Found 788 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Apelin receptor
(Homo sapiens (Human)) | BDBM269508
(US10058550, Example 27.0 | US10058550, Example 549...)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1 |r,wU:3.3,2.1,(6.11,-3.4,;4.62,-3,;4.22,-1.51,;2.73,-1.11,;2.33,.38,;1.64,-2.2,;.56,-3.29,;2.73,-3.29,;.56,-1.11,;-.93,-1.51,;-1.41,-2.97,;-2.95,-2.97,;-3.42,-1.51,;-4.91,-1.11,;-5.31,.38,;-6.8,.78,;-7.89,-.31,;-7.49,-1.8,;-8.58,-2.89,;-8.18,-4.38,;-6,-2.2,;-2.18,-.6,;-2.18,1.3,;-3.51,2.07,;-4.85,1.3,;-6.18,2.07,;-3.51,3.61,;-2.18,4.38,;-.84,3.61,;-.84,2.07,;.49,1.3,;1.82,2.07,;5.31,-.42,;6.8,-.82,;7.89,.27,;7.49,1.76,;8.58,2.85,;6,2.16,;4.91,1.07,)| Show InChI InChI=1S/C25H29N7O6S/c1-15-13-26-23(27-14-15)22(38-6)16(2)39(33,34)31-25-30-29-24(17-9-7-12-20(28-17)37-5)32(25)21-18(35-3)10-8-11-19(21)36-4/h7-14,16,22H,1-6H3,(H,30,31)/t16-,22-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.190 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269513
(N-(4-(2,6-dimethoxyphenyl)-5-(6-methyl-2-pyridinyl...)Show SMILES CCS(=O)(=O)Nc1nnc(-c2cccc(C)n2)n1-c1c(OC)cccc1OC |(5.82,.28,;5.82,-1.26,;4.49,-2.03,;3.72,-3.36,;5.26,-3.36,;3.16,-1.26,;1.82,-2.03,;1.35,-3.49,;-.19,-3.49,;-.67,-2.03,;-2.16,-1.63,;-2.56,-.14,;-4.04,.25,;-5.13,-.83,;-4.73,-2.32,;-5.82,-3.41,;-3.25,-2.72,;.58,-1.13,;.58,.41,;1.91,1.18,;3.24,.41,;4.58,1.18,;1.91,2.72,;.58,3.49,;-.76,2.72,;-.76,1.18,;-2.09,.41,;-3.43,1.18,)| Show InChI InChI=1S/C18H21N5O4S/c1-5-28(24,25)22-18-21-20-17(13-9-6-8-12(2)19-13)23(18)16-14(26-3)10-7-11-15(16)27-4/h6-11H,5H2,1-4H3,(H,21,22) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 830 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269528
((1S,2R)—N-(4-(2,6-dimethoxyphenyl)-5-(3-pyrid...)Show SMILES CO[C@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cccnc2)n1-c1c(OC)cccc1OC)c1cnc(C)cn1 |r,wD:3.3,2.1,(4.99,-8.8,;5.76,-7.47,;4.99,-6.14,;3.45,-6.14,;2.68,-4.8,;2.68,-7.47,;1.91,-8.8,;4.01,-8.24,;1.34,-6.7,;.01,-7.47,;.01,-9.01,;-1.46,-9.49,;-2.36,-8.24,;-3.85,-7.84,;-4.94,-8.93,;-6.42,-8.53,;-6.82,-7.04,;-5.73,-5.96,;-4.25,-6.35,;-1.46,-6.99,;-2.29,-4.55,;-3.77,-4.15,;-4.86,-5.24,;-6.35,-4.84,;-4.17,-2.66,;-3.08,-1.58,;-1.6,-1.97,;-1.2,-3.46,;.29,-3.86,;1.38,-2.77,;5.76,-4.8,;7.3,-4.8,;8.07,-3.47,;7.3,-2.14,;8.07,-.8,;5.76,-2.14,;4.99,-3.47,)| Show InChI InChI=1S/C24H27N7O5S/c1-15-12-27-18(14-26-15)22(36-5)16(2)37(32,33)30-24-29-28-23(17-8-7-11-25-13-17)31(24)21-19(34-3)9-6-10-20(21)35-4/h6-14,16,22H,1-5H3,(H,29,30)/t16-,22-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.26 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM359748
((1R,2S)-N-(4-(3-cyanophenyl)-5-(6-methoxy-2-pyridi...)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1cccc(c1)C#N)c1ncc(C)cn1 |r| Show InChI InChI=1S/C24H24N8O4S/c1-15-13-26-22(27-14-15)21(36-4)16(2)37(33,34)31-24-30-29-23(19-9-6-10-20(28-19)35-3)32(24)18-8-5-7-17(11-18)12-25/h5-11,13-14,16,21H,1-4H3,(H,30,31)/t16-,21-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 31 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269553
((1R,2S)-N-(4-(2-chlorophenyl)-5-(6-methoxy-2-pyrid...)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1ccccc1Cl)c1ncc(C)cn1 |r,wU:3.3,2.1,(5.9,-3.92,;4.57,-3.15,;4.57,-1.61,;3.23,-.84,;3.23,.7,;1.9,-1.61,;1.13,-2.94,;2.67,-2.94,;.57,-.84,;-.77,-1.61,;-1.24,-3.07,;-2.78,-3.07,;-3.26,-1.61,;-4.75,-1.21,;-5.15,.28,;-6.63,.68,;-7.72,-.41,;-7.32,-1.9,;-8.41,-2.99,;-9.9,-2.59,;-5.84,-2.3,;-2.01,-.7,;-2.01,.84,;-3.35,1.61,;-3.35,3.15,;-2.01,3.92,;-.68,3.15,;-.68,1.61,;.65,.84,;5.9,-.84,;7.23,-1.61,;8.57,-.84,;8.57,.7,;9.9,1.47,;7.23,1.47,;5.9,.7,)| Show InChI InChI=1S/C23H24ClN7O4S/c1-14-12-25-21(26-13-14)20(35-4)15(2)36(32,33)30-23-29-28-22(17-9-7-11-19(27-17)34-3)31(23)18-10-6-5-8-16(18)24/h5-13,15,20H,1-4H3,(H,29,30)/t15-,20-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 2.10 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269554
((1R,2S)-N-(4-(2,3-dimethylphenyl)-5-(6-methoxy-2-p...)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1cccc(C)c1C)c1ncc(C)cn1 |r,wU:3.3,2.1,(5.9,-3.92,;4.57,-3.15,;4.57,-1.61,;3.23,-.84,;3.23,.7,;1.9,-1.61,;1.13,-2.94,;2.67,-2.94,;.57,-.84,;-.77,-1.61,;-1.24,-3.07,;-2.78,-3.07,;-3.26,-1.61,;-4.75,-1.21,;-5.15,.28,;-6.63,.68,;-7.72,-.41,;-7.32,-1.9,;-8.41,-2.99,;-9.9,-2.59,;-5.84,-2.3,;-2.01,-.7,;-2.01,.84,;-3.35,1.61,;-3.35,3.15,;-2.01,3.92,;-.68,3.15,;.65,3.92,;-.68,1.61,;.65,.84,;5.9,-.84,;7.23,-1.61,;8.57,-.84,;8.57,.7,;9.9,1.47,;7.23,1.47,;5.9,.7,)| Show InChI InChI=1S/C25H29N7O4S/c1-15-13-26-23(27-14-15)22(36-6)18(4)37(33,34)31-25-30-29-24(19-10-8-12-21(28-19)35-5)32(25)20-11-7-9-16(2)17(20)3/h7-14,18,22H,1-6H3,(H,30,31)/t18-,22-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 2.60 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269557
((1R,2S)-N-(4-(2,6-dichlorophenyl)-5-(6-methoxy-2-p...)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(Cl)cccc1Cl)c1ncc(C)cn1 |r,wU:3.3,2.1,(7.52,-1.62,;5.98,-1.62,;5.21,-.28,;3.67,-.28,;2.9,1.05,;2.9,-1.62,;2.13,-2.95,;4.24,-2.39,;1.57,-.85,;.24,-1.62,;.24,-3.16,;-1.23,-3.63,;-2.13,-2.39,;-3.67,-2.39,;-4.44,-1.05,;-5.98,-1.05,;-6.75,-2.39,;-5.98,-3.72,;-6.75,-5.05,;-8.29,-5.05,;-4.44,-3.72,;-1.23,-1.14,;-1.63,.35,;-.54,1.44,;.95,1.04,;-.94,2.92,;-2.42,3.32,;-3.51,2.23,;-3.11,.75,;-4.2,-.34,;5.98,1.05,;7.52,1.05,;8.29,2.39,;7.52,3.72,;8.29,5.05,;5.98,3.72,;5.21,2.39,)| Show InChI InChI=1S/C23H23Cl2N7O4S/c1-13-11-26-21(27-12-13)20(36-4)14(2)37(33,34)31-23-30-29-22(17-9-6-10-18(28-17)35-3)32(23)19-15(24)7-5-8-16(19)25/h5-12,14,20H,1-4H3,(H,30,31)/t14-,20-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.760 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269578
