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USPatent US9120812

Compile Data Set for Download or QSAR

Found 515 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM178284
PNG
(US9120812, 69)
Show SMILES CN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccncc4)cc3)c2C1=O)N1CC2CCC(C1)O2 |TLB:9:31:34.35:38|
Show InChI InChI=1S/C28H31N7O4/c1-28(2)16-34(3)25(36)22-23(32-26(33-24(22)39-28)35-14-20-8-9-21(15-35)38-20)17-4-6-18(7-5-17)30-27(37)31-19-10-12-29-13-11-19/h4-7,10-13,20-21H,8-9,14-16H2,1-3H3,(H2,29,30,31,37)
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n/an/a 6n/an/an/an/a7.525



Sanofi

US Patent


Assay Description
The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...

US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM178350
PNG
(US9120812, 135)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccon4)c(F)c3)c2C1=O)N1CC2CCC(C1)O2 |TLB:10:32:35.36:39|
Show InChI InChI=1S/C27H30FN7O5/c1-4-34-14-27(2,3)40-23-21(24(34)36)22(31-25(32-23)35-12-16-6-7-17(13-35)39-16)15-5-8-19(18(28)11-15)29-26(37)30-20-9-10-38-33-20/h5,8-11,16-17H,4,6-7,12-14H2,1-3H3,(H2,29,30,33,37)
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n/an/a 11n/an/an/an/a7.525



Sanofi

US Patent


Assay Description
The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...

US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM178395
PNG
(US9120812, 180)
Show SMILES COCCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccon4)cc3)c2C1=O)N1CCOC[C@@H]1C |r|
Show InChI InChI=1S/C27H33N7O6/c1-17-15-38-14-11-34(17)25-30-22(18-5-7-19(8-6-18)28-26(36)29-20-9-12-39-32-20)21-23(31-25)40-27(2,3)16-33(24(21)35)10-13-37-4/h5-9,12,17H,10-11,13-16H2,1-4H3,(H2,28,29,32,36)/t17-/m0/s1
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n/an/a 11n/an/an/an/a7.525



Sanofi

US Patent


Assay Description
The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...

US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM178283
PNG
(US9120812, 68)
Show SMILES CN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccncc4)cc3)c2C1=O)N1C2CCC1COC2
Show InChI InChI=1S/C28H31N7O4/c1-28(2)16-34(3)25(36)22-23(32-26(33-24(22)39-28)35-20-8-9-21(35)15-38-14-20)17-4-6-18(7-5-17)30-27(37)31-19-10-12-29-13-11-19/h4-7,10-13,20-21H,8-9,14-16H2,1-3H3,(H2,29,30,31,37)
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n/an/a 12n/an/an/an/a7.525



Sanofi

US Patent


Assay Description
The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...

US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM178388
PNG
(US9120812, 173)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(OC)cn4)cc3)c2C1=O)N1CCOC[C@@H]1C |r|
Show InChI InChI=1S/C29H35N7O5/c1-6-35-17-29(3,4)41-25-23(26(35)37)24(33-27(34-25)36-13-14-40-16-18(36)2)19-7-9-20(10-8-19)31-28(38)32-22-12-11-21(39-5)15-30-22/h7-12,15,18H,6,13-14,16-17H2,1-5H3,(H2,30,31,32,38)/t18-/m0/s1
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n/an/a 12n/an/an/an/a7.525



Sanofi

US Patent


Assay Description
The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...

US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM178230
PNG
(US9120812, 15)
Show SMILES Cc1cc(NC(=O)Nc2ccc(cc2)-c2nc(nc3OC(C)(C)CN(C4CCOCC4)C(=O)c23)N2CC3CCC(C2)O3)no1 |THB:16:34:41:37.38|
Show InChI InChI=1S/C31H37N7O6/c1-18-14-24(36-44-18)33-30(40)32-20-6-4-19(5-7-20)26-25-27(35-29(34-26)37-15-22-8-9-23(16-37)42-22)43-31(2,3)17-38(28(25)39)21-10-12-41-13-11-21/h4-7,14,21-23H,8-13,15-17H2,1-3H3,(H2,32,33,36,40)
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n/an/a 12n/an/an/an/a7.525



Sanofi

US Patent


Assay Description
The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...

