Found 29 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50369371
(CHEMBL1790750)Show SMILES CC[C@@H](C)[C@@H](CN(CC(=O)N[C@@H](CCO)C(O)=O)Cc1cccc2ccccc12)NC[C@@H](N)CS Show InChI InChI=1S/C26H40N4O4S/c1-3-18(2)24(28-13-21(27)17-35)15-30(16-25(32)29-23(11-12-31)26(33)34)14-20-9-6-8-19-7-4-5-10-22(19)20/h4-10,18,21,23-24,28,31,35H,3,11-17,27H2,1-2H3,(H,29,32)(H,33,34)/t18-,21-,23+,24-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.123 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of [3H]FPP incorporation into recombinant human Ha-Ras by Farnesyltransferase |
J Med Chem 41: 2651-6 (1998)
Article DOI: 10.1021/jm9800907
BindingDB Entry DOI: 10.7270/Q2WW7JCV |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50366557
(CHEMBL1790748)Show SMILES CC[C@@H](C)[C@@H](CN(CC(=O)N[C@@H](CCSC)C(O)=O)Cc1ccccc1)NC[C@@H](N)CS Show InChI InChI=1S/C23H40N4O3S2/c1-4-17(2)21(25-12-19(24)16-31)14-27(13-18-8-6-5-7-9-18)15-22(28)26-20(23(29)30)10-11-32-3/h5-9,17,19-21,25,31H,4,10-16,24H2,1-3H3,(H,26,28)(H,29,30)/t17-,19-,20+,21-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of [3H]FPP incorporation into recombinant human Ha-Ras by Farnesyltransferase |
J Med Chem 41: 2651-6 (1998)
Article DOI: 10.1021/jm9800907
BindingDB Entry DOI: 10.7270/Q2WW7JCV |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50369364
(CHEMBL1790760)Show SMILES CC[C@@H](C)[C@@H](CN(CC(=O)N[C@@H](CCSC)C(O)=O)Cc1ccccc1)NCCCS Show InChI InChI=1S/C23H39N3O3S2/c1-4-18(2)21(24-12-8-13-30)16-26(15-19-9-6-5-7-10-19)17-22(27)25-20(23(28)29)11-14-31-3/h5-7,9-10,18,20-21,24,30H,4,8,11-17H2,1-3H3,(H,25,27)(H,28,29)/t18-,20+,21-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of [3H]FPP incorporation into recombinant human Ha-Ras by Farnesyltransferase |
J Med Chem 41: 2651-6 (1998)
Article DOI: 10.1021/jm9800907
BindingDB Entry DOI: 10.7270/Q2WW7JCV |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50369370
(CHEMBL1790745)Show SMILES CC[C@@H](C)[C@@H](CN[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCSC)C(O)=O)NC[C@@H](N)CS Show InChI InChI=1S/C23H40N4O3S2/c1-4-16(2)21(25-13-18(24)15-31)14-26-20(12-17-8-6-5-7-9-17)22(28)27-19(23(29)30)10-11-32-3/h5-9,16,18-21,25-26,31H,4,10-15,24H2,1-3H3,(H,27,28)(H,29,30)/t16-,18-,19+,20+,21-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of [3H]FPP incorporation into recombinant human Ha-Ras by Farnesyltransferase |
J Med Chem 41: 2651-6 (1998)
Article DOI: 10.1021/jm9800907
BindingDB Entry DOI: 10.7270/Q2WW7JCV |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50369371
(CHEMBL1790750)Show SMILES CC[C@@H](C)[C@@H](CN(CC(=O)N[C@@H](CCO)C(O)=O)Cc1cccc2ccccc12)NC[C@@H](N)CS Show InChI InChI=1S/C26H40N4O4S/c1-3-18(2)24(28-13-21(27)17-35)15-30(16-25(32)29-23(11-12-31)26(33)34)14-20-9-6-8-19-7-4-5-10-22(19)20/h4-10,18,21,23-24,28,31,35H,3,11-17,27H2,1-2H3,(H,29,32)(H,33,34)/t18-,21-,23+,24-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine Geranylgeranyl transferase type I |
