nc1ccc2nc(C)n(Cc3ccc(cc3F)-c3ccccc3S(=O)(=O)NC(=O)OCCC3CC3)c(=O)c2c1
Show InChI InChI=1S/C31H32FN5O6S/c1-19-33-27-13-12-23(34-30(39)36(2)3)17-25(27)29(38)37(19)18-22-11-10-21(16-26(22)32)24-6-4-5-7-28(24)44(41,42)35-31(40)43-15-14-20-8-9-20/h4-7,10-13,16-17,20H,8-9,14-15,18H2,1-3H3,(H,34,39)(H,35,40)
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n/an/a 2.30n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against AT2 receptor of rat adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(RABBIT)		BDBM50283303
PNG
(2-methyl-3-(3-fluoro-2'-(2-cyclopropylethyloxycarb...)
Show SMILES CN(C)C(=O)Nc1ccc2nc(C)n(Cc3ccc(cc3F)-c3ccccc3S(=O)(=O)NC(=O)OCCC3CC3)c(=O)c2c1
Show InChI InChI=1S/C31H32FN5O6S/c1-19-33-27-13-12-23(34-30(39)36(2)3)17-25(27)29(38)37(19)18-22-11-10-21(16-26(22)32)24-6-4-5-7-28(24)44(41,42)35-31(40)43-15-14-20-8-9-20/h4-7,10-13,16-17,20H,8-9,14-15,18H2,1-3H3,(H,34,39)(H,35,40)
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n/an/a 2.30n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of rabbit aorta membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(RAT)		BDBM50283303
PNG
(2-methyl-3-(3-fluoro-2'-(2-cyclopropylethyloxycarb...)
Show SMILES CN(C)C(=O)Nc1ccc2nc(C)n(Cc3ccc(cc3F)-c3ccccc3S(=O)(=O)NC(=O)OCCC3CC3)c(=O)c2c1
Show InChI InChI=1S/C31H32FN5O6S/c1-19-33-27-13-12-23(34-30(39)36(2)3)17-25(27)29(38)37(19)18-22-11-10-21(16-26(22)32)24-6-4-5-7-28(24)44(41,42)35-31(40)43-15-14-20-8-9-20/h4-7,10-13,16-17,20H,8-9,14-15,18H2,1-3H3,(H,34,39)(H,35,40)
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n/an/a 2.40n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against AT2 receptor of rat adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(RAT)		BDBM50049181
PNG
(2-Butyl-3-(2'-(butyloxycarbonylaminosulphonyl)-bip...)
Show SMILES CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1
Show InChI InChI=1S/C35H43N5O6S/c1-6-8-14-32-37-30-20-19-27(36-34(42)39(5)24(3)4)22-29(30)33(41)40(32)23-25-15-17-26(18-16-25)28-12-10-11-13-31(28)47(44,45)38-35(43)46-21-9-7-2/h10-13,15-20,22,24H,6-9,14,21,23H2,1-5H3,(H,36,42)(H,38,43)
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n/an/a 2.40n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II, type 2 of rat midbrain membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(RAT)		BDBM50283301
PNG
(2-ethyl-3-(3-fluoro-2'-(butyloxycarbonylaminosulph...)
Show SMILES CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1
Show InChI InChI=1S/C33H36FN5O7S/c1-3-5-16-46-33(42)37-47(43,44)29-9-7-6-8-25(29)22-10-11-23(27(34)19-22)21-39-30(4-2)36-28-13-12-24(20-26(28)31(39)40)35-32(41)38-14-17-45-18-15-38/h6-13,19-20H,3-5,14-18,21H2,1-2H3,(H,35,41)(H,37,42)
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n/an/a 2.5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against AT2 receptor of rat adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(Homo sapiens (Human))		BDBM50283312
PNG
(4'-[2-Ethyl-6-(3-isopropyl-ureido)-4-oxo-4H-quinaz...)
Show SMILES CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1
Show InChI InChI=1S/C36H35F2N5O5S/c1-5-22-11-15-27(30(38)17-22)34(44)42-49(47,48)32-10-8-7-9-26(32)23-12-13-24(29(37)18-23)20-43-33(6-2)41-31-16-14-25(19-28(31)35(43)45)40-36(46)39-21(3)4/h7-19,21H,5-6,20H2,1-4H3,(H,42,44)(H2,39,40,46)
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n/an/a 3.10n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against AT2 receptor of human adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(Homo sapiens (Human))		BDBM50283317
PNG
(2-Propyl-3-(3-fluoro-2'-(3-methylbutyloxycarbonyla...)
