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USPatent US9815850

Compile Data Set for Download or QSAR

Found 266 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM356230
PNG
(US10604535, Example 2B | US9815850, Compound 2 | U...)
Show SMILES CN1c2ccccc2C(F)CC(NC(=O)c2cc(Cc3ccccc3)on2)C1=O
Show InChI InChI=1S/C22H20FN3O3/c1-26-20-10-6-5-9-16(20)17(23)13-19(22(26)28)24-21(27)18-12-15(29-25-18)11-14-7-3-2-4-8-14/h2-10,12,17,19H,11,13H2,1H3,(H,24,27)
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Denali Therapeutics Inc.

US Patent


Assay Description
ollowing this reaction, 10 uL of ADP-Glo reagent (Promega) was added to each well and incubated for 40 min at room temperature. This stops the kinase...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM356230
PNG
(US10604535, Example 2B | US9815850, Compound 2 | U...)
Show SMILES CN1c2ccccc2C(F)CC(NC(=O)c2cc(Cc3ccccc3)on2)C1=O
Show InChI InChI=1S/C22H20FN3O3/c1-26-20-10-6-5-9-16(20)17(23)13-19(22(26)28)24-21(27)18-12-15(29-25-18)11-14-7-3-2-4-8-14/h2-10,12,17,19H,11,13H2,1H3,(H,24,27)
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM356243
PNG
(US10604535, Example 11A | US9815850, Compound 11 |...)
Show SMILES CN1c2ccccc2[C@H](F)C[C@H](NC(=O)c2nnc(Cc3ccccc3)[nH]2)C1=O |r|
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM356248
PNG
(US10604535, Example 12B | US9815850, Compound 12B ...)
Show SMILES CN1c2ccccc2[C@H](F)C[C@@H](NC(=O)c2nnc(Cc3ccccc3)[nH]2)C1=O |r|
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM356267
PNG
(US10604535, Example 35 | US9815850, Compound 35 | ...)
Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2nnc([nH]2)C2(CC2)c2ccccc2)C1=O |r|
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM356282
PNG
(US10604535, Example 54B | US9815850, Compound 54A ...)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2nnc([nH]2)C2CCc3ccccc23)C1=O |r|
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM356286
PNG
(US10604535, Example 57 | US9815850, Compound 57 | ...)
Show SMILES Fc1cn(Cc2ccccc2)nc1C(=O)N[C@H]1COc2cccnc2NC1=O |r|
Show InChI InChI=1S/C19H16FN5O3/c20-13-10-25(9-12-5-2-1-3-6-12)24-16(13)19(27)22-14-11-28-15-7-4-8-21-17(15)23-18(14)26/h1-8,10,14H,9,11H2,(H,22,27)(H,21,23,26)/t14-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM356291
PNG
(US10604535, Example 61 | US9815850, Compound 61 | ...)
Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2coc(n2)C2(CC2)c2ccccc2)C1=O |r|
Show InChI InChI=1S/C23H21N3O4/c1-26-18-9-5-6-10-19(18)29-14-17(21(26)28)24-20(27)16-13-30-22(25-16)23(11-12-23)15-7-3-2-4-8-15/h2-10,13,17H,11-12,14H2,1H3,(H,24,27)/t17-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM356293
PNG
(US10604535, Example 63 | US9815850, Compound 63 | ...)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2ncc(s2)C2(CC2)c2ccccc2)C1=O |r|
Show InChI InChI=1S/C22H20N4O3S/c1-26-18-16(8-5-11-23-18)29-13-15(21(26)28)25-19(27)20-24-12-17(30-20)22(9-10-22)14-6-3-2-4-7-14/h2-8,11-12,15H,9-10,13H2,1H3,(H,25,27)/t15-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM356303
PNG
(US9815850, Compound 70A)
Show SMILES O=C(N[C@H]1COc2ccccc2-n2cnnc12)c1cc(Cc2ccccc2)[nH]n1 |r|
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM356326
PNG
(US10604535, Example 86 | US9815850, Compound 86 | ...)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2ncc(Cc3ccccc3)s2)C1=O |r|
Show InChI InChI=1S/C20H18N4O3S/c1-24-17-16(8-5-9-21-17)27-12-15(20(24)26)23-18(25)19-22-11-14(28-19)10-13-6-3-2-4-7-13/h2-9,11,15H,10,12H2,1H3,(H,23,25)/t15-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM356343
PNG
(US10604535, Example 100B | US9815850, Compound 100...)
