Compile Data Set for Download or QSAR

Found 635 hits with Last Name = 'barker' and Initial = 'g'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Neuronal acetylcholine receptor subunit alpha-9 (RAT)	BDBM82070 (CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...) Show SMILES CN1CCC[C@H]1c1cccnc1 |r| Show InChI InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
SIBIA Neurosciences Inc. Curated by ChEMBL					Assay Description Binding affinity towards Nicotinic acetylcholine receptor by the displacement of [3H]-nicotine from rat cortical membranes				J Med Chem 42: 1684-6 (1999) Article DOI: 10.1021/jm990035d BindingDB Entry DOI: 10.7270/Q2QC02PQ
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM385701 (4-{7-[(oxetan-3- ylmethyl)amino]- [1,2,4]triazolo[...) Show SMILES N#Cc1ccc(cc1)-c1cc(NCC2COC2)cc2ncnn12 Show InChI InChI=1S/C17H15N5O/c18-7-12-1-3-14(4-2-12)16-5-15(19-8-13-9-23-10-13)6-17-20-11-21-22(16)17/h1-6,11,13,19H,8-10H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze					Assay Description The IC50 values for the PHD1 enzyme (residues 1-407) were determined by mixing increasing amounts of a compound of the invention with a fixed amount ...				Bioorg Med Chem 16: 7424-8 (2008) BindingDB Entry DOI: 10.7270/Q2QJ7KMD
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM385676 (4-{5- [(cyclopropylmethyl) amino]-[1,2,4] triazolo...) Show SMILES N#Cc1ccc(cc1)-c1cc(NCC2CC2)nc2ncnn12 Show InChI InChI=1S/C16H14N6/c17-8-11-3-5-13(6-4-11)14-7-15(18-9-12-1-2-12)21-16-19-10-20-22(14)16/h3-7,10,12H,1-2,9H2,(H,18,19,20,21)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze					Assay Description The IC50 values for the PHD1 enzyme (residues 1-407) were determined by mixing increasing amounts of a compound of the invention with a fixed amount ...				Bioorg Med Chem 16: 7424-8 (2008) BindingDB Entry DOI: 10.7270/Q2QJ7KMD
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM385711 (4-(7-{[(4- fluorophenyl) methyl]amino}- [1,2,4]tri...) Show SMILES Fc1ccc(CNc2cc(-c3ccc(cc3)C#N)n3ncnc3c2)cc1 Show InChI InChI=1S/C20H14FN5/c21-17-7-3-15(4-8-17)12-23-18-9-19(26-20(10-18)24-13-25-26)16-5-1-14(11-22)2-6-16/h1-10,13,23H,12H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze					Assay Description The IC50 values for the PHD1 enzyme (residues 1-407) were determined by mixing increasing amounts of a compound of the invention with a fixed amount ...				Bioorg Med Chem 16: 7424-8 (2008) BindingDB Entry DOI: 10.7270/Q2QJ7KMD
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM50239931 (CHEMBL4067995 | US10287286, Example 142) Show SMILES CC(=O)Nc1cc(-c2ccc(cc2)C#N)n2ncnc2c1 Show InChI InChI=1S/C15H11N5O/c1-10(21)19-13-6-14(20-15(7-13)17-9-18-20)12-4-2-11(8-16)3-5-12/h2-7,9H,1H3,(H,19,21)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze					Assay Description The IC50 values for the PHD1 enzyme (residues 1-407) were determined by mixing increasing amounts of a compound of the invention with a fixed amount ...				Bioorg Med Chem 16: 7424-8 (2008) BindingDB Entry DOI: 10.7270/Q2QJ7KMD
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM50239931 (CHEMBL4067995 | US10287286, Example 142) Show SMILES CC(=O)Nc1cc(-c2ccc(cc2)C#N)n2ncnc2c1 Show InChI InChI=1S/C15H11N5O/c1-10(21)19-13-6-14(20-15(7-13)17-9-18-20)12-4-2-11(8-16)3-5-12/h2-7,9H,1H3,(H,19,21)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Inc. Curated by ChEMBL					Assay Description Inhibition of full length HIF-PHD1 (unknown origin) expressed in baculovirus infected sf9 cells using DLDLEMLAPYIPMDDDFQL/2-Oxoglutarate as substrate...				J Med Chem 60: 5663-5672 (2017) Article DOI: 10.1021/acs.jmedchem.7b00352 BindingDB Entry DOI: 10.7270/Q2GQ70XZ
