| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Transitional endoplasmic reticulum ATPase |
|---|
| Ligand | BDBM536821 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Biological Assay |
|---|
| IC50 | 260±n/a nM |
|---|
| Citation |  Huryn, DM; Wipf, P; LaPorte, MG; Colombo, R; Kovaliov, M; Lim, C; Alverez, CN; Yue, Z; Samankumara, LP; Chatterley, AJ; Yan, Y; Liang, M; Green, NJ; Baldwin, ET; Moore, WJ; Arkin, M; Neitz, RJ; Ang, K; Bryant, C; Bulfer, S Phenyl indole allosteric inhibitors of P97 ATPase US Patent US11247985 Publication Date 2/15/2022 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Transitional endoplasmic reticulum ATPase |
|---|
| Name: | Transitional endoplasmic reticulum ATPase |
|---|
| Synonyms: | TERA_HUMAN | Transitional endoplasmic reticulum ATPase | VCP | Valosin containing protein, p97 subunit | Valosin-containing protein |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 89300.63 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P55072 |
|---|
| Residue: | 806 |
|---|
| Sequence: | MASGADSKGDDLSTAILKQKNRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLK
GKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPID
DTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDT
VIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRG
ILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAI
IFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRF
GRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAAL
QAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIG
GLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFI
SIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRV
INQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKAN
LRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRERERQTNPSAM
EVEEDDPVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPSGNQGG
AGPSQGSGGGTGGSVYTEDNDDDLYG
|
|
|
|---|
| BDBM536821 |
|---|
| n/a |
|---|
| Name | BDBM536821 |
|---|
| Synonyms: | US11247985, Table 3.125 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C31H43N5 |
|---|
| Mol. Mass. | 485.7066 |
|---|
| SMILES | CN1CCN(CC1)C1(CNC2CCN(CC2)c2cccc(c2)-c2cc3ccccc3[nH]2)CCCCC1 |
|---|
| Structure | 
|
|---|
Search and Browse
