Reaction Details |
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Target | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [432-779] |
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Ligand | BDBM14769 |
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Substrate/Competitor | BDBM10851 |
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Meas. Tech. | Phosphodiesterase (PDE) Inhibition Assay |
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IC50 | 14000±n/a nM |
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Citation | Card, GL; England, BP; Suzuki, Y; Fong, D; Powell, B; Lee, B; Luu, C; Tabrizizad, M; Gillette, S; Ibrahim, PN; Artis, DR; Bollag, G; Milburn, MV; Kim, SH; Schlessinger, J; Zhang, KY Structural basis for the activity of drugs that inhibit phosphodiesterases. Structure12:2233-47 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [432-779] |
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Name: | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [432-779] |
Synonyms: | PDE10A | PDE10_HUMAN | Phosphodiesterase Type 10 (PDE10A) | cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase 10A |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 40036.62 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant catalytic domain (M432-D779) of human PDE10A. |
Residue: | 348 |
Sequence: | MEKLSYHSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTS
CFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACL
CHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQ
VLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKL
WPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTL
TQILPPTEPLLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASED
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BDBM14769 |
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BDBM10851 |
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Name | BDBM14769 |
Synonyms: | 6-(3,4-Dimethoxy-phenyl)-4,5-dimethyl-4,5-dihydro-2H-pyridazin-3-one | 6-(4-(difluoromethoxy)-3-methoxyphenyl)pyridazin-3(2H)-one | 6-(4-Difluoromethoxy-3-methoxy-phenyl)-2H-pyridazin-3-one | 6-[4-(difluoromethoxy)-3-methoxyphenyl]-2,3-dihydropyridazin-3-one | CHEMBL313842 | Zaradaverine | Zardaverine |
Type | Small organic molecule |
Emp. Form. | C12H10F2N2O3 |
Mol. Mass. | 268.2162 |
SMILES | COc1cc(ccc1OC(F)F)-c1ccc(=O)[nH]n1 |
Structure |
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