((1R,2R)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-p...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)[C@H](OC(C)C)c2ncc(C)cn2)nnc1-c1cncc(C)c1 |r,wU:18.19,wD:16.17,(-6.76,2.38,;-5.43,1.61,;-4.09,2.38,;-4.09,3.92,;-2.76,4.69,;-1.42,3.92,;-1.42,2.38,;-.09,1.61,;1.24,2.38,;-2.76,1.61,;-2.76,.07,;-1.51,-.84,;-.18,-.07,;1.15,-.84,;.38,-2.17,;1.92,-2.17,;2.49,-.07,;2.49,1.47,;3.82,-.84,;3.82,-2.38,;5.16,-3.15,;6.49,-2.38,;5.16,-4.69,;5.16,-.07,;6.49,-.84,;7.82,-.07,;7.82,1.47,;9.16,2.24,;6.49,2.24,;5.16,1.47,;-1.99,-2.3,;-3.53,-2.3,;-4,-.84,;-5.49,-.44,;-5.89,1.05,;-7.38,1.45,;-8.47,.36,;-8.07,-1.13,;-9.16,-2.22,;-6.58,-1.53,)| Show InChI InChI=1S/C27H33N7O5S/c1-16(2)39-24(25-29-13-18(4)14-30-25)19(5)40(35,36)33-27-32-31-26(20-11-17(3)12-28-15-20)34(27)23-21(37-6)9-8-10-22(23)38-7/h8-16,19,24H,1-7H3,(H,32,33)/t19-,24+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 140 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269585
((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methyl-2-p...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](O)c2ncc(C)cn2)nnc1-c1cccc(C)n1 |r,wU:16.17,18.19,(-6.76,1.22,;-5.43,.45,;-4.09,1.22,;-4.09,2.76,;-2.76,3.53,;-1.42,2.76,;-1.42,1.22,;-.09,.45,;1.24,1.22,;-2.76,.45,;-2.76,-1.09,;-1.51,-1.99,;-.18,-1.22,;1.15,-1.99,;.38,-3.33,;1.92,-3.33,;2.49,-1.22,;2.49,.32,;3.82,-1.99,;3.82,-3.53,;5.16,-1.22,;6.49,-1.99,;7.82,-1.22,;7.82,.32,;9.16,1.09,;6.49,1.09,;5.16,.32,;-1.99,-3.46,;-3.53,-3.46,;-4,-1.99,;-5.49,-1.59,;-5.89,-.11,;-7.38,.29,;-8.47,-.8,;-8.07,-2.28,;-9.16,-3.37,;-6.58,-2.68,)| Show InChI InChI=1S/C24H27N7O5S/c1-14-12-25-22(26-13-14)21(32)16(3)37(33,34)30-24-29-28-23(17-9-6-8-15(2)27-17)31(24)20-18(35-4)10-7-11-19(20)36-5/h6-13,16,21,32H,1-5H3,(H,29,30)/t16-,21-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| MCE
PC cid
PC sid
PDB
UniChem
| PDB
US Patent
| n/a | n/a | n/a | n/a | 2.30 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Apelin receptor
(Homo sapiens (Human)) | BDBM269589
((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methyl-2-p...)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(C)n2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1 |r,wU:3.3,2.1,(5.16,-3.92,;3.82,-3.15,;3.82,-1.61,;2.49,-.84,;2.49,.7,;1.15,-1.61,;.38,-2.94,;1.92,-2.94,;-.18,-.84,;-1.51,-1.61,;-1.99,-3.07,;-3.53,-3.07,;-4,-1.61,;-5.49,-1.21,;-5.89,.28,;-7.38,.68,;-8.47,-.41,;-8.07,-1.9,;-9.16,-2.99,;-6.58,-2.3,;-2.76,-.7,;-2.76,.84,;-4.09,1.61,;-5.43,.84,;-6.76,1.61,;-4.09,3.15,;-2.76,3.92,;-1.42,3.15,;-1.42,1.61,;-.09,.84,;1.24,1.61,;5.16,-.84,;6.49,-1.61,;7.82,-.84,;7.82,.7,;9.16,1.47,;6.49,1.47,;5.16,.7,)| Show InChI InChI=1S/C25H29N7O5S/c1-15-13-26-23(27-14-15)22(37-6)17(3)38(33,34)31-25-30-29-24(18-10-7-9-16(2)28-18)32(25)21-19(35-4)11-8-12-20(21)36-5/h7-14,17,22H,1-6H3,(H,30,31)/t17-,22-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.510 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269590
((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(2-methyl-4-p...)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2ccnc(C)c2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1 |r,wU:3.3,2.1,(5.16,-3.92,;3.82,-3.15,;3.82,-1.61,;2.49,-.84,;2.49,.7,;1.15,-1.61,;.38,-2.94,;1.92,-2.94,;-.18,-.84,;-1.51,-1.61,;-1.99,-3.07,;-3.53,-3.07,;-4,-1.61,;-5.49,-1.21,;-5.89,.28,;-7.38,.68,;-8.47,-.41,;-8.07,-1.9,;-9.16,-2.99,;-6.58,-2.3,;-2.76,-.7,;-2.76,.84,;-4.09,1.61,;-5.43,.84,;-6.76,1.61,;-4.09,3.15,;-2.76,3.92,;-1.42,3.15,;-1.42,1.61,;-.09,.84,;1.24,1.61,;5.16,-.84,;6.49,-1.61,;7.82,-.84,;7.82,.7,;9.16,1.47,;6.49,1.47,;5.16,.7,)| Show InChI InChI=1S/C25H29N7O5S/c1-15-13-27-23(28-14-15)22(37-6)17(3)38(33,34)31-25-30-29-24(18-10-11-26-16(2)12-18)32(25)21-19(35-4)8-7-9-20(21)36-5/h7-14,17,22H,1-6H3,(H,30,31)/t17-,22-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269596
((1S,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)Show SMILES CCO[C@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1 |r,wU:4.4,wD:3.2,(4.86,-4.69,;4.86,-3.15,;3.53,-2.38,;3.53,-.84,;2.2,-.07,;2.2,1.47,;.86,-.84,;.09,-2.17,;1.63,-2.17,;-.47,-.07,;-1.81,-.84,;-2.28,-2.3,;-3.82,-2.3,;-4.3,-.84,;-5.78,-.44,;-6.55,.89,;-8.09,.89,;-8.86,-.44,;-8.09,-1.77,;-8.86,-3.11,;-10.4,-3.11,;-6.55,-1.77,;-3.05,.07,;-3.05,1.61,;-1.59,2.32,;-.25,1.55,;1.08,2.33,;-1.72,3.92,;-3.05,4.69,;-4.38,3.92,;-4.38,2.38,;-5.72,1.61,;-7.05,2.38,;4.86,-.07,;6.2,-.84,;7.53,-.07,;7.53,1.47,;8.86,2.24,;6.2,2.24,;4.86,1.47,)| Show InChI InChI=1S/C26H31N7O6S/c1-7-39-23(24-27-14-16(2)15-28-24)17(3)40(34,35)32-26-31-30-25(18-10-8-13-21(29-18)38-6)33(26)22-19(36-4)11-9-12-20(22)37-5/h8-15,17,23H,7H2,1-6H3,(H,31,32)/t17-,23+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 5.30 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM359812
((2R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-pyr...)Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@H](C)Cc2ncc(F)cn2)n1-c1c(OC)cccc1OC |r,wD:16.17,(-8.12,-10.54,;-8.89,-9.2,;-8.12,-7.87,;-8.89,-6.54,;-8.12,-5.2,;-6.58,-5.2,;-5.81,-6.54,;-6.58,-7.87,;-4.27,-6.54,;-3.79,-8,;-2.25,-8,;-1.78,-6.54,;-.45,-5.77,;.89,-6.54,;.12,-7.87,;1.66,-7.87,;2.22,-5.77,;2.22,-4.23,;3.56,-6.54,;4.89,-5.77,;6.22,-6.54,;7.56,-5.77,;7.56,-4.23,;8.89,-3.46,;6.22,-3.46,;4.89,-4.23,;-3.02,-5.63,;-3.02,-4.09,;-4.36,-3.32,;-5.69,-4.09,;-7.03,-3.32,;-4.36,-1.78,;-3.02,-1.01,;-1.69,-1.78,;-1.69,-3.32,;-.36,-4.09,;.98,-3.32,)| Show InChI InChI=1S/C23H24FN7O5S/c1-14(11-19-25-12-15(24)13-26-19)37(32,33)30-23-29-28-22(16-7-5-10-20(27-16)36-4)31(23)21-17(34-2)8-6-9-18(21)35-3/h5-10,12-14H,11H2,1-4H3,(H,29,30)/t14-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.27 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM359815
