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USPatent US10059709

Compile data set for download or QSAR
Found 84 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM270876
PNG
(US10059709, 22)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)n1cnc2cnc3[nH]ccc3c12 |r,wU:9.12,wD:6.5,(5.75,2.78,;4.41,2.01,;3.08,2.78,;3.85,4.12,;2.31,1.45,;1.75,3.55,;.41,2.78,;-.92,3.55,;-2.26,2.78,;-2.26,1.24,;-.92,.47,;.41,1.24,;-3.59,.47,;-5.12,.63,;-5.75,-.77,;-4.6,-1.81,;-4.6,-3.35,;-3.27,-4.12,;-1.93,-3.35,;-.47,-3.82,;.43,-2.58,;-.47,-1.33,;-1.93,-1.81,;-3.27,-1.04,)|
Show InChI InChI=1S/C16H21N5O2S/c1-17-24(22,23)9-11-2-4-12(5-3-11)21-10-20-14-8-19-16-13(15(14)21)6-7-18-16/h6-8,10-12,17H,2-5,9H2,1H3,(H,18,19)/t11-,12-
PDB

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n/an/a 10n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM270872
PNG
(US10059709, 18)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1c(cnc2[nH]ccc12)[N+]([O-])=O |r,wU:9.12,wD:6.5,(6.67,2.8,;5.33,2.03,;4,2.8,;4.77,4.13,;3.23,1.46,;2.67,3.57,;1.33,2.8,;,3.57,;-1.33,2.8,;-1.33,1.26,;,.49,;1.33,1.26,;-2.67,.49,;-4,1.26,;-2.67,-1.05,;-4,-1.82,;-4,-3.36,;-2.67,-4.13,;-1.33,-3.36,;.13,-3.84,;1.04,-2.59,;.13,-1.35,;-1.33,-1.82,;-5.33,-1.05,;-5.33,.49,;-6.67,-1.82,)|
Show InChI InChI=1S/C16H23N5O4S/c1-17-26(24,25)10-11-3-5-12(6-4-11)20(2)15-13-7-8-18-16(13)19-9-14(15)21(22)23/h7-9,11-12,17H,3-6,10H2,1-2H3,(H,18,19)/t11-,12-
PDB

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n/an/a 21n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM270880
PNG
(US10059709, 26)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1c(cnc2[nH]ccc12)C#N |r,wU:9.12,wD:6.5,(6.67,2.8,;5.33,2.03,;4,2.8,;4.77,4.13,;3.23,1.46,;2.67,3.57,;1.33,2.8,;,3.57,;-1.33,2.8,;-1.33,1.26,;,.49,;1.33,1.26,;-2.67,.49,;-4,1.26,;-2.67,-1.05,;-4,-1.82,;-4,-3.36,;-2.67,-4.13,;-1.33,-3.36,;.13,-3.84,;1.04,-2.59,;.13,-1.35,;-1.33,-1.82,;-5.33,-1.05,;-6.67,-.28,)|
Show InChI InChI=1S/C17H23N5O2S/c1-19-25(23,24)11-12-3-5-14(6-4-12)22(2)16-13(9-18)10-21-17-15(16)7-8-20-17/h7-8,10,12,14,19H,3-6,11H2,1-2H3,(H,20,21)/t12-,14-
PDB

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n/an/a 34n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM270879
PNG
(US10059709, 25)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)Oc1c(cnc2[nH]ccc12)[N+]([O-])=O |r,wU:6.5,wD:9.12,(6.67,2.8,;5.33,2.03,;4,2.8,;4.77,4.13,;3.23,1.46,;2.67,3.57,;1.33,2.8,;1.33,1.26,;,.49,;-1.33,1.26,;-1.33,2.8,;,3.57,;-2.67,.49,;-2.67,-1.05,;-4,-1.82,;-4,-3.36,;-2.67,-4.13,;-1.33,-3.36,;.13,-3.84,;1.04,-2.59,;.13,-1.35,;-1.33,-1.82,;-5.33,-1.05,;-5.33,.49,;-6.67,-1.82,)|
Show InChI InChI=1S/C15H20N4O5S/c1-16-25(22,23)9-10-2-4-11(5-3-10)24-14-12-6-7-17-15(12)18-8-13(14)19(20)21/h6-8,10-11,16H,2-5,9H2,1H3,(H,17,18)/t10-,11-
PDB

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n/an/a 71n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM270876
PNG
(US10059709, 22)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)n1cnc2cnc3[nH]ccc3c12 |r,wU:9.12,wD:6.5,(5.75,2.78,;4.41,2.01,;3.08,2.78,;3.85,4.12,;2.31,1.45,;1.75,3.55,;.41,2.78,;-.92,3.55,;-2.26,2.78,;-2.26,1.24,;-.92,.47,;.41,1.24,;-3.59,.47,;-5.12,.63,;-5.75,-.77,;-4.6,-1.81,;-4.6,-3.35,;-3.27,-4.12,;-1.93,-3.35,;-.47,-3.82,;.43,-2.58,;-.47,-1.33,;-1.93,-1.81,;-3.27,-1.04,)|
Show InChI InChI=1S/C16H21N5O2S/c1-17-24(22,23)9-11-2-4-12(5-3-11)21-10-20-14-8-19-16-13(15(14)21)6-7-18-16/h6-8,10-12,17H,2-5,9H2,1H3,(H,18,19)/t11-,12-
PDB

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n/an/a 130n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM270876
PNG
(US10059709, 22)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)n1cnc2cnc3[nH]ccc3c12 |r,wU:9.12,wD:6.5,(5.75,2.78,;4.41,2.01,;3.08,2.78,;3.85,4.12,;2.31,1.45,;1.75,3.55,;.41,2.78,;-.92,3.55,;-2.26,2.78,;-2.26,1.24,;-.92,.47,;.41,1.24,;-3.59,.47,;-5.12,.63,;-5.75,-.77,;-4.6,-1.81,;-4.6,-3.35,;-3.27,-4.12,;-1.93,-3.35,;-.47,-3.82,;.43,-2.58,;-.47,-1.33,;-1.93,-1.81,;-3.27,-1.04,)|
Show InChI InChI=1S/C16H21N5O2S/c1-17-24(22,23)9-11-2-4-12(5-3-11)21-10-20-14-8-19-16-13(15(14)21)6-7-18-16/h6-8,10-12,17H,2-5,9H2,1H3,(H,18,19)/t11-,12-
PDB

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n/an/a 260n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM270872
PNG
(US10059709, 18)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1c(cnc2[nH]ccc12)[N+]([O-])=O |r,wU:9.12,wD:6.5,(6.67,2.8,;5.33,2.03,;4,2.8,;4.77,4.13,;3.23,1.46,;2.67,3.57,;1.33,2.8,;,3.57,;-1.33,2.8,;-1.33,1.26,;,.49,;1.33,1.26,;-2.67,.49,;-4,1.26,;-2.67,-1.05,;-4,-1.82,;-4,-3.36,;-2.67,-4.13,;-1.33,-3.36,;.13,-3.84,;1.04,-2.59,;.13,-1.35,;-1.33,-1.82,;-5.33,-1.05,;-5.33,.49,;-6.67,-1.82,)|
Show InChI InChI=1S/C16H23N5O4S/c1-17-26(24,25)10-11-3-5-12(6-4-11)20(2)15-13-7-8-18-16(13)19-9-14(15)21(22)23/h7-9,11-12,17H,3-6,10H2,1-2H3,(H,18,19)/t11-,12-
PDB

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n/an/a 390n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM270882
PNG
(US10059709, 28)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnn2cccc12 |r,wU:9.12,wD:6.5,(5.33,2.8,;4,2.03,;2.67,2.8,;3.44,4.13,;1.9,1.46,;1.33,3.57,;,2.8,;-1.33,3.57,;-2.67,2.8,;-2.67,1.26,;-1.33,.49,;,1.26,;-4,.49,;-5.33,1.26,;-4,-1.05,;-5.33,-1.82,;-5.33,-3.36,;-4,-4.13,;-2.67,-3.36,;-1.2,-3.84,;-.3,-2.59,;-1.2,-1.35,;-2.67,-1.82,)|
Show InChI InChI=1S/C15H23N5O2S/c1-16-23(21,22)10-12-5-7-13(8-6-12)19(2)15-14-4-3-9-20(14)18-11-17-15/h3-4,9,11-13,16H,5-8,10H2,1-2H3/t12-,13-
PDB

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n/an/a 550n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM270856
PNG
(US10059709, 2)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]cnc12 |r,wU:9.12,wD:6.5,(5.33,2.8,;4,2.03,;2.67,2.8,;3.44,4.13,;1.9,1.46,;1.33,3.57,;,2.8,;-1.33,3.57,;-2.67,2.8,;-2.67,1.26,;-1.33,.49,;,1.26,;-4,.49,;-5.33,1.26,;-4,-1.05,;-5.33,-1.82,;-5.33,-3.36,;-4,-4.13,;-2.67,-3.36,;-1.2,-3.84,;-.3,-2.59,;-1.2,-1.35,;-2.67,-1.82,)|
Show InChI InChI=1S/C14H22N6O2S/c1-15-23(21,22)7-10-3-5-11(6-4-10)20(2)14-12-13(17-8-16-12)18-9-19-14/h8-11,15H,3-7H2,1-2H3,(H,16,17,18,19)/t10-,11-
PDB

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n/an/a 582n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM270855
PNG
(US10059709, 1)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]c(C)nc12 |r,wU:9.12,wD:6.5,(5.33,2.8,;4,2.03,;2.67,2.8,;3.44,4.13,;1.9,1.46,;1.33,3.57,;,2.8,;-1.33,3.57,;-2.67,2.8,;-2.67,1.26,;-1.33,.49,;,1.26,;-4,.49,;-5.33,1.26,;-4,-1.05,;-5.33,-1.82,;-5.33,-3.36,;-4,-4.13,;-2.67,-3.36,;-1.2,-3.84,;-.3,-2.59,;1.24,-2.59,;-1.2,-1.35,;-2.67,-1.82,)|
Show InChI InChI=1S/C15H24N6O2S/c1-10-19-13-14(20-10)17-9-18-15(13)21(3)12-6-4-11(5-7-12)8-24(22,23)16-2/h9,11-12,16H,4-8H2,1-3H3,(H,17,18,19,20)/t11-,12-
PDB