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM385707 (4-(7-{[2- (dimethylamino) ethyl]amino}- [1,2,4]tri...) Show SMILES CN(C)CCNc1cc(-c2ccc(cc2)C#N)n2ncnc2c1 Show InChI InChI=1S/C17H18N6/c1-22(2)8-7-19-15-9-16(23-17(10-15)20-12-21-23)14-5-3-13(11-18)4-6-14/h3-6,9-10,12,19H,7-8H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze					Assay Description The IC50 values for the PHD1 enzyme (residues 1-407) were determined by mixing increasing amounts of a compound of the invention with a fixed amount ...				Bioorg Med Chem 16: 7424-8 (2008) BindingDB Entry DOI: 10.7270/Q2QJ7KMD
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM385693 (4-{7- [(cyclopropyl- methyl) amino]- [1,2,4]triazo...) Show SMILES N#Cc1ccc(cc1)-c1cc(NCC2CC2)cc2ncnn12 Show InChI InChI=1S/C17H15N5/c18-9-12-3-5-14(6-4-12)16-7-15(19-10-13-1-2-13)8-17-20-11-21-22(16)17/h3-8,11,13,19H,1-2,10H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze					Assay Description The IC50 values for the PHD1 enzyme (residues 1-407) were determined by mixing increasing amounts of a compound of the invention with a fixed amount ...				Bioorg Med Chem 16: 7424-8 (2008) BindingDB Entry DOI: 10.7270/Q2QJ7KMD
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM385702 (4-{7-[(3,3,3- trifluoropropyl) amino]- [1,2,4]tria...) Show SMILES FC(F)(F)CCNc1cc(-c2ccc(cc2)C#N)n2ncnc2c1 Show InChI InChI=1S/C16H12F3N5/c17-16(18,19)5-6-21-13-7-14(24-15(8-13)22-10-23-24)12-3-1-11(9-20)2-4-12/h1-4,7-8,10,21H,5-6H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze					Assay Description The IC50 values for the PHD1 enzyme (residues 1-407) were determined by mixing increasing amounts of a compound of the invention with a fixed amount ...				Bioorg Med Chem 16: 7424-8 (2008) BindingDB Entry DOI: 10.7270/Q2QJ7KMD
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM50239883 (CHEMBL4090769 | US10287286, Example 5) Show SMILES Fc1cc(ccc1C#N)-c1cccc2ncnn12 Show InChI InChI=1S/C13H7FN4/c14-11-6-9(4-5-10(11)7-15)12-2-1-3-13-16-8-17-18(12)13/h1-6,8H	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze					Assay Description The IC50 values for the PHD1 enzyme (residues 1-407) were determined by mixing increasing amounts of a compound of the invention with a fixed amount ...				Bioorg Med Chem 16: 7424-8 (2008) BindingDB Entry DOI: 10.7270/Q2QJ7KMD
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM385700 (4-{7-[(2,2- difluoroethyl) amino]- [1,2,4]triazolo...) Show SMILES FC(F)CNc1cc(-c2ccc(cc2)C#N)n2ncnc2c1 Show InChI InChI=1S/C15H11F2N5/c16-14(17)8-19-12-5-13(22-15(6-12)20-9-21-22)11-3-1-10(7-18)2-4-11/h1-6,9,14,19H,8H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze					Assay Description The IC50 values for the PHD1 enzyme (residues 1-407) were determined by mixing increasing amounts of a compound of the invention with a fixed amount ...				Bioorg Med Chem 16: 7424-8 (2008) BindingDB Entry DOI: 10.7270/Q2QJ7KMD
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM50239883 (CHEMBL4090769 | US10287286, Example 5) Show SMILES Fc1cc(ccc1C#N)-c1cccc2ncnn12 Show InChI InChI=1S/C13H7FN4/c14-11-6-9(4-5-10(11)7-15)12-2-1-3-13-16-8-17-18(12)13/h1-6,8H	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Inc. Curated by ChEMBL					Assay Description Inhibition of full length HIF-PHD1 (unknown origin) expressed in baculovirus infected sf9 cells using DLDLEMLAPYIPMDDDFQL/2-Oxoglutarate as substrate...				J Med Chem 60: 5663-5672 (2017) Article DOI: 10.1021/acs.jmedchem.7b00352 BindingDB Entry DOI: 10.7270/Q2GQ70XZ
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM385674 (4-[5- (dimethylamino)- [1,2,4]triazolo[1,5- a]pyri...) Show SMILES CN(C)c1cc(-c2ccc(cc2)C#N)n2ncnc2n1 Show InChI InChI=1S/C14H12N6/c1-19(2)13-7-12(20-14(18-13)16-9-17-20)11-5-3-10(8-15)4-6-11/h3-7,9H,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze					Assay Description The IC50 values for the PHD1 enzyme (residues 1-407) were determined by mixing increasing amounts of a compound of the invention with a fixed amount ...				Bioorg Med Chem 16: 7424-8 (2008) BindingDB Entry DOI: 10.7270/Q2QJ7KMD
