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USPatent US8895592

Compile data set for download or QSAR
Found 76 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM139889
PNG
(US8895592, 19)
Show SMILES CC(C)Cn1cc(s\c1=N/C(=O)c1cc(ccc1OCCO)C(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C21H27F3N2O3S/c1-13(2)11-26-12-17(20(3,4)5)30-19(26)25-18(28)15-10-14(21(22,23)24)6-7-16(15)29-9-8-27/h6-7,10,12-13,27H,8-9,11H2,1-5H3/b25-19-
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AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM139889
PNG
(US8895592, 19)
Show SMILES CC(C)Cn1cc(s\c1=N/C(=O)c1cc(ccc1OCCO)C(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C21H27F3N2O3S/c1-13(2)11-26-12-17(20(3,4)5)30-19(26)25-18(28)15-10-14(21(22,23)24)6-7-16(15)29-9-8-27/h6-7,10,12-13,27H,8-9,11H2,1-5H3/b25-19-
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AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM139900
PNG
(US8895592, 30)
Show SMILES CC(C)(C)NOc1ccc(cc1C(=O)\N=c1/sc(cn1CCC#C)C(C)(C)C)C(F)(F)F
Show InChI InChI=1S/C23H28F3N3O2S/c1-8-9-12-29-14-18(21(2,3)4)32-20(29)27-19(30)16-13-15(23(24,25)26)10-11-17(16)31-28-22(5,6)7/h1,10-11,13-14,28H,9,12H2,2-7H3/b27-20-
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US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM139906
PNG
(US8895592, 37)
Show SMILES CCCCn1cc(s\c1=N/C(=O)c1cc(ccc1NNC(=O)c1cccnc1)C(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C25H28F3N5O2S/c1-5-6-12-33-15-20(24(2,3)4)36-23(33)30-22(35)18-13-17(25(26,27)28)9-10-19(18)31-32-21(34)16-8-7-11-29-14-16/h7-11,13-15,31H,5-6,12H2,1-4H3,(H,32,34)/b30-23-
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US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM139902
PNG
(US8895592, 32)
Show SMILES CCCCn1cc(s\c1=N/C(=O)c1cc(ccc1OCC(C)(C)O)C(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C23H31F3N2O3S/c1-7-8-11-28-13-18(21(2,3)4)32-20(28)27-19(29)16-12-15(23(24,25)26)9-10-17(16)31-14-22(5,6)30/h9-10,12-13,30H,7-8,11,14H2,1-6H3/b27-20-
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US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM139893
PNG
(US8895592, 23)
Show SMILES CCCCn1cc(s\c1=N/C(=O)c1cc(ccc1ONC(C)(C)C)C(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C23H32F3N3O2S/c1-8-9-12-29-14-18(21(2,3)4)32-20(29)27-19(30)16-13-15(23(24,25)26)10-11-17(16)31-28-22(5,6)7/h10-11,13-14,28H,8-9,12H2,1-7H3/b27-20-
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US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM139885
PNG
(US8895592, 15)
Show SMILES CC(C)Cn1cc(s\c1=N/C(=O)c1cc(Cl)ccc1OC1CC1)C(C)(C)C
Show InChI InChI=1S/C21H27ClN2O2S/c1-13(2)11-24-12-18(21(3,4)5)27-20(24)23-19(25)16-10-14(22)6-9-17(16)26-15-7-8-15/h6,9-10,12-13,15H,7-8,11H2,1-5H3/b23-20-
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US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM139887
PNG
(US8895592, 17)
Show SMILES CC(C)(C)c1cn(CCC(F)(F)F)\c(=N\C(=O)c2cc(ccc2OC2CCC2)C#N)s1
Show InChI InChI=1S/C22H24F3N3O2S/c1-21(2,3)18-13-28(10-9-22(23,24)25)20(31-18)27-19(29)16-11-14(12-26)7-8-17(16)30-15-5-4-6-15/h7-8,11,13,15H,4-6,9-10H2,1-3H3/b27-20-
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US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM139907
PNG
(US8895592, 38)
Show SMILES CCCCn1cc(s\c1=N/C(=O)c1cc(ccc1NNC(=O)c1ccncc1)C(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C25H28F3N5O2S/c1-5-6-13-33-15-20(24(2,3)4)36-23(33)30-22(35)18-14-17(25(26,27)28)7-8-19(18)31-32-21(34)16-9-11-29-12-10-16/h7-12,14-15,31H,5-6,13H2,1-4H3,(H,32,34)/b30-23-
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US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM139872
PNG
(US8895592, 2)
Show SMILES CCCCn1cc(s\c1=N/C(=O)c1cc(Cl)ccc1OCC(N)=O)C(C)(C)C
