Reaction Details |
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Target | Dimer of Gag-Pol polyprotein [489-587] |
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Ligand | BDBM706 |
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Substrate/Competitor | HIV-1 Protease substrate |
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Meas. Tech. | Protease Inhibition Assay |
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pH | 6±n/a |
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Temperature | 310.15±n/a K |
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Comments | At inhibitor concentrition of 5 uM, 38% protease activity is inhibited. |
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Citation | Mimoto, T; Kato, R; Takaku, H; Nojima, S; Terashima, K; Misawa, S; Fukazawa, T; Ueno, T; Sato, H; Shintani, M; Kiso, Y; Hayashi, H Structure-activity relationship of small-sized HIV protease inhibitors containing allophenylnorstatine. J Med Chem42:1789-802 (1999) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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Dimer of Gag-Pol polyprotein [489-587] |
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Name: | Dimer of Gag-Pol polyprotein [489-587] |
Synonyms: | HIV-1 Protease |
Type: | Protein Complex |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 2 components. |
Component 1 |
Name: | Gag-Pol polyprotein [489-587] |
Synonyms: | HIV protease | HIV-1 Protease (NY5-type sequence) | HIV-1 Protease chain A | HIV-1 Protease chain B | POL_HV1N5 | gag-pol |
Type: | Enzyme Subunit |
Mol. Mass.: | 10822.21 |
Organism: | Human immunodeficiency virus type 1 |
Description: | P12497[489-587] |
Residue: | 99 |
Sequence: | PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
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Component 2 |
Name: | Gag-Pol polyprotein [489-587] |
Synonyms: | HIV protease | HIV-1 Protease (NY5-type sequence) | HIV-1 Protease chain A | HIV-1 Protease chain B | POL_HV1N5 | gag-pol |
Type: | Enzyme Subunit |
Mol. Mass.: | 10822.21 |
Organism: | Human immunodeficiency virus type 1 |
Description: | P12497[489-587] |
Residue: | 99 |
Sequence: | PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
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BDBM706 |
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HIV-1 Protease substrate |
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Name: | HIV-1 Protease substrate |
Synonyms: | n/a |
Type: | Peptide |
Mol. Mass.: | 2535.82 |
Organism: | Synthetic peptide |
Description: | n/a |
Residue: | 22 |
Sequence: | H-Ser-Gln-Asn-Tyr-Pro-Ile-Val-OH
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