((2R)-N-(4-(2,6-dimethoxyphenyl)-5-(2-methyl-4-pyri...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)Cc2ncc(F)cn2)nnc1-c1ccnc(C)c1 |r,wD:16.17,(-7.03,-3.35,;-5.69,-4.12,;-4.36,-3.35,;-4.36,-1.81,;-3.02,-1.04,;-1.69,-1.81,;-1.69,-3.35,;-.36,-4.12,;.98,-3.35,;-3.02,-4.12,;-3.02,-5.66,;-1.78,-6.57,;-.45,-5.8,;.89,-6.57,;.12,-7.9,;1.66,-7.9,;2.22,-5.8,;2.22,-4.26,;3.56,-6.57,;4.89,-5.8,;6.22,-6.57,;7.56,-5.8,;7.56,-4.26,;8.89,-3.49,;6.22,-3.49,;4.89,-4.26,;-2.25,-8.03,;-3.79,-8.03,;-4.27,-6.57,;-5.81,-6.57,;-6.58,-5.23,;-8.12,-5.23,;-8.89,-6.57,;-8.12,-7.9,;-8.89,-9.23,;-6.58,-7.9,)| Show InChI InChI=1S/C23H24FN7O4S/c1-14-10-16(8-9-25-14)22-28-29-23(31(22)21-18(34-3)6-5-7-19(21)35-4)30-36(32,33)15(2)11-20-26-12-17(24)13-27-20/h5-10,12-13,15H,11H2,1-4H3,(H,29,30)/t15-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 5.80 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269625
((2S)-N-(4-(2,6-dimethoxyphenyl)-5-(3-methoxy-2-pyr...)Show SMILES COc1cccnc1-c1nnc(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)n1-c1c(OC)cccc1OC |r,wU:16.17,(-6.58,-4.76,;-5.81,-3.43,;-6.58,-2.1,;-8.12,-2.1,;-8.89,-.76,;-8.12,.57,;-6.58,.57,;-5.81,-.76,;-4.27,-.76,;-3.79,-2.23,;-2.25,-2.23,;-1.78,-.76,;-.45,.01,;.89,-.76,;.12,-2.1,;1.66,-2.1,;2.22,.01,;2.22,1.55,;3.56,-.76,;4.89,.01,;6.22,-.76,;7.56,.01,;7.56,1.55,;8.89,2.32,;6.22,2.32,;4.89,1.55,;-3.02,.14,;-3.02,1.68,;-1.69,2.45,;-.36,1.68,;.98,2.45,;-1.69,3.99,;-3.02,4.76,;-4.36,3.99,;-4.36,2.45,;-5.69,1.68,;-7.03,2.45,)| Show InChI InChI=1S/C23H24FN7O5S/c1-14(11-19-26-12-15(24)13-27-19)37(32,33)30-23-29-28-22(20-16(34-2)9-6-10-25-20)31(23)21-17(35-3)7-5-8-18(21)36-4/h5-10,12-14H,11H2,1-4H3,(H,29,30)/t14-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 150 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269631
((2S)-N-(4-(2,6-dimethoxyphenyl)-5-(4-methoxy-2-pyr...)Show SMILES COc1ccnc(c1)-c1nnc(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)n1-c1c(OC)cccc1OC |r,wU:16.17,(-10.43,2.57,;-8.89,2.57,;-8.12,1.24,;-8.89,-.1,;-8.12,-1.43,;-6.58,-1.43,;-5.81,-.1,;-6.58,1.24,;-4.27,-.1,;-3.79,-1.56,;-2.25,-1.56,;-1.78,-.1,;-.45,.67,;.89,-.1,;.12,-1.43,;1.66,-1.43,;2.22,.67,;2.22,2.21,;3.56,-.1,;4.89,.67,;6.22,-.1,;7.56,.67,;7.56,2.21,;8.89,2.98,;6.22,2.98,;4.89,2.21,;-3.02,.81,;-3.02,2.35,;-1.69,3.12,;-.36,2.35,;.98,3.12,;-1.69,4.66,;-3.02,5.43,;-4.36,4.66,;-4.36,3.12,;-5.69,2.35,;-7.03,3.12,)| Show InChI InChI=1S/C23H24FN7O5S/c1-14(10-20-26-12-15(24)13-27-20)37(32,33)30-23-29-28-22(17-11-16(34-2)8-9-25-17)31(23)21-18(35-3)6-5-7-19(21)36-4/h5-9,11-14H,10H2,1-4H3,(H,29,30)/t14-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 14 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269632
((2R)-N-(5-(5-bromo-3-pyridinyl)-4-(2,6-dimethoxyph...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)nnc1-c1cc(Br)ccn1 |r,wU:16.17,(.98,3.12,;-.36,2.35,;-1.69,3.12,;-1.69,4.66,;-3.02,5.43,;-4.36,4.66,;-4.36,3.12,;-5.69,2.35,;-7.03,3.12,;-3.02,2.35,;-3.02,.81,;-1.78,-.1,;-.45,.67,;.89,-.1,;.12,-1.43,;1.66,-1.43,;2.22,.67,;2.22,2.21,;3.56,-.1,;4.89,.67,;6.22,-.1,;7.56,.67,;7.56,2.21,;8.89,2.98,;6.22,2.98,;4.89,2.21,;-2.25,-1.56,;-3.79,-1.56,;-4.27,-.1,;-5.81,-.1,;-6.58,1.24,;-8.12,1.24,;-8.89,2.57,;-8.89,-.1,;-8.12,-1.43,;-6.58,-1.43,)| Show InChI InChI=1S/C22H21BrFN7O4S/c1-13(9-19-26-11-15(24)12-27-19)36(32,33)30-22-29-28-21(16-10-14(23)7-8-25-16)31(22)20-17(34-2)5-4-6-18(20)35-3/h4-8,10-13H,9H2,1-3H3,(H,29,30)/t13-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 2.10 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269636
((2S)-N-(5-(6-cyano-2-pyridinyl)-4-(2,6-dimethoxyph...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)nnc1-c1cccc(n1)C#N |r,wU:16.17,(1.36,2.45,;.03,1.68,;-1.31,2.45,;-1.31,3.99,;-2.64,4.76,;-3.97,3.99,;-3.97,2.45,;-5.31,1.68,;-6.64,2.45,;-2.64,1.68,;-2.64,.14,;-1.39,-.76,;-.06,.01,;1.27,-.76,;.5,-2.1,;2.04,-2.1,;2.61,.01,;2.61,1.55,;3.94,-.76,;5.27,.01,;6.61,-.76,;7.94,.01,;7.94,1.55,;9.28,2.32,;6.61,2.32,;5.27,1.55,;-1.87,-2.23,;-3.41,-2.23,;-3.89,-.76,;-5.43,-.76,;-6.2,.57,;-7.74,.57,;-8.51,-.76,;-7.75,-2.19,;-6.2,-2.1,;-8.5,-3.54,;-9.25,-4.88,)| Show InChI InChI=1S/C23H21FN8O4S/c1-14(10-20-26-12-15(24)13-27-20)37(33,34)31-23-30-29-22(17-7-4-6-16(11-25)28-17)32(23)21-18(35-2)8-5-9-19(21)36-3/h4-9,12-14H,10H2,1-3H3,(H,30,31)/t14-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 120 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269640
((2S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methoxy-2-pyr...)Show SMILES COc1ccc(nc1)-c1nnc(NS(=O)(=O)[C@@H](C)Cc2ncc(C)cn2)n1-c1c(OC)cccc1OC |r,wU:16.17,(-10.43,-.7,;-9.66,-2.03,;-8.12,-2.03,;-7.35,-.7,;-5.81,-.7,;-5.04,-2.03,;-5.81,-3.36,;-7.35,-3.36,;-3.5,-2.03,;-3.02,-3.49,;-1.48,-3.49,;-1.01,-2.03,;.32,-1.26,;1.66,-2.03,;.89,-3.36,;2.43,-3.36,;2.99,-1.26,;2.99,.28,;4.33,-2.03,;5.66,-1.26,;6.99,-2.03,;8.33,-1.26,;8.33,.28,;9.66,1.05,;6.99,1.05,;5.66,.28,;-2.25,-1.13,;-2.25,.41,;-.92,1.18,;.41,.41,;1.75,1.18,;-.92,2.72,;-2.25,3.49,;-3.59,2.72,;-3.59,1.18,;-4.92,.41,;-6.26,1.18,)| Show InChI InChI=1S/C24H27N7O5S/c1-15-12-26-21(27-13-15)11-16(2)37(32,33)30-24-29-28-23(18-10-9-17(34-3)14-25-18)31(24)22-19(35-4)7-6-8-20(22)36-5/h6-10,12-14,16H,11H2,1-5H3,(H,29,30)/t16-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 150 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269642