Show InChI InChI=1S/C20H26ClN3O3S/c1-5-6-9-24-11-16(20(2,3)4)28-19(24)23-18(26)14-10-13(21)7-8-15(14)27-12-17(22)25/h7-8,10-11H,5-6,9,12H2,1-4H3,(H2,22,25)/b23-19-
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US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM139902
PNG
(US8895592, 32)
Show SMILES CCCCn1cc(s\c1=N/C(=O)c1cc(ccc1OCC(C)(C)O)C(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C23H31F3N2O3S/c1-7-8-11-28-13-18(21(2,3)4)32-20(28)27-19(29)16-12-15(23(24,25)26)9-10-17(16)31-14-22(5,6)30/h9-10,12-13,30H,7-8,11,14H2,1-6H3/b27-20-
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US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM139905
PNG
(US8895592, 36)
Show SMILES CCCCn1c2cccnc2sc1=NC(=O)c1cc(ccc1OC[C@H](C)O)C(F)(F)F |w:13.15|
Show InChI InChI=1S/C21H22F3N3O3S/c1-3-4-10-27-16-6-5-9-25-19(16)31-20(27)26-18(29)15-11-14(21(22,23)24)7-8-17(15)30-12-13(2)28/h5-9,11,13,28H,3-4,10,12H2,1-2H3/b26-20-/t13-/m0/s1
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US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM139888
PNG
(US8895592, 18)
Show SMILES CC(C)Cn1cc(s\c1=N/C(=O)c1cc(ccc1OCCOC(C)=O)C(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C23H29F3N2O4S/c1-14(2)12-28-13-19(22(4,5)6)33-21(28)27-20(30)17-11-16(23(24,25)26)7-8-18(17)32-10-9-31-15(3)29/h7-8,11,13-14H,9-10,12H2,1-6H3/b27-21-
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US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM139895
PNG
(US8895592, 25)
Show SMILES CCCCn1c2cnccc2s\c1=N/C(=O)c1cc(ccc1OCCNC(C)=O)C(F)(F)F
Show InChI InChI=1S/C22H23F3N4O3S/c1-3-4-10-29-17-13-26-8-7-19(17)33-21(29)28-20(31)16-12-15(22(23,24)25)5-6-18(16)32-11-9-27-14(2)30/h5-8,12-13H,3-4,9-11H2,1-2H3,(H,27,30)/b28-21-
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US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM139906
PNG
(US8895592, 37)
Show SMILES CCCCn1cc(s\c1=N/C(=O)c1cc(ccc1NNC(=O)c1cccnc1)C(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C25H28F3N5O2S/c1-5-6-12-33-15-20(24(2,3)4)36-23(33)30-22(35)18-13-17(25(26,27)28)9-10-19(18)31-32-21(34)16-8-7-11-29-14-16/h7-11,13-15,31H,5-6,12H2,1-4H3,(H,32,34)/b30-23-
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US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM139901
PNG
(US8895592, 31)
Show SMILES CC(C)(C)NOc1ccc(cc1C(=O)\N=c1/sc(cn1CC=C=C)C(C)(C)C)C(F)(F)F
Show InChI InChI=1S/C23H28F3N3O2S/c1-8-9-12-29-14-18(21(2,3)4)32-20(29)27-19(30)16-13-15(23(24,25)26)10-11-17(16)31-28-22(5,6)7/h9-11,13-14,28H,1,12H2,2-7H3/b27-20-
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US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM139899
PNG
(US8895592, 29)
Show SMILES CCCCn1c2cnccc2s\c1=N/C(=O)c1cc(ccc1OC[C@H](C)O)C(F)(F)F
Show InChI InChI=1S/C21H22F3N3O3S/c1-3-4-9-27-16-11-25-8-7-18(16)31-20(27)26-19(29)15-10-14(21(22,23)24)5-6-17(15)30-12-13(2)28/h5-8,10-11,13,28H,3-4,9,12H2,1-2H3/b26-20-/t13-/m0/s1
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US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM139905
PNG
(US8895592, 36)
Show SMILES CCCCn1c2cccnc2sc1=NC(=O)c1cc(ccc1OC[C@H](C)O)C(F)(F)F |w:13.15|
Show InChI InChI=1S/C21H22F3N3O3S/c1-3-4-10-27-16-6-5-9-25-19(16)31-20(27)26-18(29)15-11-14(21(22,23)24)7-8-17(15)30-12-13(2)28/h5-9,11,13,28H,3-4,10,12H2,1-2H3/b26-20-/t13-/m0/s1
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US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM139907
PNG
(US8895592, 38)
Show SMILES CCCCn1cc(s\c1=N/C(=O)c1cc(ccc1NNC(=O)c1ccncc1)C(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C25H28F3N5O2S/c1-5-6-13-33-15-20(24(2,3)4)36-23(33)30-22(35)18-14-17(25(26,27)28)7-8-19(18)31-32-21(34)16-9-11-29-12-10-16/h7-12,14-15,31H,5-6,13H2,1-4H3,(H,32,34)/b30-23-
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US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM139878