J Med Chem 41: 2651-6 (1998)
Article DOI: 10.1021/jm9800907
BindingDB Entry DOI: 10.7270/Q2WW7JCV |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50407296
(CHEMBL2052018 | L-731735)Show SMILES CC[C@H](C)[C@@H](CN[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCO)C(O)=O)NC[C@@H](N)CS Show InChI InChI=1S/C19H40N4O4S/c1-5-12(3)16(21-9-14(20)11-28)10-22-17(13(4)6-2)18(25)23-15(7-8-24)19(26)27/h12-17,21-22,24,28H,5-11,20H2,1-4H3,(H,23,25)(H,26,27)/t12-,13-,14+,15-,16+,17-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MCE
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of [3H]FPP incorporation into recombinant human Ha-Ras by Farnesyltransferase |
J Med Chem 41: 2651-6 (1998)
Article DOI: 10.1021/jm9800907
BindingDB Entry DOI: 10.7270/Q2WW7JCV |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50369368
(CHEMBL1790744)Show SMILES CCC[C@H](N(C)C[C@@H](NC[C@@H](N)CS)[C@H](C)CC)C(=O)N[C@@H](CCO)C(O)=O Show InChI InChI=1S/C19H40N4O4S/c1-5-7-17(18(25)22-15(8-9-24)19(26)27)23(4)11-16(13(3)6-2)21-10-14(20)12-28/h13-17,21,24,28H,5-12,20H2,1-4H3,(H,22,25)(H,26,27)/t13-,14-,15+,16-,17+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of [3H]FPP incorporation into recombinant human Ha-Ras by Farnesyltransferase |
J Med Chem 41: 2651-6 (1998)
Article DOI: 10.1021/jm9800907
BindingDB Entry DOI: 10.7270/Q2WW7JCV |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50369372
(CHEMBL1790756)Show SMILES CC[C@@H](C)[C@@H](CN(C)[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(O)=O)NC[C@@H](N)CS Show InChI InChI=1S/C21H44N4O3S2/c1-7-14(3)18(23-11-16(22)13-29)12-25(5)19(15(4)8-2)20(26)24-17(21(27)28)9-10-30-6/h14-19,23,29H,7-13,22H2,1-6H3,(H,24,26)(H,27,28)/t14-,15+,16-,17+,18-,19+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of [3H]FPP incorporation into recombinant human Ha-Ras by Farnesyltransferase |
J Med Chem 41: 2651-6 (1998)
Article DOI: 10.1021/jm9800907
BindingDB Entry DOI: 10.7270/Q2WW7JCV |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50369366
(CHEMBL1790752)Show SMILES CC[C@@H](C)[C@@H](CN[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCO)C(O)=O)NC[C@@H](N)CS Show InChI InChI=1S/C22H38N4O4S/c1-3-15(2)20(24-12-17(23)14-31)13-25-19(11-16-7-5-4-6-8-16)21(28)26-18(9-10-27)22(29)30/h4-8,15,17-20,24-25,27,31H,3,9-14,23H2,1-2H3,(H,26,28)(H,29,30)/t15-,17-,18+,19+,20-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine brain Farnesyltransferase at 1 nM |
J Med Chem 41: 2651-6 (1998)
Article DOI: 10.1021/jm9800907
BindingDB Entry DOI: 10.7270/Q2WW7JCV |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50369375
(CHEMBL1790753)Show SMILES CCC[C@H](NC[C@@H](NC[C@@H](N)CS)[C@H](C)CC)C(=O)N[C@@H](CCO)C(O)=O Show InChI InChI=1S/C18H38N4O4S/c1-4-6-14(17(24)22-15(7-8-23)18(25)26)21-10-16(12(3)5-2)20-9-13(19)11-27/h12-16,20-21,23,27H,4-11,19H2,1-3H3,(H,22,24)(H,25,26)/t12-,13-,14+,15+,16-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine brain Farnesyltransferase at 10 pM |