US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM178399
PNG
(US9120812, 184)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4cc(OC)ccn4)cc3)c2C1=O)N1CCOC[C@@H]1C |r|
Show InChI InChI=1S/C29H35N7O5/c1-6-35-17-29(3,4)41-25-23(26(35)37)24(33-27(34-25)36-13-14-40-16-18(36)2)19-7-9-20(10-8-19)31-28(38)32-22-15-21(39-5)11-12-30-22/h7-12,15,18H,6,13-14,16-17H2,1-5H3,(H2,30,31,32,38)/t18-/m0/s1
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n/an/a 12n/an/an/an/a7.525



Sanofi

US Patent


Assay Description
The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...

US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM178436
PNG
(US9120812, 221)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccccn4)cc3)c2C1=O)N1CCOC[C@@H]1C |r|
Show InChI InChI=1S/C28H33N7O4/c1-5-34-17-28(3,4)39-24-22(25(34)36)23(32-26(33-24)35-14-15-38-16-18(35)2)19-9-11-20(12-10-19)30-27(37)31-21-8-6-7-13-29-21/h6-13,18H,5,14-17H2,1-4H3,(H2,29,30,31,37)/t18-/m0/s1
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n/an/a 13n/an/an/an/a7.525



Sanofi

US Patent


Assay Description
The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...

US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM178341
PNG
(US9120812, 126)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4cnn(C)c4)cc3)c2C1=O)N1CC2CCC(C1)O2 |TLB:10:32:35.36:39|
Show InChI InChI=1S/C28H34N8O4/c1-5-35-16-28(2,3)40-24-22(25(35)37)23(32-26(33-24)36-14-20-10-11-21(15-36)39-20)17-6-8-18(9-7-17)30-27(38)31-19-12-29-34(4)13-19/h6-9,12-13,20-21H,5,10-11,14-16H2,1-4H3,(H2,30,31,38)
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n/an/a 13n/an/an/an/a7.525



Sanofi

US Patent


Assay Description
The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...

US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM178226
PNG
(US9120812, 11)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)NC)cc3F)c2C1=O)N1CCOC[C@@H]1C |r|
Show InChI InChI=1S/C24H31FN6O4/c1-6-30-13-24(3,4)35-20-18(21(30)32)19(28-22(29-20)31-9-10-34-12-14(31)2)16-8-7-15(11-17(16)25)27-23(33)26-5/h7-8,11,14H,6,9-10,12-13H2,1-5H3,(H2,26,27,33)/t14-/m0/s1
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n/an/a 13n/an/an/an/a7.525



Sanofi

US Patent


Assay Description
The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...

US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM178236
PNG
(US9120812, 21)
Show SMILES COc1ccnc(NC(=O)Nc2ccc(cc2)-c2nc(nc3OC(C)(C)CN(C)C(=O)c23)N2CC3CCC(C2)O3)c1 |TLB:19:32:35.36:39|
Show InChI InChI=1S/C29H33N7O5/c1-29(2)16-35(3)26(37)23-24(33-27(34-25(23)41-29)36-14-20-9-10-21(15-36)40-20)17-5-7-18(8-6-17)31-28(38)32-22-13-19(39-4)11-12-30-22/h5-8,11-13,20-21H,9-10,14-16H2,1-4H3,(H2,30,31,32,38)
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n/an/a 15n/an/an/an/a7.525



Sanofi

US Patent


Assay Description
The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...

US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM178282
PNG
(US9120812, 67)
Show SMILES CN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(C)nc4)c(F)c3)c2C1=O)N1C2CCC1COC2
Show InChI InChI=1S/C29H32FN7O4/c1-16-5-7-18(12-31-16)32-28(39)33-22-10-6-17(11-21(22)30)24-23-25(41-29(2,3)15-36(4)26(23)38)35-27(34-24)37-19-8-9-20(37)14-40-13-19/h5-7,10-12,19-20H,8-9,13-15H2,1-4H3,(H2,32,33,39)
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n/an/a 15n/an/an/an/a7.525



Sanofi

US Patent


Assay Description
The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...

