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PubMed code 8027985

Compile data set for download or QSAR
Found 66 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase transforming protein Src


(Avian sarcoma virus)		BDBM4020
PNG
(2-{[4-(acetyloxy)-1-methyl-3-(phenylcarbamoyl)-1H-...)
Show SMILES CC(=O)Oc1cccc2n(C)c(SSc3c(C(=O)Nc4ccccc4)c4c(OC(C)=O)cccc4n3C)c(C(=O)Nc3ccccc3)c12
Show InChI InChI=1S/C36H30N4O6S2/c1-21(41)45-27-19-11-17-25-29(27)31(33(43)37-23-13-7-5-8-14-23)35(39(25)3)47-48-36-32(34(44)38-24-15-9-6-10-16-24)30-26(40(36)4)18-12-20-28(30)46-22(2)42/h5-20H,1-4H3,(H,37,43)(H,38,44)
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n/an/a 650n/an/an/an/a7.525



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM4042
PNG
(1-methyl-N-phenyl-2-sulfanylidene-2,3-dihydro-1H-i...)
Show SMILES CN1C(=S)C(C(=O)Nc2ccccc2)c2ccccc12
Show InChI InChI=1S/C16H14N2OS/c1-18-13-10-6-5-9-12(13)14(16(18)20)15(19)17-11-7-3-2-4-8-11/h2-10,14H,1H3,(H,17,19)
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n/an/a 1.00E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase transforming protein Src


(Avian sarcoma virus)		BDBM4016
PNG
(1-methyl-2-{[1-methyl-3-(phenylcarbamoyl)-1H-indol...)
Show SMILES Cn1c(SSc2c(C(=O)Nc3ccccc3)c3ccccc3n2C)c(C(=O)Nc2ccccc2)c2ccccc12
Show InChI InChI=1S/C32H26N4O2S2/c1-35-25-19-11-9-17-23(25)27(29(37)33-21-13-5-3-6-14-21)31(35)39-40-32-28(24-18-10-12-20-26(24)36(32)2)30(38)34-22-15-7-4-8-16-22/h3-20H,1-2H3,(H,33,37)(H,34,38)
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n/an/a 3.20E+3n/an/an/an/a7.525



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase transforming protein Src


(Avian sarcoma virus)		BDBM4034
PNG
(2-{[6-(acetyloxy)-1-methyl-3-(phenylcarbamoyl)-1H-...)
Show SMILES CC(=O)Oc1ccc2c(C(=O)Nc3ccccc3)c(SSc3c(C(=O)Nc4ccccc4)c4ccc(OC(C)=O)cc4n3C)n(C)c2c1
Show InChI InChI=1S/C36H30N4O6S2/c1-21(41)45-25-15-17-27-29(19-25)39(3)35(31(27)33(43)37-23-11-7-5-8-12-23)47-48-36-32(34(44)38-24-13-9-6-10-14-24)28-18-16-26(46-22(2)42)20-30(28)40(36)4/h5-20H,1-4H3,(H,37,43)(H,38,44)
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n/an/a 3.50E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM4033
PNG
(6-methoxy-2-{[6-methoxy-1-methyl-3-(phenylcarbamoy...)
Show SMILES COc1ccc2c(C(=O)Nc3ccccc3)c(SSc3c(C(=O)Nc4ccccc4)c4ccc(OC)cc4n3C)n(C)c2c1
Show InChI InChI=1S/C34H30N4O4S2/c1-37-27-19-23(41-3)15-17-25(27)29(31(39)35-21-11-7-5-8-12-21)33(37)43-44-34-30(32(40)36-22-13-9-6-10-14-22)26-18-16-24(42-4)20-28(26)38(34)2/h5-20H,1-4H3,(H,35,39)(H,36,40)
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n/an/a 3.60E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase transforming protein Src


(Avian sarcoma virus)		BDBM4038
PNG
(7-methoxy-2-{[7-methoxy-1-methyl-3-(phenylcarbamoy...)
Show SMILES COc1cccc2c(C(=O)Nc3ccccc3)c(SSc3c(C(=O)Nc4ccccc4)c4cccc(OC)c4n3C)n(C)c12
Show InChI InChI=1S/C34H30N4O4S2/c1-37-29-23(17-11-19-25(29)41-3)27(31(39)35-21-13-7-5-8-14-21)33(37)43-44-34-28(32(40)36-22-15-9-6-10-16-22)24-18-12-20-26(42-4)30(24)38(34)2/h5-20H,1-4H3,(H,35,39)(H,36,40)
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n/an/a 3.60E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase transforming protein Src


(Avian sarcoma virus)		BDBM4033
PNG
(6-methoxy-2-{[6-methoxy-1-methyl-3-(phenylcarbamoy...)
Show SMILES COc1ccc2c(C(=O)Nc3ccccc3)c(SSc3c(C(=O)Nc4ccccc4)c4ccc(OC)cc4n3C)n(C)c2c1
Show InChI InChI=1S/C34H30N4O4S2/c1-37-27-19-23(41-3)15-17-25(27)29(31(39)35-21-11-7-5-8-12-21)33(37)43-44-34-30(32(40)36-22-13-9-6-10-14-22)26-18-16-24(42-4)20-28(26)38(34)2/h5-20H,1-4H3,(H,35,39)(H,36,40)
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n/an/a 3.60E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase transforming protein Src


