Ki Summary

Reaction Details

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Target

Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114]

Ligand

BDBM305707

Substrate/Competitor

n/a

Meas. Tech.

A RET Enzyme Assay

IC50

4.00±n/a nM

Citation

Andrews, SW; Aronow, S; Blake, JF; Brandhuber, BJ; Collier, J; Cook, A; Haas, J; Jiang, Y; Kolakowski, GR; McFaddin, EA; McKenney, ML; McNulty, OT; Metcalf, AT; Moreno, DA; Ramann, GA; Tang, TP; Ren, L; Walls, SM Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors US Patent US10172845 Publication Date 1/8/2019

More Info.:

Get all data from this article, Assay Method

Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114]

Name:

Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114]

Synonyms:

Type:

n/a

Mol. Mass.:

51535.16

Organism:

Homo sapiens (Human)

Description:

P07949[658-1114]

Residue:

457

Sequence:

HCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKW
EFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFN
VLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSS
LDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSR
DVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPP
ERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLD
LAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPL
TRADGTNTGFPRYPNDSVYANWMLSPSAAKLMDTFDS

BDBM305707

n/a

Name

BDBM305707

Synonyms:

N-((3S,4S)-1-(5-(3-cyano- 6-ethoxypyrazolo[1,5- a]pyridin-4-yl)pyridin-2- yl)-3-hydroxypiperidin-4- yl)-5-fluoro-2- methylbenzamide | US10144734, Example 725 | US10172845, Example 725 | US10441581, Example 725 | US10881652, Example 725 | US11648243, Example 725

Type

Small organic molecule

Emp. Form.

C28H27FN6O3

Mol. Mass.

514.5508

SMILES

CCOc1cc(-c2ccc(nc2)N2CC[C@H](NC(=O)c3cc(F)ccc3C)[C@@H](O)C2)c2c(cnn2c1)C#N |r|

Structure