J Med Chem 41: 2651-6 (1998)
Article DOI: 10.1021/jm9800907
BindingDB Entry DOI: 10.7270/Q2WW7JCV |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50369367
(CHEMBL1790757)Show SMILES CC[C@@H](C)[C@@H](CN[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(O)=O)NC[C@@H](N)CS Show InChI InChI=1S/C20H42N4O3S2/c1-6-13(3)17(22-10-15(21)12-28)11-23-18(14(4)7-2)19(25)24-16(20(26)27)8-9-29-5/h13-18,22-23,28H,6-12,21H2,1-5H3,(H,24,25)(H,26,27)/t13-,14+,15-,16+,17-,18+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of [3H]FPP incorporation into recombinant human Ha-Ras by Farnesyltransferase |
J Med Chem 41: 2651-6 (1998)
Article DOI: 10.1021/jm9800907
BindingDB Entry DOI: 10.7270/Q2WW7JCV |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50369363
(CHEMBL1790747)Show SMILES CC[C@@H](C)[C@@H](CN(C)[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCSC)C(O)=O)NC[C@@H](N)CS Show InChI InChI=1S/C24H42N4O3S2/c1-5-17(2)21(26-14-19(25)16-32)15-28(3)22(13-18-9-7-6-8-10-18)23(29)27-20(24(30)31)11-12-33-4/h6-10,17,19-22,26,32H,5,11-16,25H2,1-4H3,(H,27,29)(H,30,31)/t17-,19-,20+,21-,22+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 42 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of [3H]FPP incorporation into recombinant human Ha-Ras by Farnesyltransferase |
J Med Chem 41: 2651-6 (1998)
Article DOI: 10.1021/jm9800907
BindingDB Entry DOI: 10.7270/Q2WW7JCV |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50369365
(CHEMBL1790754)Show SMILES CC[C@@H](C)[C@@H](CN(C)CC(=O)N[C@@H](CCO)C(O)=O)NC[C@@H](N)CS Show InChI InChI=1S/C16H34N4O4S/c1-4-11(2)14(18-7-12(17)10-25)8-20(3)9-15(22)19-13(5-6-21)16(23)24/h11-14,18,21,25H,4-10,17H2,1-3H3,(H,19,22)(H,23,24)/t11-,12-,13+,14-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 83 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine brain Farnesyltransferase at 10 pM |
J Med Chem 41: 2651-6 (1998)
Article DOI: 10.1021/jm9800907
BindingDB Entry DOI: 10.7270/Q2WW7JCV |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Mus musculus) | BDBM50065394
((S)-2-(2-{[(S)-2-((R)-2-Amino-3-mercapto-propylami...)Show SMILES CCC(C)[C@@H](CN(CC(=O)N[C@@H](CCSC)C(=O)OC)Cc1ccccc1)NC[C@@H](N)CS Show InChI InChI=1S/C24H42N4O3S2/c1-5-18(2)22(26-13-20(25)17-32)15-28(14-19-9-7-6-8-10-19)16-23(29)27-21(11-12-33-4)24(30)31-3/h6-10,18,20-22,26,32H,5,11-17,25H2,1-4H3,(H,27,29)/t18?,20-,21+,22-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of post-translational processing of v-Ras protein in NIH3T3 cells |
J Med Chem 41: 2651-6 (1998)
Article DOI: 10.1021/jm9800907
BindingDB Entry DOI: 10.7270/Q2WW7JCV |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50369369
