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USPatent US9751854

Compile Data Set for Download or QSAR

Found 484 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM338097
PNG
(US9751854, Compound I-273 | US9802960, Compound I-...)
Show SMILES CCN(C)S(=O)(=O)Nc1cc(cnc1C)-c1ccnc(NC(C)=O)c1
Show InChI InChI=1S/C16H21N5O3S/c1-5-21(4)25(23,24)20-15-8-14(10-18-11(15)2)13-6-7-17-16(9-13)19-12(3)22/h6-10,20H,5H2,1-4H3,(H,17,19,22)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9751854 (2017)


BindingDB Entry DOI: 10.7270/Q2KS6TNJ
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM338135
PNG
(US9751854, Compound I-311 | US9802960, Compound I-...)
Show SMILES CN(C)S(=O)(=O)Nc1cc(cnc1C)-c1ccnc(NC(=O)C2CC2)c1
Show InChI InChI=1S/C17H21N5O3S/c1-11-15(21-26(24,25)22(2)3)8-14(10-19-11)13-6-7-18-16(9-13)20-17(23)12-4-5-12/h6-10,12,21H,4-5H2,1-3H3,(H,18,20,23)
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n/an/a<10n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9751854 (2017)


BindingDB Entry DOI: 10.7270/Q2KS6TNJ
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM338194
PNG
(US9751854, Compound I-375 | US9802960, Compound I-...)
Show SMILES COc1nc(C)nc(Nc2cc(ccn2)-c2cnc(C)c(NS(=O)(=O)c3ccc(F)cc3F)c2)n1
Show InChI InChI=1S/C22H19F2N7O3S/c1-12-18(31-35(32,33)19-5-4-16(23)10-17(19)24)8-15(11-26-12)14-6-7-25-20(9-14)29-21-27-13(2)28-22(30-21)34-3/h4-11,31H,1-3H3,(H,25,27,28,29,30)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9751854 (2017)


BindingDB Entry DOI: 10.7270/Q2KS6TNJ
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM338251
PNG
(US9751854, Compound I-435 | US9802960, Compound I-...)
Show SMILES CN(C)S(=O)(=O)Nc1c(Cl)ncc(c1C)-c1ccnc(Nc2ccnc(n2)C2CC2)c1
Show InChI InChI=1S/C20H22ClN7O2S/c1-12-15(11-24-19(21)18(12)27-31(29,30)28(2)3)14-6-8-22-17(10-14)25-16-7-9-23-20(26-16)13-4-5-13/h6-11,13,27H,4-5H2,1-3H3,(H,22,23,25,26)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9751854 (2017)


BindingDB Entry DOI: 10.7270/Q2KS6TNJ
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM338257
PNG
(US9751854, Compound I-441 | US9802960, Compound I-...)
Show SMILES Cc1ncc(cc1NS(=O)(=O)c1ccc(Cl)cc1F)-c1ccnc(NC(=O)C2CC2(F)F)c1
Show InChI InChI=1S/C21H16ClF3N4O3S/c1-11-17(29-33(31,32)18-3-2-14(22)8-16(18)23)6-13(10-27-11)12-4-5-26-19(7-12)28-20(30)15-9-21(15,24)25/h2-8,10,15,29H,9H2,1H3,(H,26,28,30)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9751854 (2017)


BindingDB Entry DOI: 10.7270/Q2KS6TNJ
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM337828
PNG
(US9751854, Compound I-11 | US9802960, Compound I-1...)
Show SMILES CC(=O)Nc1cc(ccn1)-c1cnc(N)c(c1)S(=O)(=O)NC12CC(C1)C2
Show InChI InChI=1S/C17H19N5O3S/c1-10(23)21-15-5-12(2-3-19-15)13-4-14(16(18)20-9-13)26(24,25)22-17-6-11(7-17)8-17/h2-5,9,11,22H,6-8H2,1H3,(H2,18,20)(H,19,21,23)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9751854 (2017)