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM385747 (US10287286, Example 150) Show SMILES Fc1cc(ccc1C#N)-c1cc(NC(=O)Nc2ccccc2)cc2ncnn12 Show InChI InChI=1S/C20H13FN6O/c21-17-8-13(6-7-14(17)11-22)18-9-16(10-19-23-12-24-27(18)19)26-20(28)25-15-4-2-1-3-5-15/h1-10,12H,(H2,25,26,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze					Assay Description The IC50 values for the PHD1 enzyme (residues 1-407) were determined by mixing increasing amounts of a compound of the invention with a fixed amount ...				Bioorg Med Chem 16: 7424-8 (2008) BindingDB Entry DOI: 10.7270/Q2QJ7KMD
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM50239889 (CHEMBL4072842 | US10287286, Example 100) Show SMILES Nc1cc(-c2ccc(cc2)C#N)n2ncnc2c1 Show InChI InChI=1S/C13H9N5/c14-7-9-1-3-10(4-2-9)12-5-11(15)6-13-16-8-17-18(12)13/h1-6,8H,15H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze					Assay Description The IC50 values for the PHD1 enzyme (residues 1-407) were determined by mixing increasing amounts of a compound of the invention with a fixed amount ...				Bioorg Med Chem 16: 7424-8 (2008) BindingDB Entry DOI: 10.7270/Q2QJ7KMD
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM385709 (4-(7-{[(2- fluorophenyl) methyl]amino}- [1,2,4]tri...) Show SMILES Fc1ccccc1CNc1cc(-c2ccc(cc2)C#N)n2ncnc2c1 Show InChI InChI=1S/C20H14FN5/c21-18-4-2-1-3-16(18)12-23-17-9-19(26-20(10-17)24-13-25-26)15-7-5-14(11-22)6-8-15/h1-10,13,23H,12H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze					Assay Description The IC50 values for the PHD1 enzyme (residues 1-407) were determined by mixing increasing amounts of a compound of the invention with a fixed amount ...				Bioorg Med Chem 16: 7424-8 (2008) BindingDB Entry DOI: 10.7270/Q2QJ7KMD
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM50239889 (CHEMBL4072842 | US10287286, Example 100) Show SMILES Nc1cc(-c2ccc(cc2)C#N)n2ncnc2c1 Show InChI InChI=1S/C13H9N5/c14-7-9-1-3-10(4-2-9)12-5-11(15)6-13-16-8-17-18(12)13/h1-6,8H,15H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Inc. Curated by ChEMBL					Assay Description Inhibition of full length HIF-PHD1 (unknown origin) expressed in baculovirus infected sf9 cells using DLDLEMLAPYIPMDDDFQL/2-Oxoglutarate as substrate...				J Med Chem 60: 5663-5672 (2017) Article DOI: 10.1021/acs.jmedchem.7b00352 BindingDB Entry DOI: 10.7270/Q2GQ70XZ
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM385792 (US10287286, Example 195 | cyclopropylmethyl N-[5-(...) Show SMILES Fc1cc(ccc1C#N)-c1cc(NC(=O)OCC2CC2)cc2ncnn12 Show InChI InChI=1S/C18H14FN5O2/c19-15-5-12(3-4-13(15)8-20)16-6-14(7-17-21-10-22-24(16)17)23-18(25)26-9-11-1-2-11/h3-7,10-11H,1-2,9H2,(H,23,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze					Assay Description The IC50 values for the PHD1 enzyme (residues 1-407) were determined by mixing increasing amounts of a compound of the invention with a fixed amount ...				Bioorg Med Chem 16: 7424-8 (2008) BindingDB Entry DOI: 10.7270/Q2QJ7KMD
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM385853 (US10287286, Example 251) Show SMILES Cc1nc(ccc1-c1cc(O)cc2ncnn12)C#N Show InChI InChI=1S/C13H9N5O/c1-8-11(3-2-9(6-14)17-8)12-4-10(19)5-13-15-7-16-18(12)13/h2-5,7,19H,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze					Assay Description The IC50 values for the PHD1 enzyme (residues 1-407) were determined by mixing increasing amounts of a compound of the invention with a fixed amount ...				Bioorg Med Chem 16: 7424-8 (2008) BindingDB Entry DOI: 10.7270/Q2QJ7KMD