Show SMILES CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C35H40FN5O7S/c1-4-7-32-38-30-13-12-26(37-34(43)40-15-18-47-19-16-40)21-28(30)33(42)41(32)22-25-11-10-24(20-29(25)36)27-8-5-6-9-31(27)49(45,46)39-35(44)48-17-14-23(2)3/h5-6,8-13,20-21,23H,4,7,14-19,22H2,1-3H3,(H,37,43)(H,39,44)
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n/an/a 3.30n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against AT2 receptor of human adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(Homo sapiens (Human))		BDBM50283316
PNG
(3'-Fluoro-4'-[6-(3-isopropyl-ureido)-4-oxo-2-propy...)
Show SMILES CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)COCC(C)C
Show InChI InChI=1S/C34H40FN5O6S/c1-6-9-31-38-29-15-14-25(37-34(43)36-22(4)5)17-27(29)33(42)40(31)18-24-13-12-23(16-28(24)35)26-10-7-8-11-30(26)47(44,45)39-32(41)20-46-19-21(2)3/h7-8,10-17,21-22H,6,9,18-20H2,1-5H3,(H,39,41)(H2,36,37,43)
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n/an/a 3.5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against AT2 receptor of human adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(RABBIT)		BDBM50283301
PNG
(2-ethyl-3-(3-fluoro-2'-(butyloxycarbonylaminosulph...)
Show SMILES CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1
Show InChI InChI=1S/C33H36FN5O7S/c1-3-5-16-46-33(42)37-47(43,44)29-9-7-6-8-25(29)22-10-11-23(27(34)19-22)21-39-30(4-2)36-28-13-12-24(20-26(28)31(39)40)35-32(41)38-14-17-45-18-15-38/h6-13,19-20H,3-5,14-18,21H2,1-2H3,(H,35,41)(H,37,42)
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n/an/a 3.80n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of rabbit aorta membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor A/B


(RAT)		BDBM50283313
PNG
(4'-[2-Ethyl-6-(3-ethyl-ureido)-4-oxo-4H-quinazolin...)
Show SMILES CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(cc3F)-c3ccccc3S(=O)(=O)NC(=O)c3ccccc3F)c(=O)c2c1
Show InChI InChI=1S/C33H29F2N5O5S/c1-3-30-38-28-16-15-22(37-33(43)36-4-2)18-25(28)32(42)40(30)19-21-14-13-20(17-27(21)35)23-9-6-8-12-29(23)46(44,45)39-31(41)24-10-5-7-11-26(24)34/h5-18H,3-4,19H2,1-2H3,(H,39,41)(H2,36,37,43)
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n/an/a 3.90n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II, type 2 of rat midbrain membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(Homo sapiens (Human))		BDBM50049181
PNG
(2-Butyl-3-(2'-(butyloxycarbonylaminosulphonyl)-bip...)
Show SMILES CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1
Show InChI InChI=1S/C35H43N5O6S/c1-6-8-14-32-37-30-20-19-27(36-34(42)39(5)24(3)4)22-29(30)33(41)40(32)23-25-15-17-26(18-16-25)28-12-10-11-13-31(28)47(44,45)38-35(43)46-21-9-7-2/h10-13,15-20,22,24H,6-9,14,21,23H2,1-5H3,(H,36,42)(H,38,43)
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n/an/a 4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of rat adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(RABBIT)		BDBM50283313
PNG
(4'-[2-Ethyl-6-(3-ethyl-ureido)-4-oxo-4H-quinazolin...)
Show SMILES CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(cc3F)-c3ccccc3S(=O)(=O)NC(=O)c3ccccc3F)c(=O)c2c1
Show InChI InChI=1S/C33H29F2N5O5S/c1-3-30-38-28-16-15-22(37-33(43)36-4-2)18-25(28)32(42)40(30)19-21-14-13-20(17-27(21)35)23-9-6-8-12-29(23)46(44,45)39-31(41)24-10-5-7-11-26(24)34/h5-18H,3-4,19H2,1-2H3,(H,39,41)(H2,36,37,43)
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n/an/a 4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of rabbit aorta membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(Homo sapiens (Human))		BDBM50283305
PNG
(3'-Fluoro-4'-[6-(3-isopropyl-ureido)-4-oxo-2-propy...)
