| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-secretase 2 |
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| Ligand | BDBM223396 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1748625 (CHEMBL4183135) |
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| IC50 | 20±n/a nM |
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| Citation |  O'Neill, BT; Beck, EM; Butler, CR; Nolan, CE; Gonzales, C; Zhang, L; Doran, SD; Lapham, K; Buzon, LM; Dutra, JK; Barreiro, G; Hou, X; Martinez-Alsina, LA; Rogers, BN; Villalobos, A; Murray, JC; Ogilvie, K; LaChapelle, EA; Chang, C; Lanyon, LF; Steppan, CM; Robshaw, A; Hales, K; Boucher, GG; Pandher, K; Houle, C; Ambroise, CW; Karanian, D; Riddell, D; Bales, KR; Brodney, MA Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, ?-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor Lacking Hypopigmentation. J Med Chem61:4476-4504 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-secretase 2 |
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| Name: | Beta-secretase 2 |
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| Synonyms: | AEPLC | ALP56 | ASP1 | ASP21 | Asp 1 | Aspartic-like protease 56 kDa | Aspartyl protease 1 | BACE2 | BACE2_HUMAN | Beta secretase 2 | Beta-secretase (BACE) | Beta-secretase 2 | Beta-secretase 2 (BACE-2) | Beta-secretase 2 precursor | Beta-site APP-cleaving enzyme 2 | Down region aspartic protease | Memapsin-1 | Membrane-associated aspartic protease 1 | beta-Secretase (BACE-2) |
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| Type: | Protein |
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| Mol. Mass.: | 56171.20 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9Y5Z0 |
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| Residue: | 518 |
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| Sequence: | MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGL
ALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAG
TPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATI
FESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVA
GSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKA
IVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISI
YLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFD
RAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCG
AILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK
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| BDBM223396 |
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| n/a |
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| Name | BDBM223396 |
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| Synonyms: | US9315520, 7 | US9315520, Example 7 | US9605007, Example 7 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H18ClN5O2S2 |
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| Mol. Mass. | 423.94 |
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| SMILES | C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2ccc(Cl)cn2)cs1 |r,c:7| |
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| Structure | 
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