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM385706 (4-{7-[(oxolan-2- ylmethyl)amino]- [1,2,4]triazolo[...) Show SMILES N#Cc1ccc(cc1)-c1cc(NCC2CCCO2)cc2ncnn12 Show InChI InChI=1S/C18H17N5O/c19-10-13-3-5-14(6-4-13)17-8-15(9-18-21-12-22-23(17)18)20-11-16-2-1-7-24-16/h3-6,8-9,12,16,20H,1-2,7,11H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze					Assay Description The IC50 values for the PHD1 enzyme (residues 1-407) were determined by mixing increasing amounts of a compound of the invention with a fixed amount ...				Bioorg Med Chem 16: 7424-8 (2008) BindingDB Entry DOI: 10.7270/Q2QJ7KMD
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM385809 (US10287286, Example 211) Show SMILES Cc1nc(nc(C)c1-c1cccc2ncnn12)C#N |(3.19,-.77,;1.85,,;1.85,1.54,;.52,2.37,;-.82,1.54,;-.82,,;-2.15,-.77,;.52,-.77,;.52,-2.31,;1.85,-3.08,;1.85,-4.62,;.52,-5.39,;-.82,-4.62,;-2.28,-5.1,;-3.19,-3.85,;-2.28,-2.6,;-.82,-3.08,;.52,3.91,;.52,5.45,)| Show InChI InChI=1S/C13H10N6/c1-8-13(9(2)18-11(6-14)17-8)10-4-3-5-12-15-7-16-19(10)12/h3-5,7H,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze					Assay Description The IC50 values for the PHD1 enzyme (residues 1-407) were determined by mixing increasing amounts of a compound of the invention with a fixed amount ...				Bioorg Med Chem 16: 7424-8 (2008) BindingDB Entry DOI: 10.7270/Q2QJ7KMD
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM50239888 (CHEMBL4094292 | US10287286, Example 103) Show SMILES CCNc1cc(-c2ccc(cc2)C#N)n2ncnc2c1 Show InChI InChI=1S/C15H13N5/c1-2-17-13-7-14(20-15(8-13)18-10-19-20)12-5-3-11(9-16)4-6-12/h3-8,10,17H,2H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze					Assay Description The IC50 values for the PHD1 enzyme (residues 1-407) were determined by mixing increasing amounts of a compound of the invention with a fixed amount ...				Bioorg Med Chem 16: 7424-8 (2008) BindingDB Entry DOI: 10.7270/Q2QJ7KMD
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM50239888 (CHEMBL4094292 | US10287286, Example 103) Show SMILES CCNc1cc(-c2ccc(cc2)C#N)n2ncnc2c1 Show InChI InChI=1S/C15H13N5/c1-2-17-13-7-14(20-15(8-13)18-10-19-20)12-5-3-11(9-16)4-6-12/h3-8,10,17H,2H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Inc. Curated by ChEMBL					Assay Description Inhibition of full length HIF-PHD1 (unknown origin) expressed in baculovirus infected sf9 cells using DLDLEMLAPYIPMDDDFQL/2-Oxoglutarate as substrate...				J Med Chem 60: 5663-5672 (2017) Article DOI: 10.1021/acs.jmedchem.7b00352 BindingDB Entry DOI: 10.7270/Q2GQ70XZ
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM385698 (4-{7-[(oxolan-3- ylmethyl)amino]- [1,2,4]triazolo[...) Show SMILES N#Cc1ccc(cc1)-c1cc(NCC2CCOC2)cc2ncnn12 Show InChI InChI=1S/C18H17N5O/c19-9-13-1-3-15(4-2-13)17-7-16(8-18-21-12-22-23(17)18)20-10-14-5-6-24-11-14/h1-4,7-8,12,14,20H,5-6,10-11H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze					Assay Description The IC50 values for the PHD1 enzyme (residues 1-407) were determined by mixing increasing amounts of a compound of the invention with a fixed amount ...				Bioorg Med Chem 16: 7424-8 (2008) BindingDB Entry DOI: 10.7270/Q2QJ7KMD
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM385851 (US10287286, Example 249) Show SMILES Cc1cc(ccc1-c1cc(O)cc2ncnn12)C#N Show InChI InChI=1S/C14H10N4O/c1-9-4-10(7-15)2-3-12(9)13-5-11(19)6-14-16-8-17-18(13)14/h2-6,8,19H,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze					Assay Description The IC50 values for the PHD1 enzyme (residues 1-407) were determined by mixing increasing amounts of a compound of the invention with a fixed amount ...				Bioorg Med Chem 16: 7424-8 (2008) BindingDB Entry DOI: 10.7270/Q2QJ7KMD