Show SMILES CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)c1ccc(CC)cc1F
Show InChI InChI=1S/C37H37F2N5O5S/c1-5-9-34-42-32-17-15-26(41-37(47)40-22(3)4)20-29(32)36(46)44(34)21-25-14-13-24(19-30(25)38)27-10-7-8-11-33(27)50(48,49)43-35(45)28-16-12-23(6-2)18-31(28)39/h7-8,10-20,22H,5-6,9,21H2,1-4H3,(H,43,45)(H2,40,41,47)
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n/an/a 4.40n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against AT2 receptor of human adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(RAT)		BDBM50283313
PNG
(4'-[2-Ethyl-6-(3-ethyl-ureido)-4-oxo-4H-quinazolin...)
Show SMILES CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(cc3F)-c3ccccc3S(=O)(=O)NC(=O)c3ccccc3F)c(=O)c2c1
Show InChI InChI=1S/C33H29F2N5O5S/c1-3-30-38-28-16-15-22(37-33(43)36-4-2)18-25(28)32(42)40(30)19-21-14-13-20(17-27(21)35)23-9-6-8-12-29(23)46(44,45)39-31(41)24-10-5-7-11-26(24)34/h5-18H,3-4,19H2,1-2H3,(H,39,41)(H2,36,37,43)
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n/an/a 4.5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against AT2 receptor of rat adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(Homo sapiens (Human))		BDBM50283310
PNG
(4'-[2-Ethyl-6-(3-isopropyl-3-methyl-ureido)-4-oxo-...)
Show SMILES CCc1ccc(cc1)C(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1
Show InChI InChI=1S/C37H38FN5O5S/c1-6-24-12-14-25(15-13-24)35(44)41-49(47,48)33-11-9-8-10-29(33)26-16-17-27(31(38)20-26)22-43-34(7-2)40-32-19-18-28(21-30(32)36(43)45)39-37(46)42(5)23(3)4/h8-21,23H,6-7,22H2,1-5H3,(H,39,46)(H,41,44)
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n/an/a 5.80n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of human adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(Homo sapiens (Human))		BDBM50049204
PNG
(2-ethyl-3-(3-fluoro-2'-(2-cyclopropylethyloxycarbo...)
Show SMILES CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC1CC1
Show InChI InChI=1S/C34H38FN5O6S/c1-5-31-37-29-15-14-25(36-33(42)39(4)21(2)3)19-27(29)32(41)40(31)20-24-13-12-23(18-28(24)35)26-8-6-7-9-30(26)47(44,45)38-34(43)46-17-16-22-10-11-22/h6-9,12-15,18-19,21-22H,5,10-11,16-17,20H2,1-4H3,(H,36,42)(H,38,43)
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n/an/a 6.20n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against AT2 receptor of human adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(Homo sapiens (Human))		BDBM50283309
PNG
(2-ethyl-3-(3-fluoro-2'-(2-cyclopropylethyloxycarbo...)
Show SMILES CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC1CC1
Show InChI InChI=1S/C33H36FN5O6S/c1-4-30-37-28-14-13-24(36-32(41)35-20(2)3)18-26(28)31(40)39(30)19-23-12-11-22(17-27(23)34)25-7-5-6-8-29(25)46(43,44)38-33(42)45-16-15-21-9-10-21/h5-8,11-14,17-18,20-21H,4,9-10,15-16,19H2,1-3H3,(H,38,42)(H2,35,36,41)
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n/an/a 6.5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against AT2 receptor of human adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(RAT)		BDBM50283303
PNG
(2-methyl-3-(3-fluoro-2'-(2-cyclopropylethyloxycarb...)
Show SMILES CN(C)C(=O)Nc1ccc2nc(C)n(Cc3ccc(cc3F)-c3ccccc3S(=O)(=O)NC(=O)OCCC3CC3)c(=O)c2c1
Show InChI InChI=1S/C31H32FN5O6S/c1-19-33-27-13-12-23(34-30(39)36(2)3)17-25(27)29(38)37(19)18-22-11-10-21(16-26(22)32)24-6-4-5-7-28(24)44(41,42)35-31(40)43-15-14-20-8-9-20/h4-7,10-13,16-17,20H,8-9,14-15,18H2,1-3H3,(H,34,39)(H,35,40)
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n/an/a 6.60n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II, type 2 of rat midbrain membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(Homo sapiens (Human))		BDBM82433
PNG
(CHEMBL302102 | L-159,689 | L-159689 | N-Pentyl-N-[...)