US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM178340
PNG
(US9120812, 125)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4cnccn4)cc3)c2C1=O)N1CC2CCC(C1)O2 |TLB:10:32:35.36:39|
Show InChI InChI=1S/C28H32N8O4/c1-4-35-16-28(2,3)40-24-22(25(35)37)23(33-26(34-24)36-14-19-9-10-20(15-36)39-19)17-5-7-18(8-6-17)31-27(38)32-21-13-29-11-12-30-21/h5-8,11-13,19-20H,4,9-10,14-16H2,1-3H3,(H2,30,31,32,38)
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n/an/a 16n/an/an/an/a7.525



Sanofi

US Patent


Assay Description
The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...

US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM178281
PNG
(US9120812, 66)
Show SMILES CN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(C)nc4)c(F)c3)c2C1=O)N1CC2CCC(C1)O2 |THB:9:33:40:36.37|
Show InChI InChI=1S/C29H32FN7O4/c1-16-5-7-18(12-31-16)32-28(39)33-22-10-6-17(11-21(22)30)24-23-25(41-29(2,3)15-36(4)26(23)38)35-27(34-24)37-13-19-8-9-20(14-37)40-19/h5-7,10-12,19-20H,8-9,13-15H2,1-4H3,(H2,32,33,39)
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n/an/a 16n/an/an/an/a7.525



Sanofi

US Patent


Assay Description
The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...

US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM178446
PNG
(US9120812, 231)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccncc4)c(F)c3)c2C1=O)N1CCOC[C@@H]1C |r|
Show InChI InChI=1S/C28H32FN7O4/c1-5-35-16-28(3,4)40-24-22(25(35)37)23(33-26(34-24)36-12-13-39-15-17(36)2)18-6-7-21(20(29)14-18)32-27(38)31-19-8-10-30-11-9-19/h6-11,14,17H,5,12-13,15-16H2,1-4H3,(H2,30,31,32,38)/t17-/m0/s1
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n/an/a 16n/an/an/an/a7.525



Sanofi

US Patent


Assay Description
The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...

US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM178342
PNG
(US9120812, 127)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4cccc(OC)c4)cc3)c2C1=O)N1CC2CCC(C1)O2 |TLB:10:34:37.38:41|
Show InChI InChI=1S/C31H36N6O5/c1-5-36-18-31(2,3)42-27-25(28(36)38)26(34-29(35-27)37-16-23-13-14-24(17-37)41-23)19-9-11-20(12-10-19)32-30(39)33-21-7-6-8-22(15-21)40-4/h6-12,15,23-24H,5,13-14,16-18H2,1-4H3,(H2,32,33,39)
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n/an/a 16n/an/an/an/a7.525



Sanofi

US Patent


Assay Description
The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...

US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM178222
PNG
(US9120812, 7)
Show SMILES CCNC(=O)Nc1ccc(cc1)-c1nc(nc2OC(C)(C)CN(CCC(O)=O)C(=O)c12)N1CC2CCC(C1)O2 |THB:14:31:38:34.35|
Show InChI InChI=1S/C27H34N6O6/c1-4-28-26(37)29-17-7-5-16(6-8-17)22-21-23(31-25(30-22)33-13-18-9-10-19(14-33)38-18)39-27(2,3)15-32(24(21)36)12-11-20(34)35/h5-8,18-19H,4,9-15H2,1-3H3,(H,34,35)(H2,28,29,37)
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n/an/a 17n/an/an/an/a7.525



Sanofi

US Patent


Assay Description
The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...

US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM178227
PNG
(US9120812, 12)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccncc4)cc3F)c2C1=O)N1CCOC[C@@H]1C |r|
Show InChI InChI=1S/C28H32FN7O4/c1-5-35-16-28(3,4)40-24-22(25(35)37)23(33-26(34-24)36-12-13-39-15-17(36)2)20-7-6-19(14-21(20)29)32-27(38)31-18-8-10-30-11-9-18/h6-11,14,17H,5,12-13,15-16H2,1-4H3,(H2,30,31,32,38)/t17-/m0/s1
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n/an/a 17n/an/an/an/a7.525



Sanofi

US Patent


Assay Description
The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...

US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM178218
PNG
(US9120812, 3)
Show SMILES CCNC(=O)Nc1ccc(cc1F)-c1nc(nc2OC(C)(C)CN(CC)C(=O)c12)N1CCOC[C@@H]1C |r|
Show InChI InChI=1S/C25H33FN6O4/c1-6-27-24(34)28-18-9-8-16(12-17(18)26)20-19-21(36-25(4,5)14-31(7-2)22(19)33)30-23(29-20)32-10-11-35-13-15(32)3/h8-9,12,15H,6-7,10-11,13-14H2,1-5H3,(H2,27,28,34)/t15-/m0/s1
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n/an/a 18n/an/an/an/a7.525



Sanofi

US Patent


Assay Description
The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...