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM385742 (US10287286, Example 146) Show SMILES Nc1cc(-c2ccc(C#N)c(F)c2)n2ncnc2c1 Show InChI InChI=1S/C13H8FN5/c14-11-3-8(1-2-9(11)6-15)12-4-10(16)5-13-17-7-18-19(12)13/h1-5,7H,16H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze					Assay Description The IC50 values for the PHD1 enzyme (residues 1-407) were determined by mixing increasing amounts of a compound of the invention with a fixed amount ...				Bioorg Med Chem 16: 7424-8 (2008) BindingDB Entry DOI: 10.7270/Q2QJ7KMD
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM385750 (N-[5-(4-cyano-3- fluorophenyl)- [1,2,4]triazolo[1,...) Show SMILES FC(F)(F)CC(=O)Nc1cc(-c2ccc(cc2)C#N)n2ncnc2c1 Show InChI InChI=1S/C16H10F3N5O/c17-16(18,19)7-15(25)23-12-5-13(24-14(6-12)21-9-22-24)11-3-1-10(8-20)2-4-11/h1-6,9H,7H2,(H,23,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze					Assay Description The IC50 values for the PHD1 enzyme (residues 1-407) were determined by mixing increasing amounts of a compound of the invention with a fixed amount ...				Bioorg Med Chem 16: 7424-8 (2008) BindingDB Entry DOI: 10.7270/Q2QJ7KMD
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM385680 (4-(5-{[3- (dimethylamino) propyl]amino}- [1,2,4]tr...) Show SMILES CN(C)CCCNc1cc(-c2ccc(cc2)C#N)n2ncnc2n1 Show InChI InChI=1S/C17H19N7/c1-23(2)9-3-8-19-16-10-15(24-17(22-16)20-12-21-24)14-6-4-13(11-18)5-7-14/h4-7,10,12H,3,8-9H2,1-2H3,(H,19,20,21,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze					Assay Description The IC50 values for the PHD1 enzyme (residues 1-407) were determined by mixing increasing amounts of a compound of the invention with a fixed amount ...				Bioorg Med Chem 16: 7424-8 (2008) BindingDB Entry DOI: 10.7270/Q2QJ7KMD
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM385710 (4-(7-{[(3- fluorophenyl) methyl]amino}- [1,2,4]tri...) Show SMILES Fc1cccc(CNc2cc(-c3ccc(cc3)C#N)n3ncnc3c2)c1 Show InChI InChI=1S/C20H14FN5/c21-17-3-1-2-15(8-17)12-23-18-9-19(26-20(10-18)24-13-25-26)16-6-4-14(11-22)5-7-16/h1-10,13,23H,12H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze					Assay Description The IC50 values for the PHD1 enzyme (residues 1-407) were determined by mixing increasing amounts of a compound of the invention with a fixed amount ...				Bioorg Med Chem 16: 7424-8 (2008) BindingDB Entry DOI: 10.7270/Q2QJ7KMD
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM386909 (US10287286, Example 260) Show SMILES Nc1cc(-c2ccc(C#N)c(F)c2F)n2ncnc2c1 Show InChI InChI=1S/C13H7F2N5/c14-12-7(5-16)1-2-9(13(12)15)10-3-8(17)4-11-18-6-19-20(10)11/h1-4,6H,17H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze					Assay Description The IC50 values for the PHD1 enzyme (residues 1-407) were determined by mixing increasing amounts of a compound of the invention with a fixed amount ...				Bioorg Med Chem 16: 7424-8 (2008) BindingDB Entry DOI: 10.7270/Q2QJ7KMD
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM385820 (US10287286, Example 219) Show SMILES Oc1cc(-c2ccc(C#N)c(F)c2)n2ncnc2c1 Show InChI InChI=1S/C13H7FN4O/c14-11-3-8(1-2-9(11)6-15)12-4-10(19)5-13-16-7-17-18(12)13/h1-5,7,19H	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze					Assay Description The IC50 values for the PHD1 enzyme (residues 1-407) were determined by mixing increasing amounts of a compound of the invention with a fixed amount ...				Bioorg Med Chem 16: 7424-8 (2008) BindingDB Entry DOI: 10.7270/Q2QJ7KMD
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM385688 (4-[5- (cyclopropylamino)- [1,2,4]triazolo[1,5- a]p...) Show SMILES N#Cc1ccc(cc1)-c1cc(NC2CC2)nc2ncnn12 Show InChI InChI=1S/C15H12N6/c16-8-10-1-3-11(4-2-10)13-7-14(19-12-5-6-12)20-15-17-9-18-21(13)15/h1-4,7,9,12H,5-6H2,(H,17,18,19,20)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze					Assay Description The IC50 values for the PHD1 enzyme (residues 1-407) were determined by mixing increasing amounts of a compound of the invention with a fixed amount ...				Bioorg Med Chem 16: 7424-8 (2008) BindingDB Entry DOI: 10.7270/Q2QJ7KMD