Show SMILES CN1c2ncccc2[C@H]2C[C@H]2[C@@H](NC(=O)c2cc(Oc3ccccc3F)ccn2)C1=O |r|
Show InChI InChI=1S/C23H19FN4O3/c1-28-21-14(5-4-9-26-21)15-12-16(15)20(23(28)30)27-22(29)18-11-13(8-10-25-18)31-19-7-3-2-6-17(19)24/h2-11,15-16,20H,12H2,1H3,(H,27,29)/t15-,16-,20-/m1/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM356392
PNG
(US10604535, Example 132 | US9815850, Compound 132 ...)
Show SMILES C[C@H]1Oc2cccnc2N(C)C(=O)[C@H]1NC(=O)c1nn(Cc2ccccc2)cc1Cl |r|
Show InChI InChI=1S/C21H20ClN5O3/c1-13-17(21(29)26(2)19-16(30-13)9-6-10-23-19)24-20(28)18-15(22)12-27(25-18)11-14-7-4-3-5-8-14/h3-10,12-13,17H,11H2,1-2H3,(H,24,28)/t13-,17+/m1/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM356398
PNG
(US10604535, Example 138 | US9815850, Compound 138 ...)
Show SMILES C[C@H]1Oc2cccnc2N(C)C(=O)[C@H]1NC(=O)c1nnc(o1)C1(CC1)c1ccccc1 |r|
Show InChI InChI=1S/C22H21N5O4/c1-13-16(20(29)27(2)17-15(30-13)9-6-12-23-17)24-18(28)19-25-26-21(31-19)22(10-11-22)14-7-4-3-5-8-14/h3-9,12-13,16H,10-11H2,1-2H3,(H,24,28)/t13-,16+/m1/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM356404
PNG
(US10604535, Example 143 | US9815850, Compound 143 ...)
Show SMILES C[C@H]1Oc2cccnc2N(C)C(=O)[C@H]1NC(=O)c1nn(Cc2ccc(F)cc2)cc1F |r|
Show InChI InChI=1S/C21H19F2N5O3/c1-12-17(21(30)27(2)19-16(31-12)4-3-9-24-19)25-20(29)18-15(23)11-28(26-18)10-13-5-7-14(22)8-6-13/h3-9,11-12,17H,10H2,1-2H3,(H,25,29)/t12-,17+/m1/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM356417
PNG
(US9815850, Compound 153 | US9896458, No. 153)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2nn(Cc3ccccc3C#N)cc2F)C1=O |r|
Show InChI InChI=1S/C21H17FN6O3/c1-27-19-17(7-4-8-24-19)31-12-16(21(27)30)25-20(29)18-15(22)11-28(26-18)10-14-6-3-2-5-13(14)9-23/h2-8,11,16H,10,12H2,1H3,(H,25,29)/t16-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM356429
PNG
(US10604535, Example 161 | US9815850, Compound 161 ...)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2nnc(Cc3cccc(c3)C#N)[nH]2)C1=O |r|
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM356435
PNG
(US10604535, Example 167 | US9815850, Compound 167)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2cc(C#N)n(Cc3cccc(c3)C#N)n2)C1=O |r|
Show InChI InChI=1S/C22H17N7O3/c1-28-20-19(6-3-7-25-20)32-13-18(22(28)31)26-21(30)17-9-16(11-24)29(27-17)12-15-5-2-4-14(8-15)10-23/h2-9,18H,12-13H2,1H3,(H,26,30)/t18-/m0/s1
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM356448
PNG
(US10604535, Example 178A | US9815850, Compound 178...)
Show SMILES CN1c2nccnc2CC[C@H](NC(=O)c2nn(Cc3ccccc3F)cc2F)C1=O |r|
Show InChI InChI=1S/C20H18F2N6O2/c1-27-18-15(23-8-9-24-18)6-7-16(20(27)30)25-19(29)17-14(22)11-28(26-17)10-12-4-2-3-5-13(12)21/h2-5,8-9,11,16H,6-7,10H2,1H3,(H,25,29)/t16-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM356455
PNG
(US10604535, Example 181B | US9815850, Compound 181...)
Show SMILES Fc1cc(F)c2NC(=O)[C@@H](NC(=O)c3nnc(Cc4cccc(c4)C#N)[nH]3)[C@H]3C[C@H]3c2c1 |r|
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM356463
PNG
(US10604535, Example 192 | US9815850, Compound 192 ...)