BindingDB Entry DOI: 10.7270/Q2KS6TNJ
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM337833
PNG
(US9751854, Compound I-16 | US9751854, Compound I-2...)
Show SMILES Cc1ncc(cc1NS(=O)(=O)c1ccc(F)cc1F)-c1ccnc(NC(=O)C2CC2(F)F)c1
Show InChI InChI=1S/C21H16F4N4O3S/c1-11-17(29-33(31,32)18-3-2-14(22)8-16(18)23)6-13(10-27-11)12-4-5-26-19(7-12)28-20(30)15-9-21(15,24)25/h2-8,10,15,29H,9H2,1H3,(H,26,28,30)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9751854 (2017)


BindingDB Entry DOI: 10.7270/Q2KS6TNJ
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM337869
PNG
(US9751854, Compound I-52 | US9802960, Compound I-5...)
Show SMILES CC(=O)Nc1cc(ccn1)-c1cnc(C)c(NS(=O)(=O)c2cc(F)ccc2F)c1
Show InChI InChI=1S/C19H16F2N4O3S/c1-11-17(25-29(27,28)18-9-15(20)3-4-16(18)21)7-14(10-23-11)13-5-6-22-19(8-13)24-12(2)26/h3-10,25H,1-2H3,(H,22,24,26)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9751854 (2017)


BindingDB Entry DOI: 10.7270/Q2KS6TNJ
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM337893
PNG
(US9751854, Compound I-74 | US9802960, Compound I-7...)
Show SMILES COc1ccccc1S(=O)(=O)Nc1cc(cnc1C)-c1ccnc(NC(C)=O)c1
Show InChI InChI=1S/C20H20N4O4S/c1-13-17(24-29(26,27)19-7-5-4-6-18(19)28-3)10-16(12-22-13)15-8-9-21-20(11-15)23-14(2)25/h4-12,24H,1-3H3,(H,21,23,25)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9751854 (2017)


BindingDB Entry DOI: 10.7270/Q2KS6TNJ
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM337919
PNG
(US9751854, Compound I-100 | US9802960, Compound I-...)
Show SMILES CNc1ncc(cc1S(=O)(=O)Nc1ccccc1)-c1ccnc(NC(C)=O)c1
Show InChI InChI=1S/C19H19N5O3S/c1-13(25)23-18-11-14(8-9-21-18)15-10-17(19(20-2)22-12-15)28(26,27)24-16-6-4-3-5-7-16/h3-12,24H,1-2H3,(H,20,22)(H,21,23,25)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9751854 (2017)


BindingDB Entry DOI: 10.7270/Q2KS6TNJ
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM337957
PNG
(US9751854, Compound I-133 | US9802960, Compound I-...)
Show SMILES CN(c1cc(cnc1N)-c1ccnc(NC(C)=O)c1)S(C)(=O)=O
Show InChI InChI=1S/C14H17N5O3S/c1-9(20)18-13-7-10(4-5-16-13)11-6-12(14(15)17-8-11)19(2)23(3,21)22/h4-8H,1-3H3,(H2,15,17)(H,16,18,20)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9751854 (2017)


BindingDB Entry DOI: 10.7270/Q2KS6TNJ
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM337965
PNG
(US9751854, Compound I-141 | US9802960, Compound I-...)
Show SMILES CNc1ncc(cc1N(CC1CC1)S(C)(=O)=O)-c1ccnc(NC(C)=O)c1
Show InChI InChI=1S/C18H23N5O3S/c1-12(24)22-17-9-14(6-7-20-17)15-8-16(18(19-2)21-10-15)23(27(3,25)26)11-13-4-5-13/h6-10,13H,4-5,11H2,1-3H3,(H,19,21)(H,20,22,24)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9751854 (2017)


BindingDB Entry DOI: 10.7270/Q2KS6TNJ
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM337974
PNG
(US9751854, Compound I-150 | US9802960, Compound I-...)
Show SMILES CC(=O)Nc1cc(ccn1)-c1cnc(C)c(NS(=O)(=O)c2c(F)cccc2F)c1
Show InChI InChI=1S/C19H16F2N4O3S/c1-11-17(25-29(27,28)19-15(20)4-3-5-16(19)21)8-14(10-23-11)13-6-7-22-18(9-13)24-12(2)26/h3-10,25H,1-2H3,(H,22,24,26)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9751854 (2017)


