| Reaction Details |
|---|
 | Report a problem with these data |
| Target | BDNF/NT-3 growth factors receptor |
|---|
| Ligand | BDBM50457825 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1760792 (CHEMBL4195800) |
|---|
| IC50 | 6.2±n/a nM |
|---|
| Citation |  Bagal, SK; Andrews, M; Bechle, BM; Bian, J; Bilsland, J; Blakemore, DC; Braganza, JF; Bungay, PJ; Corbett, MS; Cronin, CN; Cui, JJ; Dias, R; Flanagan, NJ; Greasley, SE; Grimley, R; James, K; Johnson, E; Kitching, L; Kraus, ML; McAlpine, I; Nagata, A; Ninkovic, S; Omoto, K; Scales, S; Skerratt, SE; Sun, J; Tran-Dubé, M; Waldron, GJ; Wang, F; Warmus, JS Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain. J Med Chem61:6779-6800 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| BDNF/NT-3 growth factors receptor |
|---|
| Name: | BDNF/NT-3 growth factors receptor |
|---|
| Synonyms: | GP145-TrkB | NTRK1/NTRK2 | NTRK2 | NTRK2_HUMAN | Neurotrophic tyrosine kinase receptor type 2 | TRKB | Trk-B | TrkB tyrosine kinase | Tropomyosin-related kinase B | Tropomyosin-related kinase B (TRKB) | Tyrosine kinase receptor B (Trk-B) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 91996.87 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q16620 |
|---|
| Residue: | 822 |
|---|
| Sequence: | MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP
NSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHI
NFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNES
SKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHM
NETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH
WCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYT
LIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPST
DVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASP
LHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVL
KRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHI
VKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQI
AAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWM
PPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQ
EVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG
|
|
|
|---|
| BDBM50457825 |
|---|
| n/a |
|---|
| Name | BDBM50457825 |
|---|
| Synonyms: | CHEMBL4207042 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H19F5N4O4 |
|---|
| Mol. Mass. | 474.3813 |
|---|
| SMILES | CNC(=O)c1cnc(N)c(O[C@H]2CN(CC2(F)F)C(=O)Cc2ccc(OC(F)(F)F)cc2)c1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