US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM178267
PNG
(US9120812, 52)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccncc4)c(F)c3)c2C1=O)N1CC2CC11CC1O2
Show InChI InChI=1S/C29H30FN7O4/c1-4-36-15-28(2,3)41-24-22(25(36)38)23(34-26(35-24)37-14-18-12-29(37)13-21(29)40-18)16-5-6-20(19(30)11-16)33-27(39)32-17-7-9-31-10-8-17/h5-11,18,21H,4,12-15H2,1-3H3,(H2,31,32,33,39)
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n/an/a 18n/an/an/an/a7.525



Sanofi

US Patent


Assay Description
The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...

US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM178422
PNG
(US9120812, 207)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)NC)c(F)c3)c2C1=O)N1C2CCC1COC2 |TLB:10:28:34.35.33:30.31|
Show InChI InChI=1S/C25H31FN6O4/c1-5-31-13-25(2,3)36-21-19(22(31)33)20(14-6-9-18(17(26)10-14)28-24(34)27-4)29-23(30-21)32-15-7-8-16(32)12-35-11-15/h6,9-10,15-16H,5,7-8,11-13H2,1-4H3,(H2,27,28,34)
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n/an/a 18n/an/an/an/a7.525



Sanofi

US Patent


Assay Description
The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...

US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM178383
PNG
(US9120812, 168 | US9120812, 169)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(C)cn4)cc3)c2C1=O)N1CCOC[C@@H]1C |r|
Show InChI InChI=1S/C29H35N7O4/c1-6-35-17-29(4,5)40-25-23(26(35)37)24(33-27(34-25)36-13-14-39-16-19(36)3)20-8-10-21(11-9-20)31-28(38)32-22-12-7-18(2)15-30-22/h7-12,15,19H,6,13-14,16-17H2,1-5H3,(H2,30,31,32,38)/t19-/m0/s1
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n/an/a 18n/an/an/an/a7.525



Sanofi

US Patent


Assay Description
The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...

US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM178374
PNG
(US9120812, 159)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccon4)c(F)c3)c2C1=O)N1CCOC[C@@H]1C |r|
Show InChI InChI=1S/C26H30FN7O5/c1-5-33-14-26(3,4)39-22-20(23(33)35)21(30-24(31-22)34-9-11-37-13-15(34)2)16-6-7-18(17(27)12-16)28-25(36)29-19-8-10-38-32-19/h6-8,10,12,15H,5,9,11,13-14H2,1-4H3,(H2,28,29,32,36)/t15-/m0/s1
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n/an/a 18n/an/an/an/a7.525



Sanofi

US Patent


Assay Description
The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...

US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM178417
PNG
(US9120812, 202)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccccc4F)cc3)c2C1=O)N1CCOC[C@@H]1C |r|
Show InChI InChI=1S/C29H33FN6O4/c1-5-35-17-29(3,4)40-25-23(26(35)37)24(33-27(34-25)36-14-15-39-16-18(36)2)19-10-12-20(13-11-19)31-28(38)32-22-9-7-6-8-21(22)30/h6-13,18H,5,14-17H2,1-4H3,(H2,31,32,38)/t18-/m0/s1
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n/an/a 19n/an/an/an/a7.525



Sanofi

US Patent


Assay Description
The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...

US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM178358
PNG
(US9120812, 143)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4cnn(C)c4)c(F)c3)c2C1=O)N1CC2CCC(C1)O2 |TLB:10:33:36.37:40|
Show InChI InChI=1S/C28H33FN8O4/c1-5-36-15-28(2,3)41-24-22(25(36)38)23(33-26(34-24)37-13-18-7-8-19(14-37)40-18)16-6-9-21(20(29)10-16)32-27(39)31-17-11-30-35(4)12-17/h6,9-12,18-19H,5,7-8,13-15H2,1-4H3,(H2,31,32,39)
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n/an/a 19n/an/an/an/a7.525



Sanofi

US Patent


Assay Description
The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...

