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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Cyclin-dependent kinase 5 activator 1 | ||
| Ligand | BDBM50261211 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1695674 (CHEMBL4046564) | ||
| IC50 | 67±n/a nM | ||
| Citation |  Park, SJ; Kim, E; Yoo, M; Lee, JY; Park, CH; Hwang, JY; Ha, JD Synthesis and biological evaluation of N9-cis-cyclobutylpurine derivatives for use as cyclin-dependent kinase (CDK) inhibitors. Bioorg Med Chem Lett27:4399-4404 (2017) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Cyclin-dependent kinase 5 activator 1 | |||
| Name: | Cyclin-dependent kinase 5 activator 1 | ||
| Synonyms: | CDK5/p35 | Cyclin-Dependent Kinase 5 (CDK5) | Cyclin-dependent kinase 5 regulatory subunit 1 | Cyclin-dependent kinase 5/CDK5 activator 1 | ||
| Type: | Protein Complex | ||
| Mol. Mass.: | n/a | ||
| Description: | n/a | ||
| Components: | This complex has 2 components. | ||
| Component 1 | |||
| Name: | Cyclin-dependent kinase 5 | ||
| Synonyms: | CDK5 | CDK5_HUMAN | CDKN5 | Cell division protein kinase 5 | Cyclin-dependent kinase 5 (CDK5/ p25) | Cyclin-dependent kinase 5 (CDK5/p35) | Cyclin-dependent-like kinase 5 | Cyclin-dependent-like kinase 5 (CDK5) | PSSALRE | Serine/threonine-protein kinase PSSALRE | Tau protein kinase II catalytic subunit | ||
| Type: | Enzyme Subunit | ||
| Mol. Mass.: | 33308.61 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | n/a | ||
| Residue: | 292 | ||
| Sequence: |
| ||
| Component 2 | |||
| Name: | Cyclin-dependent kinase 5 activator 1 | ||
| Synonyms: | CD5R1_HUMAN | CDK5R | CDK5R1 | Cyclin-Dependent Kinase 5 Activator 1, p35 | Cyclin-dependent kinase 5 (CDK5/p25) | Cyclin-dependent kinase 5 regulatory subunit 1 | NCK5A | TPKII regulatory subunit | p35 | ||
| Type: | Enzyme Subunit | ||
| Mol. Mass.: | 34077.43 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q15078 | ||
| Residue: | 307 | ||
| Sequence: |
| ||
| BDBM50261211 | |||
| n/a | |||
| Name | BDBM50261211 | ||
| Synonyms: | CHEMBL4094891 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H23N7O2 | ||
| Mol. Mass. | 429.4744 | ||
| SMILES | COc1cccc(Nc2ncnc3n(cnc23)[C@@H]2C[C@@H](C2)NC(=O)c2cccc(C)n2)c1 |r,wU:17.18,19.23,(16.66,-26.35,;15.34,-25.58,;15.33,-24.04,;13.98,-23.27,;13.99,-21.72,;15.34,-20.96,;16.66,-21.74,;18.01,-20.97,;19.35,-21.76,;19.35,-23.3,;20.69,-24.07,;22.02,-23.3,;22.02,-21.75,;23.17,-20.71,;22.55,-19.33,;21.02,-19.48,;20.69,-20.98,;24.67,-20.96,;25.58,-22.22,;26.82,-21.33,;25.91,-20.07,;28.34,-21.57,;29.31,-20.39,;30.84,-20.63,;28.76,-18.95,;27.24,-18.7,;26.68,-17.26,;27.67,-16.05,;29.19,-16.31,;30.18,-15.11,;29.74,-17.76,;16.66,-23.28,)| | ||
| Structure | 
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