(CHEMBL1790759)Show SMILES CC[C@@H](C)[C@@H](CN(CC(=O)N[C@@H](CCSC)C(O)=O)Cc1ccccc1)NC(=O)CCS Show InChI InChI=1S/C23H37N3O4S2/c1-4-17(2)20(25-21(27)10-12-31)15-26(14-18-8-6-5-7-9-18)16-22(28)24-19(23(29)30)11-13-32-3/h5-9,17,19-20,31H,4,10-16H2,1-3H3,(H,24,28)(H,25,27)(H,29,30)/t17-,19+,20-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-FPP incorporation into recombinant human Ha-Ras by Farnesyltransferase |
J Med Chem 41: 2651-6 (1998)
Article DOI: 10.1021/jm9800907
BindingDB Entry DOI: 10.7270/Q2WW7JCV |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50366557
(CHEMBL1790748)Show SMILES CC[C@@H](C)[C@@H](CN(CC(=O)N[C@@H](CCSC)C(O)=O)Cc1ccccc1)NC[C@@H](N)CS Show InChI InChI=1S/C23H40N4O3S2/c1-4-17(2)21(25-12-19(24)16-31)14-27(13-18-8-6-5-7-9-18)15-22(28)26-20(23(29)30)10-11-32-3/h5-9,17,19-21,25,31H,4,10-16,24H2,1-3H3,(H,26,28)(H,29,30)/t17-,19-,20+,21-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 450 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine Geranylgeranyl transferase type I |
J Med Chem 41: 2651-6 (1998)
Article DOI: 10.1021/jm9800907
BindingDB Entry DOI: 10.7270/Q2WW7JCV |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Mus musculus) | BDBM50369376
(CHEMBL1790751)Show SMILES CC[C@@H](C)[C@@H](CN(CC(=O)N[C@@H](CCSC)C(=O)OC)Cc1cccc2ccccc12)NC[C@@H](N)CS Show InChI InChI=1S/C28H44N4O3S2/c1-5-20(2)26(30-15-23(29)19-36)17-32(16-22-11-8-10-21-9-6-7-12-24(21)22)18-27(33)31-25(13-14-37-4)28(34)35-3/h6-12,20,23,25-26,30,36H,5,13-19,29H2,1-4H3,(H,31,33)/t20-,23-,25+,26-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of post-translational processing of v-Ras protein in NIH3T3 cells |
J Med Chem 41: 2651-6 (1998)
Article DOI: 10.1021/jm9800907
BindingDB Entry DOI: 10.7270/Q2WW7JCV |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50369377
(CHEMBL1790746)Show SMILES CC[C@@H](C)[C@@H](CN(Cc1ccccc1)[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCSC)C(O)=O)NC[C@@H](N)CS Show InChI InChI=1S/C30H46N4O3S2/c1-4-22(2)27(32-18-25(31)21-38)20-34(19-24-13-9-6-10-14-24)28(17-23-11-7-5-8-12-23)29(35)33-26(30(36)37)15-16-39-3/h5-14,22,25-28,32,38H,4,15-21,31H2,1-3H3,(H,33,35)(H,36,37)/t22-,25-,26+,27-,28+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of [3H]FPP incorporation into recombinant human Ha-Ras by Farnesyltransferase |
J Med Chem 41: 2651-6 (1998)
Article DOI: 10.1021/jm9800907
BindingDB Entry DOI: 10.7270/Q2WW7JCV |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50369373
(CHEMBL1790743)Show SMILES CC[C@@H](C)[C@@H](CN(C)[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCO)C(O)=O)NC[C@@H](N)CS Show InChI InChI=1S/C23H40N4O4S/c1-4-16(2)20(25-13-18(24)15-32)14-27(3)21(12-17-8-6-5-7-9-17)22(29)26-19(10-11-28)23(30)31/h5-9,16,18-21,25,28,32H,4,10-15,24H2,1-3H3,(H,26,29)(H,30,31)/t16-,18-,19+,20-,21+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of [3H]FPP incorporation into recombinant human Ha-Ras by Farnesyltransferase |
J Med Chem 41: 2651-6 (1998)
Article DOI: 10.1021/jm9800907