US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM178231
PNG
(US9120812, 16)
Show SMILES Cn1ccc(NC(=O)Nc2ccc(cc2)-c2nc(nc3OC(C)(C)CN(C4CCOCC4)C(=O)c23)N2CC3CCC(C2)O3)n1 |THB:17:35:42:38.39|
Show InChI InChI=1S/C31H38N8O5/c1-31(2)18-39(21-11-14-42-15-12-21)28(40)25-26(34-29(35-27(25)44-31)38-16-22-8-9-23(17-38)43-22)19-4-6-20(7-5-19)32-30(41)33-24-10-13-37(3)36-24/h4-7,10,13,21-23H,8-9,11-12,14-18H2,1-3H3,(H2,32,33,36,41)
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n/an/a 19n/an/an/an/a7.525



Sanofi

US Patent


Assay Description
The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...

US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM178337
PNG
(US9120812, 122)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccn(C)n4)cc3)c2C1=O)N1CC2CCC(C1)O2 |TLB:10:32:35.36:39|
Show InChI InChI=1S/C28H34N8O4/c1-5-35-16-28(2,3)40-24-22(25(35)37)23(31-26(32-24)36-14-19-10-11-20(15-36)39-19)17-6-8-18(9-7-17)29-27(38)30-21-12-13-34(4)33-21/h6-9,12-13,19-20H,5,10-11,14-16H2,1-4H3,(H2,29,30,33,38)
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n/an/a 19n/an/an/an/a7.525



Sanofi

US Patent


Assay Description
The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...

US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM178438
PNG
(US9120812, 223)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4cccnc4)c(F)c3)c2C1=O)N1CC2CCC(C1)O2 |TLB:10:33:36.37:40|
Show InChI InChI=1S/C29H32FN7O4/c1-4-36-16-29(2,3)41-25-23(26(36)38)24(34-27(35-25)37-14-19-8-9-20(15-37)40-19)17-7-10-22(21(30)12-17)33-28(39)32-18-6-5-11-31-13-18/h5-7,10-13,19-20H,4,8-9,14-16H2,1-3H3,(H2,32,33,39)
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n/an/a 20n/an/an/an/a7.525



Sanofi

US Patent


Assay Description
The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...

US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM178266
PNG
(US9120812, 51)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccncc4)c(F)c3)c2C1=O)N1C2CCC1COC2 |TLB:10:33:39.40.38:35.36|
Show InChI InChI=1S/C29H32FN7O4/c1-4-36-16-29(2,3)41-25-23(26(36)38)24(34-27(35-25)37-19-6-7-20(37)15-40-14-19)17-5-8-22(21(30)13-17)33-28(39)32-18-9-11-31-12-10-18/h5,8-13,19-20H,4,6-7,14-16H2,1-3H3,(H2,31,32,33,39)
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n/an/a 20n/an/an/an/a7.525



Sanofi

US Patent


Assay Description
The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...

US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM178387
PNG
(US9120812, 172)
Show SMILES COCCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccon4)cc3)c2C1=O)N1CC2CCC(C1)O2 |THB:12:33:40:36.37|
Show InChI InChI=1S/C28H33N7O6/c1-28(2)16-34(11-13-38-3)25(36)22-23(17-4-6-18(7-5-17)29-27(37)30-21-10-12-39-33-21)31-26(32-24(22)41-28)35-14-19-8-9-20(15-35)40-19/h4-7,10,12,19-20H,8-9,11,13-16H2,1-3H3,(H2,29,30,33,37)
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Sanofi

US Patent


Assay Description
The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...

US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM178298
PNG
(US9120812, 83)
Show SMILES CN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccncc4)c(F)c3)c2C1=O)N1CC2CCC(C1)O2 |THB:9:32:39:35.36|
Show InChI InChI=1S/C28H30FN7O4/c1-28(2)15-35(3)25(37)22-23(33-26(34-24(22)40-28)36-13-18-5-6-19(14-36)39-18)16-4-7-21(20(29)12-16)32-27(38)31-17-8-10-30-11-9-17/h4,7-12,18-19H,5-6,13-15H2,1-3H3,(H2,30,31,32,38)
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Sanofi

US Patent


Assay Description
The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...

