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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Transitional endoplasmic reticulum ATPase | ||
| Ligand | BDBM50468115 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Biological Assay | ||
| IC50 | 175±n/a nM | ||
| Citation |  Huryn, DM; Wipf, P; LaPorte, MG; Colombo, R; Kovaliov, M; Lim, C; Alverez, CN; Yue, Z; Samankumara, LP; Chatterley, AJ; Yan, Y; Liang, M; Green, NJ; Baldwin, ET; Moore, WJ; Arkin, M; Neitz, RJ; Ang, K; Bryant, C; Bulfer, S Phenyl indole allosteric inhibitors of P97 ATPase US Patent US11247985 Publication Date 2/15/2022 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Transitional endoplasmic reticulum ATPase | |||
| Name: | Transitional endoplasmic reticulum ATPase | ||
| Synonyms: | TERA_HUMAN | Transitional endoplasmic reticulum ATPase | VCP | Valosin containing protein, p97 subunit | Valosin-containing protein | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 89300.63 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P55072 | ||
| Residue: | 806 | ||
| Sequence: |
| ||
| BDBM50468115 | |||
| n/a | |||
| Name | BDBM50468115 | ||
| Synonyms: | CHEMBL4278176 | US11247985, Table 3.117 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H36FN3 | ||
| Mol. Mass. | 433.6039 | ||
| SMILES | CC(C)N1CCC(CC1)N[C@H]1CC[C@@H](CC1)c1cccc(c1)-c1cc2cc(F)ccc2[nH]1 |r,wU:13.17,wD:10.10,(52.21,-2.26,;51.43,-3.58,;52.19,-4.92,;49.89,-3.58,;49.13,-2.23,;47.59,-2.23,;46.81,-3.53,;47.56,-4.87,;49.1,-4.87,;45.28,-3.53,;44.49,-4.83,;42.95,-4.83,;42.18,-6.15,;42.94,-7.49,;44.47,-7.49,;45.26,-6.18,;42.16,-8.82,;42.93,-10.16,;42.16,-11.49,;40.62,-11.49,;39.85,-10.14,;40.62,-8.82,;38.31,-10.14,;37.41,-11.4,;35.94,-10.92,;34.6,-11.68,;33.27,-10.91,;31.94,-11.69,;33.27,-9.37,;34.6,-8.59,;35.94,-9.37,;37.41,-8.89,)| | ||
| Structure | 
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