Reaction Details |
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Target | Bone morphogenetic protein receptor type-1A |
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Ligand | BDBM280358 |
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Substrate/Competitor | n/a |
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Meas. Tech. | In Vitro Kinase Assay - Inhibition of ALK1/2/3/4/5/6 Kinases |
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IC50 | >100000±n/a nM |
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Citation | Rai, R; Chakravarty, S; Pujala, B; Shinde, BU; Nayak, AK; Agarwal, AK; Ramachandran, SA; Pham, SM Compounds and methods of use US Patent US11702401 Publication Date 7/18/2023 |
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More Info.: | Get all data from this article, Assay Method |
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Bone morphogenetic protein receptor type-1A |
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Name: | Bone morphogenetic protein receptor type-1A |
Synonyms: | ACVRLK3 | ALK3 | Activin receptor-like kinase 3 (ALK-3) | BMPR1A | BMR1A_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 60204.46 |
Organism: | Homo sapiens (Human) |
Description: | P36894 |
Residue: | 532 |
Sequence: | MPQLYIYIRLLGAYLFIISRVQGQNLDSMLHGTGMKSDSDQKKSENGVTLAPEDTLPFLK
CYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRR
TIECCRTNLCNQYLQPTLPPVVIGPFFDGSIRWLVLLISMAVCIIAMIIFSSCFCYKHYC
KSISSRRRYNRDLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQV
GKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTG
SWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAH
RDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLDESLNKN
HFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLR
PIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVESQDVKI
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BDBM280358 |
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n/a |
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Name | BDBM280358 |
Synonyms: | 4-[[2-(5-chloro-2-fluoro-phenyl)-5-vinyl-4-pyridyl]amino]-N-[(1R)-1-(hydroxy methyl)-2-methyl-propyl]pyridine-3-carboxamide | US10030004, Compound 25a | US10501436, Compound 25a | US11053216, Compound 25a | US11702401, Compound 25a |
Type | Small organic molecule |
Emp. Form. | C25H26ClFN4O2 |
Mol. Mass. | 468.951 |
SMILES | CC(C)[C@H](CO)NC(=O)c1cnccc1Nc1cc(ncc1C(C)=C)-c1cc(Cl)ccc1F |r| |
Structure |
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