(Avian sarcoma virus)		BDBM4027
PNG
(2,2 -Dithiobis( 5-hydroxy- 1-methyl-N-phenylindole...)
Show SMILES Cn1c(SSc2c(C(=O)Nc3ccccc3)c3cc(O)ccc3n2C)c(C(=O)Nc2ccccc2)c2cc(O)ccc12
Show InChI InChI=1S/C32H26N4O4S2/c1-35-25-15-13-21(37)17-23(25)27(29(39)33-19-9-5-3-6-10-19)31(35)41-42-32-28(30(40)34-20-11-7-4-8-12-20)24-18-22(38)14-16-26(24)36(32)2/h3-18,37-38H,1-2H3,(H,33,39)(H,34,40)
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n/an/a 3.90E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM4022
PNG
(5-chloro-2-{[5-chloro-1-methyl-3-(phenylcarbamoyl)...)
Show SMILES Cn1c(SSc2c(C(=O)Nc3ccccc3)c3cc(Cl)ccc3n2C)c(C(=O)Nc2ccccc2)c2cc(Cl)ccc12
Show InChI InChI=1S/C32H24Cl2N4O2S2/c1-37-25-15-13-19(33)17-23(25)27(29(39)35-21-9-5-3-6-10-21)31(37)41-42-32-28(30(40)36-22-11-7-4-8-12-22)24-18-20(34)14-16-26(24)38(32)2/h3-18H,1-2H3,(H,35,39)(H,36,40)
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n/an/a 4.30E+3n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase transforming protein Src


(Avian sarcoma virus)		BDBM4029
PNG
(5-cyano-2-{[5-cyano-1-methyl-3-(phenylcarbamoyl)-1...)
Show SMILES Cn1c(SSc2c(C(=O)Nc3ccccc3)c3cc(ccc3n2C)C#N)c(C(=O)Nc2ccccc2)c2cc(ccc12)C#N
Show InChI InChI=1S/C34H24N6O2S2/c1-39-27-15-13-21(19-35)17-25(27)29(31(41)37-23-9-5-3-6-10-23)33(39)43-44-34-30(32(42)38-24-11-7-4-8-12-24)26-18-22(20-36)14-16-28(26)40(34)2/h3-18H,1-2H3,(H,37,41)(H,38,42)
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n/an/a 4.50E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM4030
PNG
(1-methyl-2-{[1-methyl-5-nitro-3-(phenylcarbamoyl)-...)
Show SMILES Cn1c(SSc2c(C(=O)Nc3ccccc3)c3cc(ccc3n2C)[N+]([O-])=O)c(C(=O)Nc2ccccc2)c2cc(ccc12)[N+]([O-])=O
Show InChI InChI=1S/C32H24N6O6S2/c1-35-25-15-13-21(37(41)42)17-23(25)27(29(39)33-19-9-5-3-6-10-19)31(35)45-46-32-28(30(40)34-20-11-7-4-8-12-20)24-18-22(38(43)44)14-16-26(24)36(32)2/h3-18H,1-2H3,(H,33,39)(H,34,40)
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n/an/a 5.00E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase transforming protein Src


(Avian sarcoma virus)		BDBM4035
PNG
(6-hydroxy-2-{[6-hydroxy-1-methyl-3-(phenylcarbamoy...)
Show SMILES Cn1c(SSc2c(C(=O)Nc3ccccc3)c3ccc(O)cc3n2C)c(C(=O)Nc2ccccc2)c2ccc(O)cc12
Show InChI InChI=1S/C32H26N4O4S2/c1-35-25-17-21(37)13-15-23(25)27(29(39)33-19-9-5-3-6-10-19)31(35)41-42-32-28(30(40)34-20-11-7-4-8-12-20)24-16-14-22(38)18-26(24)36(32)2/h3-18,37-38H,1-2H3,(H,33,39)(H,34,40)
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n/an/a 5.10E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase transforming protein Src


(Avian sarcoma virus)		BDBM4041
PNG
(1-methyl-2-{[1-methyl-3-(phenylcarbamoyl)-1H-pyrro...)
Show SMILES Cn1c(SSc2c(C(=O)Nc3ccccc3)c3cccnc3n2C)c(C(=O)Nc2ccccc2)c2cccnc12
Show InChI InChI=1S/C30H24N6O2S2/c1-35-25-21(15-9-17-31-25)23(27(37)33-19-11-5-3-6-12-19)29(35)39-40-30-24(22-16-10-18-32-26(22)36(30)2)28(38)34-20-13-7-4-8-14-20/h3-18H,1-2H3,(H,33,37)(H,34,38)
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n/an/a 5.20E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM4026
PNG
(2-{[5-(acetyloxy)-1-methyl-3-(phenylcarbamoyl)-1H-...)
Show SMILES CC(=O)Oc1ccc2n(C)c(SSc3c(C(=O)Nc4ccccc4)c4cc(OC(C)=O)ccc4n3C)c(C(=O)Nc3ccccc3)c2c1
Show InChI InChI=1S/C36H30N4O6S2/c1-21(41)45-25-15-17-29-27(19-25)31(33(43)37-23-11-7-5-8-12-23)35(39(29)3)47-48-36-32(34(44)38-24-13-9-6-10-14-24)28-20-26(46-22(2)42)16-18-30(28)40(36)4/h5-20H,1-4H3,(H,37,43)(H,38,44)
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n/an/a 5.30E+3n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase transforming protein Src


(Avian sarcoma virus)		BDBM4028
PNG
(1-methyl-2-{[1-methyl-3-(phenylcarbamoyl)-5-(trifl...)
Show SMILES Cn1c(SSc2c(C(=O)Nc3ccccc3)c3cc(ccc3n2C)C(F)(F)F)c(C(=O)Nc2ccccc2)c2cc(ccc12)C(F)(F)F
Show InChI InChI=1S/C34H24F6N4O2S2/c1-43-25-15-13-19(33(35,36)37)17-23(25)27(29(45)41-21-9-5-3-6-10-21)31(43)47-48-32-28(30(46)42-22-11-7-4-8-12-22)24-18-20(34(38,39)40)14-16-26(24)44(32)2/h3-18H,1-2H3,(H,41,45)(H,42,46)
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n/an/a 5.80E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase transforming protein Src