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM385708 (4-[7-(benzylamino)- [1,2,4]triazolo[1,5- a]pyridin...) Show SMILES N#Cc1ccc(cc1)-c1cc(NCc2ccccc2)cc2ncnn12 Show InChI InChI=1S/C20H15N5/c21-12-15-6-8-17(9-7-15)19-10-18(11-20-23-14-24-25(19)20)22-13-16-4-2-1-3-5-16/h1-11,14,22H,13H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze					Assay Description The IC50 values for the PHD1 enzyme (residues 1-407) were determined by mixing increasing amounts of a compound of the invention with a fixed amount ...				Bioorg Med Chem 16: 7424-8 (2008) BindingDB Entry DOI: 10.7270/Q2QJ7KMD
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM385771 (N-[5-(4-cyano-3- fluorophenyl)- [1,2,4]triazolo[1,...) Show SMILES Fc1cc(ccc1C#N)-c1cc(NC(=O)C2CC2)cc2ncnn12 Show InChI InChI=1S/C17H12FN5O/c18-14-5-11(3-4-12(14)8-19)15-6-13(22-17(24)10-1-2-10)7-16-20-9-21-23(15)16/h3-7,9-10H,1-2H2,(H,22,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze					Assay Description The IC50 values for the PHD1 enzyme (residues 1-407) were determined by mixing increasing amounts of a compound of the invention with a fixed amount ...				Bioorg Med Chem 16: 7424-8 (2008) BindingDB Entry DOI: 10.7270/Q2QJ7KMD
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM50239915 (CHEMBL4067559 | US10287286, Example 6) Show SMILES Fc1cc(cc(F)c1C#N)-c1cccc2ncnn12 Show InChI InChI=1S/C13H6F2N4/c14-10-4-8(5-11(15)9(10)6-16)12-2-1-3-13-17-7-18-19(12)13/h1-5,7H	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze					Assay Description The IC50 values for the PHD1 enzyme (residues 1-407) were determined by mixing increasing amounts of a compound of the invention with a fixed amount ...				Bioorg Med Chem 16: 7424-8 (2008) BindingDB Entry DOI: 10.7270/Q2QJ7KMD
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM50239915 (CHEMBL4067559 | US10287286, Example 6) Show SMILES Fc1cc(cc(F)c1C#N)-c1cccc2ncnn12 Show InChI InChI=1S/C13H6F2N4/c14-10-4-8(5-11(15)9(10)6-16)12-2-1-3-13-17-7-18-19(12)13/h1-5,7H	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Inc. Curated by ChEMBL					Assay Description Inhibition of full length HIF-PHD1 (unknown origin) expressed in baculovirus infected sf9 cells using DLDLEMLAPYIPMDDDFQL/2-Oxoglutarate as substrate...				J Med Chem 60: 5663-5672 (2017) Article DOI: 10.1021/acs.jmedchem.7b00352 BindingDB Entry DOI: 10.7270/Q2GQ70XZ
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM385694 (4-{7-(2- methoxyethyl) amino}- [1,2,4]triazolo[1,5...) Show SMILES COCCNc1cc(-c2ccc(cc2)C#N)n2ncnc2c1 Show InChI InChI=1S/C16H15N5O/c1-22-7-6-18-14-8-15(21-16(9-14)19-11-20-21)13-4-2-12(10-17)3-5-13/h2-5,8-9,11,18H,6-7H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze					Assay Description The IC50 values for the PHD1 enzyme (residues 1-407) were determined by mixing increasing amounts of a compound of the invention with a fixed amount ...				Bioorg Med Chem 16: 7424-8 (2008) BindingDB Entry DOI: 10.7270/Q2QJ7KMD
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM50239937 (CHEMBL4083851 | US10287286, Example 3) Show SMILES N#Cc1ccc(cc1)-c1cccc2ncnn12 Show InChI InChI=1S/C13H8N4/c14-8-10-4-6-11(7-5-10)12-2-1-3-13-15-9-16-17(12)13/h1-7,9H	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB US Patent	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze					Assay Description The IC50 values for the PHD1 enzyme (residues 1-407) were determined by mixing increasing amounts of a compound of the invention with a fixed amount ...				Bioorg Med Chem 16: 7424-8 (2008) BindingDB Entry DOI: 10.7270/Q2QJ7KMD
