Found 390 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Apelin receptor
(Homo sapiens (Human)) | BDBM310228
(US10150760, Example 15.0 | US10150760, Example 16....)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)nnc1C1CCOCC1 |r,wU:16.17,(-7.03,5.8,;-5.69,5.03,;-4.36,5.8,;-4.36,7.34,;-3.02,8.11,;-1.69,7.34,;-1.69,5.8,;-.36,5.03,;.98,5.8,;-3.02,5.03,;-3.02,3.49,;-1.78,2.59,;-.45,3.36,;.89,2.59,;2.22,1.82,;-.45,1.82,;2.22,3.36,;2.22,4.9,;3.56,2.59,;4.89,3.36,;6.22,2.59,;7.56,3.36,;7.56,4.9,;8.89,5.67,;6.22,5.67,;4.89,4.9,;-2.25,1.13,;-3.79,1.13,;-4.27,2.59,;-5.81,2.59,;-6.58,3.92,;-8.12,3.92,;-8.89,2.59,;-8.12,1.26,;-6.58,1.26,)| Show InChI InChI=1S/C22H27FN6O5S/c1-14(11-19-24-12-16(23)13-25-19)35(30,31)28-22-27-26-21(15-7-9-34-10-8-15)29(22)20-17(32-2)5-4-6-18(20)33-3/h4-6,12-15H,7-11H2,1-3H3,(H,27,28)/t14-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 810 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310277
(US10150760, Example 73.0 | US10150760, Example 74....)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2OCC[C@H]2C)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1 |r,wU:3.3,2.1,wD:13.12,17.18,(4.49,-3.92,;3.16,-3.15,;3.16,-1.61,;1.82,-.84,;1.82,.7,;.49,-1.61,;-.28,-2.94,;1.26,-2.94,;-.84,-.84,;-2.18,-1.61,;-2.65,-3.07,;-4.19,-3.07,;-4.67,-1.61,;-6,-.84,;-6.48,.63,;-8.02,.63,;-8.49,-.84,;-7.25,-1.74,;-7.25,-3.28,;-3.42,-.7,;-3.42,.84,;-4.76,1.61,;-6.09,1.13,;-7.42,1.9,;-4.76,3.15,;-3.42,3.92,;-2.09,3.15,;-2.09,1.61,;-.75,.84,;.58,1.61,;4.49,-.84,;5.83,-1.61,;7.16,-.84,;7.16,.7,;8.49,1.47,;5.83,1.47,;4.49,.7,)| Show InChI InChI=1S/C23H29ClN6O6S/c1-13-9-10-36-19(13)22-27-28-23(30(22)18-16(33-3)7-6-8-17(18)34-4)29-37(31,32)14(2)20(35-5)21-25-11-15(24)12-26-21/h6-8,11-14,19-20H,9-10H2,1-5H3,(H,28,29)/t13-,14+,19+,20+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310279
(US10150760, Example 75.0 | US10150760, Example 76....)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)nnc1[C@H]1OCC[C@H]1C |r,wU:16.17,18.19,wD:30.32,34.38,(-7.42,1.58,;-6.09,.81,;-4.76,1.29,;-4.76,2.83,;-3.42,3.6,;-2.09,2.83,;-2.09,1.29,;-.75,.52,;.58,1.29,;-3.42,.52,;-3.42,-1.02,;-2.18,-1.92,;-.84,-1.15,;.49,-1.92,;-.28,-3.26,;1.26,-3.26,;1.82,-1.16,;1.82,.39,;3.16,-1.93,;3.16,-3.46,;4.49,-1.15,;5.83,-1.92,;7.16,-1.15,;7.16,.39,;8.49,1.16,;5.83,1.16,;4.49,.39,;-2.65,-3.39,;-4.19,-3.39,;-4.67,-1.92,;-6,-1.15,;-6.48,.31,;-8.02,.31,;-8.49,-1.15,;-7.25,-2.06,;-7.25,-3.6,)| Show InChI InChI=1S/C23H29ClN6O5S/c1-13-9-10-35-20(13)22-27-28-23(30(22)19-17(33-4)7-6-8-18(19)34-5)29-36(31,32)15(3)14(2)21-25-11-16(24)12-26-21/h6-8,11-15,20H,9-10H2,1-5H3,(H,28,29)/t13-,14+,15+,20+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 210 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310299
(US10150760, Example 95.0 | US10150760, Example 96....)Show SMILES COc1ncnc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(C)cn2)nnc1[C@H]1CCCO1 |r,wU:16.17,wD:18.19,33.35,(-7.42,2.38,;-6.09,1.61,;-4.76,2.38,;-4.76,3.92,;-3.42,4.69,;-2.09,3.92,;-2.09,2.38,;-.75,1.61,;.58,2.38,;-3.42,1.61,;-3.42,.07,;-2.18,-.84,;-.84,-.07,;.49,-.84,;-.28,-2.17,;1.26,-2.17,;1.82,-.07,;1.82,1.47,;3.16,-.84,;3.16,-2.38,;4.49,-3.15,;5.83,-2.38,;4.49,-4.69,;4.49,-.07,;5.83,-.84,;7.16,-.07,;7.16,1.47,;8.49,2.24,;5.83,2.24,;4.49,1.47,;-2.65,-2.3,;-4.19,-2.3,;-4.67,-.84,;-6,-.07,;-6.48,1.4,;-8.02,1.4,;-8.49,-.07,;-7.25,-.97,)| Show InChI InChI=1S/C23H32N8O6S/c1-13(2)37-18(19-24-10-14(3)11-25-19)15(4)38(32,33)30-23-29-28-20(16-8-7-9-36-16)31(23)17-21(34-5)26-12-27-22(17)35-6/h10-13,15-16,18H,7-9H2,1-6H3,(H,29,30)/t15-,16+,18+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 15 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310305
(US10150760, Example 101.0 | US10150760, Example 10...)Show SMILES COc1ncnc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)nnc1[C@H]1CCCOC1 |r,wU:16.17,18.19,wD:30.32,(-7.1,1.22,;-5.77,.45,;-4.44,1.22,;-4.44,2.76,;-3.1,3.53,;-1.77,2.76,;-1.77,1.22,;-.44,.45,;.9,1.22,;-3.1,.45,;-3.1,-1.09,;-1.86,-1.99,;-.52,-1.22,;.81,-1.99,;.04,-3.33,;1.58,-3.33,;2.14,-1.22,;2.14,.32,;3.48,-1.99,;3.48,-3.53,;4.81,-1.22,;6.14,-1.99,;7.48,-1.22,;7.48,.32,;8.81,1.09,;6.14,1.09,;4.81,.32,;-2.33,-3.46,;-3.87,-3.46,;-4.35,-1.99,;-5.84,-1.59,;-6.24,-.11,;-7.72,.29,;-8.81,-.8,;-8.41,-2.28,;-6.93,-2.68,)| Show InChI InChI=1S/C21H27ClN8O5S/c1-12(17-23-8-15(22)9-24-17)13(2)36(31,32)29-21-28-27-18(14-6-5-7-35-10-14)30(21)16-19(33-3)25-11-26-20(16)34-4/h8-9,11-14H,5-7,10H2,1-4H3,(H,28,29)/t12-,13-,14-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 5.20 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310310