(Avian sarcoma virus)		BDBM4021
PNG
(5-fluoro-2-{[5-fluoro-1-methyl-3-(phenylcarbamoyl)...)
Show SMILES Cn1c(SSc2c(C(=O)Nc3ccccc3)c3cc(F)ccc3n2C)c(C(=O)Nc2ccccc2)c2cc(F)ccc12
Show InChI InChI=1S/C32H24F2N4O2S2/c1-37-25-15-13-19(33)17-23(25)27(29(39)35-21-9-5-3-6-10-21)31(37)41-42-32-28(30(40)36-22-11-7-4-8-12-22)24-18-20(34)14-16-26(24)38(32)2/h3-18H,1-2H3,(H,35,39)(H,36,40)
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n/an/a 6.00E+3n/an/an/an/a7.525



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM4038
PNG
(7-methoxy-2-{[7-methoxy-1-methyl-3-(phenylcarbamoy...)
Show SMILES COc1cccc2c(C(=O)Nc3ccccc3)c(SSc3c(C(=O)Nc4ccccc4)c4cccc(OC)c4n3C)n(C)c12
Show InChI InChI=1S/C34H30N4O4S2/c1-37-29-23(17-11-19-25(29)41-3)27(31(39)35-21-13-7-5-8-14-21)33(37)43-44-34-28(32(40)36-22-15-9-6-10-16-22)24-18-12-20-26(42-4)30(24)38(34)2/h5-20H,1-4H3,(H,35,39)(H,36,40)
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n/an/a 6.50E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase transforming protein Src


(Avian sarcoma virus)		BDBM4030
PNG
(1-methyl-2-{[1-methyl-5-nitro-3-(phenylcarbamoyl)-...)
Show SMILES Cn1c(SSc2c(C(=O)Nc3ccccc3)c3cc(ccc3n2C)[N+]([O-])=O)c(C(=O)Nc2ccccc2)c2cc(ccc12)[N+]([O-])=O
Show InChI InChI=1S/C32H24N6O6S2/c1-35-25-15-13-21(37(41)42)17-23(25)27(29(39)33-19-9-5-3-6-10-19)31(35)45-46-32-28(30(40)34-20-11-7-4-8-12-20)24-18-22(38(43)44)14-16-26(24)36(32)2/h3-18H,1-2H3,(H,33,39)(H,34,40)
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n/an/a 7.20E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase transforming protein Src


(Avian sarcoma virus)		BDBM4026
PNG
(2-{[5-(acetyloxy)-1-methyl-3-(phenylcarbamoyl)-1H-...)
Show SMILES CC(=O)Oc1ccc2n(C)c(SSc3c(C(=O)Nc4ccccc4)c4cc(OC(C)=O)ccc4n3C)c(C(=O)Nc3ccccc3)c2c1
Show InChI InChI=1S/C36H30N4O6S2/c1-21(41)45-25-15-17-29-27(19-25)31(33(43)37-23-11-7-5-8-12-23)35(39(29)3)47-48-36-32(34(44)38-24-13-9-6-10-14-24)28-20-26(46-22(2)42)16-18-30(28)40(36)4/h5-20H,1-4H3,(H,37,43)(H,38,44)
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n/an/a 7.70E+3n/an/an/an/a7.525



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase transforming protein Src


(Avian sarcoma virus)		BDBM4042
PNG
(1-methyl-N-phenyl-2-sulfanylidene-2,3-dihydro-1H-i...)
Show SMILES CN1C(=S)C(C(=O)Nc2ccccc2)c2ccccc12
Show InChI InChI=1S/C16H14N2OS/c1-18-13-10-6-5-9-12(13)14(16(18)20)15(19)17-11-7-3-2-4-8-11/h2-10,14H,1H3,(H,17,19)
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n/an/a 9.70E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM4039
PNG
(2-{[7-(acetyloxy)-1-methyl-3-(phenylcarbamoyl)-1H-...)
Show SMILES CC(=O)Oc1cccc2c(C(=O)Nc3ccccc3)c(SSc3c(C(=O)Nc4ccccc4)c4cccc(OC(C)=O)c4n3C)n(C)c12
Show InChI InChI=1S/C36H30N4O6S2/c1-21(41)45-27-19-11-17-25-29(33(43)37-23-13-7-5-8-14-23)35(39(3)31(25)27)47-48-36-30(34(44)38-24-15-9-6-10-16-24)26-18-12-20-28(46-22(2)42)32(26)40(36)4/h5-20H,1-4H3,(H,37,43)(H,38,44)
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n/an/a 9.90E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM4016
PNG
(1-methyl-2-{[1-methyl-3-(phenylcarbamoyl)-1H-indol...)
Show SMILES Cn1c(SSc2c(C(=O)Nc3ccccc3)c3ccccc3n2C)c(C(=O)Nc2ccccc2)c2ccccc12
Show InChI InChI=1S/C32H26N4O2S2/c1-35-25-19-11-9-17-23(25)27(29(37)33-21-13-5-3-6-14-21)31(35)39-40-32-28(24-18-10-12-20-26(24)36(32)2)30(38)34-22-15-7-4-8-16-22/h3-20H,1-2H3,(H,33,37)(H,34,38)
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n/an/a 1.00E+4n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase transforming protein Src


