| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase receptor UFO |
|---|
| Ligand | BDBM27890 |
|---|
| Substrate/Competitor | polyGlu4Tyr |
|---|
| Meas. Tech. | Axl Enzyme Inhibition Assay |
|---|
| Temperature | 298.15±n/a K |
|---|
| IC50 | >500±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Huang, H; Hutta, DA; Rinker, JM; Hu, H; Parsons, WH; Schubert, C; Desjarlais, RL; Crysler, CS; Chaikin, MA; Donatelli, RR; Chen, Y; Cheng, D; Zhou, Z; Yurkow, E; Manthey, CL; Player, MR Pyrido[2,3-d]pyrimidin-5-ones: A Novel Class of Antiinflammatory Macrophage Colony-Stimulating Factor-1 Receptor Inhibitors (dagger). J Med Chem52:1081-99 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Tyrosine-protein kinase receptor UFO |
|---|
| Name: | Tyrosine-protein kinase receptor UFO |
|---|
| Synonyms: | AXL | AXL oncogene | TEL/AXL | Tyrosine-protein kinase receptor UFO (AXL) | UFO | UFO_HUMAN |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 98316.97 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P30530 |
|---|
| Residue: | 894 |
|---|
| Sequence: | MAWRCPRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNITGARGLTGTLRCQLQV
QGEPPEVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVF
LGHQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDAVPL
ATAPGHGPQRSLHVPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQQPRNLHLVSRQPTE
LEVAWTPGLSGIYPLTHCTLQAVLSDDGMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLH
PHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPRAPL
QGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLP
VPLEAWRPGQAQPVHQLVKEPSTPAFSWPWWYVLLGAVVAAACVLILALFLVHRRKKETR
YGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGK
TLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRL
IGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGM
EYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIES
LADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYA
LMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGYPEPPGAAGGA
DPPTQPDPKDSCSCLTAAEVHPAGRYVLCPSTTPSPAQPADRGSPAAPGQEDGA
|
|
|
|---|
| BDBM27890 |
|---|
| polyGlu4Tyr |
|---|
| Name: | polyGlu4Tyr |
|---|
| Synonyms: | n/a |
|---|
| Type: | Random copolymer |
|---|
| Mol. Mass.: | 358.43 |
|---|
| Organism: | n/a |
|---|
| Description: | n/a |
|---|
| Residue: | 3 |
|---|
| Sequence: | |
|---|
Search and Browse