(US10150760, Example 106.0 | US10150760, Example 10...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2cnc(C)cn2)nnc1[C@H]1CCCCO1 |r,wU:16.17,18.19,wD:30.32,(-7.1,1.22,;-5.77,.45,;-4.44,1.22,;-4.44,2.76,;-3.1,3.53,;-1.77,2.76,;-1.77,1.22,;-.44,.45,;.9,1.22,;-3.1,.45,;-3.1,-1.09,;-1.86,-1.99,;-.52,-1.22,;.81,-1.99,;.04,-3.33,;1.58,-3.33,;2.14,-1.22,;2.14,.32,;3.48,-1.99,;3.48,-3.53,;4.81,-1.22,;4.81,.32,;6.14,1.09,;7.48,.32,;8.81,1.09,;7.48,-1.22,;6.14,-1.99,;-2.33,-3.46,;-3.87,-3.46,;-4.35,-1.99,;-5.84,-1.59,;-6.24,-.11,;-7.72,.29,;-8.81,-.8,;-8.41,-2.28,;-6.93,-2.68,)| Show InChI InChI=1S/C24H32N6O5S/c1-15-13-26-18(14-25-15)16(2)17(3)36(31,32)29-24-28-27-23(21-9-6-7-12-35-21)30(24)22-19(33-4)10-8-11-20(22)34-5/h8,10-11,13-14,16-17,21H,6-7,9,12H2,1-5H3,(H,28,29)/t16-,17-,21+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 53 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310312
((1R,2S)-1-(5-chloropyrimidin-2-yl)-N-(4-(2,6-dimet...)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2CCC(C)(C)O2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1 |r,wU:3.3,2.1,wD:13.12,(5.16,-3.92,;3.83,-3.15,;3.83,-1.61,;2.49,-.84,;2.49,.7,;1.16,-1.61,;.39,-2.94,;1.93,-2.94,;-.18,-.84,;-1.51,-1.61,;-1.99,-3.07,;-3.53,-3.07,;-4,-1.61,;-5.33,-.84,;-5.81,.63,;-7.35,.63,;-7.83,-.84,;-9.16,-1.61,;-9.16,-.07,;-6.58,-1.74,;-2.76,-.7,;-2.76,.84,;-4.09,1.61,;-5.42,.84,;-6.76,1.61,;-4.09,3.15,;-2.76,3.92,;-1.42,3.15,;-1.42,1.61,;-.09,.84,;1.25,1.61,;5.16,-.84,;6.49,-1.61,;7.83,-.84,;7.83,.7,;9.16,1.47,;6.49,1.47,;5.16,.7,)| Show InChI InChI=1S/C24H31ClN6O6S/c1-14(20(36-6)21-26-12-15(25)13-27-21)38(32,33)30-23-29-28-22(18-10-11-24(2,3)37-18)31(23)19-16(34-4)8-7-9-17(19)35-5/h7-9,12-14,18,20H,10-11H2,1-6H3,(H,29,30)/t14-,18+,20-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.160 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310325
(US10150760, Example 121.0 | US10150760, Example 12...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(C)cn2)nnc1[C@@H]1CCO[C@@H]1C |r,wU:30.32,16.17,18.19,34.38,(-7.42,1.29,;-6.09,.52,;-4.76,1.29,;-4.76,2.83,;-3.42,3.6,;-2.09,2.83,;-2.09,1.29,;-.75,.52,;.58,1.29,;-3.42,.52,;-3.42,-1.02,;-2.18,-1.93,;-.84,-1.15,;.49,-1.93,;-.28,-3.26,;1.26,-3.26,;1.82,-1.15,;1.82,.38,;3.16,-1.93,;3.16,-3.47,;4.49,-1.15,;5.83,-1.93,;7.16,-1.15,;7.16,.38,;8.49,1.15,;5.83,1.15,;4.49,.38,;-2.65,-3.39,;-4.19,-3.39,;-4.67,-1.93,;-6,-1.15,;-6.48,.31,;-8.02,.31,;-8.49,-1.15,;-7.25,-2.06,;-7.25,-3.6,)| Show InChI InChI=1S/C24H32N6O5S/c1-14-12-25-22(26-13-14)15(2)17(4)36(31,32)29-24-28-27-23(18-10-11-35-16(18)3)30(24)21-19(33-5)8-7-9-20(21)34-6/h7-9,12-13,15-18H,10-11H2,1-6H3,(H,28,29)/t15-,16+,17-,18+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 880 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310325
(US10150760, Example 121.0 | US10150760, Example 12...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(C)cn2)nnc1[C@@H]1CCO[C@@H]1C |r,wU:30.32,16.17,18.19,34.38,(-7.42,1.29,;-6.09,.52,;-4.76,1.29,;-4.76,2.83,;-3.42,3.6,;-2.09,2.83,;-2.09,1.29,;-.75,.52,;.58,1.29,;-3.42,.52,;-3.42,-1.02,;-2.18,-1.93,;-.84,-1.15,;.49,-1.93,;-.28,-3.26,;1.26,-3.26,;1.82,-1.15,;1.82,.38,;3.16,-1.93,;3.16,-3.47,;4.49,-1.15,;5.83,-1.93,;7.16,-1.15,;7.16,.38,;8.49,1.15,;5.83,1.15,;4.49,.38,;-2.65,-3.39,;-4.19,-3.39,;-4.67,-1.93,;-6,-1.15,;-6.48,.31,;-8.02,.31,;-8.49,-1.15,;-7.25,-2.06,;-7.25,-3.6,)| Show InChI InChI=1S/C24H32N6O5S/c1-14-12-25-22(26-13-14)15(2)17(4)36(31,32)29-24-28-27-23(18-10-11-35-16(18)3)30(24)21-19(33-5)8-7-9-20(21)34-6/h7-9,12-13,15-18H,10-11H2,1-6H3,(H,28,29)/t15-,16+,17-,18+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 700 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310338
(US10150760, Example 134.0 | US10150760, Example 13...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2cnc(C)cn2)nnc1[C@H]1CCCOC1 |r,wU:16.17,18.19,wD:30.32,(-7.1,1.22,;-5.77,.45,;-4.44,1.22,;-4.44,2.76,;-3.1,3.53,;-1.77,2.76,;-1.77,1.22,;-.44,.45,;.9,1.22,;-3.1,.45,;-3.1,-1.09,;-1.86,-1.99,;-.52,-1.22,;.81,-1.99,;.04,-3.33,;1.58,-3.33,;2.14,-1.22,;2.14,.32,;3.48,-1.99,;3.48,-3.53,;4.81,-1.22,;4.81,.32,;6.14,1.09,;7.48,.32,;8.81,1.09,;7.48,-1.22,;6.14,-1.99,;-2.33,-3.46,;-3.87,-3.46,;-4.35,-1.99,;-5.84,-1.59,;-6.24,-.11,;-7.72,.29,;-8.81,-.8,;-8.41,-2.28,;-6.93,-2.68,)| Show InChI InChI=1S/C24H32N6O5S/c1-15-12-26-19(13-25-15)16(2)17(3)36(31,32)29-24-28-27-23(18-8-7-11-35-14-18)30(24)22-20(33-4)9-6-10-21(22)34-5/h6,9-10,12-13,16-18H,7-8,11,14H2,1-5H3,(H,28,29)/t16-,17-,18-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 35 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310340
(US10150760, Example 136.0 | US10150760, Example 13...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(C)cn2)nnc1[C@H]1CCCOC1 |r,wU:16.17,wD:33.35,18.19,(-7.1,2.38,;-5.77,1.61,;-4.44,2.38,;-4.44,3.92,;-3.1,4.69,;-1.77,3.92,;-1.77,2.38,;-.44,1.61,;.9,2.38,;-3.1,1.61,;-3.1,.07,;-1.86,-.84,;-.52,-.07,;.81,-.84,;.04,-2.17,;1.58,-2.17,;2.14,-.07,;2.14,1.47,;3.48,-.84,;3.48,-2.38,;4.81,-3.15,;4.81,-4.69,;6.14,-2.38,;4.81,-.07,;6.14,-.84,;7.48,-.07,;7.48,1.47,;8.81,2.24,;6.14,2.24,;4.81,1.47,;-2.33,-2.3,;-3.87,-2.3,;-4.35,-.84,;-5.84,-.44,;-6.24,1.05,;-7.72,1.45,;-8.81,.36,;-8.41,-1.13,;-6.93,-1.53,)| Show InChI InChI=1S/C26H36N6O6S/c1-16(2)38-23(24-27-13-17(3)14-28-24)18(4)39(33,34)31-26-30-29-25(19-9-8-12-37-15-19)32(26)22-20(35-5)10-7-11-21(22)36-6/h7,10-11,13-14,16,18-19,23H,8-9,12,15H2,1-6H3,(H,30,31)/t18-,19-,23+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 4.80 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310342