(Avian sarcoma virus)		BDBM4039
PNG
(2-{[7-(acetyloxy)-1-methyl-3-(phenylcarbamoyl)-1H-...)
Show SMILES CC(=O)Oc1cccc2c(C(=O)Nc3ccccc3)c(SSc3c(C(=O)Nc4ccccc4)c4cccc(OC(C)=O)c4n3C)n(C)c12
Show InChI InChI=1S/C36H30N4O6S2/c1-21(41)45-27-19-11-17-25-29(33(43)37-23-13-7-5-8-14-23)35(39(3)31(25)27)47-48-36-30(34(44)38-24-15-9-6-10-16-24)26-18-12-20-28(46-22(2)42)32(26)40(36)4/h5-20H,1-4H3,(H,37,43)(H,38,44)
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n/an/a 1.11E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM4023
PNG
(5-bromo-2-{[5-bromo-1-methyl-3-(phenylcarbamoyl)-1...)
Show SMILES Cn1c(SSc2c(C(=O)Nc3ccccc3)c3cc(Br)ccc3n2C)c(C(=O)Nc2ccccc2)c2cc(Br)ccc12
Show InChI InChI=1S/C32H24Br2N4O2S2/c1-37-25-15-13-19(33)17-23(25)27(29(39)35-21-9-5-3-6-10-21)31(37)41-42-32-28(30(40)36-22-11-7-4-8-12-22)24-18-20(34)14-16-26(24)38(32)2/h3-18H,1-2H3,(H,35,39)(H,36,40)
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n/an/a 1.14E+4n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM4020
PNG
(2-{[4-(acetyloxy)-1-methyl-3-(phenylcarbamoyl)-1H-...)
Show SMILES CC(=O)Oc1cccc2n(C)c(SSc3c(C(=O)Nc4ccccc4)c4c(OC(C)=O)cccc4n3C)c(C(=O)Nc3ccccc3)c12
Show InChI InChI=1S/C36H30N4O6S2/c1-21(41)45-27-19-11-17-25-29(27)31(33(43)37-23-13-7-5-8-14-23)35(39(25)3)47-48-36-32(34(44)38-24-15-9-6-10-16-24)30-26(40(36)4)18-12-20-28(30)46-22(2)42/h5-20H,1-4H3,(H,37,43)(H,38,44)
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n/an/a 2.00E+4n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM4041
PNG
(1-methyl-2-{[1-methyl-3-(phenylcarbamoyl)-1H-pyrro...)
Show SMILES Cn1c(SSc2c(C(=O)Nc3ccccc3)c3cccnc3n2C)c(C(=O)Nc2ccccc2)c2cccnc12
Show InChI InChI=1S/C30H24N6O2S2/c1-35-25-21(15-9-17-31-25)23(27(37)33-19-11-5-3-6-12-19)29(35)39-40-30-24(22-16-10-18-32-26(22)36(30)2)28(38)34-20-13-7-4-8-14-20/h3-18H,1-2H3,(H,33,37)(H,34,38)
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n/an/a 2.23E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase transforming protein Src


(Avian sarcoma virus)		BDBM4044
PNG
(1,3-dihydro-1-methyl-N-phenyl-2-thioxo-2H-pyrrolo[...)
Show SMILES CN1C(=S)C(C(=O)Nc2ccccc2)c2cccnc12
Show InChI InChI=1S/C15H13N3OS/c1-18-13-11(8-5-9-16-13)12(15(18)20)14(19)17-10-6-3-2-4-7-10/h2-9,12H,1H3,(H,17,19)
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n/an/a 3.07E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM4027
PNG
(2,2 -Dithiobis( 5-hydroxy- 1-methyl-N-phenylindole...)
Show SMILES Cn1c(SSc2c(C(=O)Nc3ccccc3)c3cc(O)ccc3n2C)c(C(=O)Nc2ccccc2)c2cc(O)ccc12
Show InChI InChI=1S/C32H26N4O4S2/c1-35-25-15-13-21(37)17-23(25)27(29(39)33-19-9-5-3-6-10-19)31(35)41-42-32-28(30(40)34-20-11-7-4-8-12-20)24-18-22(38)14-16-26(24)36(32)2/h3-18,37-38H,1-2H3,(H,33,39)(H,34,40)
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n/an/a 4.05E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM4035
PNG
(6-hydroxy-2-{[6-hydroxy-1-methyl-3-(phenylcarbamoy...)
Show SMILES Cn1c(SSc2c(C(=O)Nc3ccccc3)c3ccc(O)cc3n2C)c(C(=O)Nc2ccccc2)c2ccc(O)cc12
Show InChI InChI=1S/C32H26N4O4S2/c1-35-25-17-21(37)13-15-23(25)27(29(39)33-19-9-5-3-6-10-19)31(35)41-42-32-28(30(40)34-20-11-7-4-8-12-20)24-16-14-22(38)18-26(24)36(32)2/h3-18,37-38H,1-2H3,(H,33,39)(H,34,40)
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n/an/a 4.40E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase transforming protein Src


(Avian sarcoma virus)		BDBM4045
PNG
(1,3-dimethyl-N-phenyl-2-sulfanylidene-2,3-dihydro-...)
Show SMILES CN1C(=S)C(C)(C(=O)Nc2ccccc2)c2ccccc12
Show InChI InChI=1S/C17H16N2OS/c1-17(15(20)18-12-8-4-3-5-9-12)13-10-6-7-11-14(13)19(2)16(17)21/h3-11H,1-2H3,(H,18,20)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase transforming protein Src


(Avian sarcoma virus)		BDBM4046
PNG
(1-Methyl-2-(methylthio)-N-phenyl-1H-indole-3-carbo...)
Show SMILES CSc1c(C(=O)Nc2ccccc2)c2ccccc2n1C
Show InChI InChI=1S/C17H16N2OS/c1-19-14-11-7-6-10-13(14)15(17(19)21-2)16(20)18-12-8-4-3-5-9-12/h3-11H,1-2H3,(H,18,20)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase transforming protein Src


