Ki Summary

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Target

Isoform 4 of Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (PDE11A1) 35-489]

Ligand

BDBM14774

Substrate/Competitor

BDBM10851

Meas. Tech.

Phosphodiesterase (PDE) Inhibition Assay

IC50

25000±n/a nM

Citation

Card, GL; England, BP; Suzuki, Y; Fong, D; Powell, B; Lee, B; Luu, C; Tabrizizad, M; Gillette, S; Ibrahim, PN; Artis, DR; Bollag, G; Milburn, MV; Kim, SH; Schlessinger, J; Zhang, KY Structural basis for the activity of drugs that inhibit phosphodiesterases. Structure12:2233-47 (2004) [PubMed] Article

More Info.:

Get all data from this article, Solution Info, Assay Method

Isoform 4 of Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (PDE11A1) 35-489]

Name:

Isoform 4 of Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (PDE11A1) 35-489]

Synonyms:

Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (PDE11A1) [135-489] | PDE11A | PDE11_HUMAN | Phosphodiesterase 11A isoform 4 | Phosphodiesterase Type 11 (PDE11A)

Type:

Enzyme Catalytic Domain

Mol. Mass.:

40811.01

Organism:

Homo sapiens (Human)

Description:

Q9HCR9-4 aa 135-489

Residue:

355

Sequence:

DVLSYHATCSKAEVDKFKAANIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQ
KFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVI
VGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSS
KEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLG
AVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICM
PLYQALVKVNVKLKPMLDSVATNRSKWEELHQKRLLASTASSSPASVMVAKEDRN

BDBM14774

BDBM10851

Name

BDBM14774

Synonyms:

3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide | CHEMBL193240 | DAXAS | ROF | Roflumilast

Type

Small organic molecule

Emp. Form.

C17H14Cl2F2N2O3

Mol. Mass.

403.207

SMILES

FC(F)Oc1ccc(cc1OCC1CC1)C(=O)Nc1c(Cl)cncc1Cl

Structure