US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM178327
PNG
(US9120812, 112)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4cccnc4)cc3)c2C1=O)N1CC2CCC(C1)O2 |TLB:10:32:35.36:39|
Show InChI InChI=1S/C29H33N7O4/c1-4-35-17-29(2,3)40-25-23(26(35)37)24(33-27(34-25)36-15-21-11-12-22(16-36)39-21)18-7-9-19(10-8-18)31-28(38)32-20-6-5-13-30-14-20/h5-10,13-14,21-22H,4,11-12,15-17H2,1-3H3,(H2,31,32,38)
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Sanofi

US Patent


Assay Description
The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...

US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM178339
PNG
(US9120812, 124)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(OC)nc4)c(F)c3)c2C1=O)N1CC2CCC(C1)O2 |TLB:10:35:38.39:42|
Show InChI InChI=1S/C30H34FN7O5/c1-5-37-16-30(2,3)43-26-24(27(37)39)25(35-28(36-26)38-14-19-8-9-20(15-38)42-19)17-6-10-22(21(31)12-17)34-29(40)33-18-7-11-23(41-4)32-13-18/h6-7,10-13,19-20H,5,8-9,14-16H2,1-4H3,(H2,33,34,40)
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n/an/a 20n/an/an/an/a7.525



Sanofi

US Patent


Assay Description
The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...

US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM178286
PNG
(US9120812, 71)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccncc4)cc3F)c2C1=O)N1CC2CCC(C1)O2
Show InChI InChI=1S/C29H32FN7O4/c1-4-36-16-29(2,3)41-25-23(26(36)38)24(34-27(35-25)37-14-19-6-7-20(15-37)40-19)21-8-5-18(13-22(21)30)33-28(39)32-17-9-11-31-12-10-17/h5,8-13,19-20H,4,6-7,14-16H2,1-3H3,(H2,31,32,33,39)
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n/an/a 21n/an/an/an/a7.525



Sanofi

US Patent


Assay Description
The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...

US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM178245
PNG
(US9120812, 30)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(nc4)N4CCOC[C@H]4C)c(F)c3)c2C1=O)N1CC2CCC(C1)O2 |r,TLB:10:40:43.44:47|
Show InChI InChI=1S/C34H41FN8O5/c1-5-41-19-34(3,4)48-30-28(31(41)44)29(39-32(40-30)42-16-23-8-9-24(17-42)47-23)21-6-10-26(25(35)14-21)38-33(45)37-22-7-11-27(36-15-22)43-12-13-46-18-20(43)2/h6-7,10-11,14-15,20,23-24H,5,8-9,12-13,16-19H2,1-4H3,(H2,37,38,45)/t20-,23?,24?/m1/s1
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n/an/a 21n/an/an/an/a7.525



Sanofi

US Patent


Assay Description
The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...

US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM178297
PNG
(US9120812, 82)
Show SMILES CN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccncc4)c(F)c3)c2C1=O)N1C2CCC1COC2
Show InChI InChI=1S/C28H30FN7O4/c1-28(2)15-35(3)25(37)22-23(33-26(34-24(22)40-28)36-18-5-6-19(36)14-39-13-18)16-4-7-21(20(29)12-16)32-27(38)31-17-8-10-30-11-9-17/h4,7-12,18-19H,5-6,13-15H2,1-3H3,(H2,30,31,32,38)
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n/an/a 21n/an/an/an/a7.525



Sanofi

US Patent


Assay Description
The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...

US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM178217
PNG
(US9120812, 2)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)NC)c(F)c3)c2C1=O)N1CCOC[C@@H]1C |r|
Show InChI InChI=1S/C24H31FN6O4/c1-6-30-13-24(3,4)35-20-18(21(30)32)19(28-22(29-20)31-9-10-34-12-14(31)2)15-7-8-17(16(25)11-15)27-23(33)26-5/h7-8,11,14H,6,9-10,12-13H2,1-5H3,(H2,26,27,33)/t14-/m0/s1
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n/an/a 22n/an/an/an/a7.525



Sanofi

US Patent


Assay Description
The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...

