Found 4 hits of Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Platelet-activating factor receptor
(RAT) | BDBM50286012
(3-{(R)-7-[1-Dimethylcarbamoyl-6-(4-fluoro-phenyl)-...)Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccn3[C@H](SCc23)c2ccc[n+]([O-])c2)c2ccc(cc12)-c1ccc(F)cc1 Show InChI InChI=1S/C29H23FN4O3S/c1-31(2)29(36)34-16-24(22-10-7-19(14-25(22)34)18-5-8-21(30)9-6-18)27(35)23-11-13-33-26(23)17-38-28(33)20-4-3-12-32(37)15-20/h3-16,28H,17H2,1-2H3/t28-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| 2.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of platelet activating factor(PAF) by binding to PAF receptor |
Bioorg Med Chem Lett 5: 2909-2912 (1995)
Article DOI: 10.1016/0960-894X(95)00510-Z BindingDB Entry DOI: 10.7270/Q2S46RXM |
More data for this Ligand-Target Pair | |
Platelet-activating factor receptor
(RAT) | BDBM50035397
(6-(4-Fluoro-phenyl)-3-((R)-3-pyridin-3-yl-1H-pyrro...)Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccn3[C@H](SCc23)c2cccnc2)c2ccc(cc12)-c1ccc(F)cc1 Show InChI InChI=1S/C29H23FN4O2S/c1-32(2)29(36)34-16-24(22-10-7-19(14-25(22)34)18-5-8-21(30)9-6-18)27(35)23-11-13-33-26(23)17-37-28(33)20-4-3-12-31-15-20/h3-16,28H,17H2,1-2H3/t28-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Similars
| Article
| 3.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of platelet activating factor (PAF) by binding to PAF receptor |
Bioorg Med Chem Lett 5: 2909-2912 (1995)
Article DOI: 10.1016/0960-894X(95)00510-Z BindingDB Entry DOI: 10.7270/Q2S46RXM |
More data for this Ligand-Target Pair | |
Platelet-activating factor receptor
(RAT) | BDBM50286013
((cis)-(2S,3R)-7-[1-Dimethylcarbamoyl-6-(4-fluoro-p...)Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccn3[C@@H](c4cccnc4)S(=O)Cc23)c2ccc(cc12)-c1ccc(F)cc1 |r| Show InChI InChI=1S/C29H23FN4O3S/c1-32(2)29(36)34-16-24(22-10-7-19(14-25(22)34)18-5-8-21(30)9-6-18)27(35)23-11-13-33-26(23)17-38(37)28(33)20-4-3-12-31-15-20/h3-16,28H,17H2,1-2H3/t28-,38?/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| 68 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of platelet activating factor(PAF) by binding to PAF receptor |
Bioorg Med Chem Lett 5: 2909-2912 (1995)
Article DOI: 10.1016/0960-894X(95)00510-Z BindingDB Entry DOI: 10.7270/Q2S46RXM |
More data for this Ligand-Target Pair | |
Platelet-activating factor receptor
(RAT) | BDBM50286013
((cis)-(2S,3R)-7-[1-Dimethylcarbamoyl-6-(4-fluoro-p...)Show SMILES CN(C)C(=O)n1cc(C(=O)c2ccn3[C@@H](c4cccnc4)S(=O)Cc23)c2ccc(cc12)-c1ccc(F)cc1 |r| Show InChI InChI=1S/C29H23FN4O3S/c1-32(2)29(36)34-16-24(22-10-7-19(14-25(22)34)18-5-8-21(30)9-6-18)27(35)23-11-13-33-26(23)17-38(37)28(33)20-4-3-12-31-15-20/h3-16,28H,17H2,1-2H3/t28-,38?/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| 68 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of platelet activating factor(PAF) by binding to PAF receptor |
Bioorg Med Chem Lett 5: 2909-2912 (1995)
Article DOI: 10.1016/0960-894X(95)00510-Z BindingDB Entry DOI: 10.7270/Q2S46RXM |
More data for this Ligand-Target Pair | |