Show SMILES CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(cc3)-c3ccccc3-c3nnn[nH]3)c(=O)c2c1
Show InChI InChI=1S/C37H37N7O2/c1-3-5-11-23-43(36(45)28-13-7-6-8-14-28)29-21-22-33-32(24-29)37(46)44(34(38-33)12-4-2)25-26-17-19-27(20-18-26)30-15-9-10-16-31(30)35-39-41-42-40-35/h6-10,13-22,24H,3-5,11-12,23,25H2,1-2H3,(H,39,40,41,42)
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n/an/a 7n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against AT2 receptor of human adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(Homo sapiens (Human))		BDBM82433
PNG
(CHEMBL302102 | L-159,689 | L-159689 | N-Pentyl-N-[...)
Show SMILES CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(cc3)-c3ccccc3-c3nnn[nH]3)c(=O)c2c1
Show InChI InChI=1S/C37H37N7O2/c1-3-5-11-23-43(36(45)28-13-7-6-8-14-28)29-21-22-33-32(24-29)37(46)44(34(38-33)12-4-2)25-26-17-19-27(20-18-26)30-15-9-10-16-31(30)35-39-41-42-40-35/h6-10,13-22,24H,3-5,11-12,23,25H2,1-2H3,(H,39,40,41,42)
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n/an/a 7n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of rat adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(Homo sapiens (Human))		BDBM50283309
PNG
(2-ethyl-3-(3-fluoro-2'-(2-cyclopropylethyloxycarbo...)
Show SMILES CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC1CC1
Show InChI InChI=1S/C33H36FN5O6S/c1-4-30-37-28-14-13-24(36-32(41)35-20(2)3)18-26(28)31(40)39(30)19-23-12-11-22(17-27(23)34)25-7-5-6-8-29(25)46(43,44)38-33(42)45-16-15-21-9-10-21/h5-8,11-14,17-18,20-21H,4,9-10,15-16,19H2,1-3H3,(H,38,42)(H2,35,36,41)
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n/an/a 7.20n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of human adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(Homo sapiens (Human))		BDBM50283318
PNG
(2-Butyl-3-(3-fluoro-2'-(butyloxycarbonylaminosulph...)
Show SMILES CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1
Show InChI InChI=1S/C35H42FN5O6S/c1-6-8-14-32-38-30-18-17-26(37-34(43)40(5)23(3)4)21-28(30)33(42)41(32)22-25-16-15-24(20-29(25)36)27-12-10-11-13-31(27)48(45,46)39-35(44)47-19-9-7-2/h10-13,15-18,20-21,23H,6-9,14,19,22H2,1-5H3,(H,37,43)(H,39,44)
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n/an/a 7.70n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against AT2 receptor of human adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(Homo sapiens (Human))		BDBM50283319
PNG
(2-Butyl-3-(3-fluoro-2'-(2-cyclopropylethyloxycarbo...)
Show SMILES CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC1CC1
Show InChI InChI=1S/C36H42FN5O6S/c1-5-6-11-33-39-31-17-16-27(38-35(44)41(4)23(2)3)21-29(31)34(43)42(33)22-26-15-14-25(20-30(26)37)28-9-7-8-10-32(28)49(46,47)40-36(45)48-19-18-24-12-13-24/h7-10,14-17,20-21,23-24H,5-6,11-13,18-19,22H2,1-4H3,(H,38,44)(H,40,45)
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n/an/a 7.80n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against AT2 receptor of human adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(Homo sapiens (Human))		BDBM50283300
PNG
(2-Butyl-3-(3-fluoro-2'-(3-methylbutyloxycarbonylam...)
Show SMILES CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C36H44FN5O6S/c1-7-8-13-33-39-31-17-16-27(38-35(44)41(6)24(4)5)21-29(31)34(43)42(33)22-26-15-14-25(20-30(26)37)28-11-9-10-12-32(28)49(46,47)40-36(45)48-19-18-23(2)3/h9-12,14-17,20-21,23-24H,7-8,13,18-19,22H2,1-6H3,(H,38,44)(H,40,45)
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n/an/a 8n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against AT2 receptor of human adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(Homo sapiens (Human))		BDBM50049204
PNG
(2-ethyl-3-(3-fluoro-2'-(2-cyclopropylethyloxycarbo...)
Show SMILES CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC1CC1
Show InChI InChI=1S/C34H38FN5O6S/c1-5-31-37-29-15-14-25(36-33(42)39(4)21(2)3)19-27(29)32(41)40(31)20-24-13-12-23(18-28(24)35)26-8-6-7-9-30(26)47(44,45)38-34(43)46-17-16-22-10-11-22/h6-9,12-15,18-19,21-22H,5,10-11,16-17,20H2,1-4H3,(H,36,42)(H,38,43)
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n/an/a 8.10n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of human adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(Homo sapiens (Human))		BDBM50283310
PNG
(4'-[2-Ethyl-6-(3-isopropyl-3-methyl-ureido)-4-oxo-...)
