| Reaction Details |
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 | Report a problem with these data |
| Target | Bone morphogenetic protein 10 |
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| Ligand | BDBM280349 |
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| Substrate/Competitor | n/a |
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| IC50 | >1000000±n/a nM |
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| Citation |  Rai, R; Chakravarty, S; Pujala, B; Shinde, BU; Nayak, AK; Agarwal, AK; Ramachandran, SA; Pham, SM Compounds and methods of use US Patent US11053216 Publication Date 7/6/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Bone morphogenetic protein 10 |
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| Name: | Bone morphogenetic protein 10 |
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| Synonyms: | Alk6 | BMP10 | BMP10_HUMAN |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 48028.70 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O95393 |
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| Residue: | 424 |
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| Sequence: | MGSLVLTLCALFCLAAYLVSGSPIMNLEQSPLEEDMSLFGDVFSEQDGVDFNTLLQSMKD
EFLKTLNLSDIPTQDSAKVDPPEYMLELYNKFATDRTSMPSANIIRSFKNEDLFSQPVSF
NGLRKYPLLFNVSIPHHEEVIMAELRLYTLVQRDRMIYDGVDRKITIFEVLESKGDNEGE
RNMLVLVSGEIYGTNSEWETFDVTDAIRRWQKSGSSTHQLEVHIESKHDEAEDASSGRLE
IDTSAQNKHNPLLIVFSDDQSSDKERKEELNEMISHEQLPELDNLGLDSFSSGPGEEALL
QMRSNIIYDSTARIRRNAKGNYCKRTPLYIDFKEIGWDSWIIAPPGYEAYECRGVCNYPL
AEHLTPTKHAIIQALVHLKNSQKASKACCVPTKLEPISILYLDKGVVTYKFKYEGMAVSE
CGCR
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| BDBM280349 |
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| n/a |
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| Name | BDBM280349 |
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| Synonyms: | (S)-4-(2-(5-chloro-2-fluorophenyl)-5-(dimethylamino)pyridin-4-ylamino)-N-(2-hydroxypropyl)nicotinamide | US10030004, Compound 16a | US10501436, Compound 16a | US11053216, Compound 16a | US11702401, Compound 16a |
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| Type | Small organic molecule |
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| Emp. Form. | C22H23ClFN5O2 |
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| Mol. Mass. | 443.902 |
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| SMILES | C[C@H](O)CNC(=O)c1cnccc1Nc1cc(ncc1N(C)C)-c1cc(Cl)ccc1F |r| |
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| Structure | 
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