Affinity Data by PubMed id=9871722

PubMed code 9871722

Found 14 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM22541 (Clobenpropit \| N''-[(4-chlorophenyl)methyl]{[3-(1H...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	PubMed	0.180	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Gliatech Inc. Curated by ChEMBL					Assay Description Inhibition of [3H]- N-alpha-methylhistamine from histamine H3 receptor				Bioorg Med Chem Lett 8: 1133-8 (1999) BindingDB Entry DOI: 10.7270/Q2GF0SPX
Gliatech Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50070217 (3-(3-Bromo-4-methoxy-phenyl)-2-[(E)-hydroxyimino]-...) Show SMILES COc1ccc(CC(N=O)C(=O)NCCc2cnc[nH]2)cc1Br Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Gliatech Inc. Curated by ChEMBL					Assay Description Inhibition of [3H]- N-alpha-methylhistamine from histamine H3 receptor				Bioorg Med Chem Lett 8: 1133-8 (1999) BindingDB Entry DOI: 10.7270/Q2GF0SPX
Gliatech Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50070214 (4-(7,7-Dimethyl-oct-3-ynyl)-1H-imidazole \| CHEMBL2...) Show SMILES CC(C)(C)CCC#CCCc1cnc[nH]1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	0.800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Gliatech Inc. Curated by ChEMBL					Assay Description Inhibition of [3H]- N-alpha-methylhistamine from histamine H3 receptor				Bioorg Med Chem Lett 8: 1133-8 (1999) BindingDB Entry DOI: 10.7270/Q2GF0SPX
Gliatech Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50070220 (4-(6-Cyclopentyl-hex-3-ynyl)-1H-imidazole \| CHEMBL...) Show SMILES C(CC1CCCC1)C#CCCc1cnc[nH]1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	0.950	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Gliatech Inc. Curated by ChEMBL					Assay Description Inhibition of [3H]- N-alpha-methylhistamine from histamine H3 receptor				Bioorg Med Chem Lett 8: 1133-8 (1999) BindingDB Entry DOI: 10.7270/Q2GF0SPX
Gliatech Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM7967 (1-methyl-5-(beta-aminoethyl)-imidazole \| 2-(1-meth...) Show SMILES Cn1cncc1CCN Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Gliatech Inc. Curated by ChEMBL					Assay Description Inhibition of [3H]- N-alpha-methylhistamine from histamine H3 receptor				Bioorg Med Chem Lett 8: 1133-8 (1999) BindingDB Entry DOI: 10.7270/Q2GF0SPX
Gliatech Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM22914 (CHEMBL260374 \| N-cyclohexyl-4-(1H-imidazol-5-yl)pi...) Show SMILES S=C(NC1CCCCC1)N1CCC(CC1)c1cnc[nH]1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	1.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Gliatech Inc. Curated by ChEMBL					Assay Description Antagonistic activity of the compound was evaluated against histamine H3 receptor using [3H]- N-alpha-methylhistamine as radioligand in experiment 2				Bioorg Med Chem Lett 8: 1133-8 (1999) BindingDB Entry DOI: 10.7270/Q2GF0SPX
Gliatech Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50070211 (4-(6-Cyclohexyl-hex-3-ynyl)-1H-imidazole \| CHEMBL1...) Show SMILES C(CC1CCCCC1)C#CCCc1cnc[nH]1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	2.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Gliatech Inc. Curated by ChEMBL					Assay Description Inhibition of [3H]- N-alpha-methylhistamine from histamine H3 receptor				Bioorg Med Chem Lett 8: 1133-8 (1999) BindingDB Entry DOI: 10.7270/Q2GF0SPX
Gliatech Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50070216 (4-(8-Phenyl-oct-3-ynyl)-1H-imidazole \| CHEMBL14811) Show SMILES C(CCc1ccccc1)CC#CCCc1cnc[nH]1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	PubMed	3.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Gliatech Inc. Curated by ChEMBL					Assay Description Inhibition of [3H]- N-alpha-methylhistamine from histamine H3 receptor				Bioorg Med Chem Lett 8: 1133-8 (1999) BindingDB Entry DOI: 10.7270/Q2GF0SPX
Gliatech Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50070212 (4-(7-Methyl-oct-3-ynyl)-1H-imidazole \| CHEMBL14497) Show SMILES CC(C)CCC#CCCc1cnc[nH]1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	3.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Gliatech Inc. Curated by ChEMBL					Assay Description Inhibition of [3H]- N-alpha-methylhistamine from histamine H3 receptor				Bioorg Med Chem Lett 8: 1133-8 (1999) BindingDB Entry DOI: 10.7270/Q2GF0SPX
Gliatech Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM22914 (CHEMBL260374 \| N-cyclohexyl-4-(1H-imidazol-5-yl)pi...) Show SMILES S=C(NC1CCCCC1)N1CCC(CC1)c1cnc[nH]1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	4.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Gliatech Inc. Curated by ChEMBL					Assay Description Antagonistic activity of the compound was evaluated against histamine H3 receptor using [3H]- N-alpha-methylhistamine as radioligand in experiment 1				Bioorg Med Chem Lett 8: 1133-8 (1999) BindingDB Entry DOI: 10.7270/Q2GF0SPX
Gliatech Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50070213 (3-(4-Chloro-benzyl)-5-[2-(1H-imidazol-4-yl)-ethyl]...) Show SMILES Clc1ccc(Cc2noc(CCc3cnc[nH]3)n2)cc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Gliatech Inc. Curated by ChEMBL					Assay Description Inhibition of [3H]- N-alpha-methylhistamine from histamine H3 receptor				Bioorg Med Chem Lett 8: 1133-8 (1999) BindingDB Entry DOI: 10.7270/Q2GF0SPX
Gliatech Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50070215 (4-Hept-3-ynyl-1H-imidazole \| CHEMBL276804) Show SMILES CCCC#CCCc1cnc[nH]1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	27	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Gliatech Inc. Curated by ChEMBL					Assay Description Inhibition of [3H]- N-alpha-methylhistamine from histamine H3 receptor				Bioorg Med Chem Lett 8: 1133-8 (1999) BindingDB Entry DOI: 10.7270/Q2GF0SPX
Gliatech Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM86490 (CAS_0 \| CHEMBL14812 \| GT 2016 \| NSC_0) Show SMILES O=C(CCCCC1CCCCC1)N1CCC(CC1)c1cnc[nH]1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Gliatech Inc. Curated by ChEMBL					Assay Description Inhibition of [3H]- N-alpha-methylhistamine from histamine H3 receptor				Bioorg Med Chem Lett 8: 1133-8 (1999) BindingDB Entry DOI: 10.7270/Q2GF0SPX
Gliatech Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50070219 (4-Hex-3-ynyl-1H-imidazole \| CHEMBL14721) Show SMILES CCC#CCCc1cnc[nH]1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	79	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Gliatech Inc. Curated by ChEMBL					Assay Description Inhibition of [3H]- N-alpha-methylhistamine from histamine H3 receptor				Bioorg Med Chem Lett 8: 1133-8 (1999) BindingDB Entry DOI: 10.7270/Q2GF0SPX
Gliatech Inc. Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%