Reaction Details | |||
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Target | GTPase KRas [G12C] | ||
Ligand | BDBM608982 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Scintillation Proximity Assay (SPA) | ||
IC50 | 55.0±n/a nM | ||
Citation | Cotesta, S; Gerspacher, M; Leblanc, C; Lorthiois, EL; Liu, B; Machauer, R; Mah, R; Mura, C; Rigollier, P; Schneider, N; Stutz, S; Vaupel, A; Warin, N; Wilcken, R Pyrazolyl derivatives useful as anti-cancer agents US Patent US11702409 Publication Date 7/18/2023 | ||
More Info.: | Get all data from this article, Assay Method | ||
GTPase KRas [G12C] | |||
Name: | GTPase KRas [G12C] | ||
Synonyms: | GTPase KRas (G12C) | KRAS | KRAS2 | RASK2 | RASK_HUMAN | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 21702.19 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P01116[G12C] | ||
Residue: | 189 | ||
Sequence: |
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BDBM608982 | |||
n/a | |||
Name | BDBM608982 | ||
Synonyms: | US11702409, Example 64a | US11702409, Example 64b | ||
Type | Small organic molecule | ||
Emp. Form. | C30H32ClN7O3 | ||
Mol. Mass. | 574.073 | ||
SMILES | COCCNC(=O)c1ccc(cn1)-c1nn(C2CC3(C2)CN(C3)C(=O)C=C)c(C)c1-c1c(Cl)c(C)cc2[nH]ncc12 |(9.67,-6.4,;9.28,-4.91,;7.79,-4.51,;7.39,-3.02,;5.9,-2.63,;4.81,-3.71,;5.13,-5.22,;3.35,-3.24,;2.2,-4.27,;.74,-3.79,;.42,-2.29,;1.56,-1.26,;3.03,-1.73,;-1.05,-1.81,;-1.52,-.35,;-3.06,-.35,;-3.83,.99,;-5.32,1.39,;-4.92,2.87,;-3.43,2.48,;-6.41,3.27,;-6.01,4.76,;-4.52,4.36,;-7.1,5.85,;-6.7,7.34,;-8.59,5.45,;-9.67,6.54,;-3.54,-1.81,;-5,-2.29,;-2.29,-2.72,;-2.29,-4.26,;-3.62,-5.03,;-4.96,-4.26,;-3.62,-6.57,;-4.96,-7.34,;-2.29,-7.34,;-.96,-6.57,;.51,-7.04,;1.41,-5.8,;.51,-4.55,;-.96,-5.03,)| | ||
Structure |