PNG
(US8895592, 8)
Show SMILES CC(C)Cn1cc(s\c1=N/C(=O)c1cc(ccc1OCC1CCOC1)C(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C24H31F3N2O3S/c1-15(2)11-29-12-20(23(3,4)5)33-22(29)28-21(30)18-10-17(24(25,26)27)6-7-19(18)32-14-16-8-9-31-13-16/h6-7,10,12,15-16H,8-9,11,13-14H2,1-5H3/b28-22-
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US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM139899
PNG
(US8895592, 29)
Show SMILES CCCCn1c2cnccc2s\c1=N/C(=O)c1cc(ccc1OC[C@H](C)O)C(F)(F)F
Show InChI InChI=1S/C21H22F3N3O3S/c1-3-4-9-27-16-11-25-8-7-18(16)31-20(27)26-19(29)15-10-14(21(22,23)24)5-6-17(15)30-12-13(2)28/h5-8,10-11,13,28H,3-4,9,12H2,1-2H3/b26-20-/t13-/m0/s1
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 2.5n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM139896
PNG
(US8895592, 26)
Show SMILES CC(C)(O)COc1ccc(cc1C(=O)\N=c1/sc2ccncc2n1CC1CCC1)C(F)(F)F
Show InChI InChI=1S/C23H24F3N3O3S/c1-22(2,31)13-32-18-7-6-15(23(24,25)26)10-16(18)20(30)28-21-29(12-14-4-3-5-14)17-11-27-9-8-19(17)33-21/h6-11,14,31H,3-5,12-13H2,1-2H3/b28-21-
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AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM139872
PNG
(US8895592, 2)
Show SMILES CCCCn1cc(s\c1=N/C(=O)c1cc(Cl)ccc1OCC(N)=O)C(C)(C)C
Show InChI InChI=1S/C20H26ClN3O3S/c1-5-6-9-24-11-16(20(2,3)4)28-19(24)23-18(26)14-10-13(21)7-8-15(14)27-12-17(22)25/h7-8,10-11H,5-6,9,12H2,1-4H3,(H2,22,25)/b23-19-
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 3.10n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM139895
PNG
(US8895592, 25)
Show SMILES CCCCn1c2cnccc2s\c1=N/C(=O)c1cc(ccc1OCCNC(C)=O)C(F)(F)F
Show InChI InChI=1S/C22H23F3N4O3S/c1-3-4-10-29-17-13-26-8-7-19(17)33-21(29)28-20(31)16-12-15(22(23,24)25)5-6-18(16)32-11-9-27-14(2)30/h5-8,12-13H,3-4,9-11H2,1-2H3,(H,27,30)/b28-21-
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AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM139878
PNG
(US8895592, 8)
Show SMILES CC(C)Cn1cc(s\c1=N/C(=O)c1cc(ccc1OCC1CCOC1)C(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C24H31F3N2O3S/c1-15(2)11-29-12-20(23(3,4)5)33-22(29)28-21(30)18-10-17(24(25,26)27)6-7-19(18)32-14-16-8-9-31-13-16/h6-7,10,12,15-16H,8-9,11,13-14H2,1-5H3/b28-22-
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AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM139874
PNG
(US8895592, 4)
Show SMILES CC(C)Cn1cc(s\c1=N/C(=O)c1cc(Cl)ccc1OCC1CCO1)C(C)(C)C
Show InChI InChI=1S/C22H29ClN2O3S/c1-14(2)11-25-12-19(22(3,4)5)29-21(25)24-20(26)17-10-15(23)6-7-18(17)28-13-16-8-9-27-16/h6-7,10,12,14,16H,8-9,11,13H2,1-5H3/b24-21-
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AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM139886
PNG
(US8895592, 16)
Show SMILES CC(C)Cn1cc(s\c1=N/C(=O)c1cc(ccc1OC1CCC1)C#N)C(C)(C)C
Show InChI InChI=1S/C23H29N3O2S/c1-15(2)13-26-14-20(23(3,4)5)29-22(26)25-21(27)18-11-16(12-24)9-10-19(18)28-17-7-6-8-17/h9-11,14-15,17H,6-8,13H2,1-5H3/b25-22-
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AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM139891
PNG
(US8895592, 21)
Show SMILES CCCCn1c2cnccc2s\c1=N/C(=O)c1cc(ccc1OCC(C)(C)O)C(F)(F)F
Show InChI InChI=1S/C22H24F3N3O3S/c1-4-5-10-28-16-12-26-9-8-18(16)32-20(28)27-19(29)15-11-14(22(23,24)25)6-7-17(15)31-13-21(2,3)30/h6-9,11-12,30H,4-5,10,13H2,1-3H3/b27-20-
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AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM139893
PNG
(US8895592, 23)
Show SMILES CCCCn1cc(s\c1=N/C(=O)c1cc(ccc1ONC(C)(C)C)C(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C23H32F3N3O2S/c1-8-9-12-29-14-18(21(2,3)4)32-20(29)27-19(30)16-13-15(23(24,25)26)10-11-17(16)31-28-22(5,6)7/h10-11,13-14,28H,8-9,12H2,1-7H3/b27-20-
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AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM139896