BindingDB Entry DOI: 10.7270/Q2WW7JCV |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50369372
(CHEMBL1790756)Show SMILES CC[C@@H](C)[C@@H](CN(C)[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(O)=O)NC[C@@H](N)CS Show InChI InChI=1S/C21H44N4O3S2/c1-7-14(3)18(23-11-16(22)13-29)12-25(5)19(15(4)8-2)20(26)24-17(21(27)28)9-10-30-6/h14-19,23,29H,7-13,22H2,1-6H3,(H,24,26)(H,27,28)/t14-,15+,16-,17+,18-,19+/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine Geranylgeranyl transferase type I |
J Med Chem 41: 2651-6 (1998)
Article DOI: 10.1021/jm9800907
BindingDB Entry DOI: 10.7270/Q2WW7JCV |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50369370
(CHEMBL1790745)Show SMILES CC[C@@H](C)[C@@H](CN[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCSC)C(O)=O)NC[C@@H](N)CS Show InChI InChI=1S/C23H40N4O3S2/c1-4-16(2)21(25-13-18(24)15-31)14-26-20(12-17-8-6-5-7-9-17)22(28)27-19(23(29)30)10-11-32-3/h5-9,16,18-21,25-26,31H,4,10-15,24H2,1-3H3,(H,27,28)(H,29,30)/t16-,18-,19+,20+,21-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.75E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine Geranylgeranyl transferase type I |
J Med Chem 41: 2651-6 (1998)
Article DOI: 10.1021/jm9800907
BindingDB Entry DOI: 10.7270/Q2WW7JCV |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50369366
(CHEMBL1790752)Show SMILES CC[C@@H](C)[C@@H](CN[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCO)C(O)=O)NC[C@@H](N)CS Show InChI InChI=1S/C22H38N4O4S/c1-3-15(2)20(24-12-17(23)14-31)13-25-19(11-16-7-5-4-6-8-16)21(28)26-18(9-10-27)22(29)30/h4-8,15,17-20,24-25,27,31H,3,9-14,23H2,1-2H3,(H,26,28)(H,29,30)/t15-,17-,18+,19+,20-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine Geranylgeranyl transferase type I |
J Med Chem 41: 2651-6 (1998)
Article DOI: 10.1021/jm9800907
BindingDB Entry DOI: 10.7270/Q2WW7JCV |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50369375
(CHEMBL1790753)Show SMILES CCC[C@H](NC[C@@H](NC[C@@H](N)CS)[C@H](C)CC)C(=O)N[C@@H](CCO)C(O)=O Show InChI InChI=1S/C18H38N4O4S/c1-4-6-14(17(24)22-15(7-8-23)18(25)26)21-10-16(12(3)5-2)20-9-13(19)11-27/h12-16,20-21,23,27H,4-11,19H2,1-3H3,(H,22,24)(H,25,26)/t12-,13-,14+,15+,16-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine Geranylgeranyl transferase type I |
J Med Chem 41: 2651-6 (1998)
Article DOI: 10.1021/jm9800907
BindingDB Entry DOI: 10.7270/Q2WW7JCV |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50369365
(CHEMBL1790754)Show SMILES CC[C@@H](C)[C@@H](CN(C)CC(=O)N[C@@H](CCO)C(O)=O)NC[C@@H](N)CS Show InChI InChI=1S/C16H34N4O4S/c1-4-11(2)14(18-7-12(17)10-25)8-20(3)9-15(22)19-13(5-6-21)16(23)24/h11-14,18,21,25H,4-10,17H2,1-3H3,(H,19,22)(H,23,24)/t11-,12-,13+,14-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine Geranylgeranyl transferase type I |
J Med Chem 41: 2651-6 (1998)
Article DOI: 10.1021/jm9800907
BindingDB Entry DOI: 10.7270/Q2WW7JCV |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Mus musculus) | BDBM50369374
