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PubMed code 9873601

Compile data set for download or QSAR
Found 45 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50071855
PNG
(4-(4-Benzyl-piperazin-1-yl)-2-trifluoromethyl-1H-b...)
Show SMILES FC(F)(F)c1nc2c(cccc2[nH]1)N1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C19H19F3N4/c20-19(21,22)18-23-15-7-4-8-16(17(15)24-18)26-11-9-25(10-12-26)13-14-5-2-1-3-6-14/h1-8H,9-13H2,(H,23,24)
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 0.510n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratory

Curated by ChEMBL


Assay Description
Affinity for Dopamine receptor D2 in rat striatal membranes for high agonist state using [3H]-quinpirole

Bioorg Med Chem Lett 8: 2675-80 (1999)


BindingDB Entry DOI: 10.7270/Q2C53K0X
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50071856
PNG
(4-(4-Benzyl-piperazin-1-yl)-1,3-dihydro-indol-2-on...)
Show SMILES O=C1Cc2c(N1)cccc2N1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C19H21N3O/c23-19-13-16-17(20-19)7-4-8-18(16)22-11-9-21(10-12-22)14-15-5-2-1-3-6-15/h1-8H,9-14H2,(H,20,23)
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 0.560n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratory

Curated by ChEMBL


Assay Description
Affinity for Dopamine receptor D2 in rat striatal membranes for high agonist state using [3H]-quinpirole

Bioorg Med Chem Lett 8: 2675-80 (1999)


BindingDB Entry DOI: 10.7270/Q2C53K0X
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50071858
PNG
(4-(4-Benzyl-piperazin-1-yl)-5-chloro-1H-indole | C...)
Show SMILES Clc1ccc2[nH]ccc2c1N1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C19H20ClN3/c20-17-6-7-18-16(8-9-21-18)19(17)23-12-10-22(11-13-23)14-15-4-2-1-3-5-15/h1-9,21H,10-14H2
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 1.70n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratory

Curated by ChEMBL


Assay Description
Affinity towards human Dopamine receptor D4.4 expressed in CHO cells using [3H]-spiperone

Bioorg Med Chem Lett 8: 2675-80 (1999)


BindingDB Entry DOI: 10.7270/Q2C53K0X
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50071853
PNG
(4-(4-Benzyl-piperazin-1-yl)-7-bromo-1H-indole | CH...)
Show SMILES Brc1ccc(N2CCN(Cc3ccccc3)CC2)c2cc[nH]c12
Show InChI InChI=1S/C19H20BrN3/c20-17-6-7-18(16-8-9-21-19(16)17)23-12-10-22(11-13-23)14-15-4-2-1-3-5-15/h1-9,21H,10-14H2
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 2.60n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratory

Curated by ChEMBL


Assay Description
Affinity towards human Dopamine receptor D4.4 expressed in CHO cells using [3H]-spiperone

Bioorg Med Chem Lett 8: 2675-80 (1999)


BindingDB Entry DOI: 10.7270/Q2C53K0X
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50071855
PNG
(4-(4-Benzyl-piperazin-1-yl)-2-trifluoromethyl-1H-b...)
Show SMILES FC(F)(F)c1nc2c(cccc2[nH]1)N1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C19H19F3N4/c20-19(21,22)18-23-15-7-4-8-16(17(15)24-18)26-11-9-25(10-12-26)13-14-5-2-1-3-6-14/h1-8H,9-13H2,(H,23,24)
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 2.90n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratory

Curated by ChEMBL


Assay Description
Affinity towards human Dopamine receptor D4.4 expressed in CHO cells using [3H]-spiperone

Bioorg Med Chem Lett 8: 2675-80 (1999)


BindingDB Entry DOI: 10.7270/Q2C53K0X
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50071856
PNG
(4-(4-Benzyl-piperazin-1-yl)-1,3-dihydro-indol-2-on...)
Show SMILES O=C1Cc2c(N1)cccc2N1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C19H21N3O/c23-19-13-16-17(20-19)7-4-8-18(16)22-11-9-21(10-12-22)14-15-5-2-1-3-6-15/h1-8H,9-14H2,(H,20,23)
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 3n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratory

Curated by ChEMBL


Assay Description
Affinity towards human Dopamine receptor D4.4 expressed in CHO cells using [3H]-spiperone

Bioorg Med Chem Lett 8: 2675-80 (1999)


BindingDB Entry DOI: 10.7270/Q2C53K0X
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50071857
PNG
(4-(4-Benzyl-piperazin-1-yl)-1H-indole | CHEMBL3280...)
Show SMILES C(N1CCN(CC1)c1cccc2[nH]ccc12)c1ccccc1
Show InChI InChI=1S/C19H21N3/c1-2-5-16(6-3-1)15-21-11-13-22(14-12-21)19-8-4-7-18-17(19)9-10-20-18/h1-10,20H,11-15H2
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 3.20n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratory

Curated by ChEMBL


Assay Description
Affinity for Dopamine receptor D2 in rat striatal membranes for high agonist state using [3H]-quinpirole

Bioorg Med Chem Lett 8: 2675-80 (1999)


BindingDB Entry DOI: 10.7270/Q2C53K0X
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50071855
PNG
(4-(4-Benzyl-piperazin-1-yl)-2-trifluoromethyl-1H-b...)
Show SMILES FC(F)(F)c1nc2c(cccc2[nH]1)N1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C19H19F3N4/c20-19(21,22)18-23-15-7-4-8-16(17(15)24-18)26-11-9-25(10-12-26)13-14-5-2-1-3-6-14/h1-8H,9-13H2,(H,23,24)
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 3.30n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratory

Curated by ChEMBL


Assay Description
Affinity of compound for the Dopamine receptor D2 in rat striatal membranes was determined for low agonist state in rat striatal membranes using [3H]...

Bioorg Med Chem Lett 8: 2675-80 (1999)


BindingDB Entry DOI: 10.7270/Q2C53K0X
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50071855
PNG
(4-(4-Benzyl-piperazin-1-yl)-2-trifluoromethyl-1H-b...)
Show SMILES FC(F)(F)c1nc2c(cccc2[nH]1)N1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C19H19F3N4/c20-19(21,22)18-23-15-7-4-8-16(17(15)24-18)26-11-9-25(10-12-26)13-14-5-2-1-3-6-14/h1-8H,9-13H2,(H,23,24)
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 4.10n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratory

Curated by ChEMBL


Assay Description
Affinity towards human Dopamine receptor D2 expressed in CHO cells using [3H]-spiperone

Bioorg Med Chem Lett 8: 2675-80 (1999)


BindingDB Entry DOI: 10.7270/Q2C53K0X
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50071856
PNG
(4-(4-Benzyl-piperazin-1-yl)-1,3-dihydro-indol-2-on...)
Show SMILES O=C1Cc2c(N1)cccc2N1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C19H21N3O/c23-19-13-16-17(20-19)7-4-8-18(16)22-11-9-21(10-12-22)14-15-5-2-1-3-6-15/h1-8H,9-14H2,(H,20,23)
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 5.40n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratory

Curated by ChEMBL


Assay Description
Affinity towards human Dopamine receptor D3 expressed in CHO cells using [3H]-spiperone

Bioorg Med Chem Lett 8: 2675-80 (1999)


BindingDB Entry DOI: 10.7270/Q2C53K0X
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50069907
PNG
(1-benzyl-4-(3-hydroxyphenyl)piperazine | 3-(4-Benz...)
Show SMILES Oc1cccc(c1)N1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C17H20N2O/c20-17-8-4-7-16(13-17)19-11-9-18(10-12-19)14-15-5-2-1-3-6-15/h1-8,13,20H,9-12,14H2
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 5.5n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratory

Curated by ChEMBL


Assay Description
Affinity for Dopamine receptor D2 in rat striatal membranes for high agonist state using [3H]-quinpirole

Bioorg Med Chem Lett 8: 2675-80 (1999)


BindingDB Entry DOI: 10.7270/Q2C53K0X
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50071856
PNG
(4-(4-Benzyl-piperazin-1-yl)-1,3-dihydro-indol-2-on...)
Show SMILES O=C1Cc2c(N1)cccc2N1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C19H21N3O/c23-19-13-16-17(20-19)7-4-8-18(16)22-11-9-21(10-12-22)14-15-5-2-1-3-6-15/h1-8H,9-14H2,(H,20,23)
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 8n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratory

Curated by ChEMBL


Assay Description
Affinity towards human Dopamine receptor D2 expressed in CHO cells using [3H]-spiperone

Bioorg Med Chem Lett 8: 2675-80 (1999)


BindingDB Entry DOI: 10.7270/Q2C53K0X
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50071856
PNG
(4-(4-Benzyl-piperazin-1-yl)-1,3-dihydro-indol-2-on...)
Show SMILES O=C1Cc2c(N1)cccc2N1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C19H21N3O/c23-19-13-16-17(20-19)7-4-8-18(16)22-11-9-21(10-12-22)14-15-5-2-1-3-6-15/h1-8H,9-14H2,(H,20,23)
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 8.10n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratory

Curated by ChEMBL


Assay Description
Affinity for Dopamine receptor D2 in rat striatal membranes for high agonist state using [3H]-quinpirole

Bioorg Med Chem Lett 8: 2675-80 (1999)


BindingDB Entry DOI: 10.7270/Q2C53K0X
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50071859
PNG
(4-(4-Benzyl-piperazin-1-yl)-5-chloro-1,3-dihydro-i...)
Show SMILES Clc1ccc2NC(=O)Cc2c1N1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C19H20ClN3O/c20-16-6-7-17-15(12-18(24)21-17)19(16)23-10-8-22(9-11-23)13-14-4-2-1-3-5-14/h1-7H,8-13H2,(H,21,24)
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 8.80n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratory

Curated by ChEMBL


Assay Description
Affinity towards human Dopamine receptor D4.4 expressed in CHO cells using [3H]-spiperone

Bioorg Med Chem Lett 8: 2675-80 (1999)


BindingDB Entry DOI: 10.7270/Q2C53K0X
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50071858
PNG
(4-(4-Benzyl-piperazin-1-yl)-5-chloro-1H-indole | C...)
Show SMILES Clc1ccc2[nH]ccc2c1N1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C19H20ClN3/c20-17-6-7-18-16(8-9-21-18)19(17)23-12-10-22(11-13-23)14-15-4-2-1-3-5-15/h1-9,21H,10-14H2
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 9.10n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratory

Curated by ChEMBL


Assay Description
Affinity of compound for the Dopamine receptor D2 in rat striatal membranes was determined for low antagonist state in rat striatal membranes using [...

Bioorg Med Chem Lett 8: 2675-80 (1999)


BindingDB Entry DOI: 10.7270/Q2C53K0X
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50071853
PNG
(4-(4-Benzyl-piperazin-1-yl)-7-bromo-1H-indole | CH...)
Show SMILES Brc1ccc(N2CCN(Cc3ccccc3)CC2)c2cc[nH]c12
Show InChI InChI=1S/C19H20BrN3/c20-17-6-7-18(16-8-9-21-19(16)17)23-12-10-22(11-13-23)14-15-4-2-1-3-5-15/h1-9,21H,10-14H2
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 12n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratory

Curated by ChEMBL


Assay Description
Affinity of compound for the Dopamine receptor D2 in rat striatal membranes was determined for low antagonist state in rat striatal membranes using [...

Bioorg Med Chem Lett 8: 2675-80 (1999)


BindingDB Entry DOI: 10.7270/Q2C53K0X
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50071854
PNG
(4-(4-Benzyl-piperazin-1-yl)-1,3-dihydro-benzoimida...)
Show SMILES O=c1[nH]c2cccc(N3CCN(Cc4ccccc4)CC3)c2[nH]1
Show InChI InChI=1S/C18H20N4O/c23-18-19-15-7-4-8-16(17(15)20-18)22-11-9-21(10-12-22)13-14-5-2-1-3-6-14/h1-8H,9-13H2,(H2,19,20,23)
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 14n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratory

Curated by ChEMBL


Assay Description
Affinity towards human Dopamine receptor D4.4 expressed in CHO cells using [3H]-spiperone

Bioorg Med Chem Lett 8: 2675-80 (1999)