Show SMILES C[C@H]1Oc2cccnc2N(C)C(=O)[C@H]1NC(=O)c1ncc(Cc2ccccc2)o1 |r|
Show InChI InChI=1S/C21H20N4O4/c1-13-17(21(27)25(2)18-16(28-13)9-6-10-22-18)24-19(26)20-23-12-15(29-20)11-14-7-4-3-5-8-14/h3-10,12-13,17H,11H2,1-2H3,(H,24,26)/t13-,17+/m1/s1
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM356464
PNG
(US10604535, Example 193 | US9815850, Compound 193 ...)
Show SMILES C[C@H]1Oc2ncccc2N(C)C(=O)[C@H]1NC(=O)c1nnc(Cc2ccccc2)o1 |r|
Show InChI InChI=1S/C20H19N5O4/c1-12-16(20(27)25(2)14-9-6-10-21-18(14)28-12)22-17(26)19-24-23-15(29-19)11-13-7-4-3-5-8-13/h3-10,12,16H,11H2,1-2H3,(H,22,26)/t12-,16+/m1/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM356471
PNG
(US10604535, Example 203 | US9815850, Compound 203 ...)
Show SMILES C[C@H]1Oc2cccnc2N(C)C(=O)[C@H]1NC(=O)c1cn(Cc2ccccc2)nn1 |r|
Show InChI InChI=1S/C20H20N6O3/c1-13-17(20(28)25(2)18-16(29-13)9-6-10-21-18)22-19(27)15-12-26(24-23-15)11-14-7-4-3-5-8-14/h3-10,12-13,17H,11H2,1-2H3,(H,22,27)/t13-,17+/m1/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM356479
PNG
(US10604535, Example 214 | US9815850, Compound 214 ...)
Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2nn(Cc3ccc(F)cn3)cc2F)C1=O |r|
Show InChI InChI=1S/C20H17F2N5O3/c1-26-16-4-2-3-5-17(16)30-11-15(20(26)29)24-19(28)18-14(22)10-27(25-18)9-13-7-6-12(21)8-23-13/h2-8,10,15H,9,11H2,1H3,(H,24,28)/t15-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM356490
PNG
(US10604535, Example 225 | US9815850, Compound 225 ...)
Show SMILES CN1c2ccccc2CC[C@H](NC(=O)c2nnc(Cc3ccccc3)o2)C1=O |r|
Show InChI InChI=1S/C21H20N4O3/c1-25-17-10-6-5-9-15(17)11-12-16(21(25)27)22-19(26)20-24-23-18(28-20)13-14-7-3-2-4-8-14/h2-10,16H,11-13H2,1H3,(H,22,26)/t16-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM356230
PNG
(US10604535, Example 2B | US9815850, Compound 2 | U...)
Show SMILES CN1c2ccccc2C(F)CC(NC(=O)c2cc(Cc3ccccc3)on2)C1=O
Show InChI InChI=1S/C22H20FN3O3/c1-26-20-10-6-5-9-16(20)17(23)13-19(22(26)28)24-21(27)18-12-15(29-25-18)11-14-7-3-2-4-8-14/h2-10,12,17,19H,11,13H2,1H3,(H,24,27)
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM356234
PNG
(US10604535, Example 4 | US9815850, Compound 4 | US...)
Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2nn(Cc3ccccc3)c(C)c2Cl)C1=O |r|
Show InChI InChI=1S/C22H21ClN4O3/c1-14-19(23)20(25-27(14)12-15-8-4-3-5-9-15)21(28)24-16-13-30-18-11-7-6-10-17(18)26(2)22(16)29/h3-11,16H,12-13H2,1-2H3,(H,24,28)/t16-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM356236
PNG
(US10604535, Example 6 | US9815850, Compound 6 | US...)
Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2nn(Cc3ccccc3)c(C)c2F)C1=O |r|
Show InChI InChI=1S/C22H21FN4O3/c1-14-19(23)20(25-27(14)12-15-8-4-3-5-9-15)21(28)24-16-13-30-18-11-7-6-10-17(18)26(2)22(16)29/h3-11,16H,12-13H2,1-2H3,(H,24,28)/t16-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM356246
PNG
(US10604535, Example 12A | US9815850, Compound 12 |...)
Show SMILES CN1c2ccccc2[C@@H](F)C[C@H](NC(=O)c2nnc(Cc3ccccc3)[nH]2)C1=O |r|
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM356280
PNG
(US9815850, Compound 51 | US9896458, No. 51)
Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2nnc([nH]2)C2CCc3ccccc23)C1=O |r|
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM356285
PNG
(US10604535, Example 56 | US9815850, Compound 56 | ...)