BindingDB Entry DOI: 10.7270/Q2KS6TNJ
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM337978
PNG
(US9751854, Compound I-154 | US9802960, Compound I-...)
Show SMILES CC(=O)Nc1cc(ccn1)-c1cnc(C)c(NS(=O)(=O)c2ccc(Cl)cc2)c1
Show InChI InChI=1S/C19H17ClN4O3S/c1-12-18(24-28(26,27)17-5-3-16(20)4-6-17)9-15(11-22-12)14-7-8-21-19(10-14)23-13(2)25/h3-11,24H,1-2H3,(H,21,23,25)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9751854 (2017)


BindingDB Entry DOI: 10.7270/Q2KS6TNJ
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM337992
PNG
(US9751854, Compound I-168 | US9802960, Compound I-...)
Show SMILES CC(=O)Nc1cc(ccn1)-c1cnc(C)c(NS(=O)(=O)c2cccc(c2)C(F)(F)F)c1
Show InChI InChI=1S/C20H17F3N4O3S/c1-12-18(27-31(29,30)17-5-3-4-16(10-17)20(21,22)23)8-15(11-25-12)14-6-7-24-19(9-14)26-13(2)28/h3-11,27H,1-2H3,(H,24,26,28)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9751854 (2017)


BindingDB Entry DOI: 10.7270/Q2KS6TNJ
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM337998
PNG
(US9751854, Compound I-174 | US9802960, Compound I-...)
Show SMILES CN(C)c1ncc(cc1C(=O)N(C)c1ccc(F)cc1F)-c1ccnc(NC(C)=O)c1
Show InChI InChI=1S/C22H21F2N5O2/c1-13(30)27-20-10-14(7-8-25-20)15-9-17(21(26-12-15)28(2)3)22(31)29(4)19-6-5-16(23)11-18(19)24/h5-12H,1-4H3,(H,25,27,30)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9751854 (2017)


BindingDB Entry DOI: 10.7270/Q2KS6TNJ
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM338063
PNG
(US9751854, Compound I-238)
Show SMILES Cc1nc(Nc2cc(ccn2)-c2cnc(Cl)c(NS(=O)(=O)c3ccc(F)cc3F)c2C)ccc1C#N
Show InChI InChI=1S/C24H17ClF2N6O2S/c1-13-18(15-7-8-29-22(9-15)32-21-6-3-16(11-28)14(2)31-21)12-30-24(25)23(13)33-36(34,35)20-5-4-17(26)10-19(20)27/h3-10,12,33H,1-2H3,(H,29,31,32)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9751854 (2017)


BindingDB Entry DOI: 10.7270/Q2KS6TNJ
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM338064
PNG
(US9751854, Compound I-239 | US9802960, Compound I-...)
Show SMILES Cc1ncc(cc1NS(=O)(=O)c1ccc(F)cc1F)-c1ccnc(Nc2ccncn2)c1
Show InChI InChI=1S/C21H16F2N6O2S/c1-13-18(29-32(30,31)19-3-2-16(22)10-17(19)23)8-15(11-26-13)14-4-7-25-21(9-14)28-20-5-6-24-12-27-20/h2-12,29H,1H3,(H,24,25,27,28)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9751854 (2017)


BindingDB Entry DOI: 10.7270/Q2KS6TNJ
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM338084
PNG
(US9751854, Compound I-259)
Show SMILES CCc1c(NS(=O)(=O)c2ccc(F)cc2F)c(Cl)ncc1-c1ccnc(Nc2ccnc(C)n2)c1
Show InChI InChI=1S/C23H19ClF2N6O2S/c1-3-16-17(14-6-8-28-21(10-14)31-20-7-9-27-13(2)30-20)12-29-23(24)22(16)32-35(33,34)19-5-4-15(25)11-18(19)26/h4-12,32H,3H2,1-2H3,(H,27,28,30,31)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9751854 (2017)