(Avian sarcoma virus)		BDBM4040
PNG
(7-hydroxy-2-{[7-hydroxy-1-methyl-3-(phenylcarbamoy...)
Show SMILES Cn1c(SSc2c(C(=O)Nc3ccccc3)c3cccc(O)c3n2C)c(C(=O)Nc2ccccc2)c2cccc(O)c12
Show InChI InChI=1S/C32H26N4O4S2/c1-35-27-21(15-9-17-23(27)37)25(29(39)33-19-11-5-3-6-12-19)31(35)41-42-32-26(30(40)34-20-13-7-4-8-14-20)22-16-10-18-24(38)28(22)36(32)2/h3-18,37-38H,1-2H3,(H,33,39)(H,34,40)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM4029
PNG
(5-cyano-2-{[5-cyano-1-methyl-3-(phenylcarbamoyl)-1...)
Show SMILES Cn1c(SSc2c(C(=O)Nc3ccccc3)c3cc(ccc3n2C)C#N)c(C(=O)Nc2ccccc2)c2cc(ccc12)C#N
Show InChI InChI=1S/C34H24N6O2S2/c1-39-27-15-13-21(19-35)17-25(27)29(31(41)37-23-9-5-3-6-10-23)33(39)43-44-34-30(32(42)38-24-11-7-4-8-12-24)26-18-22(20-36)14-16-28(26)40(34)2/h3-18H,1-2H3,(H,37,41)(H,38,42)
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n/an/a 5.41E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase transforming protein Src


(Avian sarcoma virus)		BDBM4047
PNG
(1-methyl-N-phenyl-2-(phenyldisulfanyl)-1H-indole-3...)
Show SMILES Cn1c(SSc2ccccc2)c(C(=O)Nc2ccccc2)c2ccccc12
Show InChI InChI=1S/C22H18N2OS2/c1-24-19-15-9-8-14-18(19)20(21(25)23-16-10-4-2-5-11-16)22(24)27-26-17-12-6-3-7-13-17/h2-15H,1H3,(H,23,25)
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase transforming protein Src


(Avian sarcoma virus)		BDBM4025
PNG
(5-methoxy-2-{[5-methoxy-1-methyl-3-(phenylcarbamoy...)
Show SMILES COc1ccc2n(C)c(SSc3c(C(=O)Nc4ccccc4)c4cc(OC)ccc4n3C)c(C(=O)Nc3ccccc3)c2c1
Show InChI InChI=1S/C34H30N4O4S2/c1-37-27-17-15-23(41-3)19-25(27)29(31(39)35-21-11-7-5-8-12-21)33(37)43-44-34-30(32(40)36-22-13-9-6-10-14-22)26-20-24(42-4)16-18-28(26)38(34)2/h5-20H,1-4H3,(H,35,39)(H,36,40)
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n/an/a>1.00E+5n/an/an/an/a7.525



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM4032
PNG
(2-{[1,6-dimethyl-3-(phenylcarbamoyl)-1H-indol-2-yl...)
Show SMILES Cc1ccc2c(C(=O)Nc3ccccc3)c(SSc3c(C(=O)Nc4ccccc4)c4ccc(C)cc4n3C)n(C)c2c1
Show InChI InChI=1S/C34H30N4O2S2/c1-21-15-17-25-27(19-21)37(3)33(29(25)31(39)35-23-11-7-5-8-12-23)41-42-34-30(32(40)36-24-13-9-6-10-14-24)26-18-16-22(2)20-28(26)38(34)4/h5-20H,1-4H3,(H,35,39)(H,36,40)
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM4036
PNG
(7-chloro-2-{[7-chloro-1-methyl-3-(phenylcarbamoyl)...)
Show SMILES Cn1c(SSc2c(C(=O)Nc3ccccc3)c3cccc(Cl)c3n2C)c(C(=O)Nc2ccccc2)c2cccc(Cl)c12
Show InChI InChI=1S/C32H24Cl2N4O2S2/c1-37-27-21(15-9-17-23(27)33)25(29(39)35-19-11-5-3-6-12-19)31(37)41-42-32-26(30(40)36-20-13-7-4-8-14-20)22-16-10-18-24(34)28(22)38(32)2/h3-18H,1-2H3,(H,35,39)(H,36,40)
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase transforming protein Src


(Avian sarcoma virus)		BDBM4031
PNG
(6-chloro-2-{[6-chloro-1-methyl-3-(phenylcarbamoyl)...)
Show SMILES Cn1c(SSc2c(C(=O)Nc3ccccc3)c3ccc(Cl)cc3n2C)c(C(=O)Nc2ccccc2)c2ccc(Cl)cc12
Show InChI InChI=1S/C32H24Cl2N4O2S2/c1-37-25-17-19(33)13-15-23(25)27(29(39)35-21-9-5-3-6-10-21)31(37)41-42-32-28(30(40)36-22-11-7-4-8-12-22)24-16-14-20(34)18-26(24)38(32)2/h3-18H,1-2H3,(H,35,39)(H,36,40)
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM4047
PNG
(1-methyl-N-phenyl-2-(phenyldisulfanyl)-1H-indole-3...)
Show SMILES Cn1c(SSc2ccccc2)c(C(=O)Nc2ccccc2)c2ccccc12
Show InChI InChI=1S/C22H18N2OS2/c1-24-19-15-9-8-14-18(19)20(21(25)23-16-10-4-2-5-11-16)22(24)27-26-17-12-6-3-7-13-17/h2-15H,1H3,(H,23,25)
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase transforming protein Src


(Avian sarcoma virus)		BDBM4043
PNG
(2-thioxo-1H-indole-3-carboxamide deriv. 9g | 5-chl...)
Show SMILES CN1C(=S)C(C(=O)Nc2ccccc2)c2cc(Cl)ccc12
Show InChI InChI=1S/C16H13ClN2OS/c1-19-13-8-7-10(17)9-12(13)14(16(19)21)15(20)18-11-5-3-2-4-6-11/h2-9,14H,1H3,(H,18,20)
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM4043
PNG
(2-thioxo-1H-indole-3-carboxamide deriv. 9g | 5-chl...)
Show SMILES CN1C(=S)C(C(=O)Nc2ccccc2)c2cc(Cl)ccc12
Show InChI InChI=1S/C16H13ClN2OS/c1-19-13-8-7-10(17)9-12(13)14(16(19)21)15(20)18-11-5-3-2-4-6-11/h2-9,14H,1H3,(H,18,20)
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM4045
PNG
(1,3-dimethyl-N-phenyl-2-sulfanylidene-2,3-dihydro-...)
Show SMILES CN1C(=S)C(C)(C(=O)Nc2ccccc2)c2ccccc12
Show InChI InChI=1S/C17H16N2OS/c1-17(15(20)18-12-8-4-3-5-9-12)13-10-6-7-11-14(13)19(2)16(17)21/h3-11H,1-2H3,(H,18,20)
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase transforming protein Src