PNG
(US8895592, 26)
Show SMILES CC(C)(O)COc1ccc(cc1C(=O)\N=c1/sc2ccncc2n1CC1CCC1)C(F)(F)F
Show InChI InChI=1S/C23H24F3N3O3S/c1-22(2,31)13-32-18-7-6-15(23(24,25)26)10-16(18)20(30)28-21-29(12-14-4-3-5-14)17-11-27-9-8-19(17)33-21/h6-11,14,31H,3-5,12-13H2,1-2H3/b28-21-
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AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM139873
PNG
(US8895592, 3)
Show SMILES CC(C)Cn1cc(s\c1=N/C(=O)c1cc(ccc1OCc1ccco1)C(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C24H27F3N2O3S/c1-15(2)12-29-13-20(23(3,4)5)33-22(29)28-21(30)18-11-16(24(25,26)27)8-9-19(18)32-14-17-7-6-10-31-17/h6-11,13,15H,12,14H2,1-5H3/b28-22-
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AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM139879
PNG
(US8895592, 9)
Show SMILES CCCCn1cc(s\c1=N/C(=O)c1cc(ccc1OC[C@@H]1CCCN1C)C(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C25H34F3N3O2S/c1-6-7-13-31-15-21(24(2,3)4)34-23(31)29-22(32)19-14-17(25(26,27)28)10-11-20(19)33-16-18-9-8-12-30(18)5/h10-11,14-15,18H,6-9,12-13,16H2,1-5H3/b29-23-/t18-/m0/s1
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AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM139897
PNG
(US8895592, 27)
Show SMILES CC(C)(O)COc1ccc(cc1C(=O)\N=c1/sc2ccncc2n1CCCC(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C22H21F6N3O3S/c1-20(2,33)12-34-16-5-4-13(22(26,27)28)10-14(16)18(32)30-19-31(9-3-7-21(23,24)25)15-11-29-8-6-17(15)35-19/h4-6,8,10-11,33H,3,7,9,12H2,1-2H3/b30-19-
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AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM139873
PNG
(US8895592, 3)
Show SMILES CC(C)Cn1cc(s\c1=N/C(=O)c1cc(ccc1OCc1ccco1)C(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C24H27F3N2O3S/c1-15(2)12-29-13-20(23(3,4)5)33-22(29)28-21(30)18-11-16(24(25,26)27)8-9-19(18)32-14-17-7-6-10-31-17/h6-11,13,15H,12,14H2,1-5H3/b28-22-
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 8.70n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM139874
PNG
(US8895592, 4)
Show SMILES CC(C)Cn1cc(s\c1=N/C(=O)c1cc(Cl)ccc1OCC1CCO1)C(C)(C)C
Show InChI InChI=1S/C22H29ClN2O3S/c1-14(2)11-25-12-19(22(3,4)5)29-21(25)24-20(26)17-10-15(23)6-7-18(17)28-13-16-8-9-27-16/h6-7,10,12,14,16H,8-9,11,13H2,1-5H3/b24-21-
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AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM139879
PNG
(US8895592, 9)
Show SMILES CCCCn1cc(s\c1=N/C(=O)c1cc(ccc1OC[C@@H]1CCCN1C)C(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C25H34F3N3O2S/c1-6-7-13-31-15-21(24(2,3)4)34-23(31)29-22(32)19-14-17(25(26,27)28)10-11-20(19)33-16-18-9-8-12-30(18)5/h10-11,14-15,18H,6-9,12-13,16H2,1-5H3/b29-23-/t18-/m0/s1
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 9.20n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM139891
PNG
(US8895592, 21)
Show SMILES CCCCn1c2cnccc2s\c1=N/C(=O)c1cc(ccc1OCC(C)(C)O)C(F)(F)F
Show InChI InChI=1S/C22H24F3N3O3S/c1-4-5-10-28-16-12-26-9-8-18(16)32-20(28)27-19(29)15-11-14(22(23,24)25)6-7-17(15)31-13-21(2,3)30/h6-9,11-12,30H,4-5,10,13H2,1-3H3/b27-20-
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AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM139885
PNG
(US8895592, 15)
Show SMILES CC(C)Cn1cc(s\c1=N/C(=O)c1cc(Cl)ccc1OC1CC1)C(C)(C)C
Show InChI InChI=1S/C21H27ClN2O2S/c1-13(2)11-24-12-18(21(3,4)5)27-20(24)23-19(25)16-10-14(22)6-9-17(16)26-15-7-8-15/h6,9-10,12-13,15H,7-8,11H2,1-5H3/b23-20-
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AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM139897
PNG
(US8895592, 27)
Show SMILES CC(C)(O)COc1ccc(cc1C(=O)\N=c1/sc2ccncc2n1CCCC(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C22H21F6N3O3S/c1-20(2,33)12-34-16-5-4-13(22(26,27)28)10-14(16)18(32)30-19-31(9-3-7-21(23,24)25)15-11-29-8-6-17(15)35-19/h4-6,8,10-11,33H,3,7,9,12H2,1-2H3/b30-19-