Show SMILES CCc1ccc(cc1)C(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1
Show InChI InChI=1S/C37H38FN5O5S/c1-6-24-12-14-25(15-13-24)35(44)41-49(47,48)33-11-9-8-10-29(33)26-16-17-27(31(38)20-26)22-43-34(7-2)40-32-19-18-28(21-30(32)36(43)45)39-37(46)42(5)23(3)4/h8-21,23H,6-7,22H2,1-5H3,(H,39,46)(H,41,44)
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n/an/a 8.90n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against AT2 receptor of human adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(Homo sapiens (Human))		BDBM50283302
PNG
(2-ethyl-3-(3-fluoro-2'-(3-methyl-butyloxycarbonyla...)
Show SMILES CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C34H40FN5O6S/c1-7-31-37-29-15-14-25(36-33(42)39(6)22(4)5)19-27(29)32(41)40(31)20-24-13-12-23(18-28(24)35)26-10-8-9-11-30(26)47(44,45)38-34(43)46-17-16-21(2)3/h8-15,18-19,21-22H,7,16-17,20H2,1-6H3,(H,36,42)(H,38,43)
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n/an/a 9.20n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against AT2 receptor of human adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(Homo sapiens (Human))		BDBM50283308
PNG
(2-ethyl-3-(3-fluoro-2'-(3-methyl-but-2-enyloxycarb...)
Show SMILES [#6]-[#6]-c1nc2ccc(-[#7]-[#6](=O)-[#7](-[#6])-[#6](-[#6])-[#6])cc2c(=O)n1-[#6]-c1ccc(cc1F)-c1ccccc1S(=O)(=O)[#7]-[#6](=O)-[#8]-[#6]\[#6]=[#6](\[#6])-[#6]
Show InChI InChI=1S/C34H38FN5O6S/c1-7-31-37-29-15-14-25(36-33(42)39(6)22(4)5)19-27(29)32(41)40(31)20-24-13-12-23(18-28(24)35)26-10-8-9-11-30(26)47(44,45)38-34(43)46-17-16-21(2)3/h8-16,18-19,22H,7,17,20H2,1-6H3,(H,36,42)(H,38,43)
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n/an/a 9.30n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against AT2 receptor of human adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(Homo sapiens (Human))		BDBM50283315
PNG
(2-Ethyl-3-(3-fluoro-2'-(2-cyclopropylethyloxycarbo...)
Show SMILES CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(cc3F)-c3ccccc3S(=O)(=O)NC(=O)OCCC3CC3)c(=O)c2c1
Show InChI InChI=1S/C32H34FN5O6S/c1-3-29-36-27-14-13-23(35-31(40)34-4-2)18-25(27)30(39)38(29)19-22-12-11-21(17-26(22)33)24-7-5-6-8-28(24)45(42,43)37-32(41)44-16-15-20-9-10-20/h5-8,11-14,17-18,20H,3-4,9-10,15-16,19H2,1-2H3,(H,37,41)(H2,34,35,40)
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n/an/a 9.80n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against AT2 receptor of human adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(Homo sapiens (Human))		BDBM50283302
PNG
(2-ethyl-3-(3-fluoro-2'-(3-methyl-butyloxycarbonyla...)
Show SMILES CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C34H40FN5O6S/c1-7-31-37-29-15-14-25(36-33(42)39(6)22(4)5)19-27(29)32(41)40(31)20-24-13-12-23(18-28(24)35)26-10-8-9-11-30(26)47(44,45)38-34(43)46-17-16-21(2)3/h8-15,18-19,21-22H,7,16-17,20H2,1-6H3,(H,36,42)(H,38,43)
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n/an/a 10n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of human adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(Homo sapiens (Human))		BDBM50283307
PNG
(4'-[2-Ethyl-6-(3-isopropyl-3-methyl-ureido)-4-oxo-...)
Show SMILES CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)COCC(C)C
Show InChI InChI=1S/C34H40FN5O6S/c1-7-31-37-29-15-14-25(36-34(43)39(6)22(4)5)17-27(29)33(42)40(31)18-24-13-12-23(16-28(24)35)26-10-8-9-11-30(26)47(44,45)38-32(41)20-46-19-21(2)3/h8-17,21-22H,7,18-20H2,1-6H3,(H,36,43)(H,38,41)
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n/an/a 11n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against AT2 receptor of human adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(Homo sapiens (Human))		BDBM50283306
PNG
(2-methyl-3-(3-fluoro-2'-(3-methyl-butyloxycarbonyl...)