(Avian sarcoma virus)		BDBM4022
PNG
(5-chloro-2-{[5-chloro-1-methyl-3-(phenylcarbamoyl)...)
Show SMILES Cn1c(SSc2c(C(=O)Nc3ccccc3)c3cc(Cl)ccc3n2C)c(C(=O)Nc2ccccc2)c2cc(Cl)ccc12
Show InChI InChI=1S/C32H24Cl2N4O2S2/c1-37-25-15-13-19(33)17-23(25)27(29(39)35-21-9-5-3-6-10-21)31(37)41-42-32-28(30(40)36-22-11-7-4-8-12-22)24-18-20(34)14-16-26(24)38(32)2/h3-18H,1-2H3,(H,35,39)(H,36,40)
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n/an/a>1.00E+5n/an/an/an/a7.525



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM4028
PNG
(1-methyl-2-{[1-methyl-3-(phenylcarbamoyl)-5-(trifl...)
Show SMILES Cn1c(SSc2c(C(=O)Nc3ccccc3)c3cc(ccc3n2C)C(F)(F)F)c(C(=O)Nc2ccccc2)c2cc(ccc12)C(F)(F)F
Show InChI InChI=1S/C34H24F6N4O2S2/c1-43-25-15-13-19(33(35,36)37)17-23(25)27(29(45)41-21-9-5-3-6-10-21)31(43)47-48-32-28(30(46)42-22-11-7-4-8-12-22)24-18-20(34(38,39)40)14-16-26(24)44(32)2/h3-18H,1-2H3,(H,41,45)(H,42,46)
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase transforming protein Src


(Avian sarcoma virus)		BDBM4036
PNG
(7-chloro-2-{[7-chloro-1-methyl-3-(phenylcarbamoyl)...)
Show SMILES Cn1c(SSc2c(C(=O)Nc3ccccc3)c3cccc(Cl)c3n2C)c(C(=O)Nc2ccccc2)c2cccc(Cl)c12
Show InChI InChI=1S/C32H24Cl2N4O2S2/c1-37-27-21(15-9-17-23(27)33)25(29(39)35-19-11-5-3-6-12-19)31(37)41-42-32-26(30(40)36-20-13-7-4-8-14-20)22-16-10-18-24(34)28(22)38(32)2/h3-18H,1-2H3,(H,35,39)(H,36,40)
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM4048
PNG
(2-(Benzyldithio)-1-methyl-N-phenyl-1H-indole-3-car...)
Show SMILES Cn1c(SSCc2ccccc2)c(C(=O)Nc2ccccc2)c2ccccc12
Show InChI InChI=1S/C23H20N2OS2/c1-25-20-15-9-8-14-19(20)21(22(26)24-18-12-6-3-7-13-18)23(25)28-27-16-17-10-4-2-5-11-17/h2-15H,16H2,1H3,(H,24,26)
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase transforming protein Src


(Avian sarcoma virus)		BDBM4032
PNG
(2-{[1,6-dimethyl-3-(phenylcarbamoyl)-1H-indol-2-yl...)
Show SMILES Cc1ccc2c(C(=O)Nc3ccccc3)c(SSc3c(C(=O)Nc4ccccc4)c4ccc(C)cc4n3C)n(C)c2c1
Show InChI InChI=1S/C34H30N4O2S2/c1-21-15-17-25-27(19-21)37(3)33(29(25)31(39)35-23-11-7-5-8-12-23)41-42-34-30(32(40)36-24-13-9-6-10-14-24)26-18-16-22(2)20-28(26)38(34)4/h5-20H,1-4H3,(H,35,39)(H,36,40)
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n/an/a 1.00E+5n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM4024
PNG
(2-{[1,5-dimethyl-3-(phenylcarbamoyl)-1H-indol-2-yl...)
Show SMILES Cc1ccc2n(C)c(SSc3c(C(=O)Nc4ccccc4)c4cc(C)ccc4n3C)c(C(=O)Nc3ccccc3)c2c1
Show InChI InChI=1S/C34H30N4O2S2/c1-21-15-17-27-25(19-21)29(31(39)35-23-11-7-5-8-12-23)33(37(27)3)41-42-34-30(32(40)36-24-13-9-6-10-14-24)26-20-22(2)16-18-28(26)38(34)4/h5-20H,1-4H3,(H,35,39)(H,36,40)
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n/an/a>1.00E+5n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase transforming protein Src


(Avian sarcoma virus)		BDBM4019
PNG
(4-methoxy-2-{[4-methoxy-1-methyl-3-(phenylcarbamoy...)
Show SMILES COc1cccc2n(C)c(SSc3c(C(=O)Nc4ccccc4)c4c(OC)cccc4n3C)c(C(=O)Nc3ccccc3)c12
Show InChI InChI=1S/C34H30N4O4S2/c1-37-23-17-11-19-25(41-3)27(23)29(31(39)35-21-13-7-5-8-14-21)33(37)43-44-34-30(32(40)36-22-15-9-6-10-16-22)28-24(38(34)2)18-12-20-26(28)42-4/h5-20H,1-4H3,(H,35,39)(H,36,40)
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n/an/a>1.00E+5n/an/an/an/a7.525



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase transforming protein Src


