| Reaction Details |
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 | Report a problem with these data |
| Target | Protease |
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| Ligand | BDBM50288356 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1729858 (CHEMBL4145136) |
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| EC50 | 165±n/a nM |
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| Citation |  Hidaka, K; Kimura, T; Sankaranarayanan, R; Wang, J; McDaniel, KF; Kempf, DJ; Kameoka, M; Adachi, M; Kuroki, R; Nguyen, JT; Hayashi, Y; Kiso, Y Identification of Highly Potent Human Immunodeficiency Virus Type-1 Protease Inhibitors against Lopinavir and Darunavir Resistant Viruses from Allophenylnorstatine-Based Peptidomimetics with P2 Tetrahydrofuranylglycine. J Med Chem61:5138-5153 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protease |
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| Name: | Protease |
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| Synonyms: | n/a |
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| Type: | Enzyme |
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| Mol. Mass.: | 10904.79 |
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| Organism: | Human immunodeficiency virus 1 (HIV-1) |
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| Description: | Q9YQ12 |
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| Residue: | 99 |
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| Sequence: | PQITLWQRPFVTIKIEGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD
QIVIEICGKKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
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| BDBM50288356 |
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| n/a |
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| Name | BDBM50288356 |
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| Synonyms: | CHEMBL4168317 |
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| Type | Small organic molecule |
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| Emp. Form. | C41H53N5O7S |
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| Mol. Mass. | 759.954 |
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| SMILES | [H][C@@](NC(=O)COc1cccc(c1)N(C)C)(C(=O)N[C@@H](Cc1ccccc1)[C@H](O)C(=O)N1CSC(C)(C)[C@H]1C(=O)NCc1c(C)cccc1C)[C@@]1([H])CCOC1 |r| |
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| Structure | 
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