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n/an/a 838n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM270880
PNG
(US10059709, 26)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1c(cnc2[nH]ccc12)C#N |r,wU:9.12,wD:6.5,(6.67,2.8,;5.33,2.03,;4,2.8,;4.77,4.13,;3.23,1.46,;2.67,3.57,;1.33,2.8,;,3.57,;-1.33,2.8,;-1.33,1.26,;,.49,;1.33,1.26,;-2.67,.49,;-4,1.26,;-2.67,-1.05,;-4,-1.82,;-4,-3.36,;-2.67,-4.13,;-1.33,-3.36,;.13,-3.84,;1.04,-2.59,;.13,-1.35,;-1.33,-1.82,;-5.33,-1.05,;-6.67,-.28,)|
Show InChI InChI=1S/C17H23N5O2S/c1-19-25(23,24)11-12-3-5-14(6-4-12)22(2)16-13(9-18)10-21-17-15(16)7-8-20-17/h7-8,10,12,14,19H,3-6,11H2,1-2H3,(H,20,21)/t12-,14-
PDB

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n/an/a 840n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM270878
PNG
(US10059709, 24)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1c(cnn2cccc12)C#N |r,wU:9.12,wD:6.5,(6.67,2.8,;5.33,2.03,;4,2.8,;4.77,4.13,;3.23,1.46,;2.67,3.57,;1.33,2.8,;,3.57,;-1.33,2.8,;-1.33,1.26,;,.49,;1.33,1.26,;-2.67,.49,;-4,1.26,;-2.67,-1.05,;-4,-1.82,;-4,-3.36,;-2.67,-4.13,;-1.33,-3.36,;.13,-3.84,;1.04,-2.59,;.13,-1.35,;-1.33,-1.82,;-5.33,-1.05,;-6.67,-.28,)|
Show InChI InChI=1S/C17H23N5O2S/c1-19-25(23,24)12-13-5-7-15(8-6-13)21(2)17-14(10-18)11-20-22-9-3-4-16(17)22/h3-4,9,11,13,15,19H,5-8,12H2,1-2H3/t13-,15-
PDB