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 10n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM139877
PNG
(US8895592, 7)
Show SMILES CC(C)Cn1cc(s\c1=N/C(=O)c1cc(ccc1OCCN1CCCC1)C(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C25H34F3N3O2S/c1-17(2)15-31-16-21(24(3,4)5)34-23(31)29-22(32)19-14-18(25(26,27)28)8-9-20(19)33-13-12-30-10-6-7-11-30/h8-9,14,16-17H,6-7,10-13,15H2,1-5H3/b29-23-
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AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM139884
PNG
(US8895592, 14)
Show SMILES CC(C)Cn1cc(s\c1=N/C(=O)c1cc(ccc1OC[C@@H]1CCN1)C(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C23H30F3N3O2S/c1-14(2)11-29-12-19(22(3,4)5)32-21(29)28-20(30)17-10-15(23(24,25)26)6-7-18(17)31-13-16-8-9-27-16/h6-7,10,12,14,16,27H,8-9,11,13H2,1-5H3/b28-21-/t16-/m0/s1
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 13n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM139900
PNG
(US8895592, 30)
Show SMILES CC(C)(C)NOc1ccc(cc1C(=O)\N=c1/sc(cn1CCC#C)C(C)(C)C)C(F)(F)F
Show InChI InChI=1S/C23H28F3N3O2S/c1-8-9-12-29-14-18(21(2,3)4)32-20(29)27-19(30)16-13-15(23(24,25)26)10-11-17(16)31-28-22(5,6)7/h1,10-11,13-14,28H,9,12H2,2-7H3/b27-20-
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 15n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM139904
PNG
(US8895592, 35)
Show SMILES CCCCn1c2cccnc2sc1=NC(=O)c1cc(ccc1OCC(C)(C)O)C(F)(F)F |w:13.15|
Show InChI InChI=1S/C22H24F3N3O3S/c1-4-5-11-28-16-7-6-10-26-19(16)32-20(28)27-18(29)15-12-14(22(23,24)25)8-9-17(15)31-13-21(2,3)30/h6-10,12,30H,4-5,11,13H2,1-3H3/b27-20-
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 15n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM139888
PNG
(US8895592, 18)
Show SMILES CC(C)Cn1cc(s\c1=N/C(=O)c1cc(ccc1OCCOC(C)=O)C(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C23H29F3N2O4S/c1-14(2)12-28-13-19(22(4,5)6)33-21(28)27-20(30)17-11-16(23(24,25)26)7-8-18(17)32-10-9-31-15(3)29/h7-8,11,13-14H,9-10,12H2,1-6H3/b27-21-
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 16n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM139901
PNG
(US8895592, 31)
Show SMILES CC(C)(C)NOc1ccc(cc1C(=O)\N=c1/sc(cn1CC=C=C)C(C)(C)C)C(F)(F)F
Show InChI InChI=1S/C23H28F3N3O2S/c1-8-9-12-29-14-18(21(2,3)4)32-20(29)27-19(30)16-13-15(23(24,25)26)10-11-17(16)31-28-22(5,6)7/h9-11,13-14,28H,1,12H2,2-7H3/b27-20-
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 17n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM139875
PNG
(US8895592, 5)
Show SMILES CC(C)Cn1cc(s\c1=N/C(=O)c1cc(ccc1OC[C@@H]1CCCN1C)C(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C25H34F3N3O2S/c1-16(2)13-31-14-21(24(3,4)5)34-23(31)29-22(32)19-12-17(25(26,27)28)9-10-20(19)33-15-18-8-7-11-30(18)6/h9-10,12,14,16,18H,7-8,11,13,15H2,1-6H3/b29-23-/t18-/m0/s1
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 18n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM139871
PNG
(US8895592, 1)
Show SMILES CC(C)Cn1cc(s\c1=N/C(=O)c1cc(Br)ccc1OC[C@@H]1CCCN1C)C(C)(C)C
Show InChI InChI=1S/C24H34BrN3O2S/c1-16(2)13-28-14-21(24(3,4)5)31-23(28)26-22(29)19-12-17(25)9-10-20(19)30-15-18-8-7-11-27(18)6/h9-10,12,14,16,18H,7-8,11,13,15H2,1-6H3/b26-23-/t18-/m0/s1
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 19n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM139882
PNG
(US8895592, 12)
Show SMILES CC(C)Cn1cc(s\c1=N/C(=O)c1cc(ccc1OC[C@@H]1CCN1C)C(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C24H32F3N3O2S/c1-15(2)12-30-13-20(23(3,4)5)33-22(30)28-21(31)18-11-16(24(25,26)27)7-8-19(18)32-14-17-9-10-29(17)6/h7-8,11,13,15,17H,9-10,12,14H2,1-6H3/b28-22-/t17-/m0/s1
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 26n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM139871
PNG
(US8895592, 1)
