Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Serine/threonine-protein kinase PLK1 | ||
| Ligand | BDBM622569 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | PLK1 Inhibition Assay | ||
| Ki | >4000±n/a nM | ||
| Citation |  LAUFFER, D; Bemis, G; Boyd, M; Deininger, D; Deng, H; Dorsch, W; Gu, W; Hoover, RR; Johnson, JR., MA; Ledeboer, MW; Ledford, B; Maltais, F; Penney, M; Takemoto, D; Waal, ND; Wang, T; Li, P PTERIDINONE COMPOUNDS AND USES THEREOF US Patent US20230312587 Publication Date 10/5/2023 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Serine/threonine-protein kinase PLK1 | |||
| Name: | Serine/threonine-protein kinase PLK1 | ||
| Synonyms: | PLK | PLK-1 | PLK1 | PLK1_HUMAN | Polo-like kinase 1 (PlK1) | Polo-like kinase 1 (Plk-1) | STPK13 | Serine/threonine-protein kinase (PLK1) | Serine/threonine-protein kinase 13 | polo-like kinase | ||
| Type: | Serine/threonine-protein kinase | ||
| Mol. Mass.: | 68277.16 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P53350 | ||
| Residue: | 603 | ||
| Sequence: |
| ||
| BDBM622569 | |||
| n/a | |||
| Name | BDBM622569 | ||
| Synonyms: | (7S)-4,7,8-trimethyl-2-((trans-3-((2-(trifluoromethyl)pyridin-4-yl)oxy)cyclobutyl)amino)-7,8-dihydropteridin-6(5H)-one | US20230312587, Compound 335 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H21F3N6O2 | ||
| Mol. Mass. | 422.4042 | ||
| SMILES | C[C@@H]1N(C)c2nc(N[C@H]3C[C@@H](C3)Oc3ccnc(c3)C(F)(F)F)nc(C)c2NC1=O |wU:8.7,1.0,wD:10.12,(,-3.08,;1.33,-2.31,;2.67,-3.08,;2.67,-4.62,;4,-2.31,;5.33,-3.08,;6.67,-2.31,;8,-3.08,;8,-4.62,;9.09,-5.71,;8,-6.8,;6.91,-5.71,;8,-8.34,;6.67,-9.11,;5.33,-8.34,;4,-9.11,;4,-10.65,;5.33,-11.42,;6.67,-10.65,;5.33,-12.96,;5.33,-14.5,;3.79,-12.96,;6.87,-12.96,;6.67,-.77,;5.33,,;5.33,1.54,;4,-.77,;2.67,,;1.33,-.77,;)| | ||
| Structure | 
| ||