((2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-ethyl-2-pyrid...)Show SMILES CCc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)n1-c1c(OC)cccc1OC |r,wU:16.17,(-8.12,-4.76,;-8.89,-3.43,;-8.12,-2.1,;-8.89,-.76,;-8.12,.57,;-6.58,.57,;-5.81,-.76,;-6.58,-2.1,;-4.27,-.76,;-3.79,-2.23,;-2.25,-2.23,;-1.78,-.76,;-.45,.01,;.89,-.76,;.12,-2.1,;1.66,-2.1,;2.22,.01,;2.22,1.55,;3.56,-.76,;4.89,.01,;6.22,-.76,;7.56,.01,;7.56,1.55,;8.89,2.32,;6.22,2.32,;4.89,1.55,;-3.02,.14,;-3.02,1.68,;-1.69,2.45,;-.36,1.68,;.98,2.45,;-1.69,3.99,;-3.02,4.76,;-4.36,3.99,;-4.36,2.45,;-5.69,1.68,;-7.03,2.45,)| Show InChI InChI=1S/C24H26FN7O4S/c1-5-17-8-6-9-18(28-17)23-29-30-24(32(23)22-19(35-3)10-7-11-20(22)36-4)31-37(33,34)15(2)12-21-26-13-16(25)14-27-21/h6-11,13-15H,5,12H2,1-4H3,(H,30,31)/t15-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.210 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269660
((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-ethyl-2-py...)Show SMILES CCc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](OC)c2ncc(C)cn2)n1-c1c(OC)cccc1OC |r,wU:16.17,18.19,(-8.12,-4.76,;-8.89,-3.43,;-8.12,-2.1,;-8.89,-.76,;-8.12,.57,;-6.58,.57,;-5.81,-.76,;-6.58,-2.1,;-4.27,-.76,;-3.79,-2.23,;-2.25,-2.23,;-1.78,-.76,;-.45,.01,;.89,-.76,;.12,-2.1,;1.66,-2.1,;2.22,.01,;2.22,1.55,;3.56,-.76,;3.56,-2.3,;2.22,-3.07,;4.89,.01,;6.22,-.76,;7.56,.01,;7.56,1.55,;8.89,2.32,;6.22,2.32,;4.89,1.55,;-3.02,.14,;-3.02,1.68,;-1.69,2.45,;-.36,1.68,;.98,2.45,;-1.69,3.99,;-3.02,4.76,;-4.36,3.99,;-4.36,2.45,;-5.69,1.68,;-7.03,2.45,)| Show InChI InChI=1S/C26H31N7O5S/c1-7-18-10-8-11-19(29-18)25-30-31-26(33(25)22-20(36-4)12-9-13-21(22)37-5)32-39(34,35)17(3)23(38-6)24-27-14-16(2)15-28-24/h8-15,17,23H,7H2,1-6H3,(H,31,32)/t17-,23-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269671
((2S,3R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-(2,2,2-tri...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(F)cn2)nnc1-c1cccc(OCC(F)(F)F)n1 |r,wU:16.17,18.19,(1.27,3.56,;.18,2.48,;-1.31,2.87,;-1.71,4.36,;-3.19,4.76,;-4.28,3.67,;-3.88,2.18,;-4.97,1.09,;-6.46,1.49,;-2.4,1.78,;-2,.3,;-.53,-.18,;.8,.59,;2.13,-.18,;1.36,-1.51,;3.47,-.95,;2.9,1.15,;2.13,2.49,;4.44,1.15,;5.21,-.18,;5.21,2.49,;6.75,2.49,;7.52,3.82,;6.75,5.16,;7.52,6.49,;5.21,5.16,;4.44,3.82,;-.53,-1.72,;-2,-2.19,;-2.9,-.95,;-4.44,-.95,;-5.21,.38,;-6.75,.38,;-7.52,-.95,;-6.75,-2.28,;-7.52,-3.62,;-9.06,-3.62,;-9.83,-4.95,;-10.6,-6.28,;-11.17,-4.18,;-8.5,-5.72,;-5.21,-2.28,)| Show InChI InChI=1S/C25H25F4N7O5S/c1-14(22-30-11-16(26)12-31-22)15(2)42(37,38)35-24-34-33-23(17-7-5-10-20(32-17)41-13-25(27,28)29)36(24)21-18(39-3)8-6-9-19(21)40-4/h5-12,14-15H,13H2,1-4H3,(H,34,35)/t14-,15-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.120 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269682
((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-(dimethyla...)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(n2)N(C)C)n1-c1c(OC)cccc1OC)c1ncc(C)cn1 |r,wU:3.3,2.1,(6.85,-3.21,;5.36,-2.82,;4.96,-1.33,;3.48,-.93,;3.08,.56,;2.39,-2.02,;1.3,-3.11,;3.48,-3.11,;1.3,-.93,;-.19,-1.33,;-.66,-2.79,;-2.2,-2.79,;-2.68,-1.33,;-4.17,-.93,;-4.57,.56,;-6.05,.96,;-7.14,-.13,;-6.74,-1.62,;-5.26,-2.02,;-7.83,-2.71,;-9.32,-2.31,;-7.43,-4.2,;-1.43,-.42,;-1.43,1.12,;-.1,1.89,;1.23,1.12,;2.57,1.89,;-.1,3.43,;-1.43,4.2,;-2.77,3.43,;-2.77,1.89,;-4.1,1.12,;-5.44,1.89,;6.05,-.24,;7.54,-.64,;8.63,.45,;8.23,1.94,;9.32,3.03,;6.74,2.34,;5.66,1.25,)| Show InChI InChI=1S/C26H32N8O5S/c1-16-14-27-24(28-15-16)23(39-7)17(2)40(35,36)32-26-31-30-25(18-10-8-13-21(29-18)33(3)4)34(26)22-19(37-5)11-9-12-20(22)38-6/h8-15,17,23H,1-7H3,(H,31,32)/t17-,23-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.210 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269702
((2S)-N-(4-(2,6-dimethoxyphenyl)-5-(4-methyl-3-pyri...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)nnc1-c1cnccc1C |r,wU:16.17,(-7.03,6.86,;-5.69,6.09,;-4.36,6.86,;-4.36,8.4,;-3.02,9.17,;-1.69,8.4,;-1.69,6.86,;-.36,6.09,;.98,6.86,;-3.02,6.09,;-3.02,4.55,;-1.78,3.65,;-.45,4.42,;.76,3.65,;.12,2.32,;1.66,2.32,;2.22,4.42,;2.22,5.96,;3.56,3.65,;4.89,4.42,;6.22,3.65,;7.56,4.42,;7.56,5.96,;8.89,6.73,;6.22,6.73,;4.89,5.96,;-2.25,2.19,;-3.79,2.19,;-4.27,3.65,;-5.81,3.65,;-6.58,4.98,;-8.12,4.98,;-8.89,3.65,;-8.12,2.32,;-6.58,2.32,;-5.81,.98,)| Show InChI InChI=1S/C23H24FN7O4S/c1-14-8-9-25-13-17(14)22-28-29-23(31(22)21-18(34-3)6-5-7-19(21)35-4)30-36(32,33)15(2)10-20-26-11-16(24)12-27-20/h5-9,11-13,15H,10H2,1-4H3,(H,29,30)/t15-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 300 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269708
((2S)-N-(4-(2,6-dimethoxyphenyl)-5-(4-methyl-2-pyri...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)nnc1-c1cc(C)ccn1 |r,wU:16.17,(-7.03,5.9,;-5.69,5.13,;-4.36,5.9,;-4.36,7.44,;-3.02,8.21,;-1.69,7.44,;-1.69,5.9,;-.36,5.13,;.98,5.9,;-3.02,5.13,;-3.02,3.59,;-1.78,2.68,;-.45,3.45,;.89,2.68,;.12,1.35,;1.66,1.35,;2.22,3.45,;2.22,4.99,;3.56,2.68,;4.89,3.45,;6.22,2.68,;7.56,3.45,;7.56,4.99,;8.89,5.76,;6.22,5.76,;4.89,4.99,;-2.25,1.22,;-3.79,1.22,;-4.27,2.68,;-5.81,2.68,;-6.58,4.02,;-8.12,4.02,;-8.89,5.35,;-8.89,2.68,;-8.12,1.35,;-6.58,1.35,)| Show InChI InChI=1S/C23H24FN7O4S/c1-14-8-9-25-17(10-14)22-28-29-23(31(22)21-18(34-3)6-5-7-19(21)35-4)30-36(32,33)15(2)11-20-26-12-16(24)13-27-20/h5-10,12-13,15H,11H2,1-4H3,(H,29,30)/t15-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 11 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269710
((2S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-fluoro-3-pyri...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)nnc1-c1cncc(F)c1 |r,wU:16.17,(-7.03,5.9,;-5.69,5.13,;-4.36,5.9,;-4.36,7.44,;-3.02,8.21,;-1.69,7.44,;-1.69,5.9,;-.36,5.13,;.98,5.9,;-3.02,5.13,;-3.02,3.59,;-1.78,2.68,;-.45,3.45,;.89,2.68,;.12,1.35,;1.66,1.35,;2.22,3.45,;2.22,4.99,;3.56,2.68,;4.89,3.45,;6.22,2.68,;7.56,3.45,;7.56,4.99,;8.89,5.76,;6.22,5.76,;4.89,4.99,;-2.25,1.22,;-3.79,1.22,;-4.27,2.68,;-5.81,2.68,;-6.58,1.35,;-8.12,1.35,;-8.89,2.68,;-8.12,4.02,;-8.89,5.35,;-6.58,4.02,)| Show InChI InChI=1S/C22H21F2N7O4S/c1-13(7-19-26-11-16(24)12-27-19)36(32,33)30-22-29-28-21(14-8-15(23)10-25-9-14)31(22)20-17(34-2)5-4-6-18(20)35-3/h4-6,8-13H,7H2,1-3H3,(H,29,30)/t13-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 9.70 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269710