BindingDB Entry DOI: 10.7270/Q2C53K0X
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50071857
PNG
(4-(4-Benzyl-piperazin-1-yl)-1H-indole | CHEMBL3280...)
Show SMILES C(N1CCN(CC1)c1cccc2[nH]ccc12)c1ccccc1
Show InChI InChI=1S/C19H21N3/c1-2-5-16(6-3-1)15-21-11-13-22(14-12-21)19-8-4-7-18-17(19)9-10-20-18/h1-10,20H,11-15H2
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 15n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratory

Curated by ChEMBL


Assay Description
Affinity towards human Dopamine receptor D4.4 expressed in CHO cells using [3H]-spiperone

Bioorg Med Chem Lett 8: 2675-80 (1999)


BindingDB Entry DOI: 10.7270/Q2C53K0X
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50071855
PNG
(4-(4-Benzyl-piperazin-1-yl)-2-trifluoromethyl-1H-b...)
Show SMILES FC(F)(F)c1nc2c(cccc2[nH]1)N1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C19H19F3N4/c20-19(21,22)18-23-15-7-4-8-16(17(15)24-18)26-11-9-25(10-12-26)13-14-5-2-1-3-6-14/h1-8H,9-13H2,(H,23,24)
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 15n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratory

Curated by ChEMBL


Assay Description
Affinity towards human Dopamine receptor D3 expressed in CHO cells using [3H]-spiperone

Bioorg Med Chem Lett 8: 2675-80 (1999)


BindingDB Entry DOI: 10.7270/Q2C53K0X
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50071857
PNG
(4-(4-Benzyl-piperazin-1-yl)-1H-indole | CHEMBL3280...)
Show SMILES C(N1CCN(CC1)c1cccc2[nH]ccc12)c1ccccc1
Show InChI InChI=1S/C19H21N3/c1-2-5-16(6-3-1)15-21-11-13-22(14-12-21)19-8-4-7-18-17(19)9-10-20-18/h1-10,20H,11-15H2
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 17n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratory

Curated by ChEMBL


Assay Description
Affinity of compound for the Dopamine receptor D2 in rat striatal membranes was determined for low antagonist state in rat striatal membranes using [...

Bioorg Med Chem Lett 8: 2675-80 (1999)


BindingDB Entry DOI: 10.7270/Q2C53K0X
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50071853
PNG
(4-(4-Benzyl-piperazin-1-yl)-7-bromo-1H-indole | CH...)
Show SMILES Brc1ccc(N2CCN(Cc3ccccc3)CC2)c2cc[nH]c12
Show InChI InChI=1S/C19H20BrN3/c20-17-6-7-18(16-8-9-21-19(16)17)23-12-10-22(11-13-23)14-15-4-2-1-3-5-15/h1-9,21H,10-14H2
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 27n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratory

Curated by ChEMBL


Assay Description
Affinity for Dopamine receptor D2 in rat striatal membranes for high agonist state using [3H]-quinpirole

Bioorg Med Chem Lett 8: 2675-80 (1999)


BindingDB Entry DOI: 10.7270/Q2C53K0X
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50069907
PNG
(1-benzyl-4-(3-hydroxyphenyl)piperazine | 3-(4-Benz...)
Show SMILES Oc1cccc(c1)N1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C17H20N2O/c20-17-8-4-7-16(13-17)19-11-9-18(10-12-19)14-15-5-2-1-3-6-15/h1-8,13,20H,9-12,14H2
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 29n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratory

Curated by ChEMBL


Assay Description
Affinity towards human Dopamine receptor D3 expressed in CHO cells using [3H]-spiperone

Bioorg Med Chem Lett 8: 2675-80 (1999)


BindingDB Entry DOI: 10.7270/Q2C53K0X
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50071857
PNG
(4-(4-Benzyl-piperazin-1-yl)-1H-indole | CHEMBL3280...)
Show SMILES C(N1CCN(CC1)c1cccc2[nH]ccc12)c1ccccc1
Show InChI InChI=1S/C19H21N3/c1-2-5-16(6-3-1)15-21-11-13-22(14-12-21)19-8-4-7-18-17(19)9-10-20-18/h1-10,20H,11-15H2
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 35n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratory

Curated by ChEMBL


Assay Description
Affinity towards human Dopamine receptor D3 expressed in CHO cells using [3H]-spiperone

Bioorg Med Chem Lett 8: 2675-80 (1999)


BindingDB Entry DOI: 10.7270/Q2C53K0X
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50071858
PNG
(4-(4-Benzyl-piperazin-1-yl)-5-chloro-1H-indole | C...)
Show SMILES Clc1ccc2[nH]ccc2c1N1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C19H20ClN3/c20-17-6-7-18-16(8-9-21-18)19(17)23-12-10-22(11-13-23)14-15-4-2-1-3-5-15/h1-9,21H,10-14H2
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 42n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratory

Curated by ChEMBL


Assay Description
Affinity of compound for the D2 receptors in rat striatal membranes was determined for low antagonist state in rat striatal membranes using [3H]-spip...

Bioorg Med Chem Lett 8: 2675-80 (1999)


BindingDB Entry DOI: 10.7270/Q2C53K0X
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50071854
PNG
(4-(4-Benzyl-piperazin-1-yl)-1,3-dihydro-benzoimida...)
Show SMILES O=c1[nH]c2cccc(N3CCN(Cc4ccccc4)CC3)c2[nH]1
Show InChI InChI=1S/C18H20N4O/c23-18-19-15-7-4-8-16(17(15)20-18)22-11-9-21(10-12-22)13-14-5-2-1-3-6-14/h1-8H,9-13H2,(H2,19,20,23)
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 45.8n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratory

Curated by ChEMBL


Assay Description
Affinity of compound for the Dopamine receptor D2 in rat striatal membranes was determined for low antagonist state in rat striatal membranes using [...

Bioorg Med Chem Lett 8: 2675-80 (1999)


BindingDB Entry DOI: 10.7270/Q2C53K0X
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50071854
PNG
(4-(4-Benzyl-piperazin-1-yl)-1,3-dihydro-benzoimida...)
Show SMILES O=c1[nH]c2cccc(N3CCN(Cc4ccccc4)CC3)c2[nH]1
Show InChI InChI=1S/C18H20N4O/c23-18-19-15-7-4-8-16(17(15)20-18)22-11-9-21(10-12-22)13-14-5-2-1-3-6-14/h1-8H,9-13H2,(H2,19,20,23)
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 46n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratory

Curated by ChEMBL


Assay Description
Affinity for Dopamine receptor D2 in rat striatal membranes for high agonist state using [3H]-quinpirole

Bioorg Med Chem Lett 8: 2675-80 (1999)


BindingDB Entry DOI: 10.7270/Q2C53K0X
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50071852
PNG
(4-(4-Benzyl-piperazin-1-yl)-1H-benzoimidazole | CH...)
Show SMILES C(N1CCN(CC1)c1cccc2[nH]cnc12)c1ccccc1
Show InChI InChI=1S/C18H20N4/c1-2-5-15(6-3-1)13-21-9-11-22(12-10-21)17-8-4-7-16-18(17)20-14-19-16/h1-8,14H,9-13H2,(H,19,20)
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 47n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratory

Curated by ChEMBL


Assay Description
Affinity towards human Dopamine receptor D4.4 expressed in CHO cells using [3H]-spiperone

Bioorg Med Chem Lett 8: 2675-80 (1999)


BindingDB Entry DOI: 10.7270/Q2C53K0X
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50071853
PNG
(4-(4-Benzyl-piperazin-1-yl)-7-bromo-1H-indole | CH...)
Show SMILES Brc1ccc(N2CCN(Cc3ccccc3)CC2)c2cc[nH]c12
Show InChI InChI=1S/C19H20BrN3/c20-17-6-7-18(16-8-9-21-19(16)17)23-12-10-22(11-13-23)14-15-4-2-1-3-5-15/h1-9,21H,10-14H2
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 47n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratory

Curated by ChEMBL


Assay Description
Affinity towards human Dopamine receptor D2 expressed in CHO cells using [3H]-spiperone

Bioorg Med Chem Lett 8: 2675-80 (1999)