Show SMILES CN1c2cccc(C#N)c2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)[nH]2)C1=O |r|
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM356308
PNG
(US10604535, Example 73 | US9815850, Compound 73 | ...)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2cc([nH]n2)C2(CC2)c2ccccc2)C1=O |r|
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM356314
PNG
(US10604535, Example 78 | US9815850, Compound 78 | ...)
Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2ncc([nH]2)C2(CC2)c2ccccc2)C1=O |r|
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM356349
PNG
(US10604535, Example 103B | US9815850, Compound 103...)
Show SMILES Fc1cc(F)c2NC(=O)[C@H](CC3(CC3)c2c1)NC(=O)c1nnc(Cc2ccccc2)[nH]1 |r|
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM356357
PNG
(US10604535, Example 108 | US9815850, Compound 108 ...)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2cnc(Cc3ccccc3)[nH]2)C1=O |r|
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM356364
PNG
(US10604535, Example 112 | US9815850, Compound 112)
Show SMILES C[C@H]1Oc2cccnc2N(C)C(=O)[C@H]1NC(=O)c1cc(Cc2ccccc2)on1 |r|
Show InChI InChI=1S/C21H20N4O4/c1-13-18(21(27)25(2)19-17(28-13)9-6-10-22-19)23-20(26)16-12-15(29-24-16)11-14-7-4-3-5-8-14/h3-10,12-13,18H,11H2,1-2H3,(H,23,26)/t13-,18+/m1/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM356366
PNG
(US9815850, Compound 114A)
Show SMILES CN1c2cnn(C)c2OC[C@H](NC(=O)c2nn(Cc3ccccc3)cc2F)C1=O |r|
Show InChI InChI=1S/C19H19FN6O3/c1-24-15-8-21-25(2)19(15)29-11-14(18(24)28)22-17(27)16-13(20)10-26(23-16)9-12-6-4-3-5-7-12/h3-8,10,14H,9,11H2,1-2H3,(H,22,27)/t14-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM356370
PNG
(US10604535, Example 117 | US9815850, Compound 117 ...)
Show SMILES C[C@H]1Oc2cccnc2N(C)C(=O)[C@H]1NC(=O)c1cc(Oc2ccccc2F)ccn1 |r|
Show InChI InChI=1S/C22H19FN4O4/c1-13-19(22(29)27(2)20-18(30-13)8-5-10-25-20)26-21(28)16-12-14(9-11-24-16)31-17-7-4-3-6-15(17)23/h3-13,19H,1-2H3,(H,26,28)/t13-,19+/m1/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM356384
PNG
(US9815850, Compound 126 | US9896458, No. 126)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2nc(F)c(Cc3ccccc3)s2)C1=O |r|
Show InChI InChI=1S/C20H17FN4O3S/c1-25-17-14(8-5-9-22-17)28-11-13(20(25)27)23-18(26)19-24-16(21)15(29-19)10-12-6-3-2-4-7-12/h2-9,13H,10-11H2,1H3,(H,23,26)/t13-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM356395
PNG
(US10604535, Example 135 | US9815850, Compound 135 ...)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2nn(Cc3cccc(F)c3)cc2F)C1=O |r|
Show InChI InChI=1S/C20H17F2N5O3/c1-26-18-16(6-3-7-23-18)30-11-15(20(26)29)24-19(28)17-14(22)10-27(25-17)9-12-4-2-5-13(21)8-12/h2-8,10,15H,9,11H2,1H3,(H,24,28)/t15-/m0/s1
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM356410
PNG
(US10604535, Example 148A | US9815850, Compound 148...)