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n/an/a 930n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM270879
PNG
(US10059709, 25)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)Oc1c(cnc2[nH]ccc12)[N+]([O-])=O |r,wU:6.5,wD:9.12,(6.67,2.8,;5.33,2.03,;4,2.8,;4.77,4.13,;3.23,1.46,;2.67,3.57,;1.33,2.8,;1.33,1.26,;,.49,;-1.33,1.26,;-1.33,2.8,;,3.57,;-2.67,.49,;-2.67,-1.05,;-4,-1.82,;-4,-3.36,;-2.67,-4.13,;-1.33,-3.36,;.13,-3.84,;1.04,-2.59,;.13,-1.35,;-1.33,-1.82,;-5.33,-1.05,;-5.33,.49,;-6.67,-1.82,)|
Show InChI InChI=1S/C15H20N4O5S/c1-16-25(22,23)9-10-2-4-11(5-3-10)24-14-12-6-7-17-15(12)18-8-13(14)19(20)21/h6-8,10-11,16H,2-5,9H2,1H3,(H,17,18)/t10-,11-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM270872
PNG
(US10059709, 18)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1c(cnc2[nH]ccc12)[N+]([O-])=O |r,wU:9.12,wD:6.5,(6.67,2.8,;5.33,2.03,;4,2.8,;4.77,4.13,;3.23,1.46,;2.67,3.57,;1.33,2.8,;,3.57,;-1.33,2.8,;-1.33,1.26,;,.49,;1.33,1.26,;-2.67,.49,;-4,1.26,;-2.67,-1.05,;-4,-1.82,;-4,-3.36,;-2.67,-4.13,;-1.33,-3.36,;.13,-3.84,;1.04,-2.59,;.13,-1.35,;-1.33,-1.82,;-5.33,-1.05,;-5.33,.49,;-6.67,-1.82,)|
Show InChI InChI=1S/C16H23N5O4S/c1-17-26(24,25)10-11-3-5-12(6-4-11)20(2)15-13-7-8-18-16(13)19-9-14(15)21(22)23/h7-9,11-12,17H,3-6,10H2,1-2H3,(H,18,19)/t11-,12-
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM270881
PNG
(US10059709, 27)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)Nc1c(cnn2cccc12)C#N |r,wU:9.12,wD:6.5,(6.67,2.8,;5.33,2.03,;4,2.8,;4.77,4.13,;3.23,1.46,;2.67,3.57,;1.33,2.8,;,3.57,;-1.33,2.8,;-1.33,1.26,;,.49,;1.33,1.26,;-2.67,.49,;-2.67,-1.05,;-4,-1.82,;-4,-3.36,;-2.67,-4.13,;-1.33,-3.36,;.13,-3.84,;1.04,-2.59,;.13,-1.35,;-1.33,-1.82,;-5.33,-1.05,;-6.67,-.28,)|
Show InChI InChI=1S/C16H21N5O2S/c1-18-24(22,23)11-12-4-6-14(7-5-12)20-16-13(9-17)10-19-21-8-2-3-15(16)21/h2-3,8,10,12,14,18,20H,4-7,11H2,1H3/t12-,14-
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM270856
PNG
(US10059709, 2)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]cnc12 |r,wU:9.12,wD:6.5,(5.33,2.8,;4,2.03,;2.67,2.8,;3.44,4.13,;1.9,1.46,;1.33,3.57,;,2.8,;-1.33,3.57,;-2.67,2.8,;-2.67,1.26,;-1.33,.49,;,1.26,;-4,.49,;-5.33,1.26,;-4,-1.05,;-5.33,-1.82,;-5.33,-3.36,;-4,-4.13,;-2.67,-3.36,;-1.2,-3.84,;-.3,-2.59,;-1.2,-1.35,;-2.67,-1.82,)|
Show InChI InChI=1S/C14H22N6O2S/c1-15-23(21,22)7-10-3-5-11(6-4-10)20(2)14-12-13(17-8-16-12)18-9-19-14/h8-11,15H,3-7H2,1-2H3,(H,16,17,18,19)/t10-,11-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM270867
PNG
(US10059709, 13)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)Nc1nc(N)ncc1Br |r,wU:9.12,wD:6.5,(6,2.8,;4.67,2.03,;3.33,2.8,;4.1,4.13,;2.56,1.46,;2,3.57,;.67,2.8,;-.67,3.57,;-2,2.8,;-2,1.26,;-.67,.49,;.67,1.26,;-3.33,.49,;-3.33,-1.05,;-2,-1.82,;-2,-3.36,;-.67,-4.13,;-3.33,-4.13,;-4.67,-3.36,;-4.67,-1.82,;-6,-1.05,)|
Show InChI InChI=1S/C12H20BrN5O2S/c1-15-21(19,20)7-8-2-4-9(5-3-8)17-11-10(13)6-16-12(14)18-11/h6,8-9,15H,2-5,7H2,1H3,(H3,14,16,17,18)/t8-,9-
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM270880
PNG
(US10059709, 26)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1c(cnc2[nH]ccc12)C#N |r,wU:9.12,wD:6.5,(6.67,2.8,;5.33,2.03,;4,2.8,;4.77,4.13,;3.23,1.46,;2.67,3.57,;1.33,2.8,;,3.57,;-1.33,2.8,;-1.33,1.26,;,.49,;1.33,1.26,;-2.67,.49,;-4,1.26,;-2.67,-1.05,;-4,-1.82,;-4,-3.36,;-2.67,-4.13,;-1.33,-3.36,;.13,-3.84,;1.04,-2.59,;.13,-1.35,;-1.33,-1.82,;-5.33,-1.05,;-6.67,-.28,)|
Show InChI InChI=1S/C17H23N5O2S/c1-19-25(23,24)11-12-3-5-14(6-4-12)22(2)16-13(9-18)10-21-17-15(16)7-8-20-17/h7-8,10,12,14,19H,3-6,11H2,1-2H3,(H,20,21)/t12-,14-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM270882
PNG
(US10059709, 28)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnn2cccc12 |r,wU:9.12,wD:6.5,(5.33,2.8,;4,2.03,;2.67,2.8,;3.44,4.13,;1.9,1.46,;1.33,3.57,;,2.8,;-1.33,3.57,;-2.67,2.8,;-2.67,1.26,;-1.33,.49,;,1.26,;-4,.49,;-5.33,1.26,;-4,-1.05,;-5.33,-1.82,;-5.33,-3.36,;-4,-4.13,;-2.67,-3.36,;-1.2,-3.84,;-.3,-2.59,;-1.2,-1.35,;-2.67,-1.82,)|
Show InChI InChI=1S/C15H23N5O2S/c1-16-23(21,22)10-12-5-7-13(8-6-12)19(2)15-14-4-3-9-20(14)18-11-17-15/h3-4,9,11-13,16H,5-8,10H2,1-2H3/t12-,13-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM270879
PNG
(US10059709, 25)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)Oc1c(cnc2[nH]ccc12)[N+]([O-])=O |r,wU:6.5,wD:9.12,(6.67,2.8,;5.33,2.03,;4,2.8,;4.77,4.13,;3.23,1.46,;2.67,3.57,;1.33,2.8,;1.33,1.26,;,.49,;-1.33,1.26,;-1.33,2.8,;,3.57,;-2.67,.49,;-2.67,-1.05,;-4,-1.82,;-4,-3.36,;-2.67,-4.13,;-1.33,-3.36,;.13,-3.84,;1.04,-2.59,;.13,-1.35,;-1.33,-1.82,;-5.33,-1.05,;-5.33,.49,;-6.67,-1.82,)|
Show InChI InChI=1S/C15H20N4O5S/c1-16-25(22,23)9-10-2-4-11(5-3-10)24-14-12-6-7-17-15(12)18-8-13(14)19(20)21/h6-8,10-11,16H,2-5,9H2,1H3,(H,17,18)/t10-,11-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM270856
PNG
(US10059709, 2)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]cnc12 |r,wU:9.12,wD:6.5,(5.33,2.8,;4,2.03,;2.67,2.8,;3.44,4.13,;1.9,1.46,;1.33,3.57,;,2.8,;-1.33,3.57,;-2.67,2.8,;-2.67,1.26,;-1.33,.49,;,1.26,;-4,.49,;-5.33,1.26,;-4,-1.05,;-5.33,-1.82,;-5.33,-3.36,;-4,-4.13,;-2.67,-3.36,;-1.2,-3.84,;-.3,-2.59,;-1.2,-1.35,;-2.67,-1.82,)|
Show InChI InChI=1S/C14H22N6O2S/c1-15-23(21,22)7-10-3-5-11(6-4-10)20(2)14-12-13(17-8-16-12)18-9-19-14/h8-11,15H,3-7H2,1-2H3,(H,16,17,18,19)/t10-,11-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM270855
PNG
(US10059709, 1)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]c(C)nc12 |r,wU:9.12,wD:6.5,(5.33,2.8,;4,2.03,;2.67,2.8,;3.44,4.13,;1.9,1.46,;1.33,3.57,;,2.8,;-1.33,3.57,;-2.67,2.8,;-2.67,1.26,;-1.33,.49,;,1.26,;-4,.49,;-5.33,1.26,;-4,-1.05,;-5.33,-1.82,;-5.33,-3.36,;-4,-4.13,;-2.67,-3.36,;-1.2,-3.84,;-.3,-2.59,;1.24,-2.59,;-1.2,-1.35,;-2.67,-1.82,)|
Show InChI InChI=1S/C15H24N6O2S/c1-10-19-13-14(20-10)17-9-18-15(13)21(3)12-6-4-11(5-7-12)8-24(22,23)16-2/h9,11-12,16H,4-8H2,1-3H3,(H,17,18,19,20)/t11-,12-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM270867
PNG
(US10059709, 13)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)Nc1nc(N)ncc1Br |r,wU:9.12,wD:6.5,(6,2.8,;4.67,2.03,;3.33,2.8,;4.1,4.13,;2.56,1.46,;2,3.57,;.67,2.8,;-.67,3.57,;-2,2.8,;-2,1.26,;-.67,.49,;.67,1.26,;-3.33,.49,;-3.33,-1.05,;-2,-1.82,;-2,-3.36,;-.67,-4.13,;-3.33,-4.13,;-4.67,-3.36,;-4.67,-1.82,;-6,-1.05,)|
Show InChI InChI=1S/C12H20BrN5O2S/c1-15-21(19,20)7-8-2-4-9(5-3-8)17-11-10(13)6-16-12(14)18-11/h6,8-9,15H,2-5,7H2,1H3,(H3,14,16,17,18)/t8-,9-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM270881
PNG
(US10059709, 27)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)Nc1c(cnn2cccc12)C#N |r,wU:9.12,wD:6.5,(6.67,2.8,;5.33,2.03,;4,2.8,;4.77,4.13,;3.23,1.46,;2.67,3.57,;1.33,2.8,;,3.57,;-1.33,2.8,;-1.33,1.26,;,.49,;1.33,1.26,;-2.67,.49,;-2.67,-1.05,;-4,-1.82,;-4,-3.36,;-2.67,-4.13,;-1.33,-3.36,;.13,-3.84,;1.04,-2.59,;.13,-1.35,;-1.33,-1.82,;-5.33,-1.05,;-6.67,-.28,)|