US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM178338
PNG
(US9120812, 123)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)NCCF)cc3)c2C1=O)N1CC2CCC(C1)O2
Show InChI InChI=1S/C26H33FN6O4/c1-4-32-15-26(2,3)37-22-20(23(32)34)21(16-5-7-17(8-6-16)29-25(35)28-12-11-27)30-24(31-22)33-13-18-9-10-19(14-33)36-18/h5-8,18-19H,4,9-15H2,1-3H3,(H2,28,29,35)
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n/an/a 22n/an/an/an/a7.525



Sanofi

US Patent


Assay Description
The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...

US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM178389
PNG
(US9120812, 174)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(nc4)N4CCN(C)CC4)cc3)c2C1=O)N1CCOC[C@@H]1C |r|
Show InChI InChI=1S/C33H43N9O4/c1-6-40-21-33(3,4)46-29-27(30(40)43)28(37-31(38-29)42-17-18-45-20-22(42)2)23-7-9-24(10-8-23)35-32(44)36-25-11-12-26(34-19-25)41-15-13-39(5)14-16-41/h7-12,19,22H,6,13-18,20-21H2,1-5H3,(H2,35,36,44)/t22-/m0/s1
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n/an/a 22n/an/an/an/a7.525



Sanofi

US Patent


Assay Description
The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...

US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM178253
PNG
(US9120812, 38)
Show SMILES CNC(=O)Nc1ccc(cc1)-c1nc(nc2OC(C)(C)CN(C)C(=O)c12)N1CC2CCC(C1)O2 |TLB:13:26:29.30:33|
Show InChI InChI=1S/C24H30N6O4/c1-24(2)13-29(4)21(31)18-19(14-5-7-15(8-6-14)26-23(32)25-3)27-22(28-20(18)34-24)30-11-16-9-10-17(12-30)33-16/h5-8,16-17H,9-13H2,1-4H3,(H2,25,26,32)
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n/an/a 22n/an/an/an/a7.525



Sanofi

US Patent


Assay Description
The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...

US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM178299
PNG
(US9120812, 84)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccccn4)cc3F)c2C1=O)N1CC2CCC(C1)O2
Show InChI InChI=1S/C29H32FN7O4/c1-4-36-16-29(2,3)41-25-23(26(36)38)24(34-27(35-25)37-14-18-9-10-19(15-37)40-18)20-11-8-17(13-21(20)30)32-28(39)33-22-7-5-6-12-31-22/h5-8,11-13,18-19H,4,9-10,14-16H2,1-3H3,(H2,31,32,33,39)
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n/an/a 23n/an/an/an/a7.525



Sanofi

US Patent


Assay Description
The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...

US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM178216
PNG
(US9120812, 1)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)NC)c(F)c3)c2C1=O)N1CC2CCC(C1)O2
Show InChI InChI=1S/C25H31FN6O4/c1-5-31-13-25(2,3)36-21-19(22(31)33)20(14-6-9-18(17(26)10-14)28-24(34)27-4)29-23(30-21)32-11-15-7-8-16(12-32)35-15/h6,9-10,15-16H,5,7-8,11-13H2,1-4H3,(H2,27,28,34)
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n/an/a 23n/an/an/an/a7.525



Sanofi

US Patent


Assay Description
The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...

US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM178287
PNG
(US9120812, 72)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(cn4)N4CCC(O)C4)cc3)c2C1=O)N1CC2CCC(C1)O2 |THB:10:38:45:41.42|
Show InChI InChI=1S/C33H40N8O5/c1-4-39-19-33(2,3)46-29-27(30(39)43)28(37-31(38-29)41-17-24-10-11-25(18-41)45-24)20-5-7-21(8-6-20)35-32(44)36-26-12-9-22(15-34-26)40-14-13-23(42)16-40/h5-9,12,15,23-25,42H,4,10-11,13-14,16-19H2,1-3H3,(H2,34,35,36,44)
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n/an/a 23n/an/an/an/a7.525



Sanofi

US Patent


Assay Description
The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...

US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM178400
PNG
(US9120812, 185)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(C)nc4)c(F)c3)c2C1=O)N1CC2CCC(C1)O2 |TLB:10:34:37.38:41|
Show InChI InChI=1S/C30H34FN7O4/c1-5-37-16-30(3,4)42-26-24(27(37)39)25(35-28(36-26)38-14-20-9-10-21(15-38)41-20)18-7-11-23(22(31)12-18)34-29(40)33-19-8-6-17(2)32-13-19/h6-8,11-13,20-21H,5,9-10,14-16H2,1-4H3,(H2,33,34,40)
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n/an/a 24n/an/an/an/a7.525



Sanofi

US Patent


Assay Description
The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...

