| Reaction Details |
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 | Report a problem with these data |
| Target | Transitional endoplasmic reticulum ATPase |
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| Ligand | BDBM536747 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biological Assay |
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| IC50 | 15.0±n/a nM |
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| Citation |  Huryn, DM; Wipf, P; LaPorte, MG; Colombo, R; Kovaliov, M; Lim, C; Alverez, CN; Yue, Z; Samankumara, LP; Chatterley, AJ; Yan, Y; Liang, M; Green, NJ; Baldwin, ET; Moore, WJ; Arkin, M; Neitz, RJ; Ang, K; Bryant, C; Bulfer, S Phenyl indole allosteric inhibitors of P97 ATPase US Patent US11247985 Publication Date 2/15/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Transitional endoplasmic reticulum ATPase |
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| Name: | Transitional endoplasmic reticulum ATPase |
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| Synonyms: | TERA_HUMAN | Transitional endoplasmic reticulum ATPase | VCP | Valosin containing protein, p97 subunit | Valosin-containing protein |
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| Type: | Enzyme |
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| Mol. Mass.: | 89300.63 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P55072 |
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| Residue: | 806 |
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| Sequence: | MASGADSKGDDLSTAILKQKNRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLK
GKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPID
DTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDT
VIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRG
ILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAI
IFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRF
GRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAAL
QAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIG
GLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFI
SIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRV
INQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKAN
LRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRERERQTNPSAM
EVEEDDPVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPSGNQGG
AGPSQGSGGGTGGSVYTEDNDDDLYG
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| BDBM536747 |
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| n/a |
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| Name | BDBM536747 |
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| Synonyms: | US11247985, Table 3.51 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H42N6 |
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| Mol. Mass. | 510.7161 |
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| SMILES | CC(C)N1CCN(CC1)C1(CNC2CCN(CC2)c2cccc(c2)-c2cc3cc(ccc3[nH]2)C#N)CCC1 |
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| Structure | 
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