Show InChI InChI=1S/C16H21N5O2S/c1-18-24(22,23)11-12-4-6-14(7-5-12)20-16-13(9-17)10-19-21-8-2-3-15(16)21/h2-3,8,10,12,14,18,20H,4-7,11H2,1H3/t12-,14-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM270855
PNG
(US10059709, 1)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]c(C)nc12 |r,wU:9.12,wD:6.5,(5.33,2.8,;4,2.03,;2.67,2.8,;3.44,4.13,;1.9,1.46,;1.33,3.57,;,2.8,;-1.33,3.57,;-2.67,2.8,;-2.67,1.26,;-1.33,.49,;,1.26,;-4,.49,;-5.33,1.26,;-4,-1.05,;-5.33,-1.82,;-5.33,-3.36,;-4,-4.13,;-2.67,-3.36,;-1.2,-3.84,;-.3,-2.59,;1.24,-2.59,;-1.2,-1.35,;-2.67,-1.82,)|
Show InChI InChI=1S/C15H24N6O2S/c1-10-19-13-14(20-10)17-9-18-15(13)21(3)12-6-4-11(5-7-12)8-24(22,23)16-2/h9,11-12,16H,4-8H2,1-3H3,(H,17,18,19,20)/t11-,12-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM270878
PNG
(US10059709, 24)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1c(cnn2cccc12)C#N |r,wU:9.12,wD:6.5,(6.67,2.8,;5.33,2.03,;4,2.8,;4.77,4.13,;3.23,1.46,;2.67,3.57,;1.33,2.8,;,3.57,;-1.33,2.8,;-1.33,1.26,;,.49,;1.33,1.26,;-2.67,.49,;-4,1.26,;-2.67,-1.05,;-4,-1.82,;-4,-3.36,;-2.67,-4.13,;-1.33,-3.36,;.13,-3.84,;1.04,-2.59,;.13,-1.35,;-1.33,-1.82,;-5.33,-1.05,;-6.67,-.28,)|
Show InChI InChI=1S/C17H23N5O2S/c1-19-25(23,24)12-13-5-7-15(8-6-13)21(2)17-14(10-18)11-20-22-9-3-4-16(17)22/h3-4,9,11,13,15,19H,5-8,12H2,1-2H3/t13-,15-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM270864
PNG
(US10059709, 10)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1cc(Cl)nc(N)n1 |r,wU:9.12,wD:6.5,(6,2.8,;4.67,2.03,;3.33,2.8,;4.1,4.13,;2.56,1.46,;2,3.57,;.67,2.8,;-.67,3.57,;-2,2.8,;-2,1.26,;-.67,.49,;.67,1.26,;-3.33,.49,;-4.67,1.26,;-3.33,-1.05,;-4.67,-1.82,;-4.67,-3.36,;-6,-4.13,;-3.33,-4.13,;-2,-3.36,;-.67,-4.13,;-2,-1.82,)|
Show InChI InChI=1S/C13H22ClN5O2S/c1-16-22(20,21)8-9-3-5-10(6-4-9)19(2)12-7-11(14)17-13(15)18-12/h7,9-10,16H,3-6,8H2,1-2H3,(H2,15,17,18)/t9-,10-
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM270865
PNG
(US10059709, 11)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)Nc1ccnc(N)n1 |r,wU:9.12,wD:6.5,(5.33,2.8,;4,2.03,;2.67,2.8,;3.44,4.13,;1.9,1.46,;1.33,3.57,;,2.8,;-1.33,3.57,;-2.67,2.8,;-2.67,1.26,;-1.33,.49,;,1.26,;-4,.49,;-4,-1.05,;-5.33,-1.82,;-5.33,-3.36,;-4,-4.13,;-2.67,-3.36,;-1.33,-4.13,;-2.67,-1.82,)|
Show InChI InChI=1S/C12H21N5O2S/c1-14-20(18,19)8-9-2-4-10(5-3-9)16-11-6-7-15-12(13)17-11/h6-7,9-10,14H,2-5,8H2,1H3,(H3,13,15,16,17)/t9-,10-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM270867
PNG
(US10059709, 13)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)Nc1nc(N)ncc1Br |r,wU:9.12,wD:6.5,(6,2.8,;4.67,2.03,;3.33,2.8,;4.1,4.13,;2.56,1.46,;2,3.57,;.67,2.8,;-.67,3.57,;-2,2.8,;-2,1.26,;-.67,.49,;.67,1.26,;-3.33,.49,;-3.33,-1.05,;-2,-1.82,;-2,-3.36,;-.67,-4.13,;-3.33,-4.13,;-4.67,-3.36,;-4.67,-1.82,;-6,-1.05,)|
Show InChI InChI=1S/C12H20BrN5O2S/c1-15-21(19,20)7-8-2-4-9(5-3-8)17-11-10(13)6-16-12(14)18-11/h6,8-9,15H,2-5,7H2,1H3,(H3,14,16,17,18)/t8-,9-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM270873
PNG
(US10059709, 19)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)Oc1ncnc2sccc12 |r,wU:6.5,wD:9.12,(5.33,2.8,;4,2.03,;2.67,2.8,;3.44,4.13,;1.9,1.46,;1.33,3.57,;,2.8,;,1.26,;-1.33,.49,;-2.67,1.26,;-2.67,2.8,;-1.33,3.57,;-4,.49,;-4,-1.05,;-5.33,-1.82,;-5.33,-3.36,;-4,-4.13,;-2.67,-3.36,;-1.2,-3.84,;-.3,-2.59,;-1.2,-1.35,;-2.67,-1.82,)|
Show InChI InChI=1S/C14H19N3O3S2/c1-15-22(18,19)8-10-2-4-11(5-3-10)20-13-12-6-7-21-14(12)17-9-16-13/h6-7,9-11,15H,2-5,8H2,1H3/t10-,11-
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM270873
PNG
(US10059709, 19)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)Oc1ncnc2sccc12 |r,wU:6.5,wD:9.12,(5.33,2.8,;4,2.03,;2.67,2.8,;3.44,4.13,;1.9,1.46,;1.33,3.57,;,2.8,;,1.26,;-1.33,.49,;-2.67,1.26,;-2.67,2.8,;-1.33,3.57,;-4,.49,;-4,-1.05,;-5.33,-1.82,;-5.33,-3.36,;-4,-4.13,;-2.67,-3.36,;-1.2,-3.84,;-.3,-2.59,;-1.2,-1.35,;-2.67,-1.82,)|
Show InChI InChI=1S/C14H19N3O3S2/c1-15-22(18,19)8-10-2-4-11(5-3-10)20-13-12-6-7-21-14(12)17-9-16-13/h6-7,9-11,15H,2-5,8H2,1H3/t10-,11-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM270882
PNG
(US10059709, 28)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnn2cccc12 |r,wU:9.12,wD:6.5,(5.33,2.8,;4,2.03,;2.67,2.8,;3.44,4.13,;1.9,1.46,;1.33,3.57,;,2.8,;-1.33,3.57,;-2.67,2.8,;-2.67,1.26,;-1.33,.49,;,1.26,;-4,.49,;-5.33,1.26,;-4,-1.05,;-5.33,-1.82,;-5.33,-3.36,;-4,-4.13,;-2.67,-3.36,;-1.2,-3.84,;-.3,-2.59,;-1.2,-1.35,;-2.67,-1.82,)|
Show InChI InChI=1S/C15H23N5O2S/c1-16-23(21,22)10-12-5-7-13(8-6-12)19(2)15-14-4-3-9-20(14)18-11-17-15/h3-4,9,11-13,16H,5-8,10H2,1-2H3/t12-,13-
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM270860
PNG
(US10059709, 6)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)Oc1ncnn2cccc12 |r,wU:6.5,wD:9.12,(5.33,2.8,;4,2.03,;2.67,2.8,;3.44,4.13,;1.9,1.46,;1.33,3.57,;,2.8,;,1.26,;-1.33,.49,;-2.67,1.26,;-2.67,2.8,;-1.33,3.57,;-4,.49,;-4,-1.05,;-5.33,-1.82,;-5.33,-3.36,;-4,-4.13,;-2.67,-3.36,;-1.2,-3.84,;-.3,-2.59,;-1.2,-1.35,;-2.67,-1.82,)|
Show InChI InChI=1S/C14H20N4O3S/c1-15-22(19,20)9-11-4-6-12(7-5-11)21-14-13-3-2-8-18(13)17-10-16-14/h2-3,8,10-12,15H,4-7,9H2,1H3/t11-,12-
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM270861
PNG
(US10059709, 7)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1nc(N)ncc1Br |r,wU:9.12,wD:6.5,(6,2.8,;4.67,2.03,;3.33,2.8,;4.1,4.13,;2.56,1.46,;2,3.57,;.67,2.8,;-.67,3.57,;-2,2.8,;-2,1.26,;-.67,.49,;.67,1.26,;-3.33,.49,;-4.67,1.26,;-3.33,-1.05,;-2,-1.82,;-2,-3.36,;-.67,-4.13,;-3.33,-4.13,;-4.67,-3.36,;-4.67,-1.82,;-6,-1.05,)|
Show InChI InChI=1S/C13H22BrN5O2S/c1-16-22(20,21)8-9-3-5-10(6-4-9)19(2)12-11(14)7-17-13(15)18-12/h7,9-10,16H,3-6,8H2,1-2H3,(H2,15,17,18)/t9-,10-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM270864
PNG
(US10059709, 10)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1cc(Cl)nc(N)n1 |r,wU:9.12,wD:6.5,(6,2.8,;4.67,2.03,;3.33,2.8,;4.1,4.13,;2.56,1.46,;2,3.57,;.67,2.8,;-.67,3.57,;-2,2.8,;-2,1.26,;-.67,.49,;.67,1.26,;-3.33,.49,;-4.67,1.26,;-3.33,-1.05,;-4.67,-1.82,;-4.67,-3.36,;-6,-4.13,;-3.33,-4.13,;-2,-3.36,;-.67,-4.13,;-2,-1.82,)|
Show InChI InChI=1S/C13H22ClN5O2S/c1-16-22(20,21)8-9-3-5-10(6-4-9)19(2)12-7-11(14)17-13(15)18-12/h7,9-10,16H,3-6,8H2,1-2H3,(H2,15,17,18)/t9-,10-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM270864
PNG
(US10059709, 10)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1cc(Cl)nc(N)n1 |r,wU:9.12,wD:6.5,(6,2.8,;4.67,2.03,;3.33,2.8,;4.1,4.13,;2.56,1.46,;2,3.57,;.67,2.8,;-.67,3.57,;-2,2.8,;-2,1.26,;-.67,.49,;.67,1.26,;-3.33,.49,;-4.67,1.26,;-3.33,-1.05,;-4.67,-1.82,;-4.67,-3.36,;-6,-4.13,;-3.33,-4.13,;-2,-3.36,;-.67,-4.13,;-2,-1.82,)|
Show InChI InChI=1S/C13H22ClN5O2S/c1-16-22(20,21)8-9-3-5-10(6-4-9)19(2)12-7-11(14)17-13(15)18-12/h7,9-10,16H,3-6,8H2,1-2H3,(H2,15,17,18)/t9-,10-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM270865
PNG
(US10059709, 11)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)Nc1ccnc(N)n1 |r,wU:9.12,wD:6.5,(5.33,2.8,;4,2.03,;2.67,2.8,;3.44,4.13,;1.9,1.46,;1.33,3.57,;,2.8,;-1.33,3.57,;-2.67,2.8,;-2.67,1.26,;-1.33,.49,;,1.26,;-4,.49,;-4,-1.05,;-5.33,-1.82,;-5.33,-3.36,;-4,-4.13,;-2.67,-3.36,;-1.33,-4.13,;-2.67,-1.82,)|