Show SMILES CC(C)CCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(C)nc3ccc(NC(=O)NC(C)C)cc3c2=O)c(F)c1
Show InChI InChI=1S/C32H36FN5O6S/c1-19(2)14-15-44-32(41)37-45(42,43)29-9-7-6-8-25(29)22-10-11-23(27(33)16-22)18-38-21(5)35-28-13-12-24(17-26(28)30(38)39)36-31(40)34-20(3)4/h6-13,16-17,19-20H,14-15,18H2,1-5H3,(H,37,41)(H2,34,36,40)
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n/an/a 11n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against AT2 receptor of human adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(Homo sapiens (Human))		BDBM50283303
PNG
(2-methyl-3-(3-fluoro-2'-(2-cyclopropylethyloxycarb...)
Show SMILES CN(C)C(=O)Nc1ccc2nc(C)n(Cc3ccc(cc3F)-c3ccccc3S(=O)(=O)NC(=O)OCCC3CC3)c(=O)c2c1
Show InChI InChI=1S/C31H32FN5O6S/c1-19-33-27-13-12-23(34-30(39)36(2)3)17-25(27)29(38)37(19)18-22-11-10-21(16-26(22)32)24-6-4-5-7-28(24)44(41,42)35-31(40)43-15-14-20-8-9-20/h4-7,10-13,16-17,20H,8-9,14-15,18H2,1-3H3,(H,34,39)(H,35,40)
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n/an/a 12n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of human adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(Homo sapiens (Human))		BDBM50283303
PNG
(2-methyl-3-(3-fluoro-2'-(2-cyclopropylethyloxycarb...)
Show SMILES CN(C)C(=O)Nc1ccc2nc(C)n(Cc3ccc(cc3F)-c3ccccc3S(=O)(=O)NC(=O)OCCC3CC3)c(=O)c2c1
Show InChI InChI=1S/C31H32FN5O6S/c1-19-33-27-13-12-23(34-30(39)36(2)3)17-25(27)29(38)37(19)18-22-11-10-21(16-26(22)32)24-6-4-5-7-28(24)44(41,42)35-31(40)43-15-14-20-8-9-20/h4-7,10-13,16-17,20H,8-9,14-15,18H2,1-3H3,(H,34,39)(H,35,40)
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n/an/a 12n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against AT2 receptor of human adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(Homo sapiens (Human))		BDBM50283315
PNG
(2-Ethyl-3-(3-fluoro-2'-(2-cyclopropylethyloxycarbo...)
Show SMILES CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(cc3F)-c3ccccc3S(=O)(=O)NC(=O)OCCC3CC3)c(=O)c2c1
Show InChI InChI=1S/C32H34FN5O6S/c1-3-29-36-27-14-13-23(35-31(40)34-4-2)18-25(27)30(39)38(29)19-22-12-11-21(17-26(22)33)24-7-5-6-8-28(24)45(42,43)37-32(41)44-16-15-20-9-10-20/h5-8,11-14,17-18,20H,3-4,9-10,15-16,19H2,1-2H3,(H,37,41)(H2,34,35,40)
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n/an/a 12n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of human adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(Homo sapiens (Human))		BDBM50283304
PNG
(2-methyl-3-(3-fluoro-2'-(3-methyl-butyloxycarbonyl...)
Show SMILES CC(C)CCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(C)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1
Show InChI InChI=1S/C33H38FN5O6S/c1-20(2)15-16-45-33(42)37-46(43,44)30-10-8-7-9-26(30)23-11-12-24(28(34)17-23)19-39-22(5)35-29-14-13-25(18-27(29)31(39)40)36-32(41)38(6)21(3)4/h7-14,17-18,20-21H,15-16,19H2,1-6H3,(H,36,41)(H,37,42)
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n/an/a 13n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against AT2 receptor of human adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(Homo sapiens (Human))		BDBM50283306
PNG
(2-methyl-3-(3-fluoro-2'-(3-methyl-butyloxycarbonyl...)
