Reaction Details | |||
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Target | Serine/threonine-protein kinase PLK1 | ||
Ligand | BDBM622567 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | PLK1 Inhibition Assay | ||
Ki | >4000±n/a nM | ||
Citation | ![]() | ||
More Info.: | Get all data from this article, Assay Method | ||
Serine/threonine-protein kinase PLK1 | |||
Name: | Serine/threonine-protein kinase PLK1 | ||
Synonyms: | PLK | PLK-1 | PLK1 | PLK1_HUMAN | Polo-like kinase 1 (PlK1) | Polo-like kinase 1 (Plk-1) | STPK13 | Serine/threonine-protein kinase (PLK1) | Serine/threonine-protein kinase 13 | polo-like kinase | ||
Type: | Serine/threonine-protein kinase | ||
Mol. Mass.: | 68277.16 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P53350 | ||
Residue: | 603 | ||
Sequence: |
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BDBM622567 | |||
n/a | |||
Name | BDBM622567 | ||
Synonyms: | (7S)-4,7,8-trimethyl-2-((cis-3-((5-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)cyclobutyl)amino)-7,8-dihydropteridin-6(5H)-one | US20230312587, Compound 275 | ||
Type | Small organic molecule | ||
Emp. Form. | C18H22F3N7O | ||
Mol. Mass. | 409.4088 | ||
SMILES | C[C@@H]1N(C)c2nc(N[C@@H]3C[C@H](Cn4nccc4C(F)(F)F)C3)nc(C)c2NC1=O |wU:8.7,10.10,1.0,(,-3.08,;1.33,-2.31,;2.67,-3.08,;2.67,-4.62,;4,-2.31,;5.33,-3.08,;6.67,-2.31,;8,-3.08,;8,-4.62,;6.91,-5.71,;8,-6.8,;8,-8.34,;9.34,-9.11,;10.74,-8.48,;11.77,-9.63,;11,-10.96,;9.5,-10.64,;8.35,-11.67,;7.21,-12.7,;7.32,-10.53,;9.38,-12.81,;9.09,-5.71,;6.67,-.77,;5.33,,;5.33,1.54,;4,-.77,;2.67,,;1.33,-.77,;)| | ||
Structure | ![]() |