Show InChI InChI=1S/C12H21N5O2S/c1-14-20(18,19)8-9-2-4-10(5-3-9)16-11-6-7-15-12(13)17-11/h6-7,9-10,14H,2-5,8H2,1H3,(H3,13,15,16,17)/t9-,10-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM270877
PNG
(US10059709, 23)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)Nc1nc(N)ncc1-c1ccccc1 |r,wU:9.12,wD:6.5,(7.34,2.8,;6,2.03,;4.67,2.8,;5.44,4.13,;3.9,1.46,;3.33,3.57,;2,2.8,;.67,3.57,;-.67,2.8,;-.67,1.26,;.67,.49,;2,1.26,;-2,.49,;-2,-1.05,;-.67,-1.82,;-.67,-3.36,;.67,-4.13,;-2,-4.13,;-3.33,-3.36,;-3.33,-1.82,;-4.67,-1.05,;-4.67,.49,;-6,1.26,;-7.34,.49,;-7.34,-1.05,;-6,-1.82,)|
Show InChI InChI=1S/C18H25N5O2S/c1-20-26(24,25)12-13-7-9-15(10-8-13)22-17-16(11-21-18(19)23-17)14-5-3-2-4-6-14/h2-6,11,13,15,20H,7-10,12H2,1H3,(H3,19,21,22,23)/t13-,15-
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM270857
PNG
(US10059709, 3)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]ncc12 |r,wU:9.12,wD:6.5,(5.33,2.8,;4,2.03,;2.67,2.8,;3.44,4.13,;1.9,1.46,;1.33,3.57,;,2.8,;-1.33,3.57,;-2.67,2.8,;-2.67,1.26,;-1.33,.49,;,1.26,;-4,.49,;-5.33,1.26,;-4,-1.05,;-5.33,-1.82,;-5.33,-3.36,;-4,-4.13,;-2.67,-3.36,;-1.2,-3.84,;-.3,-2.59,;-1.2,-1.35,;-2.67,-1.82,)|
Show InChI InChI=1S/C14H22N6O2S/c1-15-23(21,22)8-10-3-5-11(6-4-10)20(2)14-12-7-18-19-13(12)16-9-17-14/h7,9-11,15H,3-6,8H2,1-2H3,(H,16,17,18,19)/t10-,11-
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM270862
PNG
(US10059709, 8)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)Nc1ncnc2sccc12 |r,wU:9.12,wD:6.5,(5.33,2.8,;4,2.03,;2.67,2.8,;3.44,4.13,;1.9,1.46,;1.33,3.57,;,2.8,;-1.33,3.57,;-2.67,2.8,;-2.67,1.26,;-1.33,.49,;,1.26,;-4,.49,;-4,-1.05,;-5.33,-1.82,;-5.33,-3.36,;-4,-4.13,;-2.67,-3.36,;-1.2,-3.84,;-.3,-2.59,;-1.2,-1.35,;-2.67,-1.82,)|
Show InChI InChI=1S/C14H20N4O2S2/c1-15-22(19,20)8-10-2-4-11(5-3-10)18-13-12-6-7-21-14(12)17-9-16-13/h6-7,9-11,15H,2-5,8H2,1H3,(H,16,17,18)/t10-,11-
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM270863
PNG
(US10059709, 9)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2sccc12 |r,wU:9.12,wD:6.5,(5.33,2.8,;4,2.03,;2.67,2.8,;3.44,4.13,;1.9,1.46,;1.33,3.57,;,2.8,;-1.33,3.57,;-2.67,2.8,;-2.67,1.26,;-1.33,.49,;,1.26,;-4,.49,;-5.33,1.26,;-4,-1.05,;-5.33,-1.82,;-5.33,-3.36,;-4,-4.13,;-2.67,-3.36,;-1.2,-3.84,;-.3,-2.59,;-1.2,-1.35,;-2.67,-1.82,)|
Show InChI InChI=1S/C15H22N4O2S2/c1-16-23(20,21)9-11-3-5-12(6-4-11)19(2)14-13-7-8-22-15(13)18-10-17-14/h7-8,10-12,16H,3-6,9H2,1-2H3/t11-,12-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM270868
PNG
(US10059709, 14)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)Nc1c(cnc2sccc12)C#N |r,wU:9.12,wD:6.5,(6.67,2.8,;5.33,2.03,;4,2.8,;4.77,4.13,;3.23,1.46,;2.67,3.57,;1.33,2.8,;,3.57,;-1.33,2.8,;-1.33,1.26,;,.49,;1.33,1.26,;-2.67,.49,;-2.67,-1.05,;-4,-1.82,;-4,-3.36,;-2.67,-4.13,;-1.33,-3.36,;.13,-3.84,;1.04,-2.59,;.13,-1.35,;-1.33,-1.82,;-5.33,-1.05,;-6.67,-.28,)|
Show InChI InChI=1S/C16H20N4O2S2/c1-18-24(21,22)10-11-2-4-13(5-3-11)20-15-12(8-17)9-19-16-14(15)6-7-23-16/h6-7,9,11,13,18H,2-5,10H2,1H3,(H,19,20)/t11-,13-
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM270869
PNG
(US10059709, 15)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)Nc1ncnn2cccc12 |r,wU:9.12,wD:6.5,(5.33,2.8,;4,2.03,;2.67,2.8,;3.44,4.13,;1.9,1.46,;1.33,3.57,;,2.8,;-1.33,3.57,;-2.67,2.8,;-2.67,1.26,;-1.33,.49,;,1.26,;-4,.49,;-4,-1.05,;-5.33,-1.82,;-5.33,-3.36,;-4,-4.13,;-2.67,-3.36,;-1.2,-3.84,;-.3,-2.59,;-1.2,-1.35,;-2.67,-1.82,)|
Show InChI InChI=1S/C14H21N5O2S/c1-15-22(20,21)9-11-4-6-12(7-5-11)18-14-13-3-2-8-19(13)17-10-16-14/h2-3,8,10-12,15H,4-7,9H2,1H3,(H,16,17,18)/t11-,12-
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM270871
PNG
(US10059709, 17)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1c(cnc2sccc12)C#N |r,wU:9.12,wD:6.5,(6.67,2.8,;5.33,2.03,;4,2.8,;4.77,4.13,;3.23,1.46,;2.67,3.57,;1.33,2.8,;,3.57,;-1.33,2.8,;-1.33,1.26,;,.49,;1.33,1.26,;-2.67,.49,;-4,1.26,;-2.67,-1.05,;-4,-1.82,;-4,-3.36,;-2.67,-4.13,;-1.33,-3.36,;.13,-3.84,;1.04,-2.59,;.13,-1.35,;-1.33,-1.82,;-5.33,-1.05,;-6.67,-.28,)|
Show InChI InChI=1S/C17H22N4O2S2/c1-19-25(22,23)11-12-3-5-14(6-4-12)21(2)16-13(9-18)10-20-17-15(16)7-8-24-17/h7-8,10,12,14,19H,3-6,11H2,1-2H3/t12-,14-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM270875
PNG
(US10059709, 21)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1nc(N)ncc1-c1ccccc1 |r,wU:9.12,wD:6.5,(7.34,2.8,;6,2.03,;4.67,2.8,;5.44,4.13,;3.9,1.46,;3.33,3.57,;2,2.8,;.67,3.57,;-.67,2.8,;-.67,1.26,;.67,.49,;2,1.26,;-2,.49,;-3.33,1.26,;-2,-1.05,;-.67,-1.82,;-.67,-3.36,;.67,-4.13,;-2,-4.13,;-3.33,-3.36,;-3.33,-1.82,;-4.67,-1.05,;-4.67,.49,;-6,1.26,;-7.34,.49,;-7.34,-1.05,;-6,-1.82,)|
Show InChI InChI=1S/C19H27N5O2S/c1-21-27(25,26)13-14-8-10-16(11-9-14)24(2)18-17(12-22-19(20)23-18)15-6-4-3-5-7-15/h3-7,12,14,16,21H,8-11,13H2,1-2H3,(H2,20,22,23)/t14-,16-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM270881
PNG
(US10059709, 27)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)Nc1c(cnn2cccc12)C#N |r,wU:9.12,wD:6.5,(6.67,2.8,;5.33,2.03,;4,2.8,;4.77,4.13,;3.23,1.46,;2.67,3.57,;1.33,2.8,;,3.57,;-1.33,2.8,;-1.33,1.26,;,.49,;1.33,1.26,;-2.67,.49,;-2.67,-1.05,;-4,-1.82,;-4,-3.36,;-2.67,-4.13,;-1.33,-3.36,;.13,-3.84,;1.04,-2.59,;.13,-1.35,;-1.33,-1.82,;-5.33,-1.05,;-6.67,-.28,)|
Show InChI InChI=1S/C16H21N5O2S/c1-18-24(22,23)11-12-4-6-14(7-5-12)20-16-13(9-17)10-19-21-8-2-3-15(16)21/h2-3,8,10,12,14,18,20H,4-7,11H2,1H3/t12-,14-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM270858
PNG
(US10059709, 4)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]c(nc12)-c1ccccc1 |r,wU:9.12,wD:6.5,(5.33,2.8,;4,2.03,;2.67,2.8,;3.44,4.13,;1.9,1.46,;1.33,3.57,;,2.8,;-1.33,3.57,;-2.67,2.8,;-2.67,1.26,;-1.33,.49,;,1.26,;-4,.49,;-5.33,1.26,;-4,-1.05,;-5.33,-1.82,;-5.33,-3.36,;-4,-4.13,;-2.67,-3.36,;-1.2,-3.84,;-.3,-2.59,;-1.2,-1.35,;-2.67,-1.82,;1.24,-2.59,;2.01,-3.93,;3.55,-3.93,;4.32,-2.59,;3.55,-1.26,;2.01,-1.26,)|
Show InChI InChI=1S/C20H26N6O2S/c1-21-29(27,28)12-14-8-10-16(11-9-14)26(2)20-17-19(22-13-23-20)25-18(24-17)15-6-4-3-5-7-15/h3-7,13-14,16,21H,8-12H2,1-2H3,(H,22,23,24,25)/t14-,16-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM270860
PNG
(US10059709, 6)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)Oc1ncnn2cccc12 |r,wU:6.5,wD:9.12,(5.33,2.8,;4,2.03,;2.67,2.8,;3.44,4.13,;1.9,1.46,;1.33,3.57,;,2.8,;,1.26,;-1.33,.49,;-2.67,1.26,;-2.67,2.8,;-1.33,3.57,;-4,.49,;-4,-1.05,;-5.33,-1.82,;-5.33,-3.36,;-4,-4.13,;-2.67,-3.36,;-1.2,-3.84,;-.3,-2.59,;-1.2,-1.35,;-2.67,-1.82,)|
Show InChI InChI=1S/C14H20N4O3S/c1-15-22(19,20)9-11-4-6-12(7-5-11)21-14-13-3-2-8-18(13)17-10-16-14/h2-3,8,10-12,15H,4-7,9H2,1H3/t11-,12-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM270860
PNG
(US10059709, 6)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)Oc1ncnn2cccc12 |r,wU:6.5,wD:9.12,(5.33,2.8,;4,2.03,;2.67,2.8,;3.44,4.13,;1.9,1.46,;1.33,3.57,;,2.8,;,1.26,;-1.33,.49,;-2.67,1.26,;-2.67,2.8,;-1.33,3.57,;-4,.49,;-4,-1.05,;-5.33,-1.82,;-5.33,-3.36,;-4,-4.13,;-2.67,-3.36,;-1.2,-3.84,;-.3,-2.59,;-1.2,-1.35,;-2.67,-1.82,)|