((2S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-fluoro-3-pyri...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)nnc1-c1cncc(F)c1 |r,wU:16.17,(-7.03,5.9,;-5.69,5.13,;-4.36,5.9,;-4.36,7.44,;-3.02,8.21,;-1.69,7.44,;-1.69,5.9,;-.36,5.13,;.98,5.9,;-3.02,5.13,;-3.02,3.59,;-1.78,2.68,;-.45,3.45,;.89,2.68,;.12,1.35,;1.66,1.35,;2.22,3.45,;2.22,4.99,;3.56,2.68,;4.89,3.45,;6.22,2.68,;7.56,3.45,;7.56,4.99,;8.89,5.76,;6.22,5.76,;4.89,4.99,;-2.25,1.22,;-3.79,1.22,;-4.27,2.68,;-5.81,2.68,;-6.58,1.35,;-8.12,1.35,;-8.89,2.68,;-8.12,4.02,;-8.89,5.35,;-6.58,4.02,)| Show InChI InChI=1S/C22H21F2N7O4S/c1-13(7-19-26-11-16(24)12-27-19)36(32,33)30-22-29-28-21(14-8-15(23)10-25-9-14)31(22)20-17(34-2)5-4-6-18(20)35-3/h4-6,8-13H,7H2,1-3H3,(H,29,30)/t13-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 88 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269713
(6-(4-(2,6-dimethoxyphenyl)-5-((((1S)-2-(5-fluoro-2...)Show SMILES CCNC(=O)c1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)n1-c1c(OC)cccc1OC |r,wU:19.20,(-5.04,2.44,;-5.81,1.1,;-7.35,1.1,;-8.12,2.44,;-9.66,2.44,;-7.35,3.77,;-8.12,5.1,;-7.35,6.44,;-5.81,6.44,;-5.04,5.1,;-5.81,3.77,;-3.5,5.1,;-3.02,3.64,;-1.48,3.64,;-1.01,5.1,;.32,5.87,;1.66,5.1,;.89,3.77,;2.43,3.77,;2.99,5.87,;2.99,7.41,;4.33,5.1,;5.66,5.87,;6.99,5.1,;8.33,5.87,;8.33,7.41,;9.66,8.18,;6.99,8.18,;5.66,7.41,;-2.25,6.01,;-2.25,7.55,;-3.59,8.32,;-4.92,7.55,;-6.26,8.32,;-3.59,9.86,;-2.25,10.63,;-.92,9.86,;-.92,8.32,;.41,7.55,;1.75,8.32,)| Show InChI InChI=1S/C25H27FN8O5S/c1-5-27-24(35)18-9-6-8-17(30-18)23-31-32-25(34(23)22-19(38-3)10-7-11-20(22)39-4)33-40(36,37)15(2)12-21-28-13-16(26)14-29-21/h6-11,13-15H,5,12H2,1-4H3,(H,27,35)(H,32,33)/t15-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 5.30 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269713
(6-(4-(2,6-dimethoxyphenyl)-5-((((1S)-2-(5-fluoro-2...)Show SMILES CCNC(=O)c1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)n1-c1c(OC)cccc1OC |r,wU:19.20,(-5.04,2.44,;-5.81,1.1,;-7.35,1.1,;-8.12,2.44,;-9.66,2.44,;-7.35,3.77,;-8.12,5.1,;-7.35,6.44,;-5.81,6.44,;-5.04,5.1,;-5.81,3.77,;-3.5,5.1,;-3.02,3.64,;-1.48,3.64,;-1.01,5.1,;.32,5.87,;1.66,5.1,;.89,3.77,;2.43,3.77,;2.99,5.87,;2.99,7.41,;4.33,5.1,;5.66,5.87,;6.99,5.1,;8.33,5.87,;8.33,7.41,;9.66,8.18,;6.99,8.18,;5.66,7.41,;-2.25,6.01,;-2.25,7.55,;-3.59,8.32,;-4.92,7.55,;-6.26,8.32,;-3.59,9.86,;-2.25,10.63,;-.92,9.86,;-.92,8.32,;.41,7.55,;1.75,8.32,)| Show InChI InChI=1S/C25H27FN8O5S/c1-5-27-24(35)18-9-6-8-17(30-18)23-31-32-25(34(23)22-19(38-3)10-7-11-20(22)39-4)33-40(36,37)15(2)12-21-28-13-16(26)14-29-21/h6-11,13-15H,5,12H2,1-4H3,(H,27,35)(H,32,33)/t15-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 4.20 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269733
((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-p...)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1ncccn1 |r,wU:3.3,2.1,(5.48,-3.92,;4.14,-3.15,;4.14,-1.61,;2.81,-.84,;2.81,.7,;1.48,-1.61,;.71,-2.94,;2.25,-2.94,;.14,-.84,;-1.19,-1.61,;-1.67,-3.07,;-3.21,-3.07,;-3.68,-1.61,;-5.17,-1.21,;-6.26,-2.3,;-7.75,-1.9,;-8.15,-.41,;-7.06,.68,;-7.45,2.16,;-5.57,.28,;-2.44,-.7,;-2.44,.84,;-3.77,1.61,;-5.1,.84,;-6.44,1.61,;-3.77,3.15,;-2.44,3.92,;-1.1,3.15,;-1.1,1.61,;.23,.84,;1.56,1.61,;5.48,-.84,;6.81,-1.61,;8.15,-.84,;8.15,.7,;6.81,1.47,;5.48,.7,)| Show InChI InChI=1S/C24H27N7O5S/c1-15-12-17(14-25-13-15)23-28-29-24(31(23)20-18(34-3)8-6-9-19(20)35-4)30-37(32,33)16(2)21(36-5)22-26-10-7-11-27-22/h6-14,16,21H,1-5H3,(H,29,30)/t16-,21-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 2.80 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM359988
((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@H](C)[C@H](O)c2ccc(F)cc2)n1-c1c(OC)cccc1OC |r,wU:18.19,wD:16.17,(-19.23,-7.92,;-19.06,-6.38,;-17.66,-5.76,;-17.5,-4.23,;-16.09,-3.6,;-14.84,-4.5,;-15.01,-6.04,;-16.41,-6.66,;-13.76,-6.94,;-13.76,-8.48,;-12.29,-8.96,;-11.39,-7.71,;-9.85,-7.71,;-9.08,-9.05,;-10.41,-9.82,;-8.31,-10.38,;-7.75,-8.28,;-7.75,-6.74,;-6.41,-9.05,;-6.41,-10.59,;-5.08,-8.28,;-3.74,-9.05,;-2.41,-8.28,;-2.41,-6.74,;-1.08,-5.97,;-3.74,-5.97,;-5.08,-6.74,;-12.29,-6.47,;-11.82,-5,;-12.85,-3.86,;-14.36,-4.18,;-15.39,-3.03,;-12.37,-2.39,;-10.87,-2.07,;-9.84,-3.22,;-10.31,-4.68,;-9.28,-5.83,;-7.78,-5.5,)| Show InChI InChI=1S/C25H26FN5O6S/c1-15(23(32)16-11-13-17(26)14-12-16)38(33,34)30-25-29-28-24(18-7-5-10-21(27-18)37-4)31(25)22-19(35-2)8-6-9-20(22)36-3/h5-15,23,32H,1-4H3,(H,29,30)/t15-,23+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 13 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM359993
((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)Show SMILES COc1cccc(n1)-c1nnc(N(CC[Si](C)(C)C)S(=O)(=O)[C@@H](C)[C@@H](O)c2ccc(F)cc2Br)n1-c1c(OC)cccc1OC |r,wU:22.23,wD:24.25,(-19.42,-10.09,;-19.74,-8.58,;-18.59,-7.55,;-18.91,-6.04,;-17.77,-5.01,;-16.3,-5.49,;-15.98,-6.99,;-17.13,-8.02,;-14.52,-7.47,;-14.04,-8.94,;-12.5,-8.94,;-12.03,-7.47,;-10.56,-6.99,;-10.24,-5.49,;-8.78,-5.01,;-8.46,-3.51,;-6.99,-3.03,;-9.6,-2.48,;-8.14,-2,;-9.42,-8.02,;-10.51,-9.11,;-9.02,-9.51,;-8.08,-7.25,;-8.08,-5.71,;-6.75,-8.02,;-6.75,-9.56,;-5.42,-7.25,;-5.42,-5.71,;-4.08,-4.94,;-2.75,-5.71,;-1.41,-4.94,;-2.75,-7.25,;-4.08,-8.02,;-4.08,-9.56,;-13.27,-6.57,;-13.27,-5.03,;-14.61,-4.26,;-15.94,-5.03,;-17.27,-4.26,;-14.61,-2.72,;-13.27,-1.95,;-11.94,-2.72,;-11.94,-4.26,;-10.6,-5.03,;-9.27,-4.26,)| Show InChI InChI=1S/C30H37BrFN5O6SSi/c1-19(28(38)21-15-14-20(32)18-22(21)31)44(39,40)36(16-17-45(5,6)7)30-35-34-29(23-10-8-13-26(33-23)43-4)37(30)27-24(41-2)11-9-12-25(27)42-3/h8-15,18-19,28,38H,16-17H2,1-7H3/t19-,28+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269768