BindingDB Entry DOI: 10.7270/Q2KS6TNJ
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM338118
PNG
(US9751854, Compound I-294 | US9802960, Compound I-...)
Show SMILES Cc1nccc(Nc2cc(c(F)cn2)-c2cnc(Cl)c(NS(=O)(=O)c3ccc(F)cc3F)c2C)n1
Show InChI InChI=1S/C22H16ClF3N6O2S/c1-11-15(14-8-20(28-10-17(14)26)31-19-5-6-27-12(2)30-19)9-29-22(23)21(11)32-35(33,34)18-4-3-13(24)7-16(18)25/h3-10,32H,1-2H3,(H,27,28,30,31)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9751854 (2017)


BindingDB Entry DOI: 10.7270/Q2KS6TNJ
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM338148
PNG
(US9751854, Compound I-326 | US9802960, Compound I-...)
Show SMILES Cc1ncc(cc1NS(=O)(=O)c1ccc(F)cc1F)-c1ccnc(NC(=O)OCc2ccn(C)n2)c1
Show InChI InChI=1S/C23H20F2N6O4S/c1-14-20(30-36(33,34)21-4-3-17(24)11-19(21)25)9-16(12-27-14)15-5-7-26-22(10-15)28-23(32)35-13-18-6-8-31(2)29-18/h3-12,30H,13H2,1-2H3,(H,26,28,32)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9751854 (2017)


BindingDB Entry DOI: 10.7270/Q2KS6TNJ
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM338171
PNG
(US9751854, Compound I-350 | US9802960, Compound I-...)
Show SMILES CCCCN(CCCC)S(=O)(=O)Nc1cc(cnc1C)-c1ccnc(NC(C)=O)c1
Show InChI InChI=1S/C21H31N5O3S/c1-5-7-11-26(12-8-6-2)30(28,29)25-20-13-19(15-23-16(20)3)18-9-10-22-21(14-18)24-17(4)27/h9-10,13-15,25H,5-8,11-12H2,1-4H3,(H,22,24,27)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9751854 (2017)


BindingDB Entry DOI: 10.7270/Q2KS6TNJ
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM338176
PNG
(US9751854, Compound I-356 | US9802960, Compound I-...)
Show SMILES CC(=O)Nc1cc(ccn1)-c1cnc(C)c(NS(=O)(=O)c2ccc(cc2F)C#N)c1
Show InChI InChI=1S/C20H16FN5O3S/c1-12-18(26-30(28,29)19-4-3-14(10-22)7-17(19)21)8-16(11-24-12)15-5-6-23-20(9-15)25-13(2)27/h3-9,11,26H,1-2H3,(H,23,25,27)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9751854 (2017)


BindingDB Entry DOI: 10.7270/Q2KS6TNJ
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM338263
PNG
(US9751854, Compound I-447 | US9802960, Compound I-...)
Show SMILES CC(=O)Nc1cc(ccn1)-c1cnc(C)c(NS(=O)(=O)N2CCOCC2)c1
Show InChI InChI=1S/C17H21N5O4S/c1-12-16(21-27(24,25)22-5-7-26-8-6-22)9-15(11-19-12)14-3-4-18-17(10-14)20-13(2)23/h3-4,9-11,21H,5-8H2,1-2H3,(H,18,20,23)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9751854 (2017)


BindingDB Entry DOI: 10.7270/Q2KS6TNJ
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM338269
PNG
(US9751854, Compound I-454 | US9802960, Compound I-...)
Show SMILES Cc1nccc(Nc2cc(ccn2)-c2c[n+]([O-])c(Cl)c(NS(=O)(=O)c3ccc(F)cc3F)c2C)n1
Show InChI InChI=1S/C22H17ClF2N6O3S/c1-12-16(14-5-7-27-20(9-14)29-19-6-8-26-13(2)28-19)11-31(32)22(23)21(12)30-35(33,34)18-4-3-15(24)10-17(18)25/h3-11,30H,1-2H3,(H,26,27,28,29)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9751854 (2017)


