Reaction Details |
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Target | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A [226-593] |
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Ligand | BDBM14776 |
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Substrate/Competitor | BDBM14391 |
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IC50 | 680±n/a nM |
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Citation | Card, GL; England, BP; Suzuki, Y; Fong, D; Powell, B; Lee, B; Luu, C; Tabrizizad, M; Gillette, S; Ibrahim, PN; Artis, DR; Bollag, G; Milburn, MV; Kim, SH; Schlessinger, J; Zhang, KY Structural basis for the activity of drugs that inhibit phosphodiesterases. Structure12:2233-47 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A [226-593] |
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Name: | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A [226-593] |
Synonyms: | High-affinity cGMP-specific 3,5-cyclic phosphodiesterase 9A | PDE9A | PDE9A_HUMAN | Phosphodiesterase Type 9 (PDE9A) |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 43183.20 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant catalytic domain (S226-A593) of human PDE9A. |
Residue: | 368 |
Sequence: | SFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLV
RDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILIL
MTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIP
PDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISN
EVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMF
ETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDV
KNSEGDCA
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BDBM14776 |
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BDBM14391 |
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Name | BDBM14776 |
Synonyms: | 2-{2-ethoxy-5-[(4-ethylpiperazine-1-)sulfonyl]phenyl}-5-methyl-7-propyl-3H,4H-imidazo[1,5-a][1,2,4]triazin-4-one | CHEMBL1520 | Vardenafil | citric acid;2-[2-ethoxy-5-(4-ethylpiperazino)sulfonyl-phenyl]-5-methyl-7-propyl-1H-imidazo[5,1-f][1,2,4]triazin-4-one |
Type | Small organic molecule |
Emp. Form. | C23H32N6O4S |
Mol. Mass. | 488.603 |
SMILES | CCCc1nc(C)c2n1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(CC)CC1 |
Structure |
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