((1R,2S)—N-(4-(2,6-dimethoxyphenyl)-5-(6-metho...)Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@H](C)[C@@H](O)c2ccc(F)cc2S(C)(=O)=O)n1-c1c(OC)cccc1OC |r,wD:18.19,16.17,(-8.62,-6.29,;-8.22,-4.81,;-6.73,-4.41,;-6.33,-2.92,;-4.85,-2.52,;-3.76,-3.61,;-4.16,-5.1,;-5.64,-5.5,;-3.07,-6.19,;-3.07,-7.73,;-1.6,-8.2,;-.7,-6.96,;.84,-6.96,;1.61,-8.29,;.28,-9.06,;2.38,-9.63,;2.95,-7.52,;2.95,-6.03,;4.24,-8.27,;4.24,-9.76,;5.53,-7.52,;5.53,-6.03,;6.82,-5.28,;8.12,-6.03,;9.41,-5.28,;8.12,-7.52,;6.82,-8.41,;6.82,-9.95,;5.28,-9.95,;6.82,-11.49,;8.36,-9.95,;-1.6,-5.71,;-1.17,-3.4,;.32,-3.01,;1.41,-4.1,;2.9,-3.7,;.72,-1.52,;-.37,-.43,;-1.86,-.83,;-2.26,-2.32,;-3.74,-2.71,;-4.83,-1.63,)| Show InChI InChI=1S/C26H28FN5O8S2/c1-15(24(33)17-13-12-16(27)14-21(17)41(5,34)35)42(36,37)31-26-30-29-25(18-8-6-11-22(28-18)40-4)32(26)23-19(38-2)9-7-10-20(23)39-3/h6-15,24,33H,1-5H3,(H,30,31)/t15-,24-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 11 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM359996
((1S,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-p...)Show SMILES COc1ccc(CN(Cc2ccc(OC)cc2)S(=O)(=O)[C@H](C)[C@H](O)c2nc(C)c(C)s2)cc1 |r| Show InChI InChI=1S/C24H30N2O5S2/c1-16-17(2)32-24(25-16)23(27)18(3)33(28,29)26(14-19-6-10-21(30-4)11-7-19)15-20-8-12-22(31-5)13-9-20/h6-13,18,23,27H,14-15H2,1-5H3/t18-,23+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.80 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM360002
((1S,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-p...)Show SMILES CO[C@@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1nc(C)c(C)s1 |r,wU:2.1,wD:3.3,(-5.81,-10.75,;-6.96,-9.72,;-6.64,-8.21,;-7.78,-7.18,;-7.46,-5.67,;-9.25,-7.65,;-10.02,-8.99,;-8.48,-8.99,;-10.39,-6.62,;-11.85,-7.1,;-12.33,-8.56,;-13.87,-8.56,;-14.35,-7.1,;-15.89,-7.1,;-16.66,-8.43,;-18.2,-8.43,;-18.97,-7.1,;-18.2,-5.77,;-18.97,-4.43,;-16.66,-5.77,;-13.1,-6.19,;-13.1,-4.65,;-14.43,-3.88,;-15.77,-4.65,;-17.1,-3.88,;-14.43,-2.34,;-13.1,-1.57,;-11.77,-2.34,;-11.77,-3.88,;-10.43,-4.65,;-9.1,-3.88,;-5.17,-7.73,;-3.93,-8.64,;-2.68,-7.73,;-1.22,-8.21,;-3.16,-6.27,;-2.25,-5.02,;-4.7,-6.27,)| Show InChI InChI=1S/C25H30N6O5S2/c1-14-11-18(13-26-12-14)23-28-29-25(31(23)21-19(34-5)9-8-10-20(21)35-6)30-38(32,33)17(4)22(36-7)24-27-15(2)16(3)37-24/h8-13,17,22H,1-7H3,(H,29,30)/t17-,22+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 2.10 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM360002
((1S,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-p...)Show SMILES CO[C@@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1nc(C)c(C)s1 |r,wU:2.1,wD:3.3,(-5.81,-10.75,;-6.96,-9.72,;-6.64,-8.21,;-7.78,-7.18,;-7.46,-5.67,;-9.25,-7.65,;-10.02,-8.99,;-8.48,-8.99,;-10.39,-6.62,;-11.85,-7.1,;-12.33,-8.56,;-13.87,-8.56,;-14.35,-7.1,;-15.89,-7.1,;-16.66,-8.43,;-18.2,-8.43,;-18.97,-7.1,;-18.2,-5.77,;-18.97,-4.43,;-16.66,-5.77,;-13.1,-6.19,;-13.1,-4.65,;-14.43,-3.88,;-15.77,-4.65,;-17.1,-3.88,;-14.43,-2.34,;-13.1,-1.57,;-11.77,-2.34,;-11.77,-3.88,;-10.43,-4.65,;-9.1,-3.88,;-5.17,-7.73,;-3.93,-8.64,;-2.68,-7.73,;-1.22,-8.21,;-3.16,-6.27,;-2.25,-5.02,;-4.7,-6.27,)| Show InChI InChI=1S/C25H30N6O5S2/c1-14-11-18(13-26-12-14)23-28-29-25(31(23)21-19(34-5)9-8-10-20(21)35-6)30-38(32,33)17(4)22(36-7)24-27-15(2)16(3)37-24/h8-13,17,22H,1-7H3,(H,29,30)/t17-,22+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 7.30 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM360017
((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-p...)Show SMILES CO[C@@H]([C@@H](C)S(=O)(=O)N(Cc1ccc(OC)cc1)Cc1ccc(OC)cc1)c1cnc(OC)cn1 |r| Show InChI InChI=1S/C25H31N3O6S/c1-18(25(34-5)23-14-27-24(33-4)15-26-23)35(29,30)28(16-19-6-10-21(31-2)11-7-19)17-20-8-12-22(32-3)13-9-20/h6-15,18,25H,16-17H2,1-5H3/t18-,25+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.660 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269792
((2R,3S)—N-(4-(2,6-dimethoxyphenyl)-5-(6-metho...)Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@H](C)[C@@H](C)c2ncc(C)cn2)n1-c1c(OC)cccc1OC |r,wD:18.19,16.17,(-10.75,-1.29,;-9.42,-2.06,;-8.07,-1.28,;-8.07,.28,;-6.72,1.06,;-5.37,.28,;-5.37,-1.28,;-6.72,-2.06,;-4.02,-2.06,;-3.54,-3.53,;-2,-3.53,;-1.53,-2.06,;-.2,-1.29,;.89,-2.38,;.12,-3.71,;1.29,-3.87,;2.38,-1.98,;2.78,-.5,;3.47,-3.07,;3.07,-4.56,;4.96,-2.67,;6.05,-3.76,;7.53,-3.36,;7.93,-1.88,;9.42,-1.48,;6.84,-.79,;5.36,-1.19,;-2.77,-1.16,;-2.77,1.48,;-4.11,2.25,;-5.44,1.48,;-6.78,2.25,;-4.11,3.79,;-2.77,4.56,;-1.44,3.79,;-1.44,2.25,;-.11,1.48,;1.25,2.21,)| Show InChI InChI=1S/C25H29N7O5S/c1-15-13-26-23(27-14-15)16(2)17(3)38(33,34)31-25-30-29-24(18-9-7-12-21(28-18)37-6)32(25)22-19(35-4)10-8-11-20(22)36-5/h7-14,16-17H,1-6H3,(H,30,31)/t16-,17-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 3.40 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269797
((1R,2S)-1-(4-cyanophenyl)-N-(4-(2,6-dimethoxypheny...)Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](O)c2ccc(cc2)C#N)n1-c1c(OC)cccc1OC |r,wU:16.17,18.19,(-10.66,6.44,;-9.12,6.44,;-8.35,5.1,;-9.12,3.77,;-8.35,2.43,;-6.81,2.43,;-6.04,3.77,;-6.81,5.1,;-4.5,3.77,;-4.03,2.3,;-2.49,2.3,;-2.01,3.77,;-.68,4.54,;.65,3.77,;1.05,2.28,;-.43,2.68,;2.19,3.77,;2.96,5.1,;2.96,2.43,;2.19,1.1,;4.5,2.43,;5.27,1.1,;6.81,1.1,;7.64,2.43,;6.81,3.77,;5.27,3.77,;9.18,2.44,;10.72,2.44,;-3.26,4.67,;-3.26,6.21,;-4.59,6.98,;-5.93,6.21,;-7.26,6.98,;-4.59,8.52,;-3.26,9.29,;-1.93,8.52,;-1.93,6.98,;-.59,6.21,;.74,6.98,)| Show InChI InChI=1S/C26H26N6O6S/c1-16(24(33)18-13-11-17(15-27)12-14-18)39(34,35)31-26-30-29-25(19-7-5-10-22(28-19)38-4)32(26)23-20(36-2)8-6-9-21(23)37-3/h5-14,16,24,33H,1-4H3,(H,30,31)/t16-,24-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269814
