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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Cyclin-A2/Cyclin-dependent kinase 2 | ||
| Ligand | BDBM50261212 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1695672 (CHEMBL4046562) | ||
| IC50 | 14±n/a nM | ||
| Citation |  Park, SJ; Kim, E; Yoo, M; Lee, JY; Park, CH; Hwang, JY; Ha, JD Synthesis and biological evaluation of N9-cis-cyclobutylpurine derivatives for use as cyclin-dependent kinase (CDK) inhibitors. Bioorg Med Chem Lett27:4399-4404 (2017) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Cyclin-A2/Cyclin-dependent kinase 2 | |||
| Name: | Cyclin-A2/Cyclin-dependent kinase 2 | ||
| Synonyms: | CDK2-CyclinA | CDK2/A | CDK2/Cyclin A | CDK2/Cyclin A2 | Cyclin A2/dependent kinase 2 | Cyclin-Dependent Kinase 2 (CDK2) | Cyclin-Dependent Kinase 2 (CDK2A) | ||
| Type: | Protein Complex | ||
| Mol. Mass.: | n/a | ||
| Description: | Cdk2/Cyclin A kinase was purified from insect cells coinfected with Cyclin A/Cdk2 baculovirus. | ||
| Components: | This complex has 2 components. | ||
| Component 1 | |||
| Name: | Cyclin-dependent kinase 2 | ||
| Synonyms: | CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase | ||
| Type: | Enzyme Subunit | ||
| Mol. Mass.: | 33938.17 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P24941 | ||
| Residue: | 298 | ||
| Sequence: |
| ||
| Component 2 | |||
| Name: | Cyclin-A2 | ||
| Synonyms: | CCN1 | CCNA | CCNA1 | CCNA2 | CCNA2_HUMAN | Cyclin A | Cyclin-A | ||
| Type: | Enzyme Subunit | ||
| Mol. Mass.: | 48550.19 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P20248 | ||
| Residue: | 432 | ||
| Sequence: |
| ||
| BDBM50261212 | |||
| n/a | |||
| Name | BDBM50261212 | ||
| Synonyms: | CHEMBL4087174 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H19F3N8O | ||
| Mol. Mass. | 468.4345 | ||
| SMILES | FC(F)(F)c1cccc(n1)C(=O)N[C@H]1C[C@H](C1)n1cnc2c(NCc3cccnc3)ncnc12 |r,wU:15.18,13.13,(34.82,-21.98,;33.34,-21.59,;32.94,-20.11,;34.42,-20.49,;32.26,-22.68,;30.77,-22.28,;29.68,-23.37,;30.08,-24.85,;31.57,-25.26,;32.66,-24.17,;31.96,-26.74,;33.47,-27.06,;30.93,-27.89,;29.43,-27.57,;28.14,-28.41,;27.29,-27.12,;28.59,-26.27,;25.79,-26.79,;25.17,-25.39,;23.64,-25.55,;23.31,-27.06,;21.98,-27.82,;20.65,-27.06,;19.32,-27.82,;17.98,-27.06,;16.64,-27.82,;15.31,-27.06,;15.31,-25.52,;16.64,-24.74,;17.98,-25.52,;21.98,-29.36,;23.31,-30.14,;24.65,-29.36,;24.65,-27.82,)| | ||
| Structure | 
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