(US10150760, Example 138.0 | US10150760, Example 13...)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2CCC(C)(C)O2)n1-c1c(OC)ncnc1OC)c1ncc(Cl)cn1 |r,wU:3.3,2.1,wD:13.12,(5.16,-3.92,;3.83,-3.15,;3.83,-1.61,;2.49,-.84,;2.49,.7,;1.16,-1.61,;.39,-2.94,;1.93,-2.94,;-.18,-.84,;-1.51,-1.61,;-1.99,-3.07,;-3.53,-3.07,;-4,-1.61,;-5.33,-.84,;-5.81,.63,;-7.35,.63,;-7.83,-.84,;-9.16,-1.61,;-9.16,-.07,;-6.58,-1.74,;-2.76,-.7,;-2.76,.84,;-4.09,1.61,;-5.42,.84,;-6.76,1.61,;-4.09,3.15,;-2.76,3.92,;-1.42,3.15,;-1.42,1.61,;-.09,.84,;1.25,1.61,;5.16,-.84,;6.49,-1.61,;7.83,-.84,;7.83,.7,;9.16,1.47,;6.49,1.47,;5.16,.7,)| Show InChI InChI=1S/C22H29ClN8O6S/c1-12(16(34-4)17-24-9-13(23)10-25-17)38(32,33)30-21-29-28-18(14-7-8-22(2,3)37-14)31(21)15-19(35-5)26-11-27-20(15)36-6/h9-12,14,16H,7-8H2,1-6H3,(H,29,30)/t12-,14+,16-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 4.80 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310353
(US10150760, Example 173.0 | US10150760, Example 17...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(cn2)C#N)nnc1[C@H]1CCOC1 |r,wU:16.17,18.19,wD:31.33,(-8.09,6.51,;-6.76,5.74,;-5.42,6.51,;-5.42,8.05,;-4.09,8.82,;-2.76,8.05,;-2.76,6.51,;-1.42,5.74,;-.09,6.51,;-4.09,5.74,;-4.09,4.2,;-2.84,3.3,;-1.51,4.07,;-.18,3.3,;-.95,1.96,;.59,1.96,;1.16,4.07,;1.16,5.61,;2.49,3.3,;2.49,1.76,;3.83,4.07,;5.16,3.3,;6.49,4.07,;6.54,5.63,;5.16,6.38,;3.83,5.61,;7.87,6.4,;9.21,7.17,;-3.32,1.83,;-4.86,1.83,;-5.33,3.3,;-6.67,4.07,;-7.3,5.38,;-8.68,5.53,;-9.16,4.07,;-7.91,3.16,)| Show InChI InChI=1S/C23H27N7O5S/c1-14(21-25-11-16(10-24)12-26-21)15(2)36(31,32)29-23-28-27-22(17-8-9-35-13-17)30(23)20-18(33-3)6-5-7-19(20)34-4/h5-7,11-12,14-15,17H,8-9,13H2,1-4H3,(H,28,29)/t14-,15-,17-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 210 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310364
(US10150760, Example 184.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(C)cn2)nnc1[C@H]1CCS(=O)(=O)C1 |r,wU:16.17,18.19,wD:30.32,(-6.76,6.24,;-5.42,5.47,;-4.09,6.24,;-4.09,7.78,;-2.76,8.55,;-1.42,7.78,;-1.42,6.24,;-.09,5.47,;1.25,6.24,;-2.76,5.47,;-2.76,3.93,;-1.51,3.02,;-.18,3.79,;1.16,3.02,;.39,1.69,;1.93,1.69,;2.49,3.79,;2.49,5.33,;3.83,3.02,;3.83,1.48,;5.16,3.79,;6.49,3.02,;7.83,3.79,;7.83,5.33,;9.16,6.1,;6.49,6.1,;5.16,5.33,;-1.99,1.56,;-3.53,1.56,;-4,3.02,;-5.33,3.79,;-5.81,5.26,;-7.35,5.26,;-7.83,3.79,;-9.16,4.56,;-9.16,3.02,;-6.58,2.89,)| Show InChI InChI=1S/C23H30N6O6S2/c1-14-11-24-21(25-12-14)15(2)16(3)37(32,33)28-23-27-26-22(17-9-10-36(30,31)13-17)29(23)20-18(34-4)7-6-8-19(20)35-5/h6-8,11-12,15-17H,9-10,13H2,1-5H3,(H,27,28)/t15-,16-,17-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.38E+3 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310373
(US10150760, Example 193.0 | US10150760, Example 19...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](O)c2ncc(C)cn2)nnc1[C@@H]1CCCCO1 |r,wU:30.32,16.17,18.19,(-7.32,7.46,;-5.99,6.69,;-4.65,7.46,;-4.65,9,;-3.32,9.77,;-1.99,9,;-1.99,7.46,;-.65,6.69,;.68,7.46,;-3.32,6.69,;-3.32,5.15,;-2.07,4.25,;-.59,4.65,;.5,3.56,;-.59,2.47,;.9,2.07,;1.99,3.96,;2.39,5.44,;3.08,2.87,;2.68,1.38,;4.57,3.27,;5.66,2.18,;7.14,2.58,;7.54,4.06,;9.03,4.46,;6.45,5.15,;4.96,4.75,;-2.55,2.78,;-4.09,2.78,;-4.57,4.25,;-6.05,4.65,;-6.45,6.13,;-7.94,6.53,;-9.03,5.44,;-8.63,3.96,;-7.14,3.56,)| Show InChI InChI=1S/C23H30N6O6S/c1-14-12-24-21(25-13-14)20(30)15(2)36(31,32)28-23-27-26-22(18-8-5-6-11-35-18)29(23)19-16(33-3)9-7-10-17(19)34-4/h7,9-10,12-13,15,18,20,30H,5-6,8,11H2,1-4H3,(H,27,28)/t15-,18-,20-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 180 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310381
(US10150760, Example 201.0 | US10150760, Example 20...)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@@H]2COCCO2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1 |r,wU:13.12,3.3,2.1,(3.77,1.54,;2.68,2.63,;3.08,4.12,;1.99,5.2,;2.39,6.69,;.5,4.81,;-.59,3.72,;.9,3.32,;-.59,5.89,;-2.07,5.5,;-2.55,4.03,;-4.09,4.03,;-4.57,5.5,;-6.05,5.89,;-6.45,7.38,;-7.94,7.78,;-9.03,6.69,;-8.63,5.2,;-7.14,4.81,;-3.32,6.4,;-3.32,7.94,;-4.65,8.71,;-5.99,7.94,;-7.32,8.71,;-4.65,10.25,;-3.32,11.02,;-1.99,10.25,;-1.99,8.71,;-.65,7.94,;.68,8.71,;4.57,4.51,;5.66,3.43,;7.14,3.82,;7.54,5.31,;9.03,5.71,;6.45,6.4,;4.96,6,)| Show InChI InChI=1S/C23H30N6O7S/c1-14-11-24-21(25-12-14)20(34-5)15(2)37(30,31)28-23-27-26-22(18-13-35-9-10-36-18)29(23)19-16(32-3)7-6-8-17(19)33-4/h6-8,11-12,15,18,20H,9-10,13H2,1-5H3,(H,27,28)/t15-,18-,20-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 31 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310389