BindingDB Entry DOI: 10.7270/Q2KS6TNJ
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM338277
PNG
(US9751854, Compound I-463 | US9802960, Compound I-...)
Show SMILES CC(=O)Nc1cc(ccn1)-c1cnc(C)c(NS(=O)(=O)c2c(Cl)cccc2Cl)c1
Show InChI InChI=1S/C19H16Cl2N4O3S/c1-11-17(25-29(27,28)19-15(20)4-3-5-16(19)21)8-14(10-23-11)13-6-7-22-18(9-13)24-12(2)26/h3-10,25H,1-2H3,(H,22,24,26)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9751854 (2017)


BindingDB Entry DOI: 10.7270/Q2KS6TNJ
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM337920
PNG
(US9751854, Compound I-101 | US9802960, Compound I-...)
Show SMILES CC(=O)Nc1cc(ccn1)-c1cnc(N)c(c1)S(=O)(=O)NC1CCCCC1
Show InChI InChI=1S/C18H23N5O3S/c1-12(24)22-17-10-13(7-8-20-17)14-9-16(18(19)21-11-14)27(25,26)23-15-5-3-2-4-6-15/h7-11,15,23H,2-6H2,1H3,(H2,19,21)(H,20,22,24)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9751854 (2017)


BindingDB Entry DOI: 10.7270/Q2KS6TNJ
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM337922
PNG
(US9751854, Compound I-103 | US9802960, Compound I-...)
Show SMILES CN1CCN(CC1)S(=O)(=O)c1c[nH]c2ncc(cc12)-c1ccnc(NC(C)=O)c1
Show InChI InChI=1S/C19H22N6O3S/c1-13(26)23-18-10-14(3-4-20-18)15-9-16-17(12-22-19(16)21-11-15)29(27,28)25-7-5-24(2)6-8-25/h3-4,9-12H,5-8H2,1-2H3,(H,21,22)(H,20,23,26)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9751854 (2017)


BindingDB Entry DOI: 10.7270/Q2KS6TNJ
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM337967
PNG
(US9751854, Compound I-143 | US9802960, Compound I-...)
Show SMILES CC(=O)Nc1cc(ccn1)-c1cnc(C)c(NS(=O)(=O)c2cc(ccc2F)C(F)(F)F)c1
Show InChI InChI=1S/C20H16F4N4O3S/c1-11-17(7-14(10-26-11)13-5-6-25-19(8-13)27-12(2)29)28-32(30,31)18-9-15(20(22,23)24)3-4-16(18)21/h3-10,28H,1-2H3,(H,25,27,29)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9751854 (2017)


BindingDB Entry DOI: 10.7270/Q2KS6TNJ
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM337979
PNG
(US9751854, Compound I-155 | US9802960, Compound I-...)
Show SMILES CC(=O)Nc1cc(ccn1)-c1cnc(C)c(NS(=O)(=O)c2cccc(F)c2)c1
Show InChI InChI=1S/C19H17FN4O3S/c1-12-18(24-28(26,27)17-5-3-4-16(20)10-17)8-15(11-22-12)14-6-7-21-19(9-14)23-13(2)25/h3-11,24H,1-2H3,(H,21,23,25)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9751854 (2017)


BindingDB Entry DOI: 10.7270/Q2KS6TNJ
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM337990
PNG
(US9751854, Compound I-166 | US9802960, Compound I-...)
Show SMILES CN(C)S(=O)(=O)c1cc(cnc1N)-c1ccnc(Nc2ncco2)c1
Show InChI InChI=1S/C15H16N6O3S/c1-21(2)25(22,23)12-7-11(9-19-14(12)16)10-3-4-17-13(8-10)20-15-18-5-6-24-15/h3-9H,1-2H3,(H2,16,19)(H,17,18,20)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9751854 (2017)