US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM178300
PNG
(US9120812, 85)
Show SMILES CN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccncc4F)cc3)c2C1=O)N1CC2CCC(C1)O2 |TLB:9:32:35.36:39|
Show InChI InChI=1S/C28H30FN7O4/c1-28(2)15-35(3)25(37)22-23(33-26(34-24(22)40-28)36-13-18-8-9-19(14-36)39-18)16-4-6-17(7-5-16)31-27(38)32-21-10-11-30-12-20(21)29/h4-7,10-12,18-19H,8-9,13-15H2,1-3H3,(H2,30,31,32,38)
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n/an/a 24n/an/an/an/a7.525



Sanofi

US Patent


Assay Description
The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...

US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM178260
PNG
(US9120812, 45)
Show SMILES CNC(=O)Nc1ccc(cc1F)-c1nc(nc2OC(C)(C)CN(C)C(=O)c12)N1CC2CCC(C1)O2 |THB:14:27:34:30.31|
Show InChI InChI=1S/C24H29FN6O4/c1-24(2)12-30(4)21(32)18-19(13-5-8-17(16(25)9-13)27-23(33)26-3)28-22(29-20(18)35-24)31-10-14-6-7-15(11-31)34-14/h5,8-9,14-15H,6-7,10-12H2,1-4H3,(H2,26,27,33)
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n/an/a 24n/an/an/an/a7.525



Sanofi

US Patent


Assay Description
The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...

US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM178279
PNG
(US9120812, 64)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(cn4)N(C)C)cc3)c2C1=O)N1CC2CCC(C1)O2 |THB:10:35:42:38.39|
Show InChI InChI=1S/C31H38N8O4/c1-6-38-18-31(2,3)43-27-25(28(38)40)26(35-29(36-27)39-16-22-12-13-23(17-39)42-22)19-7-9-20(10-8-19)33-30(41)34-24-14-11-21(15-32-24)37(4)5/h7-11,14-15,22-23H,6,12-13,16-18H2,1-5H3,(H2,32,33,34,41)
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Sanofi

US Patent


Assay Description
The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...

US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM178406
PNG
(US9120812, 191)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(F)cc4F)cc3)c2C1=O)N1CCOC[C@@H]1C |r|
Show InChI InChI=1S/C29H32F2N6O4/c1-5-36-16-29(3,4)41-25-23(26(36)38)24(34-27(35-25)37-12-13-40-15-17(37)2)18-6-9-20(10-7-18)32-28(39)33-22-11-8-19(30)14-21(22)31/h6-11,14,17H,5,12-13,15-16H2,1-4H3,(H2,32,33,39)/t17-/m0/s1
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Sanofi

US Patent


Assay Description
The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...

US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM178248
PNG
(US9120812, 33)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccccn4)cc3)c2C1=O)N1CC2CCC(C1)O2 |TLB:10:32:35.36:39|
Show InChI InChI=1S/C29H33N7O4/c1-4-35-17-29(2,3)40-25-23(26(35)37)24(33-27(34-25)36-15-20-12-13-21(16-36)39-20)18-8-10-19(11-9-18)31-28(38)32-22-7-5-6-14-30-22/h5-11,14,20-21H,4,12-13,15-17H2,1-3H3,(H2,30,31,32,38)
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n/an/a 24n/an/an/an/a7.525



Sanofi

US Patent


Assay Description
The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...

US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM178332
PNG
(US9120812, 117)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)NCCO)cc3)c2C1=O)N1CC2CCC(C1)O2 |TLB:10:29:32.33:36|
Show InChI InChI=1S/C26H34N6O5/c1-4-31-15-26(2,3)37-22-20(23(31)34)21(16-5-7-17(8-6-16)28-25(35)27-11-12-33)29-24(30-22)32-13-18-9-10-19(14-32)36-18/h5-8,18-19,33H,4,9-15H2,1-3H3,(H2,27,28,35)
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n/an/a 25n/an/an/an/a7.525



Sanofi

US Patent


Assay Description
The test detects the phosphorylation of the substrate GFP-4EBP1 using a terbium-labelled antibody that is specific for the phospho-Thr46 epitope. Bin...

US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 515 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%