| Reaction Details |
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 | Report a problem with these data |
| Target | Oxysterols receptor LXR-alpha [197-447] |
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| Ligand | BDBM35099 |
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| Substrate/Competitor | BDBM19993 |
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| Meas. Tech. | LXRbeta Binding Assay (IC50) and LAFbeta Functional Assay (EC50) |
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| IC50 | 6.6±n/a nM |
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| Citation |  Bernotas, RC; Kaufman, DH; Singhaus, RR; Ullrich, J; Unwalla, R; Quinet, E; Nambi, P; Wilhelmsson, A; Goos-Nilsson, A; Wrobel, J 4-(3-aryloxyaryl)quinoline alcohols are liver X receptor agonists. Bioorg Med Chem17:8086-92 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Oxysterols receptor LXR-alpha [197-447] |
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| Name: | Oxysterols receptor LXR-alpha [197-447] |
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| Synonyms: | LXRA | Liver X Receptor alpha (LXR-alpha) | NR1H3 | NR1H3_HUMAN | Nuclear orphan receptor LXR-alpha | Nuclear receptor subfamily 1 group H member 3 | Oxysterols receptor LXR-alpha |
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| Type: | Receptor |
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| Mol. Mass.: | 28986.41 |
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| Organism: | Homo sapiens (Human) |
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| Description: | LXR alpha ligand binding domain (amino acid residues 197-447) with an N-terminal biotinylation tag expressed in E.coli, was used for the binding assays. |
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| Residue: | 251 |
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| Sequence: | SSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQQRFAH
FTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFL
KDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQL
QVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLP
PLLSEIWDVHE
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| BDBM35099 |
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| BDBM19993 |
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| Name | BDBM35099 |
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| Synonyms: | biarylether alcohol quinoline, 5i |
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| Type | Small organic molecule |
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| Emp. Form. | C25H22ClNO2 |
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| Mol. Mass. | 403.901 |
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| SMILES | Cc1cnc2c(Cl)cccc2c1-c1cccc(Oc2cccc(c2)C(C)(C)O)c1 |
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| Structure | 
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