BindingDB Entry DOI: 10.7270/Q2KS6TNJ
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM337994
PNG
(US9751854, Compound I-170 | US9802960, Compound I-...)
Show SMILES CC(=O)Nc1cc(ccn1)-c1cnc(N)c(c1)S(=O)(=O)Nc1ccc(F)cc1F
Show InChI InChI=1S/C18H15F2N5O3S/c1-10(26)24-17-7-11(4-5-22-17)12-6-16(18(21)23-9-12)29(27,28)25-15-3-2-13(19)8-14(15)20/h2-9,25H,1H3,(H2,21,23)(H,22,24,26)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9751854 (2017)


BindingDB Entry DOI: 10.7270/Q2KS6TNJ
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM338019
PNG
(US9751854, Compound I-195 | US9802960, Compound I-...)
Show SMILES COC(=O)Nc1cc(ccn1)-c1cnc(C)c(NS(=O)(=O)c2ccc(F)cc2F)c1
Show InChI InChI=1S/C19H16F2N4O4S/c1-11-16(25-30(27,28)17-4-3-14(20)9-15(17)21)7-13(10-23-11)12-5-6-22-18(8-12)24-19(26)29-2/h3-10,25H,1-2H3,(H,22,24,26)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9751854 (2017)


BindingDB Entry DOI: 10.7270/Q2KS6TNJ
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM338042
PNG
(US9751854, Compound I-217 | US9802960, Compound I-...)
Show SMILES CN(C)S(=O)(=O)Nc1cc(cnc1C)-c1ccnc(Nc2ccncn2)c1
Show InChI InChI=1S/C17H19N7O2S/c1-12-15(23-27(25,26)24(2)3)8-14(10-20-12)13-4-7-19-17(9-13)22-16-5-6-18-11-21-16/h4-11,23H,1-3H3,(H,18,19,21,22)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9751854 (2017)


BindingDB Entry DOI: 10.7270/Q2KS6TNJ
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM338106
PNG
(US9751854, Compound I-282 | US9802960, Compound I-...)
Show SMILES Cc1c(NS(=O)(=O)c2ccc(F)cc2F)c(Cl)ncc1-c1ccnc(Nc2ccncn2)c1
Show InChI InChI=1S/C21H15ClF2N6O2S/c1-12-15(13-4-7-26-19(8-13)29-18-5-6-25-11-28-18)10-27-21(22)20(12)30-33(31,32)17-3-2-14(23)9-16(17)24/h2-11,30H,1H3,(H,25,26,28,29)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9751854 (2017)


BindingDB Entry DOI: 10.7270/Q2KS6TNJ
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM338113
PNG
(US9751854, Compound I-289 | US9802960, Compound I-...)
Show SMILES Cc1ncc(cc1NS(=O)(=O)c1ccc(F)cc1F)-c1ccnc(Nc2ccc(C#N)c(C)n2)c1
Show InChI InChI=1S/C24H18F2N6O2S/c1-14-17(12-27)3-6-23(30-14)31-24-10-16(7-8-28-24)18-9-21(15(2)29-13-18)32-35(33,34)22-5-4-19(25)11-20(22)26/h3-11,13,32H,1-2H3,(H,28,30,31)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9751854 (2017)


BindingDB Entry DOI: 10.7270/Q2KS6TNJ
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM338133
PNG
(US9751854, Compound I-309 | US9802960, Compound I-...)
Show SMILES Cc1c(NS(=O)(=O)c2ccccc2)c(Cl)ncc1-c1ccnc(Nc2ccncn2)c1
Show InChI InChI=1S/C21H17ClN6O2S/c1-14-17(15-7-10-24-19(11-15)27-18-8-9-23-13-26-18)12-25-21(22)20(14)28-31(29,30)16-5-3-2-4-6-16/h2-13,28H,1H3,(H,23,24,26,27)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9751854 (2017)


