| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Bromodomain-containing protein 3 |
|---|
| Ligand | BDBM50210164 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1682914 (CHEMBL4033191) |
|---|
| IC50 | 59±n/a nM |
|---|
| Citation |  Ouyang, L; Zhang, L; Liu, J; Fu, L; Yao, D; Zhao, Y; Zhang, S; Wang, G; He, G; Liu, B Discovery of a Small-Molecule Bromodomain-Containing Protein 4 (BRD4) Inhibitor That Induces AMP-Activated Protein Kinase-Modulated Autophagy-Associated Cell Death in Breast Cancer. J Med Chem60:9990-10012 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Bromodomain-containing protein 3 |
|---|
| Name: | Bromodomain-containing protein 3 |
|---|
| Synonyms: | BRD3 | BRD3_HUMAN | Bromodomain and extra-terminal motif (BET) | Bromodomain-containing protein 3 | Bromodomain-containing protein 3 (BRD3) | KIAA0043 | RING3-like protein | RING3L |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 79571.81 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q15059 |
|---|
| Residue: | 726 |
|---|
| Sequence: | MSTATTVAPAGIPATPGPVNPPPPEVSNPSKPGRKTNQLQYMQNVVVKTLWKHQFAWPFY
QPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSASECMQDFNTMFTNCYIYNKPTD
DIVLMAQALEKIFLQKVAQMPQEEVELLPPAPKGKGRKPAAGAQSAGTQQVAAVSSVSPA
TPFQSVPPTVSQTPVIAATPVPTITANVTSVPVPPAAAPPPPATPIVPVVPPTPPVVKKK
GVKRKADTTTPTTSAITASRSESPPPLSDPKQAKVVARRESGGRPIKPPKKDLEDGEVPQ
HAGKKGKLSEHLRYCDSILREMLSKKHAAYAWPFYKPVDAEALELHDYHDIIKHPMDLST
VKRKMDGREYPDAQGFAADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPV
EAPALPAPAAPMVSKGAESSRSSEESSSDSGSSDSEEERATRLAELQEQLKAVHEQLAAL
SQAPVNKPKKKKEKKEKEKKKKDKEKEKEKHKVKAEEEKKAKVAPPAKQAQQKKAPAKKA
NSTTTAGRQLKKGGKQASASYDSEEEEEGLPMSYDEKRQLSLDINRLPGEKLGRVVHIIQ
SREPSLRDSNPDEIEIDFETLKPTTLRELERYVKSCLQKKQRKPFSASGKKQAAKSKEEL
AQEKKKELEKRLQDVSGQLSSSKKPARKEKPGSAPSGGPSRLSSSSSSESGSSSSSGSSS
DSSDSE
|
|
|
|---|
| BDBM50210164 |
|---|
| n/a |
|---|
| Name | BDBM50210164 |
|---|
| Synonyms: | CHEMBL2132936 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H25ClN4O2S |
|---|
| Mol. Mass. | 456.988 |
|---|
| SMILES | Cc1nnc2C(CC(=O)OC(C)(C)C)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1 |c:14| |
|---|
| Structure | 
|
|---|
Search and Browse