					More data for this Ligand-Target Pair				3D Structure (crystal)
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM50239937 (CHEMBL4083851 | US10287286, Example 3) Show SMILES N#Cc1ccc(cc1)-c1cccc2ncnn12 Show InChI InChI=1S/C13H8N4/c14-8-10-4-6-11(7-5-10)12-2-1-3-13-15-9-16-17(12)13/h1-7,9H	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Inc. Curated by ChEMBL					Assay Description Inhibition of full length HIF-PHD1 (unknown origin) expressed in baculovirus infected sf9 cells using DLDLEMLAPYIPMDDDFQL/2-Oxoglutarate as substrate...				J Med Chem 60: 5663-5672 (2017) Article DOI: 10.1021/acs.jmedchem.7b00352 BindingDB Entry DOI: 10.7270/Q2GQ70XZ
					More data for this Ligand-Target Pair				3D Structure (crystal)
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM385850 (US10287286, Example 248) Show SMILES Cc1cc(ncc1-c1cc(N)cc2ncnn12)C#N Show InChI InChI=1S/C13H10N6/c1-8-2-10(5-14)16-6-11(8)12-3-9(15)4-13-17-7-18-19(12)13/h2-4,6-7H,15H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze					Assay Description The IC50 values for the PHD1 enzyme (residues 1-407) were determined by mixing increasing amounts of a compound of the invention with a fixed amount ...				Bioorg Med Chem 16: 7424-8 (2008) BindingDB Entry DOI: 10.7270/Q2QJ7KMD
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM385808 (US10287286, Example 210) Show SMILES Nc1cc(-c2ccc(cc2F)C#N)n2ncnc2c1 Show InChI InChI=1S/C13H8FN5/c14-11-3-8(6-15)1-2-10(11)12-4-9(16)5-13-17-7-18-19(12)13/h1-5,7H,16H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze					Assay Description The IC50 values for the PHD1 enzyme (residues 1-407) were determined by mixing increasing amounts of a compound of the invention with a fixed amount ...				Bioorg Med Chem 16: 7424-8 (2008) BindingDB Entry DOI: 10.7270/Q2QJ7KMD
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM385697 (4-{7-[(oxan-4- ylmethyl)amino]- [1,2,4]triazolo[1,...) Show SMILES N#Cc1ccc(cc1)-c1cc(NCC2CCOCC2)cc2ncnn12 Show InChI InChI=1S/C19H19N5O/c20-11-14-1-3-16(4-2-14)18-9-17(10-19-22-13-23-24(18)19)21-12-15-5-7-25-8-6-15/h1-4,9-10,13,15,21H,5-8,12H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze					Assay Description The IC50 values for the PHD1 enzyme (residues 1-407) were determined by mixing increasing amounts of a compound of the invention with a fixed amount ...				Bioorg Med Chem 16: 7424-8 (2008) BindingDB Entry DOI: 10.7270/Q2QJ7KMD
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM50239890 (CHEMBL4095005 | US10287286, Example 4) Show SMILES Cc1cc(-c2ccc(cc2)C#N)n2ncnc2c1 Show InChI InChI=1S/C14H10N4/c1-10-6-13(18-14(7-10)16-9-17-18)12-4-2-11(8-15)3-5-12/h2-7,9H,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	US Patent	n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze					Assay Description The IC50 values for the PHD1 enzyme (residues 1-407) were determined by mixing increasing amounts of a compound of the invention with a fixed amount ...				Bioorg Med Chem 16: 7424-8 (2008) BindingDB Entry DOI: 10.7270/Q2QJ7KMD
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM50239890 (CHEMBL4095005 | US10287286, Example 4) Show SMILES Cc1cc(-c2ccc(cc2)C#N)n2ncnc2c1 Show InChI InChI=1S/C14H10N4/c1-10-6-13(18-14(7-10)16-9-17-18)12-4-2-11(8-15)3-5-12/h2-7,9H,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Inc. Curated by ChEMBL					Assay Description Inhibition of full length HIF-PHD1 (unknown origin) expressed in baculovirus infected sf9 cells using DLDLEMLAPYIPMDDDFQL/2-Oxoglutarate as substrate...				J Med Chem 60: 5663-5672 (2017) Article DOI: 10.1021/acs.jmedchem.7b00352 BindingDB Entry DOI: 10.7270/Q2GQ70XZ
