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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase BTK | ||
| Ligand | BDBM394250 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Lanthscreen Eu Kinase Binding Assay | ||
| IC50 | 0.300±n/a nM | ||
| Citation |  Bosanac, T; Bentzien, J; Burke, MJ; Fryer, RM; Larson, ET; Mao, W; McKibben, BP; Shen, Y; Soleymanzadeh, F; Tschantz, MA Heteroaromatic compounds as BTK inhibitors US Patent US9975882 Publication Date 5/22/2018 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase BTK | |||
| Name: | Tyrosine-protein kinase BTK | ||
| Synonyms: | AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 76289.95 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q06187 | ||
| Residue: | 659 | ||
| Sequence: |
| ||
| BDBM394250 | |||
| n/a | |||
| Name | BDBM394250 | ||
| Synonyms: | US9975882, Example 41 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C27H29N7O2 | ||
| Mol. Mass. | 483.5649 | ||
| SMILES | NC(=O)c1c(N)n(nc1-c1cnn(Cc2ccccc2)c1)[C@H]1C[C@]2(C1)CCN(C2)C(=O)C#CC1CC1 |r,wU:21.23,wD:23.26,(-5.89,7.15,;-4.35,7.15,;-3.58,8.48,;-3.58,5.81,;-4.06,4.35,;-5.39,3.58,;-2.81,3.44,;-1.57,4.35,;-2.04,5.81,;-1.27,7.15,;-1.75,8.61,;-.5,9.52,;.74,8.61,;2.23,9.01,;3.32,7.92,;2.92,6.43,;4.01,5.35,;5.5,5.74,;5.89,7.23,;4.81,8.32,;.27,7.15,;-2.81,1.9,;-1.73,.82,;-2.81,-.27,;-3.9,.82,;-4.06,-1.18,;-3.58,-2.64,;-2.04,-2.64,;-1.57,-1.18,;-1.27,-3.98,;.27,-3.98,;-2.04,-5.31,;-2.81,-6.64,;-3.58,-7.98,;-4.92,-8.75,;-3.58,-9.52,)| | ||
| Structure | 
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