Show SMILES CC(C)Cn1cc(s\c1=N/C(=O)c1cc(Br)ccc1OC[C@@H]1CCCN1C)C(C)(C)C
Show InChI InChI=1S/C24H34BrN3O2S/c1-16(2)13-28-14-21(24(3,4)5)31-23(28)26-22(29)19-12-17(25)9-10-20(19)30-15-18-8-7-11-27(18)6/h9-10,12,14,16,18H,7-8,11,13,15H2,1-6H3/b26-23-/t18-/m0/s1
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 27n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM139904
PNG
(US8895592, 35)
Show SMILES CCCCn1c2cccnc2sc1=NC(=O)c1cc(ccc1OCC(C)(C)O)C(F)(F)F |w:13.15|
Show InChI InChI=1S/C22H24F3N3O3S/c1-4-5-11-28-16-7-6-10-26-19(16)32-20(28)27-18(29)15-12-14(22(23,24)25)8-9-17(15)31-13-21(2,3)30/h6-10,12,30H,4-5,11,13H2,1-3H3/b27-20-
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 28n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM139894
PNG
(US8895592, 24)
Show SMILES CN1CCC[C@H]1COc1ccc(cc1C(=O)\N=c1/sc(C)c(C)n1CC1CC1)C(F)(F)F
Show InChI InChI=1S/C23H28F3N3O2S/c1-14-15(2)32-22(29(14)12-16-6-7-16)27-21(30)19-11-17(23(24,25)26)8-9-20(19)31-13-18-5-4-10-28(18)3/h8-9,11,16,18H,4-7,10,12-13H2,1-3H3/b27-22-/t18-/m0/s1
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 30n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM139881
PNG
(US8895592, 11)
Show SMILES CN1CCC[C@H]1COc1ccc(cc1C(=O)\N=c1/sc(cn1CC1(O)CCC1)C(C)(C)C)C(F)(F)F
Show InChI InChI=1S/C26H34F3N3O3S/c1-24(2,3)21-14-32(16-25(34)10-6-11-25)23(36-21)30-22(33)19-13-17(26(27,28)29)8-9-20(19)35-15-18-7-5-12-31(18)4/h8-9,13-14,18,34H,5-7,10-12,15-16H2,1-4H3/b30-23-/t18-/m0/s1
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 32n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM139877
PNG
(US8895592, 7)
Show SMILES CC(C)Cn1cc(s\c1=N/C(=O)c1cc(ccc1OCCN1CCCC1)C(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C25H34F3N3O2S/c1-17(2)15-31-16-21(24(3,4)5)34-23(31)29-22(32)19-14-18(25(26,27)28)8-9-20(19)33-13-12-30-10-6-7-11-30/h8-9,14,16-17H,6-7,10-13,15H2,1-5H3/b29-23-
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 32n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM139903
PNG
(US8895592, 33)
Show SMILES CCCCn1c2cnccc2s\c1=N/C(=O)c1cc(ccc1OC[C@@H]1CCCN1C)C(F)(F)F
Show InChI InChI=1S/C24H27F3N4O2S/c1-3-4-12-31-19-14-28-10-9-21(19)34-23(31)29-22(32)18-13-16(24(25,26)27)7-8-20(18)33-15-17-6-5-11-30(17)2/h7-10,13-14,17H,3-6,11-12,15H2,1-2H3/b29-23-/t17-/m0/s1
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 34n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM139894
PNG
(US8895592, 24)
Show SMILES CN1CCC[C@H]1COc1ccc(cc1C(=O)\N=c1/sc(C)c(C)n1CC1CC1)C(F)(F)F
Show InChI InChI=1S/C23H28F3N3O2S/c1-14-15(2)32-22(29(14)12-16-6-7-16)27-21(30)19-11-17(23(24,25)26)8-9-20(19)31-13-18-5-4-10-28(18)3/h8-9,11,16,18H,4-7,10,12-13H2,1-3H3/b27-22-/t18-/m0/s1
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 35n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM139890
PNG
(US8895592, 20)
Show SMILES CCCCn1c2cnccc2s\c1=N/C(=O)c1cc(ccc1OCCC(C)(C)O)C(F)(F)F
Show InChI InChI=1S/C23H26F3N3O3S/c1-4-5-11-29-17-14-27-10-8-19(17)33-21(29)28-20(30)16-13-15(23(24,25)26)6-7-18(16)32-12-9-22(2,3)31/h6-8,10,13-14,31H,4-5,9,11-12H2,1-3H3/b28-21-
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 35n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM139903
PNG
(US8895592, 33)
Show SMILES CCCCn1c2cnccc2s\c1=N/C(=O)c1cc(ccc1OC[C@@H]1CCCN1C)C(F)(F)F
Show InChI InChI=1S/C24H27F3N4O2S/c1-3-4-12-31-19-14-28-10-9-21(19)34-23(31)29-22(32)18-13-16(24(25,26)27)7-8-20(18)33-15-17-6-5-11-30(17)2/h7-10,13-14,17H,3-6,11-12,15H2,1-2H3/b29-23-/t17-/m0/s1
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 35n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM139882
PNG
(US8895592, 12)
Show SMILES CC(C)Cn1cc(s\c1=N/C(=O)c1cc(ccc1OC[C@@H]1CCN1C)C(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C24H32F3N3O2S/c1-15(2)12-30-13-20(23(3,4)5)33-22(30)28-21(31)18-11-16(24(25,26)27)7-8-19(18)32-14-17-9-10-29(17)6/h7-8,11,13,15,17H,9-10,12,14H2,1-6H3/b28-22-/t17-/m0/s1