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM385773 (US10287286, Example 176) Show SMILES N#Cc1ccc(cc1)-c1cc(SCc2ccccc2)cc2ncnn12 Show InChI InChI=1S/C20H14N4S/c21-12-15-6-8-17(9-7-15)19-10-18(11-20-22-14-23-24(19)20)25-13-16-4-2-1-3-5-16/h1-11,14H,13H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze					Assay Description The IC50 values for the PHD1 enzyme (residues 1-407) were determined by mixing increasing amounts of a compound of the invention with a fixed amount ...				Bioorg Med Chem 16: 7424-8 (2008) BindingDB Entry DOI: 10.7270/Q2QJ7KMD
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM385749 (N-[5-(4- cyanophenyl)- [1,2,4]triazolo[1,5- a]pyri...) Show SMILES O=C(Cc1ccccc1)Nc1cc(-c2ccc(cc2)C#N)n2ncnc2c1 Show InChI InChI=1S/C21H15N5O/c22-13-16-6-8-17(9-7-16)19-11-18(12-20-23-14-24-26(19)20)25-21(27)10-15-4-2-1-3-5-15/h1-9,11-12,14H,10H2,(H,25,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze					Assay Description The IC50 values for the PHD1 enzyme (residues 1-407) were determined by mixing increasing amounts of a compound of the invention with a fixed amount ...				Bioorg Med Chem 16: 7424-8 (2008) BindingDB Entry DOI: 10.7270/Q2QJ7KMD
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM385748 (N-[5-(4- cyanophenyl)- [1,2,4]triazolo[1,5- a]pyri...) Show SMILES COCCC(=O)Nc1cc(-c2ccc(cc2)C#N)n2ncnc2c1 Show InChI InChI=1S/C17H15N5O2/c1-24-7-6-17(23)21-14-8-15(22-16(9-14)19-11-20-22)13-4-2-12(10-18)3-5-13/h2-5,8-9,11H,6-7H2,1H3,(H,21,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze					Assay Description The IC50 values for the PHD1 enzyme (residues 1-407) were determined by mixing increasing amounts of a compound of the invention with a fixed amount ...				Bioorg Med Chem 16: 7424-8 (2008) BindingDB Entry DOI: 10.7270/Q2QJ7KMD
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM385722 (2-fluoro-4-(7-{[(3- methyloxetan-3- yl)methyl]amin...) Show SMILES CC1(CNc2cc(-c3ccc(C#N)c(F)c3)n3ncnc3c2)COC1 Show InChI InChI=1S/C18H16FN5O/c1-18(9-25-10-18)8-21-14-5-16(24-17(6-14)22-11-23-24)12-2-3-13(7-20)15(19)4-12/h2-6,11,21H,8-10H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze					Assay Description The IC50 values for the PHD1 enzyme (residues 1-407) were determined by mixing increasing amounts of a compound of the invention with a fixed amount ...				Bioorg Med Chem 16: 7424-8 (2008) BindingDB Entry DOI: 10.7270/Q2QJ7KMD
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM385766 (N-[5-(4-cyano-3- fluorophenyl)- [1,2,4]triazolo[1,...) Show SMILES Fc1cc(ccc1C#N)-c1cc(NC(=O)CC2CC2)cc2ncnn12 Show InChI InChI=1S/C18H14FN5O/c19-15-6-12(3-4-13(15)9-20)16-7-14(8-17-21-10-22-24(16)17)23-18(25)5-11-1-2-11/h3-4,6-8,10-11H,1-2,5H2,(H,23,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	49	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze					Assay Description The IC50 values for the PHD1 enzyme (residues 1-407) were determined by mixing increasing amounts of a compound of the invention with a fixed amount ...				Bioorg Med Chem 16: 7424-8 (2008) BindingDB Entry DOI: 10.7270/Q2QJ7KMD
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN2 (Homo sapiens (Human))	BDBM385713 (4-[7-(benzyloxy)- [1,2,4]triazolo[1,5- a]pyridin-5...) Show SMILES N#Cc1ccc(cc1)-c1cc(OCc2ccccc2)cc2ncnn12 Show InChI InChI=1S/C20H14N4O/c21-12-15-6-8-17(9-7-15)19-10-18(11-20-22-14-23-24(19)20)25-13-16-4-2-1-3-5-16/h1-11,14H,13H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	49	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze					Assay Description The IC50 values for the PHD1 enzyme (residues 1-407) were determined by mixing increasing amounts of a compound of the invention with a fixed amount ...				Bioorg Med Chem 16: 7424-8 (2008) BindingDB Entry DOI: 10.7270/Q2QJ7KMD
					More data for this Ligand-Target Pair

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