| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase 17A |
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| Ligand | BDBM50274640 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1714184 (CHEMBL4124233) |
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| IC50 | 10.0±n/a nM |
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| Citation |  Pemberton, N; Mogemark, M; Arlbrandt, S; Bold, P; Cox, RJ; Gardelli, C; Holden, NS; Karabelas, K; Karlsson, J; Lever, S; Li, X; Lindmark, H; Norberg, M; Perry, MWD; Petersen, J; Rodrigo Blomqvist, S; Thomas, M; Tyrchan, C; Westin Eriksson, A; Zlatoidsky, P; ึster, L Discovery of Highly Isoform Selective Orally Bioavailable Phosphoinositide 3-Kinase (PI3K)-? Inhibitors. J Med Chem61:5435-5441 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase 17A |
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| Name: | Serine/threonine-protein kinase 17A |
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| Synonyms: | DRAK1 | ST17A_HUMAN | STK17A |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 46544.04 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_109255245 |
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| Residue: | 414 |
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| Sequence: | MIPLEKPGSGGSSPGATSGSGRAGRGLSGPCRPPPPPQARGLLTEIRAVVRTEPFQDGYS
LCPGRELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVLELAQDNPW
VINLHEVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGVHFLHTR
DVVHLDLKPQNILLTSESPLGDIKIVDFGLSRILKNSEELREIMGTPEYVAPEILSYDPI
SMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSESAVDFIRT
LLVKKPEDRATAEECLKHPWLTQSSIQEPSFRMEKALEEANALQEGHSVPEINSDTDKSE
TKESIVTEELIVVTSYTLGQCRQSEKEKMEQKAISKRFKFEEPLLQEIPGEFIY
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| BDBM50274640 |
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| n/a |
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| Name | BDBM50274640 |
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| Synonyms: | CHEMBL4126445 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H23N3O2S |
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| Mol. Mass. | 369.481 |
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| SMILES | C[C@@H](C1CC1)N1Cc2cc(cc(C)c2C1=O)-c1sc(NC(C)=O)nc1C |r| |
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| Structure | 
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