((2R)—N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-...)Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)C[C@@H](O)c2cc(C)no2)n1-c1c(OC)cccc1OC |r,wD:17.18,(-7.29,-14.62,;-7.69,-13.13,;-6.6,-12.04,;-7,-10.55,;-5.91,-9.46,;-4.42,-9.86,;-4.02,-11.35,;-5.11,-12.44,;-2.69,-12.12,;-2.21,-13.58,;-.67,-13.58,;-.2,-12.12,;1.14,-11.35,;2.47,-12.12,;1.38,-13.21,;3.56,-13.21,;3.56,-11.03,;5.05,-11.43,;5.44,-12.92,;6.13,-10.34,;6.13,-8.8,;7.6,-8.32,;8.37,-6.99,;8.5,-9.57,;7.6,-10.81,;-1.44,-11.21,;-1.44,-9.31,;-2.78,-8.54,;-4.11,-9.31,;-5.45,-8.54,;-2.78,-7,;-1.44,-6.23,;-.11,-7,;-.11,-8.54,;1.22,-9.31,;2.56,-8.54,)| Show InChI InChI=1S/C22H24N6O7S/c1-13-11-18(35-26-13)15(29)12-36(30,31)27-22-25-24-21(14-7-5-10-19(23-14)34-4)28(22)20-16(32-2)8-6-9-17(20)33-3/h5-11,15,29H,12H2,1-4H3,(H,25,27)/t15-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 4.5 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM360063
((1R,2S)-1-(4-cyano-2-fluorophenyl)-N-(4-(2,6-dimet...)Show SMILES CO[C@@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1ccc(cc1F)C#N |r,wU:2.1,wD:3.3,(3.06,2.09,;4.15,3.18,;3.75,4.67,;2.26,5.07,;1.86,6.55,;1.17,3.98,;.08,2.89,;2.26,2.89,;.08,5.07,;-1.4,4.67,;-1.88,3.2,;-3.42,3.2,;-3.9,4.67,;-5.38,5.07,;-5.78,6.55,;-7.27,6.95,;-8.36,5.86,;-7.96,4.37,;-9.05,3.29,;-6.47,3.98,;-2.65,5.57,;-2.65,7.11,;-3.98,7.88,;-5.32,7.11,;-6.65,7.88,;-3.98,9.42,;-2.65,10.19,;-1.32,9.42,;-1.32,7.88,;.02,7.11,;1.35,7.88,;4.84,5.76,;4.44,7.24,;5.53,8.33,;7.02,7.93,;7.41,6.45,;6.33,5.36,;6.72,3.87,;8.1,9.02,;9.19,10.11,)| Show InChI InChI=1S/C27H27FN6O5S/c1-16-11-19(15-30-14-16)26-31-32-27(34(26)24-22(37-3)7-6-8-23(24)38-4)33-40(35,36)17(2)25(39-5)20-10-9-18(13-29)12-21(20)28/h6-12,14-15,17,25H,1-5H3,(H,32,33)/t17-,25+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 43 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269837
((1R,2R)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methy...)Show SMILES CO[C@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1ncc(F)cn1 |r,wU:3.3,wD:2.1,(3.03,-11.82,;4.36,-11.05,;4.36,-9.51,;3.03,-8.74,;3.03,-7.2,;1.69,-9.51,;.92,-10.85,;2.46,-10.85,;.36,-8.74,;-.98,-9.51,;-1.45,-10.98,;-2.99,-10.98,;-3.47,-9.51,;-4.95,-9.11,;-5.72,-10.45,;-7.26,-10.45,;-8.03,-9.11,;-7.26,-7.78,;-8.03,-6.45,;-5.72,-7.78,;-2.22,-8.61,;-2.22,-7.07,;-.84,-6.32,;.49,-7.09,;1.83,-6.32,;-.89,-4.76,;-2.22,-3.99,;-3.56,-4.76,;-3.56,-6.3,;-4.89,-7.07,;-6.22,-6.3,;5.69,-8.74,;7.03,-9.51,;8.36,-8.74,;8.36,-7.2,;9.69,-6.43,;7.03,-6.43,;5.69,-7.2,)| Show InChI InChI=1S/C24H26FN7O5S/c1-14-9-16(11-26-10-14)23-29-30-24(32(23)20-18(35-3)7-6-8-19(20)36-4)31-38(33,34)15(2)21(37-5)22-27-12-17(25)13-28-22/h6-13,15,21H,1-5H3,(H,30,31)/t15-,21+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 10 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269852
((1R,2S)-1-amino-N-(4-(2,6-dimethoxyphenyl)-5-(6-me...)Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@H](C)[C@H](N)c2ncc(C)cn2)n1-c1c(OC)cccc1OC |r,wU:18.19,wD:16.17,(-8.84,-11.47,;-7.35,-11.86,;-6.95,-13.35,;-8.04,-14.44,;-7.64,-15.93,;-6.15,-16.33,;-5.06,-15.24,;-5.46,-13.75,;-3.58,-15.64,;-3.1,-17.1,;-1.56,-17.1,;-1.09,-15.64,;.25,-14.87,;1.58,-15.64,;.81,-16.97,;2.35,-16.97,;2.92,-14.87,;2.92,-13.33,;4.25,-15.64,;4.25,-17.18,;5.58,-14.87,;6.92,-15.64,;8.25,-14.87,;8.25,-13.33,;9.58,-12.56,;6.92,-12.56,;5.58,-13.33,;-2.33,-14.73,;-2.33,-13.19,;-3.67,-12.42,;-5,-13.19,;-6.33,-12.42,;-3.67,-10.88,;-2.33,-10.11,;-1,-10.88,;-1,-12.42,;.34,-13.19,;1.67,-12.42,)| Show InChI InChI=1S/C24H28N8O5S/c1-14-12-26-22(27-13-14)20(25)15(2)38(33,34)31-24-30-29-23(16-8-6-11-19(28-16)37-5)32(24)21-17(35-3)9-7-10-18(21)36-4/h6-13,15,20H,25H2,1-5H3,(H,30,31)/t15-,20+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 23 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269852
((1R,2S)-1-amino-N-(4-(2,6-dimethoxyphenyl)-5-(6-me...)Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@H](C)[C@H](N)c2ncc(C)cn2)n1-c1c(OC)cccc1OC |r,wU:18.19,wD:16.17,(-8.84,-11.47,;-7.35,-11.86,;-6.95,-13.35,;-8.04,-14.44,;-7.64,-15.93,;-6.15,-16.33,;-5.06,-15.24,;-5.46,-13.75,;-3.58,-15.64,;-3.1,-17.1,;-1.56,-17.1,;-1.09,-15.64,;.25,-14.87,;1.58,-15.64,;.81,-16.97,;2.35,-16.97,;2.92,-14.87,;2.92,-13.33,;4.25,-15.64,;4.25,-17.18,;5.58,-14.87,;6.92,-15.64,;8.25,-14.87,;8.25,-13.33,;9.58,-12.56,;6.92,-12.56,;5.58,-13.33,;-2.33,-14.73,;-2.33,-13.19,;-3.67,-12.42,;-5,-13.19,;-6.33,-12.42,;-3.67,-10.88,;-2.33,-10.11,;-1,-10.88,;-1,-12.42,;.34,-13.19,;1.67,-12.42,)| Show InChI InChI=1S/C24H28N8O5S/c1-14-12-26-22(27-13-14)20(25)15(2)38(33,34)31-24-30-29-23(16-8-6-11-19(28-16)37-5)32(24)21-17(35-3)9-7-10-18(21)36-4/h6-13,15,20H,25H2,1-5H3,(H,30,31)/t15-,20+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.570 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269868
((1S,2R)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methy...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](OCCO)c2ncc(C)cn2)nnc1-c1cncc(C)c1 |r,wU:18.19,16.17,(1.57,-2.91,;.24,-3.68,;-1.1,-2.91,;-1.14,-1.35,;-2.48,-.58,;-3.81,-1.35,;-3.81,-2.89,;-5.15,-3.66,;-6.48,-2.89,;-2.48,-3.66,;-2.48,-5.2,;-1.23,-6.1,;.1,-5.33,;1.44,-6.1,;.67,-7.43,;2.21,-7.43,;2.77,-5.33,;2.77,-3.79,;4.1,-6.1,;4.1,-7.64,;5.44,-8.41,;5.44,-9.95,;6.77,-10.72,;5.44,-5.33,;6.77,-6.1,;8.1,-5.33,;8.1,-3.79,;9.44,-3.02,;6.77,-3.02,;5.44,-3.79,;-1.71,-7.57,;-3.25,-7.57,;-3.72,-6.1,;-5.21,-5.7,;-5.98,-7.04,;-7.52,-7.04,;-8.29,-5.7,;-7.52,-4.37,;-8.29,-3.04,;-5.98,-4.37,)| Show InChI InChI=1S/C26H31N7O6S/c1-16-11-19(15-27-12-16)25-30-31-26(33(25)22-20(37-4)7-6-8-21(22)38-5)32-40(35,36)18(3)23(39-10-9-34)24-28-13-17(2)14-29-24/h6-8,11-15,18,23,34H,9-10H2,1-5H3,(H,31,32)/t18-,23-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 12 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269870