(US10150760, Example 209.0 | US10150760, Example 21...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(C)cn2)nnc1[C@H]1CCC(C)(C)O1 |r,wU:16.17,wD:33.35,18.19,(-6.76,8.59,;-5.42,7.82,;-4.09,8.59,;-4.09,10.13,;-2.76,10.9,;-1.42,10.13,;-1.42,8.59,;-.09,7.82,;1.25,8.59,;-2.76,7.82,;-2.76,6.28,;-1.51,5.37,;-.18,6.14,;1.16,5.37,;.39,4.04,;1.93,4.04,;2.49,6.14,;2.49,7.68,;3.83,5.37,;3.83,3.83,;5.16,3.06,;5.16,1.52,;6.49,3.83,;5.16,6.14,;6.49,5.37,;7.83,6.14,;7.83,7.68,;9.16,8.45,;6.49,8.45,;5.16,7.68,;-1.99,3.91,;-3.53,3.91,;-4,5.37,;-5.33,6.14,;-5.81,7.61,;-7.35,7.61,;-7.83,6.14,;-9.16,6.91,;-9.16,5.37,;-6.58,5.24,)| Show InChI InChI=1S/C27H38N6O6S/c1-16(2)38-23(24-28-14-17(3)15-29-24)18(4)40(34,35)32-26-31-30-25(21-12-13-27(5,6)39-21)33(26)22-19(36-7)10-9-11-20(22)37-8/h9-11,14-16,18,21,23H,12-13H2,1-8H3,(H,31,32)/t18-,21+,23+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.620 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310391
(US10150760, Example 211.0 | US10150760, Example 21...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2cnc(C)cn2)nnc1[C@H]1CCCCO1 |r,wU:16.17,wD:33.35,18.19,(-7.1,8.53,;-5.77,7.76,;-4.44,8.53,;-4.44,10.07,;-3.1,10.84,;-1.77,10.07,;-1.77,8.53,;-.44,7.76,;.9,8.53,;-3.1,7.76,;-3.1,6.22,;-1.86,5.32,;-.52,6.09,;.81,5.32,;.04,3.98,;1.58,3.98,;2.14,6.09,;2.14,7.63,;3.48,5.32,;3.48,3.78,;4.81,3.01,;4.81,1.47,;6.14,3.78,;4.81,6.09,;4.81,7.63,;6.14,8.4,;7.48,7.63,;8.81,8.4,;7.48,6.09,;6.14,5.32,;-2.33,3.85,;-3.87,3.85,;-4.35,5.32,;-5.84,5.71,;-6.24,7.2,;-7.72,7.6,;-8.81,6.51,;-8.41,5.02,;-6.93,4.63,)| Show InChI InChI=1S/C26H36N6O6S/c1-16(2)38-24(19-15-27-17(3)14-28-19)18(4)39(33,34)31-26-30-29-25(22-10-7-8-13-37-22)32(26)23-20(35-5)11-9-12-21(23)36-6/h9,11-12,14-16,18,22,24H,7-8,10,13H2,1-6H3,(H,30,31)/t18-,22+,24+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 190 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310403
(US10150760, Example 223.0 | US10150760, Example 22...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(C)cn2)nnc1[C@H]1CCCS1 |r,wU:16.17,18.19,wD:30.32,(-7.42,6.24,;-6.09,5.47,;-4.76,6.24,;-4.76,7.78,;-3.42,8.55,;-2.09,7.78,;-2.09,6.24,;-.75,5.47,;.58,6.24,;-3.42,5.47,;-3.42,3.93,;-2.18,3.02,;-.84,3.79,;.49,3.02,;-.28,1.69,;1.26,1.69,;1.82,3.79,;1.82,5.33,;3.16,3.02,;3.16,1.48,;4.49,3.79,;5.83,3.02,;7.16,3.79,;7.16,5.33,;8.49,6.1,;5.83,6.1,;4.49,5.33,;-2.65,1.56,;-4.19,1.56,;-4.67,3.02,;-6,3.79,;-6.48,5.26,;-8.02,5.26,;-8.49,3.79,;-7.25,2.89,)| Show InChI InChI=1S/C23H30N6O4S2/c1-14-12-24-21(25-13-14)15(2)16(3)35(30,31)28-23-27-26-22(19-10-7-11-34-19)29(23)20-17(32-4)8-6-9-18(20)33-5/h6,8-9,12-13,15-16,19H,7,10-11H2,1-5H3,(H,27,28)/t15-,16-,19+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 12 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310424
(US10150760, Example 247.0 | US10150760, Example 24...)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@@H]2COCCO2)n1C1CCOCC1)c1ncc(Cl)cn1 |r| Show InChI InChI=1S/C19H27ClN6O6S/c1-12(16(29-2)17-21-9-13(20)10-22-17)33(27,28)25-19-24-23-18(15-11-31-7-8-32-15)26(19)14-3-5-30-6-4-14/h9-10,12,14-16H,3-8,11H2,1-2H3,(H,24,25)/t12-,15-,16-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.580 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310437
(US10150760, Example 260.0 | US10150760, Example 26...)Show SMILES CC(C)O[C@H]([C@H](C)S(=O)(=O)Nc1nnc([C@@H]2CCCO2)n1C1CCOCC1)c1cnc(C)cn1 |r| Show InChI InChI=1S/C22H34N6O5S/c1-14(2)33-20(18-13-23-15(3)12-24-18)16(4)34(29,30)27-22-26-25-21(19-6-5-9-32-19)28(22)17-7-10-31-11-8-17/h12-14,16-17,19-20H,5-11H2,1-4H3,(H,26,27)/t16-,19-,20+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | >4.20E+3 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310437
(US10150760, Example 260.0 | US10150760, Example 26...)Show SMILES CC(C)O[C@H]([C@H](C)S(=O)(=O)Nc1nnc([C@@H]2CCCO2)n1C1CCOCC1)c1cnc(C)cn1 |r| Show InChI InChI=1S/C22H34N6O5S/c1-14(2)33-20(18-13-23-15(3)12-24-18)16(4)34(29,30)27-22-26-25-21(19-6-5-9-32-19)28(22)17-7-10-31-11-8-17/h12-14,16-17,19-20H,5-11H2,1-4H3,(H,26,27)/t16-,19-,20+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 150 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310448
(US10150760, Example 271.0 | US10150760, Example 27...)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@@H]2COCCO2)n1C1(C)CC1)c1ncc(Cl)cn1 |r| Show InChI InChI=1S/C18H25ClN6O5S/c1-11(14(28-3)15-20-8-12(19)9-21-15)31(26,27)24-17-23-22-16(13-10-29-6-7-30-13)25(17)18(2)4-5-18/h8-9,11,13-14H,4-7,10H2,1-3H3,(H,23,24)/t11-,13-,14-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.01E+3 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310466
(US10150760, Example 289.0 | US10150760, Example 29...)Show SMILES COCC1(CC1)n1c(NS(=O)(=O)[C@@H](C)[C@H](OC)c2ncc(Cl)cn2)nnc1[C@H]1CCC(C)(C)O1 |r| Show InChI InChI=1S/C21H31ClN6O5S/c1-13(16(32-5)17-23-10-14(22)11-24-17)34(29,30)27-19-26-25-18(15-6-7-20(2,3)33-15)28(19)21(8-9-21)12-31-4/h10-11,13,15-16H,6-9,12H2,1-5H3,(H,26,27)/t13-,15+,16-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 23 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310470