Show InChI InChI=1S/C14H20N4O3S/c1-15-22(19,20)9-11-4-6-12(7-5-11)21-14-13-3-2-8-18(13)17-10-16-14/h2-3,8,10-12,15H,4-7,9H2,1H3/t11-,12-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM270861
PNG
(US10059709, 7)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1nc(N)ncc1Br |r,wU:9.12,wD:6.5,(6,2.8,;4.67,2.03,;3.33,2.8,;4.1,4.13,;2.56,1.46,;2,3.57,;.67,2.8,;-.67,3.57,;-2,2.8,;-2,1.26,;-.67,.49,;.67,1.26,;-3.33,.49,;-4.67,1.26,;-3.33,-1.05,;-2,-1.82,;-2,-3.36,;-.67,-4.13,;-3.33,-4.13,;-4.67,-3.36,;-4.67,-1.82,;-6,-1.05,)|
Show InChI InChI=1S/C13H22BrN5O2S/c1-16-22(20,21)8-9-3-5-10(6-4-9)19(2)12-11(14)7-17-13(15)18-12/h7,9-10,16H,3-6,8H2,1-2H3,(H2,15,17,18)/t9-,10-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM270863
PNG
(US10059709, 9)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2sccc12 |r,wU:9.12,wD:6.5,(5.33,2.8,;4,2.03,;2.67,2.8,;3.44,4.13,;1.9,1.46,;1.33,3.57,;,2.8,;-1.33,3.57,;-2.67,2.8,;-2.67,1.26,;-1.33,.49,;,1.26,;-4,.49,;-5.33,1.26,;-4,-1.05,;-5.33,-1.82,;-5.33,-3.36,;-4,-4.13,;-2.67,-3.36,;-1.2,-3.84,;-.3,-2.59,;-1.2,-1.35,;-2.67,-1.82,)|
Show InChI InChI=1S/C15H22N4O2S2/c1-16-23(20,21)9-11-3-5-12(6-4-11)19(2)14-13-7-8-22-15(13)18-10-17-14/h7-8,10-12,16H,3-6,9H2,1-2H3/t11-,12-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM270869
PNG
(US10059709, 15)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)Nc1ncnn2cccc12 |r,wU:9.12,wD:6.5,(5.33,2.8,;4,2.03,;2.67,2.8,;3.44,4.13,;1.9,1.46,;1.33,3.57,;,2.8,;-1.33,3.57,;-2.67,2.8,;-2.67,1.26,;-1.33,.49,;,1.26,;-4,.49,;-4,-1.05,;-5.33,-1.82,;-5.33,-3.36,;-4,-4.13,;-2.67,-3.36,;-1.2,-3.84,;-.3,-2.59,;-1.2,-1.35,;-2.67,-1.82,)|
Show InChI InChI=1S/C14H21N5O2S/c1-15-22(20,21)9-11-4-6-12(7-5-11)18-14-13-3-2-8-19(13)17-10-16-14/h2-3,8,10-12,15H,4-7,9H2,1H3,(H,16,17,18)/t11-,12-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM270870
PNG
(US10059709, 16)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ccnc(N)n1 |r,wU:9.12,wD:6.5,(5.33,2.8,;4,2.03,;2.67,2.8,;3.44,4.13,;1.9,1.46,;1.33,3.57,;,2.8,;-1.33,3.57,;-2.67,2.8,;-2.67,1.26,;-1.33,.49,;,1.26,;-4,.49,;-5.33,1.26,;-4,-1.05,;-5.33,-1.82,;-5.33,-3.36,;-4,-4.13,;-2.67,-3.36,;-1.33,-4.13,;-2.67,-1.82,)|
Show InChI InChI=1S/C13H23N5O2S/c1-15-21(19,20)9-10-3-5-11(6-4-10)18(2)12-7-8-16-13(14)17-12/h7-8,10-11,15H,3-6,9H2,1-2H3,(H2,14,16,17)/t10-,11-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM270871
PNG
(US10059709, 17)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1c(cnc2sccc12)C#N |r,wU:9.12,wD:6.5,(6.67,2.8,;5.33,2.03,;4,2.8,;4.77,4.13,;3.23,1.46,;2.67,3.57,;1.33,2.8,;,3.57,;-1.33,2.8,;-1.33,1.26,;,.49,;1.33,1.26,;-2.67,.49,;-4,1.26,;-2.67,-1.05,;-4,-1.82,;-4,-3.36,;-2.67,-4.13,;-1.33,-3.36,;.13,-3.84,;1.04,-2.59,;.13,-1.35,;-1.33,-1.82,;-5.33,-1.05,;-6.67,-.28,)|
Show InChI InChI=1S/C17H22N4O2S2/c1-19-25(22,23)11-12-3-5-14(6-4-12)21(2)16-13(9-18)10-20-17-15(16)7-8-24-17/h7-8,10,12,14,19H,3-6,11H2,1-2H3/t12-,14-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM270862
PNG
(US10059709, 8)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)Nc1ncnc2sccc12 |r,wU:9.12,wD:6.5,(5.33,2.8,;4,2.03,;2.67,2.8,;3.44,4.13,;1.9,1.46,;1.33,3.57,;,2.8,;-1.33,3.57,;-2.67,2.8,;-2.67,1.26,;-1.33,.49,;,1.26,;-4,.49,;-4,-1.05,;-5.33,-1.82,;-5.33,-3.36,;-4,-4.13,;-2.67,-3.36,;-1.2,-3.84,;-.3,-2.59,;-1.2,-1.35,;-2.67,-1.82,)|
Show InChI InChI=1S/C14H20N4O2S2/c1-15-22(19,20)8-10-2-4-11(5-3-10)18-13-12-6-7-21-14(12)17-9-16-13/h6-7,9-11,15H,2-5,8H2,1H3,(H,16,17,18)/t10-,11-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM270865
PNG
(US10059709, 11)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)Nc1ccnc(N)n1 |r,wU:9.12,wD:6.5,(5.33,2.8,;4,2.03,;2.67,2.8,;3.44,4.13,;1.9,1.46,;1.33,3.57,;,2.8,;-1.33,3.57,;-2.67,2.8,;-2.67,1.26,;-1.33,.49,;,1.26,;-4,.49,;-4,-1.05,;-5.33,-1.82,;-5.33,-3.36,;-4,-4.13,;-2.67,-3.36,;-1.33,-4.13,;-2.67,-1.82,)|
Show InChI InChI=1S/C12H21N5O2S/c1-14-20(18,19)8-9-2-4-10(5-3-9)16-11-6-7-15-12(13)17-11/h6-7,9-10,14H,2-5,8H2,1H3,(H3,13,15,16,17)/t9-,10-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM270868
PNG
(US10059709, 14)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)Nc1c(cnc2sccc12)C#N |r,wU:9.12,wD:6.5,(6.67,2.8,;5.33,2.03,;4,2.8,;4.77,4.13,;3.23,1.46,;2.67,3.57,;1.33,2.8,;,3.57,;-1.33,2.8,;-1.33,1.26,;,.49,;1.33,1.26,;-2.67,.49,;-2.67,-1.05,;-4,-1.82,;-4,-3.36,;-2.67,-4.13,;-1.33,-3.36,;.13,-3.84,;1.04,-2.59,;.13,-1.35,;-1.33,-1.82,;-5.33,-1.05,;-6.67,-.28,)|
Show InChI InChI=1S/C16H20N4O2S2/c1-18-24(21,22)10-11-2-4-13(5-3-11)20-15-12(8-17)9-19-16-14(15)6-7-23-16/h6-7,9,11,13,18H,2-5,10H2,1H3,(H,19,20)/t11-,13-
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM270873
PNG
(US10059709, 19)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)Oc1ncnc2sccc12 |r,wU:6.5,wD:9.12,(5.33,2.8,;4,2.03,;2.67,2.8,;3.44,4.13,;1.9,1.46,;1.33,3.57,;,2.8,;,1.26,;-1.33,.49,;-2.67,1.26,;-2.67,2.8,;-1.33,3.57,;-4,.49,;-4,-1.05,;-5.33,-1.82,;-5.33,-3.36,;-4,-4.13,;-2.67,-3.36,;-1.2,-3.84,;-.3,-2.59,;-1.2,-1.35,;-2.67,-1.82,)|
Show InChI InChI=1S/C14H19N3O3S2/c1-15-22(18,19)8-10-2-4-11(5-3-10)20-13-12-6-7-21-14(12)17-9-16-13/h6-7,9-11,15H,2-5,8H2,1H3/t10-,11-
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM270874
PNG
(US10059709, 20)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)Oc1c(cnc2sccc12)C#N |r,wU:6.5,wD:9.12,(6,2.8,;4.67,2.03,;3.33,2.8,;4.1,4.13,;2.56,1.46,;2,3.57,;.67,2.8,;.67,1.26,;-.67,.49,;-2,1.26,;-2,2.8,;-.67,3.57,;-3.33,.49,;-3.33,-1.05,;-4.67,-1.82,;-4.67,-3.36,;-3.33,-4.13,;-2,-3.36,;-.54,-3.84,;.37,-2.59,;-.54,-1.35,;-2,-1.82,;-6,-1.05,;-6,.49,)|
Show InChI InChI=1S/C16H19N3O3S2/c1-18-24(20,21)10-11-2-4-13(5-3-11)22-15-12(8-17)9-19-16-14(15)6-7-23-16/h6-7,9,11,13,18H,2-5,10H2,1H3/t11-,13-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM270875
PNG
(US10059709, 21)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1nc(N)ncc1-c1ccccc1 |r,wU:9.12,wD:6.5,(7.34,2.8,;6,2.03,;4.67,2.8,;5.44,4.13,;3.9,1.46,;3.33,3.57,;2,2.8,;.67,3.57,;-.67,2.8,;-.67,1.26,;.67,.49,;2,1.26,;-2,.49,;-3.33,1.26,;-2,-1.05,;-.67,-1.82,;-.67,-3.36,;.67,-4.13,;-2,-4.13,;-3.33,-3.36,;-3.33,-1.82,;-4.67,-1.05,;-4.67,.49,;-6,1.26,;-7.34,.49,;-7.34,-1.05,;-6,-1.82,)|
Show InChI InChI=1S/C19H27N5O2S/c1-21-27(25,26)13-14-8-10-16(11-9-14)24(2)18-17(12-22-19(20)23-18)15-6-4-3-5-7-15/h3-7,12,14,16,21H,8-11,13H2,1-2H3,(H2,20,22,23)/t14-,16-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM270857
PNG
(US10059709, 3)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]ncc12 |r,wU:9.12,wD:6.5,(5.33,2.8,;4,2.03,;2.67,2.8,;3.44,4.13,;1.9,1.46,;1.33,3.57,;,2.8,;-1.33,3.57,;-2.67,2.8,;-2.67,1.26,;-1.33,.49,;,1.26,;-4,.49,;-5.33,1.26,;-4,-1.05,;-5.33,-1.82,;-5.33,-3.36,;-4,-4.13,;-2.67,-3.36,;-1.2,-3.84,;-.3,-2.59,;-1.2,-1.35,;-2.67,-1.82,)|
