| Reaction Details |
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 | Report a problem with these data |
| Target | Prolyl hydroxylase EGLN2 |
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| Ligand | BDBM385722 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | PHD1 Enzyme Assay |
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| IC50 | 47.0±n/a nM |
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| Citation |  Ahmed, S; Barker, G; Canning, H; Davenport, R; Harrison, D; Jenkins, K; Livermore, D; Wright, S; Kinsella, N Compounds US Patent US10287286 Publication Date 5/14/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Prolyl hydroxylase EGLN2 |
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| Name: | Prolyl hydroxylase EGLN2 |
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| Synonyms: | EGLN2 | EGLN2_HUMAN | EIT6 | Egl nine homolog 2 | Estrogen-induced tag 6 | HIF prolyl hydroxylase | HIF-PH1 | HIF-prolyl hydroxylase 1 | HPH-3 | Hypoxia-inducible factor prolyl hydroxylase | PHD1 | Prolyl hydroxylase domain-containing protein 1 | Prolyl hydroxylase domain-containing protein 1 (PHD1) |
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| Type: | Protein |
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| Mol. Mass.: | 43657.01 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96KS0 |
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| Residue: | 407 |
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| Sequence: | MDSPCQPQPLSQALPQLPGSSSEPLEPEPGRARMGVESYLPCPLLPSYHCPGVPSEASAG
SGTPRATATSTTASPLRDGFGGQDGGELRPLQSEGAAALVTKGCQRLAAQGARPEAPKRK
WAEDGGDAPSPSKRPWARQENQEAEREGGMSCSCSSGSGEASAGLMEEALPSAPERLALD
YIVPCMRYYGICVKDSFLGAALGGRVLAEVEALKRGGRLRDGQLVSQRAIPPRSIRGDQI
AWVEGHEPGCRSIGALMAHVDAVIRHCAGRLGSYVINGRTKAMVACYPGNGLGYVRHVDN
PHGDGRCITCIYYLNQNWDVKVHGGLLQIFPEGRPVVANIEPLFDRLLIFWSDRRNPHEV
KPAYATRYAITVWYFDAKERAAAKDKYQLASGQKGVQVPVSQPPTPT
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| BDBM385722 |
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| n/a |
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| Name | BDBM385722 |
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| Synonyms: | 2-fluoro-4-(7-{[(3- methyloxetan-3- yl)methyl]amino}- [1,2,4]triazolo[1,5- a]pyridin-5- yl)benzonitrile | US10287286, Example 127 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H16FN5O |
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| Mol. Mass. | 337.3509 |
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| SMILES | CC1(CNc2cc(-c3ccc(C#N)c(F)c3)n3ncnc3c2)COC1 |
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| Structure | 
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