(US10150760, Example 293.0)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@@H]2CN(C)C(=O)C2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1 |r,wU:3.3,2.1,wD:13.12,(5.16,-3.92,;3.83,-3.15,;3.83,-1.61,;2.49,-.84,;2.49,.7,;1.16,-1.61,;.39,-2.94,;1.93,-2.94,;-.18,-.84,;-1.51,-1.61,;-1.99,-3.07,;-3.53,-3.07,;-4,-1.61,;-5.33,-.84,;-6.58,-1.74,;-7.83,-.84,;-9.16,-1.61,;-7.35,.63,;-8.12,1.96,;-5.81,.63,;-2.76,-.7,;-2.76,.84,;-4.09,1.61,;-5.42,.84,;-6.76,1.61,;-4.09,3.15,;-2.76,3.92,;-1.42,3.15,;-1.42,1.61,;-.09,.84,;1.25,1.61,;5.16,-.84,;6.49,-1.61,;7.83,-.84,;7.83,.7,;9.16,1.47,;6.49,1.47,;5.16,.7,)| Show InChI InChI=1S/C23H28ClN7O6S/c1-13(20(37-5)21-25-10-15(24)11-26-21)38(33,34)29-23-28-27-22(14-9-18(32)30(2)12-14)31(23)19-16(35-3)7-6-8-17(19)36-4/h6-8,10-11,13-14,20H,9,12H2,1-5H3,(H,28,29)/t13-,14-,20-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 100 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310478
(US10150760, Example 301.0 | US10150760, Example 30...)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2COCCO2)n1C(C)C)c1ncc(Cl)cn1 |r| Show InChI InChI=1S/C17H25ClN6O5S/c1-10(2)24-16(13-9-28-5-6-29-13)21-22-17(24)23-30(25,26)11(3)14(27-4)15-19-7-12(18)8-20-15/h7-8,10-11,13-14H,5-6,9H2,1-4H3,(H,22,23)/t11-,13+,14-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 2.90E+3 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310478
(US10150760, Example 301.0 | US10150760, Example 30...)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2COCCO2)n1C(C)C)c1ncc(Cl)cn1 |r| Show InChI InChI=1S/C17H25ClN6O5S/c1-10(2)24-16(13-9-28-5-6-29-13)21-22-17(24)23-30(25,26)11(3)14(27-4)15-19-7-12(18)8-20-15/h7-8,10-11,13-14H,5-6,9H2,1-4H3,(H,22,23)/t11-,13+,14-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 710 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310481
(US10150760, Example 304.0 | US10150760, Example 34...)Show SMILES COCC1(CC1)n1c(NS(=O)(=O)[C@@H](C)[C@H](OC)c2ncc(Cl)cn2)nnc1[C@H]1COCCO1 |r| Show InChI InChI=1S/C19H27ClN6O6S/c1-12(15(30-3)16-21-8-13(20)9-22-16)33(27,28)25-18-24-23-17(14-10-31-6-7-32-14)26(18)19(4-5-19)11-29-2/h8-9,12,14-15H,4-7,10-11H2,1-3H3,(H,24,25)/t12-,14+,15-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 210 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310526
(US10150760, Example 352.0)Show SMILES CC(C)O[C@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2CC[C@@H](C)O2)n1C1CC1)c1ncc(Cl)cn1 |r| Show InChI InChI=1S/C20H29ClN6O4S/c1-11(2)30-17(18-22-9-14(21)10-23-18)13(4)32(28,29)26-20-25-24-19(27(20)15-6-7-15)16-8-5-12(3)31-16/h9-13,15-17H,5-8H2,1-4H3,(H,25,26)/t12-,13+,16-,17-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.49E+3 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310534
(US10150760, Example 360.0 | US10150760, Example 36...)Show SMILES COCC(COC)n1c(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(F)cn2)nnc1[C@H]1CC[C@@H](C)O1 |r| Show InChI InChI=1S/C22H35FN6O6S/c1-13(2)34-19(20-24-9-16(23)10-25-20)15(4)36(30,31)28-22-27-26-21(18-8-7-14(3)35-18)29(22)17(11-32-5)12-33-6/h9-10,13-15,17-19H,7-8,11-12H2,1-6H3,(H,27,28)/t14-,15+,18-,19-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 310 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310544
(US10150760, Example 370.0 | US10150760, Example 37...)Show SMILES COCC(COC)n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(OC)cn2)nnc1[C@H]1CC[C@@H](C)O1 |r| Show InChI InChI=1S/C21H34N6O6S/c1-13-7-8-18(33-13)20-24-25-21(27(20)16(11-30-4)12-31-5)26-34(28,29)15(3)14(2)19-22-9-17(32-6)10-23-19/h9-10,13-16,18H,7-8,11-12H2,1-6H3,(H,25,26)/t13-,14+,15+,18-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 620 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310554
(US10150760, Example 380.0 | US10150760, Example 38...)Show SMILES COCC(COC)n1c(NS(=O)(=O)[C@@H](C)[C@H](OC)c2ccc(Cl)cn2)nnc1[C@H]1CC[C@@H](C)O1 |r| Show InChI InChI=1S/C21H32ClN5O6S/c1-13-6-9-18(33-13)20-24-25-21(27(20)16(11-30-3)12-31-4)26-34(28,29)14(2)19(32-5)17-8-7-15(22)10-23-17/h7-8,10,13-14,16,18-19H,6,9,11-12H2,1-5H3,(H,25,26)/t13-,14+,18-,19+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 2.10 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310567
(US10150760, Example 395.0 | US10150760, Example 39...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(F)cn2)nnc1[C@@H]1COC(C)(C)C1 |r,wU:18.19,16.17,wD:30.32,(-6.83,5.91,;-5.49,5.14,;-4.16,5.91,;-4.16,7.45,;-2.82,8.22,;-1.49,7.45,;-1.49,5.91,;-.16,5.14,;1.18,5.91,;-2.82,5.14,;-2.82,3.6,;-1.58,2.69,;-.24,3.46,;1.09,2.69,;-.24,1.92,;2.42,1.92,;2.42,3.46,;2.42,5,;3.76,2.69,;3.76,1.15,;5.09,3.46,;5.09,5,;6.42,5.77,;7.76,5,;9.09,5.77,;7.76,3.46,;6.42,2.69,;-2.05,1.23,;-3.59,1.23,;-4.07,2.69,;-5.54,3.17,;-6.78,2.26,;-8.03,3.17,;-7.55,4.63,;-7.55,6.17,;-9.09,4.63,;-6.01,4.63,)| Show InChI InChI=1S/C24H31FN6O5S/c1-14(21-26-11-17(25)12-27-21)15(2)37(32,33)30-23-29-28-22(16-10-24(3,4)36-13-16)31(23)20-18(34-5)8-7-9-19(20)35-6/h7-9,11-12,14-16H,10,13H2,1-6H3,(H,29,30)/t14-,15-,16-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 58 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310573