Show InChI InChI=1S/C14H22N6O2S/c1-15-23(21,22)8-10-3-5-11(6-4-10)20(2)14-12-7-18-19-13(12)16-9-17-14/h7,9-11,15H,3-6,8H2,1-2H3,(H,16,17,18,19)/t10-,11-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM270859
PNG
(US10059709, 5)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]c(Cc3ccccc3)nc12 |r,wU:9.12,wD:6.5,(5.33,4.03,;4,3.26,;2.67,4.03,;3.44,5.36,;1.9,2.69,;1.33,4.8,;,4.03,;-1.33,4.8,;-2.67,4.03,;-2.67,2.49,;-1.33,1.72,;,2.49,;-4,1.72,;-5.33,2.49,;-4,.18,;-5.33,-.59,;-5.33,-2.13,;-4,-2.9,;-2.67,-2.13,;-1.2,-2.61,;-.3,-1.36,;1.24,-1.36,;2.01,-2.69,;1.24,-4.03,;2.01,-5.36,;3.55,-5.36,;4.32,-4.03,;3.55,-2.69,;-1.2,-.12,;-2.67,-.59,)|
Show InChI InChI=1S/C21H28N6O2S/c1-22-30(28,29)13-16-8-10-17(11-9-16)27(2)21-19-20(23-14-24-21)26-18(25-19)12-15-6-4-3-5-7-15/h3-7,14,16-17,22H,8-13H2,1-2H3,(H,23,24,25,26)/t16-,17-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM270863
PNG
(US10059709, 9)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2sccc12 |r,wU:9.12,wD:6.5,(5.33,2.8,;4,2.03,;2.67,2.8,;3.44,4.13,;1.9,1.46,;1.33,3.57,;,2.8,;-1.33,3.57,;-2.67,2.8,;-2.67,1.26,;-1.33,.49,;,1.26,;-4,.49,;-5.33,1.26,;-4,-1.05,;-5.33,-1.82,;-5.33,-3.36,;-4,-4.13,;-2.67,-3.36,;-1.2,-3.84,;-.3,-2.59,;-1.2,-1.35,;-2.67,-1.82,)|
Show InChI InChI=1S/C15H22N4O2S2/c1-16-23(20,21)9-11-3-5-12(6-4-11)19(2)14-13-7-8-22-15(13)18-10-17-14/h7-8,10-12,16H,3-6,9H2,1-2H3/t11-,12-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM270866
PNG
(US10059709, 12)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)Nc1nc(N)ncc1C |r,wU:9.12,wD:6.5,(6,2.8,;4.67,2.03,;3.33,2.8,;4.1,4.13,;2.56,1.46,;2,3.57,;.67,2.8,;-.67,3.57,;-2,2.8,;-2,1.26,;-.67,.49,;.67,1.26,;-3.33,.49,;-3.33,-1.05,;-2,-1.82,;-2,-3.36,;-.67,-4.13,;-3.33,-4.13,;-4.67,-3.36,;-4.67,-1.82,;-6,-1.05,)|
Show InChI InChI=1S/C13H23N5O2S/c1-9-7-16-13(14)18-12(9)17-11-5-3-10(4-6-11)8-21(19,20)15-2/h7,10-11,15H,3-6,8H2,1-2H3,(H3,14,16,17,18)/t10-,11-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM270866
PNG
(US10059709, 12)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)Nc1nc(N)ncc1C |r,wU:9.12,wD:6.5,(6,2.8,;4.67,2.03,;3.33,2.8,;4.1,4.13,;2.56,1.46,;2,3.57,;.67,2.8,;-.67,3.57,;-2,2.8,;-2,1.26,;-.67,.49,;.67,1.26,;-3.33,.49,;-3.33,-1.05,;-2,-1.82,;-2,-3.36,;-.67,-4.13,;-3.33,-4.13,;-4.67,-3.36,;-4.67,-1.82,;-6,-1.05,)|
Show InChI InChI=1S/C13H23N5O2S/c1-9-7-16-13(14)18-12(9)17-11-5-3-10(4-6-11)8-21(19,20)15-2/h7,10-11,15H,3-6,8H2,1-2H3,(H3,14,16,17,18)/t10-,11-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM270869
PNG
(US10059709, 15)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)Nc1ncnn2cccc12 |r,wU:9.12,wD:6.5,(5.33,2.8,;4,2.03,;2.67,2.8,;3.44,4.13,;1.9,1.46,;1.33,3.57,;,2.8,;-1.33,3.57,;-2.67,2.8,;-2.67,1.26,;-1.33,.49,;,1.26,;-4,.49,;-4,-1.05,;-5.33,-1.82,;-5.33,-3.36,;-4,-4.13,;-2.67,-3.36,;-1.2,-3.84,;-.3,-2.59,;-1.2,-1.35,;-2.67,-1.82,)|
Show InChI InChI=1S/C14H21N5O2S/c1-15-22(20,21)9-11-4-6-12(7-5-11)18-14-13-3-2-8-19(13)17-10-16-14/h2-3,8,10-12,15H,4-7,9H2,1H3,(H,16,17,18)/t11-,12-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM270874
PNG
(US10059709, 20)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)Oc1c(cnc2sccc12)C#N |r,wU:6.5,wD:9.12,(6,2.8,;4.67,2.03,;3.33,2.8,;4.1,4.13,;2.56,1.46,;2,3.57,;.67,2.8,;.67,1.26,;-.67,.49,;-2,1.26,;-2,2.8,;-.67,3.57,;-3.33,.49,;-3.33,-1.05,;-4.67,-1.82,;-4.67,-3.36,;-3.33,-4.13,;-2,-3.36,;-.54,-3.84,;.37,-2.59,;-.54,-1.35,;-2,-1.82,;-6,-1.05,;-6,.49,)|
Show InChI InChI=1S/C16H19N3O3S2/c1-18-24(20,21)10-11-2-4-13(5-3-11)22-15-12(8-17)9-19-16-14(15)6-7-23-16/h6-7,9,11,13,18H,2-5,10H2,1H3/t11-,13-
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM270874
PNG
(US10059709, 20)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)Oc1c(cnc2sccc12)C#N |r,wU:6.5,wD:9.12,(6,2.8,;4.67,2.03,;3.33,2.8,;4.1,4.13,;2.56,1.46,;2,3.57,;.67,2.8,;.67,1.26,;-.67,.49,;-2,1.26,;-2,2.8,;-.67,3.57,;-3.33,.49,;-3.33,-1.05,;-4.67,-1.82,;-4.67,-3.36,;-3.33,-4.13,;-2,-3.36,;-.54,-3.84,;.37,-2.59,;-.54,-1.35,;-2,-1.82,;-6,-1.05,;-6,.49,)|
Show InChI InChI=1S/C16H19N3O3S2/c1-18-24(20,21)10-11-2-4-13(5-3-11)22-15-12(8-17)9-19-16-14(15)6-7-23-16/h6-7,9,11,13,18H,2-5,10H2,1H3/t11-,13-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM270857
PNG
(US10059709, 3)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]ncc12 |r,wU:9.12,wD:6.5,(5.33,2.8,;4,2.03,;2.67,2.8,;3.44,4.13,;1.9,1.46,;1.33,3.57,;,2.8,;-1.33,3.57,;-2.67,2.8,;-2.67,1.26,;-1.33,.49,;,1.26,;-4,.49,;-5.33,1.26,;-4,-1.05,;-5.33,-1.82,;-5.33,-3.36,;-4,-4.13,;-2.67,-3.36,;-1.2,-3.84,;-.3,-2.59,;-1.2,-1.35,;-2.67,-1.82,)|
Show InChI InChI=1S/C14H22N6O2S/c1-15-23(21,22)8-10-3-5-11(6-4-10)20(2)14-12-7-18-19-13(12)16-9-17-14/h7,9-11,15H,3-6,8H2,1-2H3,(H,16,17,18,19)/t10-,11-
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM270870
PNG
(US10059709, 16)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ccnc(N)n1 |r,wU:9.12,wD:6.5,(5.33,2.8,;4,2.03,;2.67,2.8,;3.44,4.13,;1.9,1.46,;1.33,3.57,;,2.8,;-1.33,3.57,;-2.67,2.8,;-2.67,1.26,;-1.33,.49,;,1.26,;-4,.49,;-5.33,1.26,;-4,-1.05,;-5.33,-1.82,;-5.33,-3.36,;-4,-4.13,;-2.67,-3.36,;-1.33,-4.13,;-2.67,-1.82,)|
Show InChI InChI=1S/C13H23N5O2S/c1-15-21(19,20)9-10-3-5-11(6-4-10)18(2)12-7-8-16-13(14)17-12/h7-8,10-11,15H,3-6,9H2,1-2H3,(H2,14,16,17)/t10-,11-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM270870
PNG
(US10059709, 16)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ccnc(N)n1 |r,wU:9.12,wD:6.5,(5.33,2.8,;4,2.03,;2.67,2.8,;3.44,4.13,;1.9,1.46,;1.33,3.57,;,2.8,;-1.33,3.57,;-2.67,2.8,;-2.67,1.26,;-1.33,.49,;,1.26,;-4,.49,;-5.33,1.26,;-4,-1.05,;-5.33,-1.82,;-5.33,-3.36,;-4,-4.13,;-2.67,-3.36,;-1.33,-4.13,;-2.67,-1.82,)|
Show InChI InChI=1S/C13H23N5O2S/c1-15-21(19,20)9-10-3-5-11(6-4-10)18(2)12-7-8-16-13(14)17-12/h7-8,10-11,15H,3-6,9H2,1-2H3,(H2,14,16,17)/t10-,11-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM270877
PNG
(US10059709, 23)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)Nc1nc(N)ncc1-c1ccccc1 |r,wU:9.12,wD:6.5,(7.34,2.8,;6,2.03,;4.67,2.8,;5.44,4.13,;3.9,1.46,;3.33,3.57,;2,2.8,;.67,3.57,;-.67,2.8,;-.67,1.26,;.67,.49,;2,1.26,;-2,.49,;-2,-1.05,;-.67,-1.82,;-.67,-3.36,;.67,-4.13,;-2,-4.13,;-3.33,-3.36,;-3.33,-1.82,;-4.67,-1.05,;-4.67,.49,;-6,1.26,;-7.34,.49,;-7.34,-1.05,;-6,-1.82,)|
Show InChI InChI=1S/C18H25N5O2S/c1-20-26(24,25)12-13-7-9-15(10-8-13)22-17-16(11-21-18(19)23-17)14-5-3-2-4-6-14/h2-6,11,13,15,20H,7-10,12H2,1H3,(H3,19,21,22,23)/t13-,15-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM270858
PNG
(US10059709, 4)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]c(nc12)-c1ccccc1 |r,wU:9.12,wD:6.5,(5.33,2.8,;4,2.03,;2.67,2.8,;3.44,4.13,;1.9,1.46,;1.33,3.57,;,2.8,;-1.33,3.57,;-2.67,2.8,;-2.67,1.26,;-1.33,.49,;,1.26,;-4,.49,;-5.33,1.26,;-4,-1.05,;-5.33,-1.82,;-5.33,-3.36,;-4,-4.13,;-2.67,-3.36,;-1.2,-3.84,;-.3,-2.59,;-1.2,-1.35,;-2.67,-1.82,;1.24,-2.59,;2.01,-3.93,;3.55,-3.93,;4.32,-2.59,;3.55,-1.26,;2.01,-1.26,)|
Show InChI InChI=1S/C20H26N6O2S/c1-21-29(27,28)12-14-8-10-16(11-9-14)26(2)20-17-19(22-13-23-20)25-18(24-17)15-6-4-3-5-7-15/h3-7,13-14,16,21H,8-12H2,1-2H3,(H,22,23,24,25)/t14-,16-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM270859