Show SMILES CC(C)CCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(C)nc3ccc(NC(=O)NC(C)C)cc3c2=O)c(F)c1
Show InChI InChI=1S/C32H36FN5O6S/c1-19(2)14-15-44-32(41)37-45(42,43)29-9-7-6-8-25(29)22-10-11-23(27(33)16-22)18-38-21(5)35-28-13-12-24(17-26(28)30(38)39)36-31(40)34-20(3)4/h6-13,16-17,19-20H,14-15,18H2,1-5H3,(H,37,41)(H2,34,36,40)
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n/an/a 15n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of human adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(Homo sapiens (Human))		BDBM50283308
PNG
(2-ethyl-3-(3-fluoro-2'-(3-methyl-but-2-enyloxycarb...)
Show SMILES [#6]-[#6]-c1nc2ccc(-[#7]-[#6](=O)-[#7](-[#6])-[#6](-[#6])-[#6])cc2c(=O)n1-[#6]-c1ccc(cc1F)-c1ccccc1S(=O)(=O)[#7]-[#6](=O)-[#8]-[#6]\[#6]=[#6](\[#6])-[#6]
Show InChI InChI=1S/C34H38FN5O6S/c1-7-31-37-29-15-14-25(36-33(42)39(6)22(4)5)19-27(29)32(41)40(31)20-24-13-12-23(18-28(24)35)26-10-8-9-11-30(26)47(44,45)38-34(43)46-17-16-21(2)3/h8-16,18-19,22H,7,17,20H2,1-6H3,(H,36,42)(H,38,43)
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n/an/a 15n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of human adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(Homo sapiens (Human))		BDBM50283314
PNG
(2-ethyl-3-(3-fluoro-2'-(3-methyl-butyloxycarbonyla...)
Show SMILES CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C34H38FN5O7S/c1-4-31-37-29-12-11-25(36-33(42)39-14-17-46-18-15-39)20-27(29)32(41)40(31)21-24-10-9-23(19-28(24)35)26-7-5-6-8-30(26)48(44,45)38-34(43)47-16-13-22(2)3/h5-12,19-20,22H,4,13-18,21H2,1-3H3,(H,36,42)(H,38,43)
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n/an/a 18n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of human adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(Homo sapiens (Human))		BDBM50283304
PNG
(2-methyl-3-(3-fluoro-2'-(3-methyl-butyloxycarbonyl...)
Show SMILES CC(C)CCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(C)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1
Show InChI InChI=1S/C33H38FN5O6S/c1-20(2)15-16-45-33(42)37-46(43,44)30-10-8-7-9-26(30)23-11-12-24(28(34)17-23)19-39-22(5)35-29-14-13-25(18-27(29)31(39)40)36-32(41)38(6)21(3)4/h7-14,17-18,20-21H,15-16,19H2,1-6H3,(H,36,41)(H,37,42)
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n/an/a 27n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of human adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(Homo sapiens (Human))		BDBM50283301
PNG
(2-ethyl-3-(3-fluoro-2'-(butyloxycarbonylaminosulph...)
Show SMILES CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1
Show InChI InChI=1S/C33H36FN5O7S/c1-3-5-16-46-33(42)37-47(43,44)29-9-7-6-8-25(29)22-10-11-23(27(34)19-22)21-39-30(4-2)36-28-13-12-24(20-26(28)31(39)40)35-32(41)38-14-17-45-18-15-38/h6-13,19-20H,3-5,14-18,21H2,1-2H3,(H,35,41)(H,37,42)
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n/an/a 32n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against AT2 receptor of human adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(Homo sapiens (Human))		BDBM50283301
PNG
(2-ethyl-3-(3-fluoro-2'-(butyloxycarbonylaminosulph...)
Show SMILES CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1
Show InChI InChI=1S/C33H36FN5O7S/c1-3-5-16-46-33(42)37-47(43,44)29-9-7-6-8-25(29)22-10-11-23(27(34)19-22)21-39-30(4-2)36-28-13-12-24(20-26(28)31(39)40)35-32(41)38-14-17-45-18-15-38/h6-13,19-20H,3-5,14-18,21H2,1-2H3,(H,35,41)(H,37,42)
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n/an/a 33n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of human adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(Homo sapiens (Human))		BDBM50283311
PNG
(2-ethyl-3-(3-fluoro-2'-(3-methyl-butyloxycarbonyla...)
Show SMILES CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C35H34FN5O6S/c1-4-32-39-29-15-14-25(38-33(42)30-10-7-8-17-37-30)20-27(29)34(43)41(32)21-24-13-12-23(19-28(24)36)26-9-5-6-11-31(26)48(45,46)40-35(44)47-18-16-22(2)3/h5-15,17,19-20,22H,4,16,18,21H2,1-3H3,(H,38,42)(H,40,44)
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n/an/a 37n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against AT2 receptor of human adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(Homo sapiens (Human))		BDBM50283313
PNG
(4'-[2-Ethyl-6-(3-ethyl-ureido)-4-oxo-4H-quinazolin...)