(US10150760, Example 401.0 | US10150760, Example 40...)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2CCOC2)n1Cc1ccon1)c1ncc(Cl)cn1 |r| Show InChI InChI=1S/C18H22ClN7O5S/c1-11(15(29-2)16-20-7-13(19)8-21-16)32(27,28)25-18-23-22-17(12-3-5-30-10-12)26(18)9-14-4-6-31-24-14/h4,6-8,11-12,15H,3,5,9-10H2,1-2H3,(H,23,25)/t11-,12-,15-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 410 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310577
(US10150760, Example 405.0 | US10150760, Example 40...)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(C2CCC(=O)N2C)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1 |r,wU:2.1,3.3,(5.29,1.1,;3.96,1.87,;3.96,3.41,;2.62,4.18,;2.62,5.72,;1.29,3.41,;-.04,2.64,;2.62,2.64,;-.04,4.18,;-1.38,3.41,;-1.85,1.94,;-3.39,1.94,;-3.87,3.41,;-5.33,3.89,;-5.81,5.35,;-7.35,5.35,;-7.83,3.89,;-9.29,3.41,;-6.58,2.98,;-6.58,1.44,;-2.62,4.31,;-2.62,5.85,;-3.96,6.62,;-5.29,5.85,;-6.63,6.62,;-3.96,8.16,;-2.62,8.93,;-1.29,8.16,;-1.29,6.62,;.04,5.85,;1.38,6.62,;5.29,4.18,;5.29,5.72,;6.62,6.49,;7.96,5.72,;9.29,6.49,;7.96,4.18,;6.62,3.41,)| Show InChI InChI=1S/C23H28ClN7O6S/c1-13(20(37-5)21-25-11-14(24)12-26-21)38(33,34)29-23-28-27-22(15-9-10-18(32)30(15)2)31(23)19-16(35-3)7-6-8-17(19)36-4/h6-8,11-13,15,20H,9-10H2,1-5H3,(H,28,29)/t13-,15?,20-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.08E+3 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310589
(US10150760, Example 417.0 | US10150760, Example 41...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(C)cn2)nnc1C1CCC(=O)N1C |r,wU:16.17,wD:18.19,(-6.63,8.17,;-5.29,7.4,;-3.96,8.17,;-3.96,9.71,;-2.62,10.48,;-1.29,9.71,;-1.29,8.17,;.04,7.4,;1.38,8.17,;-2.62,7.4,;-2.62,5.86,;-1.38,4.96,;-.04,5.73,;1.29,4.96,;-.04,4.19,;2.62,4.19,;2.62,5.73,;2.62,7.27,;3.96,4.96,;3.96,3.42,;5.29,2.65,;6.62,3.42,;5.29,1.11,;5.29,5.73,;5.29,7.27,;6.62,8.04,;7.96,7.27,;9.29,8.04,;7.96,5.73,;6.62,4.96,;-1.85,3.49,;-3.39,3.49,;-3.87,4.96,;-5.33,5.43,;-5.81,6.9,;-7.35,6.9,;-7.83,5.43,;-9.29,4.96,;-6.58,4.53,;-6.58,2.99,)| Show InChI InChI=1S/C26H35N7O6S/c1-15(2)39-23(24-27-13-16(3)14-28-24)17(4)40(35,36)31-26-30-29-25(18-11-12-21(34)32(18)5)33(26)22-19(37-6)9-8-10-20(22)38-7/h8-10,13-15,17-18,23H,11-12H2,1-7H3,(H,30,31)/t17-,18?,23+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
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| PC cid
PC sid
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| US Patent
| n/a | n/a | n/a | n/a | 350 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310602
(US10150760, Example 436.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)c2ccccc2)nnc1[C@H]1CCCO1 |r,wD:27.29,16.17,(2.03,6.6,;.69,5.83,;-.64,6.6,;-.69,8.17,;-2.02,8.94,;-3.36,8.17,;-3.36,6.63,;-4.69,5.86,;-6.02,6.63,;-2.02,5.86,;-2.02,4.32,;-.78,3.41,;.56,4.18,;1.89,3.41,;.56,2.64,;3.22,2.64,;3.22,4.18,;3.22,5.72,;4.56,3.41,;5.89,4.18,;7.23,3.41,;7.23,1.87,;5.89,1.1,;4.56,1.87,;-1.25,1.95,;-2.79,1.95,;-3.27,3.41,;-4.73,3.89,;-5.21,5.35,;-6.75,5.35,;-7.23,3.89,;-5.98,2.98,)| Show InChI InChI=1S/C22H26N4O5S/c1-15(16-9-5-4-6-10-16)32(27,28)25-22-24-23-21(19-13-8-14-31-19)26(22)20-17(29-2)11-7-12-18(20)30-3/h4-7,9-12,15,19H,8,13-14H2,1-3H3,(H,24,25)/t15-,19-/m1/s1 | PDB
Reactome pathway
KEGG
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B.MOAD
antibodypedia
GoogleScholar
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| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 2.65E+3 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310607
(US10150760, Example 441.0 | US10150760, Example 44...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)nnc1[C@@H]1CO[C@@H](C)C1 |r,wU:33.36,18.19,16.17,wD:30.32,(-7.28,6.81,;-5.95,6.04,;-4.62,6.81,;-4.62,8.35,;-3.28,9.12,;-1.95,8.35,;-1.95,6.81,;-.61,6.04,;.72,6.81,;-3.28,6.04,;-3.28,4.5,;-2.04,3.6,;-.7,4.37,;.39,3.28,;-1.1,2.88,;1.48,2.19,;1.87,3.68,;2.27,5.17,;2.96,2.59,;2.56,1.1,;4.45,2.99,;4.85,4.48,;6.34,4.87,;7.43,3.79,;8.91,4.18,;7.03,2.3,;5.54,1.9,;-2.51,2.13,;-4.05,2.13,;-4.53,3.6,;-5.99,4.08,;-7.24,3.17,;-8.48,4.08,;-8.01,5.54,;-8.91,6.79,;-6.47,5.54,)| Show InChI InChI=1S/C23H29ClN6O5S/c1-13-9-16(12-35-13)22-27-28-23(30(22)20-18(33-4)7-6-8-19(20)34-5)29-36(31,32)15(3)14(2)21-25-10-17(24)11-26-21/h6-8,10-11,13-16H,9,12H2,1-5H3,(H,28,29)/t13-,14-,15-,16-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310228
(US10150760, Example 15.0 | US10150760, Example 16....)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)nnc1C1CCOCC1 |r,wU:16.17,(-7.03,5.8,;-5.69,5.03,;-4.36,5.8,;-4.36,7.34,;-3.02,8.11,;-1.69,7.34,;-1.69,5.8,;-.36,5.03,;.98,5.8,;-3.02,5.03,;-3.02,3.49,;-1.78,2.59,;-.45,3.36,;.89,2.59,;2.22,1.82,;-.45,1.82,;2.22,3.36,;2.22,4.9,;3.56,2.59,;4.89,3.36,;6.22,2.59,;7.56,3.36,;7.56,4.9,;8.89,5.67,;6.22,5.67,;4.89,4.9,;-2.25,1.13,;-3.79,1.13,;-4.27,2.59,;-5.81,2.59,;-6.58,3.92,;-8.12,3.92,;-8.89,2.59,;-8.12,1.26,;-6.58,1.26,)| Show InChI InChI=1S/C22H27FN6O5S/c1-14(11-19-24-12-16(23)13-25-19)35(30,31)28-22-27-26-21(15-7-9-34-10-8-15)29(22)20-17(32-2)5-4-6-18(20)33-3/h4-6,12-15H,7-11H2,1-3H3,(H,27,28)/t14-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 380 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310237
