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TargetSerine/threonine-protein kinase PLK1
LigandBDBM622567
Substrate/Competitorn/a
Meas. Tech.PLK1 Inhibition Assay
Ki>4000±n/a nM
Citation LAUFFER, DBemis, GBoyd, MDeininger, DDeng, HDorsch, WGu, WHoover, RRJohnson, JR., MALedeboer, MWLedford, BMaltais, FPenney, MTakemoto, DWaal, NDWang, TLi, P PTERIDINONE COMPOUNDS AND USES THEREOF US Patent US20230312587 Publication Date 10/5/2023
More Info.:Get all data from this article,  Assay Method
 
Serine/threonine-protein kinase PLK1
Name:Serine/threonine-protein kinase PLK1
Synonyms:PLK | PLK-1 | PLK1 | PLK1_HUMAN | Polo-like kinase 1 (PlK1) | Polo-like kinase 1 (Plk-1) | STPK13 | Serine/threonine-protein kinase (PLK1) | Serine/threonine-protein kinase 13 | polo-like kinase
Type:Serine/threonine-protein kinase
Mol. Mass.:68277.16
Organism:Homo sapiens (Human)
Description:P53350
Residue:603
Sequence:
MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLG
KGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFF
EDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLG
NLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCI
MYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELL
NDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEE
PVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDK
YGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLK
YFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTK
LILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRL
KAS
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  Blast E-value cutoff:
BDBM622567
n/a
NameBDBM622567
Synonyms:(7S)-4,7,8-trimethyl-2-((cis-3-((5-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)cyclobutyl)amino)-7,8-dihydropteridin-6(5H)-one | US20230312587, Compound 275
TypeSmall organic molecule
Emp. Form.C18H22F3N7O
Mol. Mass.409.4088
SMILESC[C@@H]1N(C)c2nc(N[C@@H]3C[C@H](Cn4nccc4C(F)(F)F)C3)nc(C)c2NC1=O |wU:8.7,10.10,1.0,(,-3.08,;1.33,-2.31,;2.67,-3.08,;2.67,-4.62,;4,-2.31,;5.33,-3.08,;6.67,-2.31,;8,-3.08,;8,-4.62,;6.91,-5.71,;8,-6.8,;8,-8.34,;9.34,-9.11,;10.74,-8.48,;11.77,-9.63,;11,-10.96,;9.5,-10.64,;8.35,-11.67,;7.21,-12.7,;7.32,-10.53,;9.38,-12.81,;9.09,-5.71,;6.67,-.77,;5.33,,;5.33,1.54,;4,-.77,;2.67,,;1.33,-.77,;)|
Structure
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