BindingDB Entry DOI: 10.7270/Q2C53K0X
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50071857
PNG
(4-(4-Benzyl-piperazin-1-yl)-1H-indole | CHEMBL3280...)
Show SMILES C(N1CCN(CC1)c1cccc2[nH]ccc12)c1ccccc1
Show InChI InChI=1S/C19H21N3/c1-2-5-16(6-3-1)15-21-11-13-22(14-12-21)19-8-4-7-18-17(19)9-10-20-18/h1-10,20H,11-15H2
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 53n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratory

Curated by ChEMBL


Assay Description
Affinity towards human Dopamine receptor D2 expressed in CHO cells using [3H]-spiperone

Bioorg Med Chem Lett 8: 2675-80 (1999)


BindingDB Entry DOI: 10.7270/Q2C53K0X
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50071853
PNG
(4-(4-Benzyl-piperazin-1-yl)-7-bromo-1H-indole | CH...)
Show SMILES Brc1ccc(N2CCN(Cc3ccccc3)CC2)c2cc[nH]c12
Show InChI InChI=1S/C19H20BrN3/c20-17-6-7-18(16-8-9-21-19(16)17)23-12-10-22(11-13-23)14-15-4-2-1-3-5-15/h1-9,21H,10-14H2
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 56n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratory

Curated by ChEMBL


Assay Description
Affinity towards human Dopamine receptor D3 expressed in CHO cells using [3H]-spiperone

Bioorg Med Chem Lett 8: 2675-80 (1999)


BindingDB Entry DOI: 10.7270/Q2C53K0X
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50071854
PNG
(4-(4-Benzyl-piperazin-1-yl)-1,3-dihydro-benzoimida...)
Show SMILES O=c1[nH]c2cccc(N3CCN(Cc4ccccc4)CC3)c2[nH]1
Show InChI InChI=1S/C18H20N4O/c23-18-19-15-7-4-8-16(17(15)20-18)22-11-9-21(10-12-22)13-14-5-2-1-3-6-14/h1-8H,9-13H2,(H2,19,20,23)
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 57n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratory

Curated by ChEMBL


Assay Description
Affinity towards human Dopamine receptor D3 expressed in CHO cells using [3H]-spiperone

Bioorg Med Chem Lett 8: 2675-80 (1999)


BindingDB Entry DOI: 10.7270/Q2C53K0X
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50071858
PNG
(4-(4-Benzyl-piperazin-1-yl)-5-chloro-1H-indole | C...)
Show SMILES Clc1ccc2[nH]ccc2c1N1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C19H20ClN3/c20-17-6-7-18-16(8-9-21-18)19(17)23-12-10-22(11-13-23)14-15-4-2-1-3-5-15/h1-9,21H,10-14H2
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 81n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratory

Curated by ChEMBL


Assay Description
Affinity towards human Dopamine receptor D2 expressed in CHO cells using [3H]-spiperone

Bioorg Med Chem Lett 8: 2675-80 (1999)


BindingDB Entry DOI: 10.7270/Q2C53K0X
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50071859
PNG
(4-(4-Benzyl-piperazin-1-yl)-5-chloro-1,3-dihydro-i...)
Show SMILES Clc1ccc2NC(=O)Cc2c1N1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C19H20ClN3O/c20-16-6-7-17-15(12-18(24)21-17)19(16)23-10-8-22(9-11-23)13-14-4-2-1-3-5-14/h1-7H,8-13H2,(H,21,24)
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 85n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratory

Curated by ChEMBL


Assay Description
Affinity for Dopamine receptor D2 in rat striatal membranes for high agonist state using [3H]-quinpirole

Bioorg Med Chem Lett 8: 2675-80 (1999)


BindingDB Entry DOI: 10.7270/Q2C53K0X
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50071854
PNG
(4-(4-Benzyl-piperazin-1-yl)-1,3-dihydro-benzoimida...)
Show SMILES O=c1[nH]c2cccc(N3CCN(Cc4ccccc4)CC3)c2[nH]1
Show InChI InChI=1S/C18H20N4O/c23-18-19-15-7-4-8-16(17(15)20-18)22-11-9-21(10-12-22)13-14-5-2-1-3-6-14/h1-8H,9-13H2,(H2,19,20,23)
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 87n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratory

Curated by ChEMBL


Assay Description
Affinity towards human Dopamine receptor D2 expressed in CHO cells using [3H]-spiperone

Bioorg Med Chem Lett 8: 2675-80 (1999)


BindingDB Entry DOI: 10.7270/Q2C53K0X
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50069907
PNG
(1-benzyl-4-(3-hydroxyphenyl)piperazine | 3-(4-Benz...)
Show SMILES Oc1cccc(c1)N1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C17H20N2O/c20-17-8-4-7-16(13-17)19-11-9-18(10-12-19)14-15-5-2-1-3-6-15/h1-8,13,20H,9-12,14H2
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 95n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratory

Curated by ChEMBL


Assay Description
Affinity of compound for the Dopamine receptor D2 in rat striatal membranes was determined for low antagonist state in rat striatal membranes using [...

Bioorg Med Chem Lett 8: 2675-80 (1999)


BindingDB Entry DOI: 10.7270/Q2C53K0X
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50071858
PNG
(4-(4-Benzyl-piperazin-1-yl)-5-chloro-1H-indole | C...)
Show SMILES Clc1ccc2[nH]ccc2c1N1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C19H20ClN3/c20-17-6-7-18-16(8-9-21-18)19(17)23-12-10-22(11-13-23)14-15-4-2-1-3-5-15/h1-9,21H,10-14H2
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 95n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratory

Curated by ChEMBL


Assay Description
Affinity towards human Dopamine receptor D3 expressed in CHO cells using [3H]-spiperone

Bioorg Med Chem Lett 8: 2675-80 (1999)


BindingDB Entry DOI: 10.7270/Q2C53K0X
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50071852
PNG
(4-(4-Benzyl-piperazin-1-yl)-1H-benzoimidazole | CH...)
Show SMILES C(N1CCN(CC1)c1cccc2[nH]cnc12)c1ccccc1
Show InChI InChI=1S/C18H20N4/c1-2-5-15(6-3-1)13-21-9-11-22(12-10-21)17-8-4-7-16-18(17)20-14-19-16/h1-8,14H,9-13H2,(H,19,20)
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 107n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratory

Curated by ChEMBL


Assay Description
Affinity of compound for the Dopamine receptor D2 in rat striatal membranes was determined for low antagonist state in rat striatal membranes using [...

Bioorg Med Chem Lett 8: 2675-80 (1999)


BindingDB Entry DOI: 10.7270/Q2C53K0X
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50071852
PNG
(4-(4-Benzyl-piperazin-1-yl)-1H-benzoimidazole | CH...)
Show SMILES C(N1CCN(CC1)c1cccc2[nH]cnc12)c1ccccc1
Show InChI InChI=1S/C18H20N4/c1-2-5-15(6-3-1)13-21-9-11-22(12-10-21)17-8-4-7-16-18(17)20-14-19-16/h1-8,14H,9-13H2,(H,19,20)
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 107n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratory

Curated by ChEMBL


Assay Description
Affinity of compound for the Dopamine receptor D2 in rat striatal membranes was determined for low antagonist state in rat striatal membranes using [...

Bioorg Med Chem Lett 8: 2675-80 (1999)


BindingDB Entry DOI: 10.7270/Q2C53K0X
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50069907
PNG
(1-benzyl-4-(3-hydroxyphenyl)piperazine | 3-(4-Benz...)
Show SMILES Oc1cccc(c1)N1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C17H20N2O/c20-17-8-4-7-16(13-17)19-11-9-18(10-12-19)14-15-5-2-1-3-6-15/h1-8,13,20H,9-12,14H2
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 246n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratory

Curated by ChEMBL


Assay Description
Affinity towards human Dopamine receptor D2 expressed in CHO cells using [3H]-spiperone

Bioorg Med Chem Lett 8: 2675-80 (1999)


BindingDB Entry DOI: 10.7270/Q2C53K0X
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50071852
PNG
(4-(4-Benzyl-piperazin-1-yl)-1H-benzoimidazole | CH...)
Show SMILES C(N1CCN(CC1)c1cccc2[nH]cnc12)c1ccccc1
Show InChI InChI=1S/C18H20N4/c1-2-5-15(6-3-1)13-21-9-11-22(12-10-21)17-8-4-7-16-18(17)20-14-19-16/h1-8,14H,9-13H2,(H,19,20)
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 258n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratory

Curated by ChEMBL


Assay Description
Affinity towards human Dopamine receptor D2 expressed in CHO cells using [3H]-spiperone

Bioorg Med Chem Lett 8: 2675-80 (1999)


BindingDB Entry DOI: 10.7270/Q2C53K0X
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50069907
PNG
(1-benzyl-4-(3-hydroxyphenyl)piperazine | 3-(4-Benz...)
Show SMILES Oc1cccc(c1)N1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C17H20N2O/c20-17-8-4-7-16(13-17)19-11-9-18(10-12-19)14-15-5-2-1-3-6-15/h1-8,13,20H,9-12,14H2
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>400n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratory

Curated by ChEMBL


Assay Description
Affinity towards human Dopamine receptor D4.4 expressed in CHO cells using [3H]-spiperone

Bioorg Med Chem Lett 8: 2675-80 (1999)


BindingDB Entry DOI: 10.7270/Q2C53K0X
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50071859
PNG
(4-(4-Benzyl-piperazin-1-yl)-5-chloro-1,3-dihydro-i...)
Show SMILES Clc1ccc2NC(=O)Cc2c1N1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C19H20ClN3O/c20-16-6-7-17-15(12-18(24)21-17)19(16)23-10-8-22(9-11-23)13-14-4-2-1-3-5-14/h1-7H,8-13H2,(H,21,24)
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 403n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratory

Curated by ChEMBL


Assay Description
Affinity for Dopamine receptor D2 in rat striatal membranes for high agonist state using [3H]-quinpirole

Bioorg Med Chem Lett 8: 2675-80 (1999)


BindingDB Entry DOI: 10.7270/Q2C53K0X
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50071859
PNG
(4-(4-Benzyl-piperazin-1-yl)-5-chloro-1,3-dihydro-i...)
Show SMILES Clc1ccc2NC(=O)Cc2c1N1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C19H20ClN3O/c20-16-6-7-17-15(12-18(24)21-17)19(16)23-10-8-22(9-11-23)13-14-4-2-1-3-5-14/h1-7H,8-13H2,(H,21,24)
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 540n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratory

Curated by ChEMBL


Assay Description
Affinity towards human Dopamine receptor D2 expressed in CHO cells using [3H]-spiperone

Bioorg Med Chem Lett 8: 2675-80 (1999)


BindingDB Entry DOI: 10.7270/Q2C53K0X
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50071859
PNG
(4-(4-Benzyl-piperazin-1-yl)-5-chloro-1,3-dihydro-i...)
Show SMILES Clc1ccc2NC(=O)Cc2c1N1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C19H20ClN3O/c20-16-6-7-17-15(12-18(24)21-17)19(16)23-10-8-22(9-11-23)13-14-4-2-1-3-5-14/h1-7H,8-13H2,(H,21,24)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
 591n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratory

Curated by ChEMBL


Assay Description
Affinity towards human Dopamine receptor D3 expressed in CHO cells using [3H]-spiperone

Bioorg Med Chem Lett 8: 2675-80 (1999)


BindingDB Entry DOI: 10.7270/Q2C53K0X
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50071852
PNG
(4-(4-Benzyl-piperazin-1-yl)-1H-benzoimidazole | CH...)
Show SMILES C(N1CCN(CC1)c1cccc2[nH]cnc12)c1ccccc1
Show InChI InChI=1S/C18H20N4/c1-2-5-15(6-3-1)13-21-9-11-22(12-10-21)17-8-4-7-16-18(17)20-14-19-16/h1-8,14H,9-13H2,(H,19,20)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
 871n/an/an/an/an/an/an/an/a



Wyeth-Ayerst Research Laboratory

Curated by ChEMBL


Assay Description
Affinity towards human Dopamine receptor D3 expressed in CHO cells using [3H]-spiperone

Bioorg Med Chem Lett 8: 2675-80 (1999)


BindingDB Entry DOI: 10.7270/Q2C53K0X
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%