BindingDB Entry DOI: 10.7270/Q2KS6TNJ
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM338191
PNG
(US9751854, Compound I-372)
Show SMILES CN(C)S(=O)(=O)Nc1cc(cnc1Cl)-c1ccnc(NC(C)=O)c1
Show InChI InChI=1S/C14H16ClN5O3S/c1-9(21)18-13-7-10(4-5-16-13)11-6-12(14(15)17-8-11)19-24(22,23)20(2)3/h4-8,19H,1-3H3,(H,16,18,21)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9751854 (2017)


BindingDB Entry DOI: 10.7270/Q2KS6TNJ
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM338201
PNG
(US9751854, Compound I-382 | US9802960, Compound I-...)
Show SMILES Cc1nc(Nc2cc(ccn2)-c2cnc(C)c(NS(=O)(=O)c3ccc(F)cc3F)c2)nc(n1)C1CC1
Show InChI InChI=1S/C24H21F2N7O2S/c1-13-20(33-36(34,35)21-6-5-18(25)11-19(21)26)9-17(12-28-13)16-7-8-27-22(10-16)31-24-30-14(2)29-23(32-24)15-3-4-15/h5-12,15,33H,3-4H2,1-2H3,(H,27,29,30,31,32)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9751854 (2017)


BindingDB Entry DOI: 10.7270/Q2KS6TNJ
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM338207
PNG
(US9751854, Compound I-389 | US9802960, Compound I-...)
Show SMILES CCOC(=O)Nc1cc(ccn1)-c1cnc(C)c(NS(=O)(=O)c2ccc(F)cc2F)c1
Show InChI InChI=1S/C20H18F2N4O4S/c1-3-30-20(27)25-19-9-13(6-7-23-19)14-8-17(12(2)24-11-14)26-31(28,29)18-5-4-15(21)10-16(18)22/h4-11,26H,3H2,1-2H3,(H,23,25,27)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9751854 (2017)


BindingDB Entry DOI: 10.7270/Q2KS6TNJ
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM338217
PNG
(US9751854, Compound I-401 | US9802960, Compound I-...)
Show SMILES CC(=O)Nc1cc(ccn1)-c1cnc(Cl)c(NS(=O)(=O)c2cc(Cl)ccc2Cl)c1C
Show InChI InChI=1S/C19H15Cl3N4O3S/c1-10-14(12-5-6-23-17(7-12)25-11(2)27)9-24-19(22)18(10)26-30(28,29)16-8-13(20)3-4-15(16)21/h3-9,26H,1-2H3,(H,23,25,27)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9751854 (2017)


BindingDB Entry DOI: 10.7270/Q2KS6TNJ
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM337844
PNG
(US9751854, Compound I-27 | US9802960, Compound I-2...)
Show SMILES CCN(CC)C(=O)c1cc(cnc1N)-c1ccnc(NC(C)=O)c1
Show InChI InChI=1S/C17H21N5O2/c1-4-22(5-2)17(24)14-8-13(10-20-16(14)18)12-6-7-19-15(9-12)21-11(3)23/h6-10H,4-5H2,1-3H3,(H2,18,20)(H,19,21,23)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9751854 (2017)


BindingDB Entry DOI: 10.7270/Q2KS6TNJ
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM337856
PNG
(US9751854, Compound I-39 | US9802960, Compound I-3...)
Show SMILES COc1ncc(cc1S(=O)(=O)Nc1ccccc1)-c1ccnc(NC(C)=O)c1
Show InChI InChI=1S/C19H18N4O4S/c1-13(24)22-18-11-14(8-9-20-18)15-10-17(19(27-2)21-12-15)28(25,26)23-16-6-4-3-5-7-16/h3-12,23H,1-2H3,(H,20,22,24)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9751854 (2017)


BindingDB Entry DOI: 10.7270/Q2KS6TNJ
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM337857
PNG
(US9751854, Compound I-40 | US9802960, Compound I-4...)
Show SMILES CN(C)S(=O)(=O)c1c[nH]c2ncc(cc12)-c1ccnc(NC(C)=O)c1
Show InChI InChI=1S/C16H17N5O3S/c1-10(22)20-15-7-11(4-5-17-15)12-6-13-14(25(23,24)21(2)3)9-19-16(13)18-8-12/h4-9H,1-3H3,(H,18,19)(H,17,20,22)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9751854 (2017)