Show SMILES CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(cc3F)-c3ccccc3S(=O)(=O)NC(=O)c3ccccc3F)c(=O)c2c1
Show InChI InChI=1S/C33H29F2N5O5S/c1-3-30-38-28-16-15-22(37-33(43)36-4-2)18-25(28)32(42)40(30)19-21-14-13-20(17-27(21)35)23-9-6-8-12-29(23)46(44,45)39-31(41)24-10-5-7-11-26(24)34/h5-18H,3-4,19H2,1-2H3,(H,39,41)(H2,36,37,43)
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n/an/a 59n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of human adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(Homo sapiens (Human))		BDBM50049181
PNG
(2-Butyl-3-(2'-(butyloxycarbonylaminosulphonyl)-bip...)
Show SMILES CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1
Show InChI InChI=1S/C35H43N5O6S/c1-6-8-14-32-37-30-20-19-27(36-34(42)39(5)24(3)4)22-29(30)33(41)40(32)23-25-15-17-26(18-16-25)28-12-10-11-13-31(28)47(44,45)38-35(43)46-21-9-7-2/h10-13,15-20,22,24H,6-9,14,21,23H2,1-5H3,(H,36,42)(H,38,43)
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n/an/a 60n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against AT2 receptor of human adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(Homo sapiens (Human))		BDBM50283314
PNG
(2-ethyl-3-(3-fluoro-2'-(3-methyl-butyloxycarbonyla...)
Show SMILES CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C34H38FN5O7S/c1-4-31-37-29-12-11-25(36-33(42)39-14-17-46-18-15-39)20-27(29)32(41)40(31)21-24-10-9-23(19-28(24)35)26-7-5-6-8-30(26)48(44,45)38-34(43)47-16-13-22(2)3/h5-12,19-20,22H,4,13-18,21H2,1-3H3,(H,36,42)(H,38,43)
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n/an/a 65n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against AT2 receptor of human adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(Homo sapiens (Human))		BDBM50283307
PNG
(4'-[2-Ethyl-6-(3-isopropyl-3-methyl-ureido)-4-oxo-...)
Show SMILES CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)COCC(C)C
Show InChI InChI=1S/C34H40FN5O6S/c1-7-31-37-29-15-14-25(36-34(43)39(6)22(4)5)17-27(29)33(42)40(31)18-24-13-12-23(16-28(24)35)26-10-8-9-11-30(26)47(44,45)38-32(41)20-46-19-21(2)3/h8-17,21-22H,7,18-20H2,1-6H3,(H,36,43)(H,38,41)
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n/an/a 65n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of human adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-2 angiotensin II receptor


(Homo sapiens (Human))		BDBM50283313
PNG
(4'-[2-Ethyl-6-(3-ethyl-ureido)-4-oxo-4H-quinazolin...)
Show SMILES CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(cc3F)-c3ccccc3S(=O)(=O)NC(=O)c3ccccc3F)c(=O)c2c1
Show InChI InChI=1S/C33H29F2N5O5S/c1-3-30-38-28-16-15-22(37-33(43)36-4-2)18-25(28)32(42)40(30)19-21-14-13-20(17-27(21)35)23-9-6-8-12-29(23)46(44,45)39-31(41)24-10-5-7-11-26(24)34/h5-18H,3-4,19H2,1-2H3,(H,39,41)(H2,36,37,43)
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n/an/a 65n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against AT2 receptor of human adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(Homo sapiens (Human))		BDBM50283311
PNG
(2-ethyl-3-(3-fluoro-2'-(3-methyl-butyloxycarbonyla...)
Show SMILES CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C35H34FN5O6S/c1-4-32-39-29-15-14-25(38-33(42)30-10-7-8-17-37-30)20-27(29)34(43)41(32)21-24-13-12-23(19-28(24)36)26-9-5-6-11-31(26)48(45,46)40-35(44)47-18-16-22(2)3/h5-15,17,19-20,22H,4,16,18,21H2,1-3H3,(H,38,42)(H,40,44)
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Article
n/an/a 85n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inhibitory concentration of the compound against Angiotensin II receptor, type 1 of human adrenal membrane

Bioorg Med Chem Lett 4: 2337-2342 (1994)


Article DOI: 10.1016/0960-894X(94)85036-4
BindingDB Entry DOI: 10.7270/Q2X066Z9
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%