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 37n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM139875
PNG
(US8895592, 5)
Show SMILES CC(C)Cn1cc(s\c1=N/C(=O)c1cc(ccc1OC[C@@H]1CCCN1C)C(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C25H34F3N3O2S/c1-16(2)13-31-14-21(24(3,4)5)34-23(31)29-22(32)19-12-17(25(26,27)28)9-10-20(19)33-15-18-8-7-11-30(18)6/h9-10,12,14,16,18H,7-8,11,13,15H2,1-6H3/b29-23-/t18-/m0/s1
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 39n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM139876
PNG
(US8895592, 6)
Show SMILES CC(C)Cn1cc(s\c1=N/C(=O)c1cc(ccc1OCCn1ccnc1)C(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C24H29F3N4O2S/c1-16(2)13-31-14-20(23(3,4)5)34-22(31)29-21(32)18-12-17(24(25,26)27)6-7-19(18)33-11-10-30-9-8-28-15-30/h6-9,12,14-16H,10-11,13H2,1-5H3/b29-22-
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 39n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM139884
PNG
(US8895592, 14)
Show SMILES CC(C)Cn1cc(s\c1=N/C(=O)c1cc(ccc1OC[C@@H]1CCN1)C(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C23H30F3N3O2S/c1-14(2)11-29-12-19(22(3,4)5)32-21(29)28-20(30)17-10-15(23(24,25)26)6-7-18(17)31-13-16-8-9-27-16/h6-7,10,12,14,16,27H,8-9,11,13H2,1-5H3/b28-21-/t16-/m0/s1
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 44n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM45989
PNG
(US8895592, 34)
Show SMILES CCCCn1c(C(=O)OC)c(s\c1=N/C(=O)c1cc(ccc1NC(C)(C)C)C(F)(F)F)C(C)C
Show InChI InChI=1S/C24H32F3N3O3S/c1-8-9-12-30-18(21(32)33-7)19(14(2)3)34-22(30)28-20(31)16-13-15(24(25,26)27)10-11-17(16)29-23(4,5)6/h10-11,13-14,29H,8-9,12H2,1-7H3/b28-22-
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 48n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM139890
PNG
(US8895592, 20)
Show SMILES CCCCn1c2cnccc2s\c1=N/C(=O)c1cc(ccc1OCCC(C)(C)O)C(F)(F)F
Show InChI InChI=1S/C23H26F3N3O3S/c1-4-5-11-29-17-14-27-10-8-19(17)33-21(29)28-20(30)16-13-15(23(24,25)26)6-7-18(16)32-12-9-22(2,3)31/h6-8,10,13-14,31H,4-5,9,11-12H2,1-3H3/b28-21-
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 48n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM139887
PNG
(US8895592, 17)
Show SMILES CC(C)(C)c1cn(CCC(F)(F)F)\c(=N\C(=O)c2cc(ccc2OC2CCC2)C#N)s1
Show InChI InChI=1S/C22H24F3N3O2S/c1-21(2,3)18-13-28(10-9-22(23,24)25)20(31-18)27-19(29)16-11-14(12-26)7-8-17(16)30-15-5-4-6-15/h7-8,11,13,15H,4-6,9-10H2,1-3H3/b27-20-
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 53n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM139892
PNG
(US8895592, 22)
Show SMILES CCCCn1c2cnccc2s\c1=N/C(=O)c1cc(ccc1ONC(C)(C)C)C(F)(F)F
Show InChI InChI=1S/C22H25F3N4O2S/c1-5-6-11-29-16-13-26-10-9-18(16)32-20(29)27-19(30)15-12-14(22(23,24)25)7-8-17(15)31-28-21(2,3)4/h7-10,12-13,28H,5-6,11H2,1-4H3/b27-20-
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 62n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM139898
PNG
(US8895592, 28)
Show SMILES CCCCn1c2cnccc2s\c1=N/C(=O)c1cc(ccc1OC[C@@H](C)O)C(F)(F)F
Show InChI InChI=1S/C21H22F3N3O3S/c1-3-4-9-27-16-11-25-8-7-18(16)31-20(27)26-19(29)15-10-14(21(22,23)24)5-6-17(15)30-12-13(2)28/h5-8,10-11,13,28H,3-4,9,12H2,1-2H3/b26-20-/t13-/m1/s1
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 63n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM139892
PNG
(US8895592, 22)
Show SMILES CCCCn1c2cnccc2s\c1=N/C(=O)c1cc(ccc1ONC(C)(C)C)C(F)(F)F
Show InChI InChI=1S/C22H25F3N4O2S/c1-5-6-11-29-16-13-26-10-9-18(16)32-20(29)27-19(30)15-12-14(22(23,24)25)7-8-17(15)31-28-21(2,3)4/h7-10,12-13,28H,5-6,11H2,1-4H3/b27-20-
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 73n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM139898
PNG
(US8895592, 28)
Show SMILES CCCCn1c2cnccc2s\c1=N/C(=O)c1cc(ccc1OC[C@@H](C)O)C(F)(F)F