BindingDB Entry DOI: 10.7270/Q2KS6TNJ
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM337876
PNG
(US9751854, Compound I-59 | US9802960, Compound I-5...)
Show SMILES CC(=O)Nc1cc(ccn1)-c1cnc(C)c(NS(=O)(=O)c2ccc(F)c(F)c2)c1
Show InChI InChI=1S/C19H16F2N4O3S/c1-11-18(25-29(27,28)15-3-4-16(20)17(21)9-15)7-14(10-23-11)13-5-6-22-19(8-13)24-12(2)26/h3-10,25H,1-2H3,(H,22,24,26)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9751854 (2017)


BindingDB Entry DOI: 10.7270/Q2KS6TNJ
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM337897
PNG
(US9751854, Compound I-78 | US9802960, Compound I-7...)
Show SMILES CC(=O)Nc1cc(ccn1)-c1cnc(C)c(NS(=O)(=O)c2cccc3ccccc23)c1
Show InChI InChI=1S/C23H20N4O3S/c1-15-21(12-19(14-25-15)18-10-11-24-23(13-18)26-16(2)28)27-31(29,30)22-9-5-7-17-6-3-4-8-20(17)22/h3-14,27H,1-2H3,(H,24,26,28)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9751854 (2017)


BindingDB Entry DOI: 10.7270/Q2KS6TNJ
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM337899
PNG
(US9751854, Compound I-80 | US9802960, Compound I-8...)
Show SMILES CC(=O)Nc1cc(ccn1)-c1cnc(C)c(NS(=O)(=O)c2ccc(C)cc2)c1
Show InChI InChI=1S/C20H20N4O3S/c1-13-4-6-18(7-5-13)28(26,27)24-19-10-17(12-22-14(19)2)16-8-9-21-20(11-16)23-15(3)25/h4-12,24H,1-3H3,(H,21,23,25)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9751854 (2017)


BindingDB Entry DOI: 10.7270/Q2KS6TNJ
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM337930
PNG
(US9751854, Compound I-111 | US9802960, Compound I-...)
Show SMILES CC(=O)Nc1cc(ccn1)-c1cnc(C)c(NS(=O)(=O)c2cc(Cl)ccc2Cl)c1
Show InChI InChI=1S/C19H16Cl2N4O3S/c1-11-17(25-29(27,28)18-9-15(20)3-4-16(18)21)7-14(10-23-11)13-5-6-22-19(8-13)24-12(2)26/h3-10,25H,1-2H3,(H,22,24,26)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9751854 (2017)


BindingDB Entry DOI: 10.7270/Q2KS6TNJ
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM337932
PNG
(US9751854, Compound I-113 | US9802960, Compound I-...)
Show SMILES CC(=O)Nc1cc(ccn1)-c1cnc(C)c(NS(=O)(=O)c2ccc(OC(F)(F)F)cc2Cl)c1
Show InChI InChI=1S/C20H16ClF3N4O4S/c1-11-17(7-14(10-26-11)13-5-6-25-19(8-13)27-12(2)29)28-33(30,31)18-4-3-15(9-16(18)21)32-20(22,23)24/h3-10,28H,1-2H3,(H,25,27,29)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9751854 (2017)


BindingDB Entry DOI: 10.7270/Q2KS6TNJ
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM337944
PNG
(US9751854, Compound I-120 | US9802960, Compound I-...)
Show SMILES CCN(CC)S(=O)(=O)c1cncc(c1)-c1ccnc(NC(C)=O)c1
Show InChI InChI=1S/C16H20N4O3S/c1-4-20(5-2)24(22,23)15-8-14(10-17-11-15)13-6-7-18-16(9-13)19-12(3)21/h6-11H,4-5H2,1-3H3,(H,18,19,21)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9751854 (2017)


BindingDB Entry DOI: 10.7270/Q2KS6TNJ
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%