((1S,2R)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methy...)Show SMILES COCCO[C@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1 |r,wD:5.4,6.6,(6.64,-12.26,;6.64,-10.72,;5.31,-9.95,;5.31,-8.41,;3.98,-7.64,;3.98,-6.1,;2.64,-5.33,;2.64,-3.79,;1.31,-6.1,;.54,-7.43,;2.08,-7.43,;-.03,-5.33,;-1.36,-6.1,;-1.84,-7.57,;-3.38,-7.57,;-3.85,-6.1,;-5.34,-5.7,;-6.11,-7.04,;-7.65,-7.04,;-8.42,-5.7,;-7.65,-4.37,;-8.42,-3.04,;-6.11,-4.37,;-2.61,-5.2,;-2.61,-3.66,;-1.22,-2.91,;.11,-3.68,;1.44,-2.91,;-1.27,-1.35,;-2.61,-.58,;-3.94,-1.35,;-3.94,-2.89,;-5.27,-3.66,;-6.61,-2.89,;5.31,-5.33,;6.64,-6.1,;7.98,-5.33,;7.98,-3.79,;9.31,-3.02,;6.64,-3.02,;5.31,-3.79,)| Show InChI InChI=1S/C27H33N7O6S/c1-17-12-20(16-28-13-17)26-31-32-27(34(26)23-21(38-5)8-7-9-22(23)39-6)33-41(35,36)19(3)24(40-11-10-37-4)25-29-14-18(2)15-30-25/h7-9,12-16,19,24H,10-11H2,1-6H3,(H,32,33)/t19-,24-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM360102
((1S,2R)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-p...)Show SMILES COCCO[C@H]([C@@H](C)S(=O)(=O)N(C)c1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1 |r,wD:6.6,5.4,(6.66,-25.04,;6.66,-23.5,;5.32,-22.73,;5.32,-21.19,;3.99,-20.42,;3.99,-18.88,;2.66,-18.11,;2.66,-16.57,;1.32,-18.88,;.55,-20.21,;2.09,-20.21,;-.01,-18.11,;.31,-16.6,;-1.48,-18.58,;-1.93,-20.08,;-3.49,-20.05,;-3.97,-18.58,;-5.43,-18.11,;-6.2,-19.44,;-7.74,-19.44,;-8.51,-18.11,;-7.74,-16.77,;-8.51,-15.44,;-6.2,-16.77,;-2.72,-17.68,;-2.72,-16.14,;-1.34,-15.39,;-.01,-16.16,;1.33,-15.39,;-1.39,-13.83,;-2.72,-13.06,;-4.06,-13.83,;-4.06,-15.37,;-5.39,-16.14,;-6.57,-15.15,;5.32,-18.11,;6.66,-18.88,;7.99,-18.11,;7.99,-16.57,;9.32,-15.8,;6.66,-15.8,;5.32,-16.57,)| Show InChI InChI=1S/C28H35N7O6S/c1-18-13-21(17-29-14-18)27-32-33-28(35(27)24-22(39-6)9-8-10-23(24)40-7)34(4)42(36,37)20(3)25(41-12-11-38-5)26-30-15-19(2)16-31-26/h8-10,13-17,20,25H,11-12H2,1-7H3/t20-,25-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 13 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269916
((2S,3R)—N-(4-(4,6-dimethoxy-5-pyrimidinyl)-5-...)Show SMILES COc1ncnc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(F)cn2)nnc1-c1cncc(C)c1 |r,wU:18.19,16.17,(2.17,-4.02,;1.08,-5.11,;-.4,-4.71,;-.8,-3.23,;-2.29,-2.83,;-3.38,-3.92,;-2.98,-5.4,;-4.07,-6.49,;-5.56,-6.09,;-1.49,-5.8,;-1.09,-7.29,;.37,-7.77,;1.7,-7,;3.04,-7.77,;2.27,-9.1,;4.37,-8.54,;3.81,-6.43,;3.04,-5.1,;5.35,-6.43,;6.12,-7.77,;6.12,-5.1,;7.66,-5.1,;8.43,-3.76,;7.66,-2.43,;8.43,-1.1,;6.12,-2.43,;5.35,-3.76,;.37,-9.31,;-1.09,-9.78,;-2,-8.54,;-3.54,-8.54,;-4.31,-7.2,;-5.85,-7.2,;-6.62,-8.54,;-5.85,-9.87,;-6.62,-11.2,;-4.31,-9.87,)| Show InChI InChI=1S/C22H24FN9O4S/c1-12-6-15(8-24-7-12)19-29-30-22(32(19)17-20(35-4)27-11-28-21(17)36-5)31-37(33,34)14(3)13(2)18-25-9-16(23)10-26-18/h6-11,13-14H,1-5H3,(H,30,31)/t13-,14-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 3.20 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269943
((1R,2R)-1-(2,4-dicyanophenyl)-N-(4-(2,6-dimethoxyp...)Show SMILES CO[C@@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ccc(cc1C#N)C#N |r,wU:2.1,wD:3.3,(-3.28,-10.32,;-2.38,-9.07,;-.85,-9.24,;.06,-7.99,;1.59,-8.15,;-.57,-6.58,;-1.97,-7.21,;.84,-5.96,;-1.19,-5.18,;-.29,-3.93,;1.25,-3.93,;1.73,-2.47,;.48,-1.56,;.48,-.02,;-.85,.75,;-.85,2.29,;.48,3.06,;1.82,2.29,;3.15,3.06,;3.15,4.6,;1.82,.75,;-.76,-2.47,;-2.23,-1.99,;-2.55,-.48,;-1.4,.55,;-1.72,2.05,;-4.01,-.01,;-5.16,-1.04,;-4.84,-2.54,;-3.37,-3.02,;-3.05,-4.53,;-4.2,-5.56,;-.22,-10.64,;1.31,-10.8,;1.94,-12.21,;1.03,-13.46,;-.5,-13.29,;-1.12,-11.89,;-2.66,-11.73,;-4.19,-11.57,;1.66,-14.86,;2.29,-16.27,)| Show InChI InChI=1S/C28H27N7O6S/c1-17(26(41-5)20-13-12-18(15-29)14-19(20)16-30)42(36,37)34-28-33-32-27(21-8-6-11-24(31-21)40-4)35(28)25-22(38-2)9-7-10-23(25)39-3/h6-14,17,26H,1-5H3,(H,33,34)/t17-,26+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.550 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269948
((2S)-2-(4-cyano-2-(methylsulfonyl)phenyl)-N-(4-(2,...)Show SMILES COc1cccc(n1)-c1nnc(N(CC[Si](C)(C)C)S(=O)(=O)C[C@@H](O)c2ccc(Cl)cc2S(C)(=O)=O)n1-c1c(OC)cccc1OC |r,wD:23.24,(-9.02,-10.12,;-9.42,-8.63,;-8.33,-7.54,;-8.73,-6.05,;-7.64,-4.96,;-6.15,-5.36,;-5.76,-6.85,;-6.84,-7.94,;-4.27,-7.25,;-3.79,-8.71,;-2.25,-8.71,;-1.78,-7.25,;-.44,-6.48,;-1.21,-7.81,;-.44,-9.14,;-1.21,-10.48,;-2.55,-9.71,;.12,-11.25,;-1.98,-11.81,;.89,-7.25,;1.66,-8.58,;.12,-8.58,;2.23,-6.48,;3.56,-7.25,;3.56,-8.79,;4.89,-6.48,;6.23,-7.25,;7.56,-6.48,;7.56,-4.94,;8.89,-4.17,;6.23,-4.17,;4.89,-4.94,;3.56,-4.17,;2.23,-4.94,;2.79,-2.83,;4.33,-2.83,;-3.02,-6.34,;-3.02,-4.8,;-4.36,-4.03,;-5.69,-4.8,;-7.02,-4.03,;-4.36,-2.49,;-3.02,-1.72,;-1.69,-2.49,;-1.69,-4.03,;-.35,-4.8,;.98,-4.03,)| Show InChI InChI=1S/C30H38ClN5O8S2Si/c1-42-24-11-9-12-25(43-2)28(24)36-29(22-10-8-13-27(32-22)44-3)33-34-30(36)35(16-17-47(5,6)7)46(40,41)19-23(37)21-15-14-20(31)18-26(21)45(4,38)39/h8-15,18,23,37H,16-17,19H2,1-7H3/t23-/m1/s1 | PDB
Reactome pathway
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UniProtKB/SwissProt
B.MOAD
antibodypedia
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AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.240 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
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