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TargetPolyunsaturated fatty acid lipoxygenase ALOX15
LigandBDBM22257
Substrate/CompetitorBDBM22231
Meas. Tech.Enzyme Inhibition Assay
IC50 55±n/a nM
Citation Weinstein, DSLiu, WNgu, KLangevine, CCombs, DWZhuang, SChen, CMadsen, CSHarper, TWRobl, JA Discovery of selective imidazole-based inhibitors of mammalian 15-lipoxygenase: highly potent against human enzyme within a cellular environment. Bioorg Med Chem Lett17:5115-20 (2007) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Polyunsaturated fatty acid lipoxygenase ALOX15
Name:Polyunsaturated fatty acid lipoxygenase ALOX15
Synonyms:15-Lipoxygenase | ALOX15 | Arachidonate 15-lipoxygenase | Erythroid cell-specific 15-lipoxygenase | LOX15_RABIT | Omega-6 lipoxygenase
Type:Enzyme
Mol. Mass.:75309.71
Organism:Oryctolagus cuniculus (rabbit)
Description:15-LO enzyme was purified from phenylhydrazine treated rabbits.
Residue:663
Sequence:
MGVYRVCVSTGASIYAGSKNKVELWLVGQHGEVELGSCLRPTRNKEEEFKVNVSKYLGSL
LFVRLRKKHFLKEDAWFCNWISVQALGAAEDKYWFPCYRWVVGDGVQSLPVGTGCTTVGD
PQGLFQKHREQELEERRKLYQWGSWKEGLILNVAGSKLTDLPVDERFLEDKKIDFEASLA
WGLAELALKNSLNILAPWKTLDDFNRIFWCGRSKLARRVRDSWQEDSLFGYQFLNGANPM
LLRRSVQLPARLVFPPGMEELQAQLEKELKAGTLFEADFALLDNIKANVILYCQQYLAAP
LVMLKLQPDGKLMPMVIQLHLPKIGSSPPPLFLPTDPPMVWLLAKCWVRSSDFQVHELNS
HLLRGHLMAEVFTVATMRCLPSIHPVFKLIVPHLRYTLEINVRARNGLVSDFGIFDQIMS
TGGGGHVQLLQQAGAFLTYRSFCPPDDLADRGLLGVESSFYAQDALRLWEIISRYVQGIM
GLYYKTDEAVRDDLELQSWCREITEIGLQGAQKQGFPTSLQSVAQACHFVTMCIFTCTGQ
HSSIHLGQLDWFTWVPNAPCTMRLPPPTTKDATLETVMATLPNLHQSSLQMSIVWQLGRD
QPIMVPLGQHQEEYFSGPEPRAVLEKFREELAIMDKEIEVRNEKLDIPYEYLRPSIVENS
VAI
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  Blast E-value cutoff:
BDBM22257
BDBM22231
NameBDBM22257
Synonyms:2,4,5-tri-substituted imidazole, 21e | 4-(3,4-dichlorophenyl)-N-{2-[5-(4-methoxyphenyl)-2-phenyl-1H-imidazol-4-yl]ethyl}piperazine-1-sulfonamide
TypeSmall organic molecule
Emp. Form.C28H29Cl2N5O3S
Mol. Mass.586.533
SMILESCOc1ccc(cc1)-c1nc([nH]c1CCNS(=O)(=O)N1CCN(CC1)c1ccc(Cl)c(Cl)c1)-c1ccccc1
Structure
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