Reaction Details |
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Target | Complement factor B |
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Ligand | BDBM182861 |
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Substrate/Competitor | n/a |
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Meas. Tech. | TR-FRET Assay |
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pH | 7.4±n/a |
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Temperature | 298.15±n/a K |
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IC50 | 4.11e+4±n/a nM |
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Comments | extracted |
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Citation | Adams, C; Ehara, T; Jendza, K; Ji, N; Karki, RG; Kawanami, T; Mainolfi, N; Powers, J; Serrano-Wu, M; Zhang, C 2-benzyl-benzimidazole complement factor B inhibitors and uses thereof US Patent US9676728 Publication Date 6/13/2017 |
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More Info.: | Get all data from this article, Assay Method |
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Complement factor B |
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Name: | Complement factor B |
Synonyms: | BF | BFD | CFAB_HUMAN | CFB |
Type: | Enzyme |
Mol. Mass.: | 85537.97 |
Organism: | Homo sapiens (Human) |
Description: | P00751 |
Residue: | 764 |
Sequence: | MGSNLSPQLCLMPFILGLLSGGVTTTPWSLARPQGSCSLEGVEIKGGSFRLLQEGQALEY
VCPSGFYPYPVQTRTCRSTGSWSTLKTQDQKTVRKAECRAIHCPRPHDFENGEYWPRSPY
YNVSDEISFHCYDGYTLRGSANRTCQVNGRWSGQTAICDNGAGYCSNPGIPIGTRKVGSQ
YRLEDSVTYHCSRGLTLRGSQRRTCQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLSSLTE
TIEGVDAEDGHGPGEQQKRKIVLDPSGSMNIYLVLDGSDSIGASNFTGAKKCLVNLIEKV
ASYGVKPRYGLVTYATYPKIWVKVSEADSSNADWVTKQLNEINYEDHKLKSGTNTKKALQ
AVYSMMSWPDDVPPEGWNRTRHVIILMTDGLHNMGGDPITVIDEIRDLLYIGKDRKNPRE
DYLDVYVFGVGPLVNQVNINALASKKDNEQHVFKVKDMENLEDVFYQMIDESQSLSLCGM
VWEHRKGTDYHKQPWQAKISVIRPSKGHESCMGAVVSEYFVLTAAHCFTVDDKEHSIKVS
VGGEKRDLEIEVVLFHPNYNINGKKEAGIPEFYDYDVALIKLKNKLKYGQTIRPICLPCT
EGTTRALRLPPTTTCQQQKEELLPAQDIKALFVSEEEKKLTRKEVYIKNGDKKGSCERDA
QYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWG
VVDVCKNQKRQKQVPAHARDFHINLFQVLPWLKEKLQDEDLGFL
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BDBM182861 |
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n/a |
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Name | BDBM182861 |
Synonyms: | US9676728, 11-B b (±)-2-(2,2,2-Trifluoro-1-methoxy-1-(2-methoxy-4,6-dimethylphenyl)ethyl)-1H-benzo[d]imidazole-5-carbonitrile |
Type | Small organic molecule |
Emp. Form. | C20H18F3N3O2 |
Mol. Mass. | 389.371 |
SMILES | COc1cc(C)cc(C)c1C(OC)(c1nc2cc(ccc2[nH]1)C#N)C(F)(F)F |
Structure |
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