(Avian sarcoma virus)		BDBM4023
PNG
(5-bromo-2-{[5-bromo-1-methyl-3-(phenylcarbamoyl)-1...)
Show SMILES Cn1c(SSc2c(C(=O)Nc3ccccc3)c3cc(Br)ccc3n2C)c(C(=O)Nc2ccccc2)c2cc(Br)ccc12
Show InChI InChI=1S/C32H24Br2N4O2S2/c1-37-25-15-13-19(33)17-23(25)27(29(39)35-21-9-5-3-6-10-21)31(37)41-42-32-28(30(40)36-22-11-7-4-8-12-22)24-18-20(34)14-16-26(24)38(32)2/h3-18H,1-2H3,(H,35,39)(H,36,40)
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n/an/a 1.00E+5n/an/an/an/a7.525



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM4040
PNG
(7-hydroxy-2-{[7-hydroxy-1-methyl-3-(phenylcarbamoy...)
Show SMILES Cn1c(SSc2c(C(=O)Nc3ccccc3)c3cccc(O)c3n2C)c(C(=O)Nc2ccccc2)c2cccc(O)c12
Show InChI InChI=1S/C32H26N4O4S2/c1-35-27-21(15-9-17-23(27)37)25(29(39)33-19-11-5-3-6-12-19)31(35)41-42-32-26(30(40)34-20-13-7-4-8-14-20)22-16-10-18-24(38)28(22)36(32)2/h3-18,37-38H,1-2H3,(H,33,39)(H,34,40)
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n/an/a 1.00E+5n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM4044
PNG
(1,3-dihydro-1-methyl-N-phenyl-2-thioxo-2H-pyrrolo[...)
Show SMILES CN1C(=S)C(C(=O)Nc2ccccc2)c2cccnc12
Show InChI InChI=1S/C15H13N3OS/c1-18-13-11(8-5-9-16-13)12(15(18)20)14(19)17-10-6-3-2-4-7-10/h2-9,12H,1H3,(H,17,19)
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM4046
PNG
(1-Methyl-2-(methylthio)-N-phenyl-1H-indole-3-carbo...)
Show SMILES CSc1c(C(=O)Nc2ccccc2)c2ccccc2n1C
Show InChI InChI=1S/C17H16N2OS/c1-19-14-11-7-6-10-13(14)15(17(19)21-2)16(20)18-12-8-4-3-5-9-12/h3-11H,1-2H3,(H,18,20)
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase transforming protein Src


(Avian sarcoma virus)		BDBM4048
PNG
(2-(Benzyldithio)-1-methyl-N-phenyl-1H-indole-3-car...)
Show SMILES Cn1c(SSCc2ccccc2)c(C(=O)Nc2ccccc2)c2ccccc12
Show InChI InChI=1S/C23H20N2OS2/c1-25-20-15-9-8-14-19(20)21(22(26)24-18-12-6-3-7-13-18)23(25)28-27-16-17-10-4-2-5-11-17/h2-15H,16H2,1H3,(H,24,26)
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM4019
PNG
(4-methoxy-2-{[4-methoxy-1-methyl-3-(phenylcarbamoy...)
Show SMILES COc1cccc2n(C)c(SSc3c(C(=O)Nc4ccccc4)c4c(OC)cccc4n3C)c(C(=O)Nc3ccccc3)c12
Show InChI InChI=1S/C34H30N4O4S2/c1-37-23-17-11-19-25(41-3)27(23)29(31(39)35-21-13-7-5-8-14-21)33(37)43-44-34-30(32(40)36-22-15-9-6-10-16-22)28-24(38(34)2)18-12-20-26(28)42-4/h5-20H,1-4H3,(H,35,39)(H,36,40)
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n/an/a>1.00E+5n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM4021
PNG
(5-fluoro-2-{[5-fluoro-1-methyl-3-(phenylcarbamoyl)...)
Show SMILES Cn1c(SSc2c(C(=O)Nc3ccccc3)c3cc(F)ccc3n2C)c(C(=O)Nc2ccccc2)c2cc(F)ccc12
Show InChI InChI=1S/C32H24F2N4O2S2/c1-37-25-15-13-19(33)17-23(25)27(29(39)35-21-9-5-3-6-10-21)31(37)41-42-32-28(30(40)36-22-11-7-4-8-12-22)24-18-20(34)14-16-26(24)38(32)2/h3-18H,1-2H3,(H,35,39)(H,36,40)
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n/an/a>1.00E+5n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase transforming protein Src


(Avian sarcoma virus)		BDBM4017
PNG
(4-chloro-2-{[4-chloro-1-methyl-3-(phenylcarbamoyl)...)
Show SMILES Cn1c(SSc2c(C(=O)Nc3ccccc3)c3c(Cl)cccc3n2C)c(C(=O)Nc2ccccc2)c2c(Cl)cccc12
Show InChI InChI=1S/C32H24Cl2N4O2S2/c1-37-23-17-9-15-21(33)25(23)27(29(39)35-19-11-5-3-6-12-19)31(37)41-42-32-28(30(40)36-20-13-7-4-8-14-20)26-22(34)16-10-18-24(26)38(32)2/h3-18H,1-2H3,(H,35,39)(H,36,40)
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n/an/a>1.00E+5n/an/an/an/a7.525



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase transforming protein Src


(Avian sarcoma virus)		BDBM4024
PNG
(2-{[1,5-dimethyl-3-(phenylcarbamoyl)-1H-indol-2-yl...)
Show SMILES Cc1ccc2n(C)c(SSc3c(C(=O)Nc4ccccc4)c4cc(C)ccc4n3C)c(C(=O)Nc3ccccc3)c2c1
Show InChI InChI=1S/C34H30N4O2S2/c1-21-15-17-27-25(19-21)29(31(39)35-23-11-7-5-8-12-23)33(37(27)3)41-42-34-30(32(40)36-24-13-9-6-10-14-24)26-20-22(2)16-18-28(26)38(34)4/h5-20H,1-4H3,(H,35,39)(H,36,40)
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n/an/a>1.00E+5n/an/an/an/a7.525