((2S,3R)-3-(5-cyano-2-pyrimidinyl)-N-(4-(2,6-dimeth...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)nnc1[C@@H]1CCCO1 |r,wU:16.17,18.19,30.32,(-9.4,16.25,;-8.07,15.48,;-6.74,16.25,;-6.74,17.79,;-5.4,18.56,;-4.07,17.79,;-4.07,16.25,;-2.74,15.48,;-1.4,16.25,;-5.4,15.48,;-5.4,13.94,;-4.16,13.03,;-2.82,13.8,;-1.49,13.03,;-.16,12.26,;-2.82,12.26,;-.16,13.8,;-.16,15.34,;1.18,13.03,;1.18,11.49,;2.51,13.8,;3.84,13.03,;5.18,13.8,;5.18,15.34,;6.51,16.11,;3.84,16.11,;2.51,15.34,;-4.63,11.57,;-6.17,11.57,;-6.65,13.03,;-8.14,13.43,;-8.61,14.89,;-10.15,14.89,;-10.63,13.43,;-9.38,12.52,)| Show InChI InChI=1S/C22H27ClN6O5S/c1-13(20-24-11-15(23)12-25-20)14(2)35(30,31)28-22-27-26-21(18-9-6-10-34-18)29(22)19-16(32-3)7-5-8-17(19)33-4/h5,7-8,11-14,18H,6,9-10H2,1-4H3,(H,27,28)/t13-,14-,18-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 4.5 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310242
(US10150760, Example 37.0)Show SMILES COc1ncnc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ccc(Cl)cn2)nnc1[C@@H]1CCOC1 |r,wU:30.32,16.17,18.19,(-7.64,1.54,;-6.31,.77,;-4.98,1.54,;-4.98,3.08,;-3.64,3.85,;-2.31,3.08,;-2.31,1.54,;-.97,.77,;.36,1.54,;-3.64,.77,;-3.64,-.77,;-2.4,-1.67,;-1.06,-.9,;.27,-1.67,;-.5,-3.01,;1.04,-3.01,;1.76,-1.28,;2.16,.21,;2.85,-2.36,;2.45,-3.85,;4.34,-1.97,;4.73,-.48,;6.22,-.08,;7.31,-1.17,;8.8,-.77,;6.91,-2.66,;5.42,-3.05,;-2.87,-3.14,;-4.41,-3.14,;-4.89,-1.67,;-6.43,-1.67,;-7.33,-.43,;-8.8,-.9,;-8.8,-2.44,;-7.33,-2.92,)| Show InChI InChI=1S/C21H26ClN7O5S/c1-12(16-6-5-15(22)9-23-16)13(2)35(30,31)28-21-27-26-18(14-7-8-34-10-14)29(21)17-19(32-3)24-11-25-20(17)33-4/h5-6,9,11-14H,7-8,10H2,1-4H3,(H,27,28)/t12-,13-,14+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 12 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310246
(US10150760, Example 41.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)nnc1[C@@H]1CCN(C1)C(=O)OC(C)(C)C |r,wU:30.32,16.17,18.19,(-5.07,2.47,;-3.73,1.7,;-2.4,2.47,;-2.4,4.01,;-1.07,4.78,;.27,4.01,;.27,2.47,;1.6,1.7,;2.94,2.47,;-1.07,1.7,;-1.07,.16,;.18,-.74,;1.51,.03,;2.85,-.74,;2.08,-2.08,;3.62,-2.08,;4.34,-.35,;4.73,1.14,;5.42,-1.43,;5.03,-2.92,;6.91,-1.04,;8,-2.12,;9.49,-1.73,;9.89,-.24,;11.37,.16,;8.8,.85,;7.31,.45,;-.3,-2.21,;-1.84,-2.21,;-2.31,-.74,;-3.85,-.74,;-4.76,.5,;-6.22,.03,;-6.22,-1.51,;-4.76,-1.99,;-7.31,-2.6,;-6.91,-4.09,;-8.8,-2.2,;-9.89,-3.29,;-11.37,-2.89,;-9.49,-4.78,;-10.98,-4.38,)| Show InChI InChI=1S/C27H36ClN7O6S/c1-16(23-29-13-19(28)14-30-23)17(2)42(37,38)33-25-32-31-24(18-11-12-34(15-18)26(36)41-27(3,4)5)35(25)22-20(39-6)9-8-10-21(22)40-7/h8-10,13-14,16-18H,11-12,15H2,1-7H3,(H,32,33)/t16-,17-,18+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
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| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 820 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310255
(US10150760, Example 51.0 | US10150760, Example 52....)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2CCCO2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1 |r,wU:3.3,2.1,wD:13.12,(4.49,-3.92,;3.16,-3.15,;3.16,-1.61,;1.82,-.84,;1.82,.7,;.49,-1.61,;-.28,-2.94,;1.26,-2.94,;-.84,-.84,;-2.18,-1.61,;-2.65,-3.07,;-4.19,-3.07,;-4.67,-1.61,;-6,-.84,;-6.48,.63,;-8.02,.63,;-8.49,-.84,;-7.25,-1.74,;-3.42,-.7,;-3.42,.84,;-4.76,1.61,;-6.09,.84,;-7.42,1.61,;-4.76,3.15,;-3.42,3.92,;-2.09,3.15,;-2.09,1.61,;-.75,.84,;.58,1.61,;4.49,-.84,;5.83,-1.61,;7.16,-.84,;7.16,.7,;8.49,1.47,;5.83,1.47,;4.49,.7,)| Show InChI InChI=1S/C22H27ClN6O6S/c1-13(19(34-4)20-24-11-14(23)12-25-20)36(30,31)28-22-27-26-21(17-9-6-10-35-17)29(22)18-15(32-2)7-5-8-16(18)33-3/h5,7-8,11-13,17,19H,6,9-10H2,1-4H3,(H,27,28)/t13-,17+,19-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.590 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310268
(US10150760, Example 64.0 | US10150760, Example 65....)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2CCCOC2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1 |r,wU:3.3,2.1,wD:13.12,(4.81,-3.92,;3.48,-3.15,;3.48,-1.61,;2.14,-.84,;2.14,.7,;.81,-1.61,;.04,-2.94,;1.58,-2.94,;-.52,-.84,;-1.86,-1.61,;-2.33,-3.07,;-3.87,-3.07,;-4.35,-1.61,;-5.84,-1.21,;-6.24,.28,;-7.72,.68,;-8.81,-.41,;-8.41,-1.9,;-6.93,-2.3,;-3.1,-.7,;-3.1,.84,;-4.44,1.61,;-5.77,.84,;-7.1,1.61,;-4.44,3.15,;-3.1,3.92,;-1.77,3.15,;-1.77,1.61,;-.44,.84,;.9,1.61,;4.81,-.84,;6.14,-1.61,;7.48,-.84,;7.48,.7,;8.81,1.47,;6.14,1.47,;4.81,.7,)| Show InChI InChI=1S/C23H29ClN6O6S/c1-14(20(35-4)21-25-11-16(24)12-26-21)37(31,32)29-23-28-27-22(15-7-6-10-36-13-15)30(23)19-17(33-2)8-5-9-18(19)34-3/h5,8-9,11-12,14-15,20H,6-7,10,13H2,1-4H3,(H,28,29)/t14-,15-,20-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 29 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310270