Show SMILES CN1c2ncccc2CC[C@H](NC(=O)c2nnc(Cc3ccccc3)o2)C1=O |r|
Show InChI InChI=1S/C20H19N5O3/c1-25-17-14(8-5-11-21-17)9-10-15(20(25)27)22-18(26)19-24-23-16(28-19)12-13-6-3-2-4-7-13/h2-8,11,15H,9-10,12H2,1H3,(H,22,26)/t15-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM356425
PNG
(US10604535, Example 158 | US9815850, Compound 158 ...)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2cc(C#N)n(Cc3ccccc3)n2)C1=O |r|
Show InChI InChI=1S/C21H18N6O3/c1-26-19-18(8-5-9-23-19)30-13-17(21(26)29)24-20(28)16-10-15(11-22)27(25-16)12-14-6-3-2-4-7-14/h2-10,17H,12-13H2,1H3,(H,24,28)/t17-/m0/s1
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM356426
PNG
(US10604535, Example 159 | US9815850, Compound 159 ...)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2cc(C#N)n(Cc3ccc(F)cc3)n2)C1=O |r|
Show InChI InChI=1S/C21H17FN6O3/c1-27-19-18(3-2-8-24-19)31-12-17(21(27)30)25-20(29)16-9-15(10-23)28(26-16)11-13-4-6-14(22)7-5-13/h2-9,17H,11-12H2,1H3,(H,25,29)/t17-/m0/s1
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM356432
PNG
(US10604535, Example 164 | US9815850, Compound 164 ...)
Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2ncc(Cc3cccc(c3)C#N)s2)C1=O |r|
Show InChI InChI=1S/C22H18N4O3S/c1-26-18-7-2-3-8-19(18)29-13-17(22(26)28)25-20(27)21-24-12-16(30-21)10-14-5-4-6-15(9-14)11-23/h2-9,12,17H,10,13H2,1H3,(H,25,27)/t17-/m0/s1
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM356296
PNG
(US10604535, Example 173 | US9815850, Compound 173 ...)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2nnc(o2)C2(CC2)c2ccccc2)C1=O |r|
Show InChI InChI=1S/C21H19N5O4/c1-26-16-15(8-5-11-22-16)29-12-14(19(26)28)23-17(27)18-24-25-20(30-18)21(9-10-21)13-6-3-2-4-7-13/h2-8,11,14H,9-10,12H2,1H3,(H,23,27)/t14-/m0/s1
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM356470
PNG
(US10604535, Example 201 | US9815850, Compound 201 ...)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2cn(Cc3ccccc3)nn2)C1=O |r|
Show InChI InChI=1S/C19H18N6O3/c1-24-17-16(8-5-9-20-17)28-12-15(19(24)27)21-18(26)14-11-25(23-22-14)10-13-6-3-2-4-7-13/h2-9,11,15H,10,12H2,1H3,(H,21,26)/t15-/m0/s1
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM356481
PNG
(US10604535, Example 216 | US9815850, Compound 216 ...)
Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2nn(Cc3ccc(Cl)cn3)cc2F)C1=O |r|
Show InChI InChI=1S/C20H17ClFN5O3/c1-26-16-4-2-3-5-17(16)30-11-15(20(26)29)24-19(28)18-14(22)10-27(25-18)9-13-7-6-12(21)8-23-13/h2-8,10,15H,9,11H2,1H3,(H,24,28)/t15-/m0/s1
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM356489
PNG
(US10604535, Example 224 | US9815850, Compound 224 ...)
Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2nn(Cc3ncccn3)cc2F)C1=O |r|
Show InChI InChI=1S/C19H17FN6O3/c1-25-14-5-2-3-6-15(14)29-11-13(19(25)28)23-18(27)17-12(20)9-26(24-17)10-16-21-7-4-8-22-16/h2-9,13H,10-11H2,1H3,(H,23,27)/t13-/m0/s1
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM356229
PNG
(US10604535, Example 1B | US9815850, Compound 1B | ...)
Show SMILES CN1c2cc(Cl)sc2CC[C@@H](NC(=O)c2cc(Cc3ccccc3)on2)C1=O |r|
Show InChI InChI=1S/C20H18ClN3O3S/c1-24-16-11-18(21)28-17(16)8-7-14(20(24)26)22-19(25)15-10-13(27-23-15)9-12-5-3-2-4-6-12/h2-6,10-11,14H,7-9H2,1H3,(H,22,25)/t14-/m1/s1
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM356240
PNG
(US10604535, Example 8 | US9815850, Compound 8 | US...)
Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2cc(on2)C2(CC2)c2ccccc2)C1=O |r|
Show InChI InChI=1S/C23H21N3O4/c1-26-18-9-5-6-10-19(18)29-14-17(22(26)28)24-21(27)16-13-20(30-25-16)23(11-12-23)15-7-3-2-4-8-15/h2-10,13,17H,11-12,14H2,1H3,(H,24,27)/t17-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
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Denali Therapeutics Inc.

US Patent


Assay Description
Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...


US Patent US9815850 (2017)


BindingDB Entry DOI: 10.7270/Q2W0987J
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%