Show InChI InChI=1S/C21H22F3N3O3S/c1-3-4-9-27-16-11-25-8-7-18(16)31-20(27)26-19(29)15-10-14(21(22,23)24)5-6-17(15)30-12-13(2)28/h5-8,10-11,13,28H,3-4,9,12H2,1-2H3/b26-20-/t13-/m1/s1
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 75n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM139883
PNG
(US8895592, 13)
Show SMILES CC(C)Cn1cc(s\c1=N/C(=O)c1cc(ccc1O[C@H]1CCN(C)C1)C(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C24H32F3N3O2S/c1-15(2)12-30-14-20(23(3,4)5)33-22(30)28-21(31)18-11-16(24(25,26)27)7-8-19(18)32-17-9-10-29(6)13-17/h7-8,11,14-15,17H,9-10,12-13H2,1-6H3/b28-22-/t17-/m0/s1
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 81n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM139881
PNG
(US8895592, 11)
Show SMILES CN1CCC[C@H]1COc1ccc(cc1C(=O)\N=c1/sc(cn1CC1(O)CCC1)C(C)(C)C)C(F)(F)F
Show InChI InChI=1S/C26H34F3N3O3S/c1-24(2,3)21-14-32(16-25(34)10-6-11-25)23(36-21)30-22(33)19-13-17(26(27,28)29)8-9-20(19)35-15-18-7-5-12-31(18)4/h8-9,13-14,18,34H,5-7,10-12,15-16H2,1-4H3/b30-23-/t18-/m0/s1
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 95n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM139886
PNG
(US8895592, 16)
Show SMILES CC(C)Cn1cc(s\c1=N/C(=O)c1cc(ccc1OC1CCC1)C#N)C(C)(C)C
Show InChI InChI=1S/C23H29N3O2S/c1-15(2)13-26-14-20(23(3,4)5)29-22(26)25-21(27)18-11-16(12-24)9-10-19(18)28-17-7-6-8-17/h9-11,14-15,17H,6-8,13H2,1-5H3/b25-22-
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 96n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM139876
PNG
(US8895592, 6)
Show SMILES CC(C)Cn1cc(s\c1=N/C(=O)c1cc(ccc1OCCn1ccnc1)C(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C24H29F3N4O2S/c1-16(2)13-31-14-20(23(3,4)5)34-22(31)29-21(32)18-12-17(24(25,26)27)6-7-19(18)33-11-10-30-9-8-28-15-30/h6-9,12,14-16H,10-11,13H2,1-5H3/b29-22-
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 96n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM139883
PNG
(US8895592, 13)
Show SMILES CC(C)Cn1cc(s\c1=N/C(=O)c1cc(ccc1O[C@H]1CCN(C)C1)C(F)(F)F)C(C)(C)C
Show InChI InChI=1S/C24H32F3N3O2S/c1-15(2)12-30-14-20(23(3,4)5)33-22(30)28-21(31)18-11-16(24(25,26)27)7-8-19(18)32-17-9-10-29(6)13-17/h7-8,11,14-15,17H,9-10,12-13H2,1-6H3/b28-22-/t17-/m0/s1
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 111n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM45989
PNG
(US8895592, 34)
Show SMILES CCCCn1c(C(=O)OC)c(s\c1=N/C(=O)c1cc(ccc1NC(C)(C)C)C(F)(F)F)C(C)C
Show InChI InChI=1S/C24H32F3N3O3S/c1-8-9-12-30-18(21(32)33-7)19(14(2)3)34-22(30)28-20(31)16-13-15(24(25,26)27)10-11-17(16)29-23(4,5)6/h10-11,13-14,29H,8-9,12H2,1-7H3/b28-22-
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 129n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM139880
PNG
(US8895592, 10)
Show SMILES CC(C)Cn1cc(s\c1=N/C(=O)c1ccccc1OC[C@@H]1CCCN1C)C(C)(C)C
Show InChI InChI=1S/C24H35N3O2S/c1-17(2)14-27-15-21(24(3,4)5)30-23(27)25-22(28)19-11-7-8-12-20(19)29-16-18-10-9-13-26(18)6/h7-8,11-12,15,17-18H,9-10,13-14,16H2,1-6H3/b25-23-/t18-/m0/s1
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 243n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM139880
PNG
(US8895592, 10)
Show SMILES CC(C)Cn1cc(s\c1=N/C(=O)c1ccccc1OC[C@@H]1CCCN1C)C(C)(C)C
Show InChI InChI=1S/C24H35N3O2S/c1-17(2)14-27-15-21(24(3,4)5)30-23(27)25-22(28)19-11-7-8-12-20(19)29-16-18-10-9-13-26(18)6/h7-8,11-12,15,17-18H,9-10,13-14,16H2,1-6H3/b25-23-/t18-/m0/s1
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 296n/an/an/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The CB1 and CB2 radioligand binding assays described herein are utilized to ascertain the selectivity of compounds of the present application for bin...

US Patent US8895592 (2014)


BindingDB Entry DOI: 10.7270/Q2CV4GDB
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%