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM4031
PNG
(6-chloro-2-{[6-chloro-1-methyl-3-(phenylcarbamoyl)...)
Show SMILES Cn1c(SSc2c(C(=O)Nc3ccccc3)c3ccc(Cl)cc3n2C)c(C(=O)Nc2ccccc2)c2ccc(Cl)cc12
Show InChI InChI=1S/C32H24Cl2N4O2S2/c1-37-25-17-19(33)13-15-23(25)27(29(39)35-21-9-5-3-6-10-21)31(37)41-42-32-28(30(40)36-22-11-7-4-8-12-22)24-16-14-20(34)18-26(24)38(32)2/h3-18H,1-2H3,(H,35,39)(H,36,40)
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM4037
PNG
(2-{[1,7-dimethyl-3-(phenylcarbamoyl)-1H-indol-2-yl...)
Show SMILES Cc1cccc2c(C(=O)Nc3ccccc3)c(SSc3c(C(=O)Nc4ccccc4)c4cccc(C)c4n3C)n(C)c12
Show InChI InChI=1S/C34H30N4O2S2/c1-21-13-11-19-25-27(31(39)35-23-15-7-5-8-16-23)33(37(3)29(21)25)41-42-34-28(32(40)36-24-17-9-6-10-18-24)26-20-12-14-22(2)30(26)38(34)4/h5-20H,1-4H3,(H,35,39)(H,36,40)
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase transforming protein Src


(Avian sarcoma virus)		BDBM4037
PNG
(2-{[1,7-dimethyl-3-(phenylcarbamoyl)-1H-indol-2-yl...)
Show SMILES Cc1cccc2c(C(=O)Nc3ccccc3)c(SSc3c(C(=O)Nc4ccccc4)c4cccc(C)c4n3C)n(C)c12
Show InChI InChI=1S/C34H30N4O2S2/c1-21-13-11-19-25-27(31(39)35-23-15-7-5-8-16-23)33(37(3)29(21)25)41-42-34-28(32(40)36-24-17-9-6-10-18-24)26-20-12-14-22(2)30(26)38(34)4/h5-20H,1-4H3,(H,35,39)(H,36,40)
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM4018
PNG
(2-{[1,4-dimethyl-3-(phenylcarbamoyl)-1H-indol-2-yl...)
Show SMILES Cc1cccc2n(C)c(SSc3c(C(=O)Nc4ccccc4)c4c(C)cccc4n3C)c(C(=O)Nc3ccccc3)c12
Show InChI InChI=1S/C34H30N4O2S2/c1-21-13-11-19-25-27(21)29(31(39)35-23-15-7-5-8-16-23)33(37(25)3)41-42-34-30(32(40)36-24-17-9-6-10-18-24)28-22(2)14-12-20-26(28)38(34)4/h5-20H,1-4H3,(H,35,39)(H,36,40)
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n/an/a>1.00E+5n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase transforming protein Src


(Avian sarcoma virus)		BDBM4018
PNG
(2-{[1,4-dimethyl-3-(phenylcarbamoyl)-1H-indol-2-yl...)
Show SMILES Cc1cccc2n(C)c(SSc3c(C(=O)Nc4ccccc4)c4c(C)cccc4n3C)c(C(=O)Nc3ccccc3)c12
Show InChI InChI=1S/C34H30N4O2S2/c1-21-13-11-19-25-27(21)29(31(39)35-23-15-7-5-8-16-23)33(37(25)3)41-42-34-30(32(40)36-24-17-9-6-10-18-24)28-22(2)14-12-20-26(28)38(34)4/h5-20H,1-4H3,(H,35,39)(H,36,40)
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n/an/a>1.00E+5n/an/an/an/a7.525



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM4034
PNG
(2-{[6-(acetyloxy)-1-methyl-3-(phenylcarbamoyl)-1H-...)
Show SMILES CC(=O)Oc1ccc2c(C(=O)Nc3ccccc3)c(SSc3c(C(=O)Nc4ccccc4)c4ccc(OC(C)=O)cc4n3C)n(C)c2c1
Show InChI InChI=1S/C36H30N4O6S2/c1-21(41)45-25-15-17-27-29(19-25)39(3)35(31(27)33(43)37-23-11-7-5-8-12-23)47-48-36-32(34(44)38-24-13-9-6-10-14-24)28-18-16-26(46-22(2)42)20-30(28)40(36)4/h5-20H,1-4H3,(H,37,43)(H,38,44)
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM4017
PNG
(4-chloro-2-{[4-chloro-1-methyl-3-(phenylcarbamoyl)...)
Show SMILES Cn1c(SSc2c(C(=O)Nc3ccccc3)c3c(Cl)cccc3n2C)c(C(=O)Nc2ccccc2)c2c(Cl)cccc12
Show InChI InChI=1S/C32H24Cl2N4O2S2/c1-37-23-17-9-15-21(33)25(23)27(29(39)35-19-11-5-3-6-12-19)31(37)41-42-32-28(30(40)36-20-13-7-4-8-14-20)26-22(34)16-10-18-24(26)38(32)2/h3-18H,1-2H3,(H,35,39)(H,36,40)
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n/an/a 1.00E+5n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM4025
PNG
(5-methoxy-2-{[5-methoxy-1-methyl-3-(phenylcarbamoy...)
Show SMILES COc1ccc2n(C)c(SSc3c(C(=O)Nc4ccccc4)c4cc(OC)ccc4n3C)c(C(=O)Nc3ccccc3)c2c1
Show InChI InChI=1S/C34H30N4O4S2/c1-37-27-17-15-23(41-3)19-25(27)29(31(39)35-21-11-7-5-8-12-21)33(37)43-44-34-30(32(40)36-22-13-9-6-10-14-22)26-20-24(42-4)16-18-28(26)38(34)2/h5-20H,1-4H3,(H,35,39)(H,36,40)
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n/an/a>1.00E+5n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...

J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%