(CHEMBL1790749)Show SMILES CC[C@@H](C)[C@@H](CN(C)[C@@H]([C@H](C)CC)C(=O)N[C@H]1CCOC1=O)NC[C@@H](N)CS Show InChI InChI=1S/C20H40N4O3S/c1-6-13(3)17(22-10-15(21)12-28)11-24(5)18(14(4)7-2)19(25)23-16-8-9-27-20(16)26/h13-18,22,28H,6-12,21H2,1-5H3,(H,23,25)/t13-,14-,15-,16+,17-,18+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of post-translational processing of v-Ras protein in NIH3T3 cells |
J Med Chem 41: 2651-6 (1998)
Article DOI: 10.1021/jm9800907
BindingDB Entry DOI: 10.7270/Q2WW7JCV |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50369364
(CHEMBL1790760)Show SMILES CC[C@@H](C)[C@@H](CN(CC(=O)N[C@@H](CCSC)C(O)=O)Cc1ccccc1)NCCCS Show InChI InChI=1S/C23H39N3O3S2/c1-4-18(2)21(24-12-8-13-30)16-26(15-19-9-6-5-7-10-19)17-22(27)25-20(23(28)29)11-14-31-3/h5-7,9-10,18,20-21,24,30H,4,8,11-17H2,1-3H3,(H,25,27)(H,28,29)/t18-,20+,21-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine Geranylgeranyl transferase type I |
J Med Chem 41: 2651-6 (1998)
Article DOI: 10.1021/jm9800907
BindingDB Entry DOI: 10.7270/Q2WW7JCV |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50369368
(CHEMBL1790744)Show SMILES CCC[C@H](N(C)C[C@@H](NC[C@@H](N)CS)[C@H](C)CC)C(=O)N[C@@H](CCO)C(O)=O Show InChI InChI=1S/C19H40N4O4S/c1-5-7-17(18(25)22-15(8-9-24)19(26)27)23(4)11-16(13(3)6-2)21-10-14(20)12-28/h13-17,21,24,28H,5-12,20H2,1-4H3,(H,22,25)(H,26,27)/t13-,14-,15+,16-,17+/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine Geranylgeranyl transferase type I |
J Med Chem 41: 2651-6 (1998)
Article DOI: 10.1021/jm9800907
BindingDB Entry DOI: 10.7270/Q2WW7JCV |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50407296
(CHEMBL2052018 | L-731735)Show SMILES CC[C@H](C)[C@@H](CN[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCO)C(O)=O)NC[C@@H](N)CS Show InChI InChI=1S/C19H40N4O4S/c1-5-12(3)16(21-9-14(20)11-28)10-22-17(13(4)6-2)18(25)23-15(7-8-24)19(26)27/h12-17,21-22,24,28H,5-11,20H2,1-4H3,(H,23,25)(H,26,27)/t12-,13-,14+,15-,16+,17-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
MCE
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of bovine Geranylgeranyl transferase type I |
J Med Chem 41: 2651-6 (1998)
Article DOI: 10.1021/jm9800907
BindingDB Entry DOI: 10.7270/Q2WW7JCV |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Mus musculus) | BDBM50369312
(CHEMBL1790758)Show SMILES CC[C@@H](C)[C@@H](CN[C@@H]([C@H](C)CC)C(=O)N[C@H]1CCOC1=O)NC[C@@H](N)CS Show InChI InChI=1S/C19H38N4O3S/c1-5-12(3)16(21-9-14(20)11-27)10-22-17(13(4)6-2)18(24)23-15-7-8-26-19(15)25/h12-17,21-22,27H,5-11,20H2,1-4H3,(H,23,24)/t12-,13-,14-,15+,16-,17+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of post-translational processing of v-Ras protein in NIH3T3 cells |
J Med Chem 41: 2651-6 (1998)
Article DOI: 10.1021/jm9800907
BindingDB Entry DOI: 10.7270/Q2WW7JCV |
More data for this
Ligand-Target Pair | |
Search and Browse