(US10150760, Example 66.0 | US10150760, Example 67....)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2cnc(C)cn2)nnc1[C@H]1CCCO1 |r,wU:16.17,wD:33.35,18.19,(-7.42,2.38,;-6.09,1.61,;-4.76,2.38,;-4.76,3.92,;-3.42,4.69,;-2.09,3.92,;-2.09,2.38,;-.75,1.61,;.58,2.38,;-3.42,1.61,;-3.42,.07,;-2.18,-.84,;-.84,-.07,;.49,-.84,;-.28,-2.17,;1.26,-2.17,;1.82,-.07,;1.82,1.47,;3.16,-.84,;3.16,-2.38,;4.49,-3.15,;4.49,-4.69,;5.83,-2.38,;4.49,-.07,;4.49,1.47,;5.83,2.24,;7.16,1.47,;8.49,2.24,;7.16,-.07,;5.83,-.84,;-2.65,-2.3,;-4.19,-2.3,;-4.67,-.84,;-6,-.07,;-6.48,1.4,;-8.02,1.4,;-8.49,-.07,;-7.25,-.97,)| Show InChI InChI=1S/C25H34N6O6S/c1-15(2)37-23(18-14-26-16(3)13-27-18)17(4)38(32,33)30-25-29-28-24(21-11-8-12-36-21)31(25)22-19(34-5)9-7-10-20(22)35-6/h7,9-10,13-15,17,21,23H,8,11-12H2,1-6H3,(H,29,30)/t17-,21+,23+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 180 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310277
(US10150760, Example 73.0 | US10150760, Example 74....)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2OCC[C@H]2C)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1 |r,wU:3.3,2.1,wD:13.12,17.18,(4.49,-3.92,;3.16,-3.15,;3.16,-1.61,;1.82,-.84,;1.82,.7,;.49,-1.61,;-.28,-2.94,;1.26,-2.94,;-.84,-.84,;-2.18,-1.61,;-2.65,-3.07,;-4.19,-3.07,;-4.67,-1.61,;-6,-.84,;-6.48,.63,;-8.02,.63,;-8.49,-.84,;-7.25,-1.74,;-7.25,-3.28,;-3.42,-.7,;-3.42,.84,;-4.76,1.61,;-6.09,1.13,;-7.42,1.9,;-4.76,3.15,;-3.42,3.92,;-2.09,3.15,;-2.09,1.61,;-.75,.84,;.58,1.61,;4.49,-.84,;5.83,-1.61,;7.16,-.84,;7.16,.7,;8.49,1.47,;5.83,1.47,;4.49,.7,)| Show InChI InChI=1S/C23H29ClN6O6S/c1-13-9-10-36-19(13)22-27-28-23(30(22)18-16(33-3)7-6-8-17(18)34-4)29-37(31,32)14(2)20(35-5)21-25-11-15(24)12-26-21/h6-8,11-14,19-20H,9-10H2,1-5H3,(H,28,29)/t13-,14+,19+,20+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 120 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310281
(US10150760, Example 77.0 | US10150760, Example 78....)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2CC[C@@H](C)O2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1 |r,wU:3.3,2.1,wD:13.12,16.16,(5.16,-3.92,;3.83,-3.15,;3.83,-1.61,;2.49,-.84,;2.49,.7,;1.16,-1.61,;.39,-2.94,;1.93,-2.94,;-.18,-.84,;-1.51,-1.61,;-1.99,-3.07,;-3.53,-3.07,;-4,-1.61,;-5.33,-.84,;-5.81,.63,;-7.35,.63,;-7.83,-.84,;-9.16,-1.61,;-6.58,-1.74,;-2.76,-.7,;-2.76,.84,;-1.42,1.61,;-.09,.84,;1.25,1.61,;-1.42,3.15,;-2.76,3.92,;-4.09,3.15,;-4.09,1.61,;-5.42,.98,;-6.76,1.75,;5.16,-.84,;6.49,-1.61,;7.83,-.84,;7.83,.7,;9.16,1.47,;6.49,1.47,;5.16,.7,)| Show InChI InChI=1S/C23H29ClN6O6S/c1-13-9-10-18(36-13)22-27-28-23(30(22)19-16(33-3)7-6-8-17(19)34-4)29-37(31,32)14(2)20(35-5)21-25-11-15(24)12-26-21/h6-8,11-14,18,20H,9-10H2,1-5H3,(H,28,29)/t13-,14+,18-,20+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 5 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310301
(US10150760, Example 97.0 | US10150760, Example 98....)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(C)cn2)nnc1[C@H]1CCCO1 |r,wU:16.17,wD:18.19,33.35,(-7.42,2.38,;-6.09,1.61,;-4.76,2.38,;-4.76,3.92,;-3.42,4.69,;-2.09,3.92,;-2.09,2.38,;-.75,1.61,;.58,2.38,;-3.42,1.61,;-3.42,.07,;-2.18,-.84,;-.84,-.07,;.49,-.84,;-.28,-2.17,;1.26,-2.17,;1.82,-.07,;1.82,1.47,;3.16,-.84,;3.16,-2.38,;4.49,-3.15,;5.83,-2.38,;4.49,-4.69,;4.49,-.07,;5.83,-.84,;7.16,-.07,;7.16,1.47,;8.49,2.24,;5.83,2.24,;4.49,1.47,;-2.65,-2.3,;-4.19,-2.3,;-4.67,-.84,;-6,-.07,;-6.48,1.4,;-8.02,1.4,;-8.49,-.07,;-7.25,-.97,)| Show InChI InChI=1S/C25H34N6O6S/c1-15(2)37-22(23-26-13-16(3)14-27-23)17(4)38(32,33)30-25-29-28-24(20-11-8-12-36-20)31(25)21-18(34-5)9-7-10-19(21)35-6/h7,9-10,13-15,17,20,22H,8,11-12H2,1-6H3,(H,29,30)/t17-,20+,22+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.780 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310316
(US10150760, Example 112.0 | US10150760, Example 11...)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2CCCCO2)n1C1(C)CC1)c1ncc(Cl)cn1 |r| Show InChI InChI=1S/C19H27ClN6O4S/c1-12(15(29-3)16-21-10-13(20)11-22-16)31(27,28)25-18-24-23-17(14-6-4-5-9-30-14)26(18)19(2)7-8-19/h10-12,14-15H,4-9H2,1-3H3,(H,24,25)/t12-,14+,15-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 14 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM310328
(US10150760, Example 124.0 | US10150760, Example 12...)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2CCOC2)n1C1(C)CC1)c1ncc(Cl)cn1 |r| Show InChI InChI=1S/C18H25ClN6O4S/c1-11(14(28-3)15-20-8-13(19)9-21-15)30(26,27)24-17-23-22-16(12-4-7-29-10-12)25(17)18(2)5-6-18/h8-9,11-12,14H,4-7,10H2,1-3H3,(H,23,24)/t11-,12-,14-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 540 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US10150760 (2018)
BindingDB Entry DOI: 10.7270/Q2MS3VVT |
More data for this
Ligand-Target Pair | |
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