Reaction Details |
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Target | Rap guanine nucleotide exchange factor 4 |
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Ligand | BDBM50241966 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1670999 (CHEMBL4021028) |
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IC50 | 7000±n/a nM |
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Citation | Ye, N; Zhu, Y; Liu, Z; Mei, FC; Chen, H; Wang, P; Cheng, X; Zhou, J Identification of novel 2-(benzo[d]isoxazol-3-yl)-2-oxo-N-phenylacetohydrazonoyl cyanide analoguesas potent EPAC antagonists. Eur J Med Chem134:62-71 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Rap guanine nucleotide exchange factor 4 |
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Name: | Rap guanine nucleotide exchange factor 4 |
Synonyms: | Cgef2 | Cgef2 | EPAC 2 | Epac2 | Exchange factor directly activated by cAMP 2 | Exchange protein directly activated by cAMP 2 | RPGF4_MOUSE | Rap guanine nucleotide exchange factor 4 | Rapgef4 | cAMP-GEFII | cAMP-dependent Rap1 guanine-nucleotide exchange factor | cAMP-regulated guanine nucleotide exchange factor II |
Type: | PROTEIN |
Mol. Mass.: | 115497.71 |
Organism: | Mus musculus |
Description: | ChEMBL_109832 |
Residue: | 1011 |
Sequence: | MVAAHAAHSQSSAEWIACLDKRPLERSSEDVDIIFTRLKGVKAFEKFHPNLLRQICLCGY
YENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDN
TPRHATIVTRESSELLRIEQEDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKENT
PLIEPHVPLRPAHTITKVPSEKILRAGKILRIAILSRAPHMIRDRKYHLKTYRQCCVGTE
LVDWMIQQTSCVHSRTQAVGMWQVLLEDGVLNHVDQERHFQDKYLFYRFLDDEREDAPLP
TEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYDELLHIKALSHL
STTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDD
FGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKV
PAGNRAANQGNSQPQQKYTVMSGTPEKILEHFLETIRLEPSLNEATDSVLNDFVMMHCVF
MPNTQLCPALVAHYHAQPSQGTEQERMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVAMA
FLEEFYVSVSDDARMMAAFKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQK
RQPIRGSDEVLFKVYCIDHTYTTIRVPVAASVKEVISAVADKLGSGEGLIIVKMNSGGEK
VVLKSNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTTGTVGTFELMSSKDLAYQM
TTYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEVCLCSQLSKR
VQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLM
DPSRNHRAYRLTAAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTART
VRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP
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BDBM50241966 |
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n/a |
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Name | BDBM50241966 |
Synonyms: | CHEMBL4092921 |
Type | Small organic molecule |
Emp. Form. | C21H12F6N4O3 |
Mol. Mass. | 482.3354 |
SMILES | COc1ccc(cc1)-c1cc(no1)C(=O)C(=N\Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F)\C#N |
Structure |
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