PNG
(US10059709, 5)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]c(Cc3ccccc3)nc12 |r,wU:9.12,wD:6.5,(5.33,4.03,;4,3.26,;2.67,4.03,;3.44,5.36,;1.9,2.69,;1.33,4.8,;,4.03,;-1.33,4.8,;-2.67,4.03,;-2.67,2.49,;-1.33,1.72,;,2.49,;-4,1.72,;-5.33,2.49,;-4,.18,;-5.33,-.59,;-5.33,-2.13,;-4,-2.9,;-2.67,-2.13,;-1.2,-2.61,;-.3,-1.36,;1.24,-1.36,;2.01,-2.69,;1.24,-4.03,;2.01,-5.36,;3.55,-5.36,;4.32,-4.03,;3.55,-2.69,;-1.2,-.12,;-2.67,-.59,)|
Show InChI InChI=1S/C21H28N6O2S/c1-22-30(28,29)13-16-8-10-17(11-9-16)27(2)21-19-20(23-14-24-21)26-18(25-19)12-15-6-4-3-5-7-15/h3-7,14,16-17,22H,8-13H2,1-2H3,(H,23,24,25,26)/t16-,17-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM270866
PNG
(US10059709, 12)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)Nc1nc(N)ncc1C |r,wU:9.12,wD:6.5,(6,2.8,;4.67,2.03,;3.33,2.8,;4.1,4.13,;2.56,1.46,;2,3.57,;.67,2.8,;-.67,3.57,;-2,2.8,;-2,1.26,;-.67,.49,;.67,1.26,;-3.33,.49,;-3.33,-1.05,;-2,-1.82,;-2,-3.36,;-.67,-4.13,;-3.33,-4.13,;-4.67,-3.36,;-4.67,-1.82,;-6,-1.05,)|
Show InChI InChI=1S/C13H23N5O2S/c1-9-7-16-13(14)18-12(9)17-11-5-3-10(4-6-11)8-21(19,20)15-2/h7,10-11,15H,3-6,8H2,1-2H3,(H3,14,16,17,18)/t10-,11-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM270868
PNG
(US10059709, 14)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)Nc1c(cnc2sccc12)C#N |r,wU:9.12,wD:6.5,(6.67,2.8,;5.33,2.03,;4,2.8,;4.77,4.13,;3.23,1.46,;2.67,3.57,;1.33,2.8,;,3.57,;-1.33,2.8,;-1.33,1.26,;,.49,;1.33,1.26,;-2.67,.49,;-2.67,-1.05,;-4,-1.82,;-4,-3.36,;-2.67,-4.13,;-1.33,-3.36,;.13,-3.84,;1.04,-2.59,;.13,-1.35,;-1.33,-1.82,;-5.33,-1.05,;-6.67,-.28,)|
Show InChI InChI=1S/C16H20N4O2S2/c1-18-24(21,22)10-11-2-4-13(5-3-11)20-15-12(8-17)9-19-16-14(15)6-7-23-16/h6-7,9,11,13,18H,2-5,10H2,1H3,(H,19,20)/t11-,13-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM270871
PNG
(US10059709, 17)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1c(cnc2sccc12)C#N |r,wU:9.12,wD:6.5,(6.67,2.8,;5.33,2.03,;4,2.8,;4.77,4.13,;3.23,1.46,;2.67,3.57,;1.33,2.8,;,3.57,;-1.33,2.8,;-1.33,1.26,;,.49,;1.33,1.26,;-2.67,.49,;-4,1.26,;-2.67,-1.05,;-4,-1.82,;-4,-3.36,;-2.67,-4.13,;-1.33,-3.36,;.13,-3.84,;1.04,-2.59,;.13,-1.35,;-1.33,-1.82,;-5.33,-1.05,;-6.67,-.28,)|
Show InChI InChI=1S/C17H22N4O2S2/c1-19-25(22,23)11-12-3-5-14(6-4-12)21(2)16-13(9-18)10-20-17-15(16)7-8-24-17/h7-8,10,12,14,19H,3-6,11H2,1-2H3/t12-,14-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM270875
PNG
(US10059709, 21)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1nc(N)ncc1-c1ccccc1 |r,wU:9.12,wD:6.5,(7.34,2.8,;6,2.03,;4.67,2.8,;5.44,4.13,;3.9,1.46,;3.33,3.57,;2,2.8,;.67,3.57,;-.67,2.8,;-.67,1.26,;.67,.49,;2,1.26,;-2,.49,;-3.33,1.26,;-2,-1.05,;-.67,-1.82,;-.67,-3.36,;.67,-4.13,;-2,-4.13,;-3.33,-3.36,;-3.33,-1.82,;-4.67,-1.05,;-4.67,.49,;-6,1.26,;-7.34,.49,;-7.34,-1.05,;-6,-1.82,)|
Show InChI InChI=1S/C19H27N5O2S/c1-21-27(25,26)13-14-8-10-16(11-9-14)24(2)18-17(12-22-19(20)23-18)15-6-4-3-5-7-15/h3-7,12,14,16,21H,8-11,13H2,1-2H3,(H2,20,22,23)/t14-,16-
PDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))		BDBM270877
PNG
(US10059709, 23)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)Nc1nc(N)ncc1-c1ccccc1 |r,wU:9.12,wD:6.5,(7.34,2.8,;6,2.03,;4.67,2.8,;5.44,4.13,;3.9,1.46,;3.33,3.57,;2,2.8,;.67,3.57,;-.67,2.8,;-.67,1.26,;.67,.49,;2,1.26,;-2,.49,;-2,-1.05,;-.67,-1.82,;-.67,-3.36,;.67,-4.13,;-2,-4.13,;-3.33,-3.36,;-3.33,-1.82,;-4.67,-1.05,;-4.67,.49,;-6,1.26,;-7.34,.49,;-7.34,-1.05,;-6,-1.82,)|
Show InChI InChI=1S/C18H25N5O2S/c1-20-26(24,25)12-13-7-9-15(10-8-13)22-17-16(11-21-18(19)23-17)14-5-3-2-4-6-14/h2-6,11,13,15,20H,7-10,12H2,1H3,(H3,19,21,22,23)/t13-,15-
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM270862
PNG
(US10059709, 8)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)Nc1ncnc2sccc12 |r,wU:9.12,wD:6.5,(5.33,2.8,;4,2.03,;2.67,2.8,;3.44,4.13,;1.9,1.46,;1.33,3.57,;,2.8,;-1.33,3.57,;-2.67,2.8,;-2.67,1.26,;-1.33,.49,;,1.26,;-4,.49,;-4,-1.05,;-5.33,-1.82,;-5.33,-3.36,;-4,-4.13,;-2.67,-3.36,;-1.2,-3.84,;-.3,-2.59,;-1.2,-1.35,;-2.67,-1.82,)|
Show InChI InChI=1S/C14H20N4O2S2/c1-15-22(19,20)8-10-2-4-11(5-3-10)18-13-12-6-7-21-14(12)17-9-16-13/h6-7,9-11,15H,2-5,8H2,1H3,(H,16,17,18)/t10-,11-
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM270861
PNG
(US10059709, 7)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1nc(N)ncc1Br |r,wU:9.12,wD:6.5,(6,2.8,;4.67,2.03,;3.33,2.8,;4.1,4.13,;2.56,1.46,;2,3.57,;.67,2.8,;-.67,3.57,;-2,2.8,;-2,1.26,;-.67,.49,;.67,1.26,;-3.33,.49,;-4.67,1.26,;-3.33,-1.05,;-2,-1.82,;-2,-3.36,;-.67,-4.13,;-3.33,-4.13,;-4.67,-3.36,;-4.67,-1.82,;-6,-1.05,)|
Show InChI InChI=1S/C13H22BrN5O2S/c1-16-22(20,21)8-9-3-5-10(6-4-9)19(2)12-11(14)7-17-13(15)18-12/h7,9-10,16H,3-6,8H2,1-2H3,(H2,15,17,18)/t9-,10-
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM270878
PNG
(US10059709, 24)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1c(cnn2cccc12)C#N |r,wU:9.12,wD:6.5,(6.67,2.8,;5.33,2.03,;4,2.8,;4.77,4.13,;3.23,1.46,;2.67,3.57,;1.33,2.8,;,3.57,;-1.33,2.8,;-1.33,1.26,;,.49,;1.33,1.26,;-2.67,.49,;-4,1.26,;-2.67,-1.05,;-4,-1.82,;-4,-3.36,;-2.67,-4.13,;-1.33,-3.36,;.13,-3.84,;1.04,-2.59,;.13,-1.35,;-1.33,-1.82,;-5.33,-1.05,;-6.67,-.28,)|
Show InChI InChI=1S/C17H23N5O2S/c1-19-25(23,24)12-13-5-7-15(8-6-13)21(2)17-14(10-18)11-20-22-9-3-4-16(17)22/h3-4,9,11,13,15,19H,5-8,12H2,1-2H3/t13-,15-
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM270858
PNG
(US10059709, 4)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]c(nc12)-c1ccccc1 |r,wU:9.12,wD:6.5,(5.33,2.8,;4,2.03,;2.67,2.8,;3.44,4.13,;1.9,1.46,;1.33,3.57,;,2.8,;-1.33,3.57,;-2.67,2.8,;-2.67,1.26,;-1.33,.49,;,1.26,;-4,.49,;-5.33,1.26,;-4,-1.05,;-5.33,-1.82,;-5.33,-3.36,;-4,-4.13,;-2.67,-3.36,;-1.2,-3.84,;-.3,-2.59,;-1.2,-1.35,;-2.67,-1.82,;1.24,-2.59,;2.01,-3.93,;3.55,-3.93,;4.32,-2.59,;3.55,-1.26,;2.01,-1.26,)|
Show InChI InChI=1S/C20H26N6O2S/c1-21-29(27,28)12-14-8-10-16(11-9-14)26(2)20-17-19(22-13-23-20)25-18(24-17)15-6-4-3-5-7-15/h3-7,13-14,16,21H,8-12H2,1-2H3,(H,22,23,24,25)/t14-,16-
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM270859
PNG
(US10059709, 5)
Show SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]c(Cc3ccccc3)nc12 |r,wU:9.12,wD:6.5,(5.33,4.03,;4,3.26,;2.67,4.03,;3.44,5.36,;1.9,2.69,;1.33,4.8,;,4.03,;-1.33,4.8,;-2.67,4.03,;-2.67,2.49,;-1.33,1.72,;,2.49,;-4,1.72,;-5.33,2.49,;-4,.18,;-5.33,-.59,;-5.33,-2.13,;-4,-2.9,;-2.67,-2.13,;-1.2,-2.61,;-.3,-1.36,;1.24,-1.36,;2.01,-2.69,;1.24,-4.03,;2.01,-5.36,;3.55,-5.36,;4.32,-4.03,;3.55,-2.69,;-1.2,-.12,;-2.67,-.59,)|
Show InChI InChI=1S/C21H28N6O2S/c1-22-30(28,29)13-16-8-10-17(11-9-16)27(2)21-19-20(23-14-24-21)26-18(25-19)12-15-6-4-3-5-7-15/h3-7,14,16-17,22H,8-13H2,1-2H3,(H,23,24,25,26)/t16-,17-
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...

US Patent US10059709 (2018)


BindingDB Entry DOI: 10.7270/Q25X2BZX
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%