| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity protein kinase CLK4 |
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| Ligand | BDBM50274640 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1714185 (CHEMBL4124234) |
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| IC50 | 126±n/a nM |
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| Citation |  Pemberton, N; Mogemark, M; Arlbrandt, S; Bold, P; Cox, RJ; Gardelli, C; Holden, NS; Karabelas, K; Karlsson, J; Lever, S; Li, X; Lindmark, H; Norberg, M; Perry, MWD; Petersen, J; Rodrigo Blomqvist, S; Thomas, M; Tyrchan, C; Westin Eriksson, A; Zlatoidsky, P; ึster, L Discovery of Highly Isoform Selective Orally Bioavailable Phosphoinositide 3-Kinase (PI3K)-? Inhibitors. J Med Chem61:5435-5441 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity protein kinase CLK4 |
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| Name: | Dual specificity protein kinase CLK4 |
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| Synonyms: | CDC-like kinase 4 | CLK4 | CLK4_HUMAN | Dual specificity protein kinase CLK1/CLK4 |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 57522.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_10190706 |
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| Residue: | 481 |
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| Sequence: | MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEAR
SLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRH
CSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHG
MDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFE
LLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYV
VKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDV
WSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEH
SSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKK
K
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| BDBM50274640 |
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| n/a |
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| Name | BDBM50274640 |
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| Synonyms: | CHEMBL4126445 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H23N3O2S |
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| Mol. Mass. | 369.481 |
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| SMILES | C[C@@H](C1CC1)N1Cc2cc(cc(C)c2C1=O)-c1sc(NC(C)=O)nc1C |r| |
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| Structure | 
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