Compile Data Set for Download or QSAR

Found 195 hits with Last Name = 'braganza' and Initial = 'jf'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM16385 (5-[3-(2-ethoxyphenyl)-[1,2,4]triazolo[3,4-a]pyridi...) Show SMILES CCOc1ccccc1-c1nnc2ccc(cn12)-c1ocnc1-c1ccc(F)cc1 Show InChI InChI=1S/C23H17FN4O2/c1-2-29-19-6-4-3-5-18(19)23-27-26-20-12-9-16(13-28(20)23)22-21(25-14-30-22)15-7-10-17(24)11-8-15/h3-14H,2H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...				Bioorg Med Chem Lett 16: 4339-44 (2006) Article DOI: 10.1016/j.bmcl.2006.05.056 BindingDB Entry DOI: 10.7270/Q2251GFZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM16384 (4-(4-fluorophenyl)-5-[3-(2-methoxyphenyl)-[1,2,4]t...) Show SMILES COc1ccccc1-c1nnc2ccc(cn12)-c1ocnc1-c1ccc(F)cc1 Show InChI InChI=1S/C22H15FN4O2/c1-28-18-5-3-2-4-17(18)22-26-25-19-11-8-15(12-27(19)22)21-20(24-13-29-21)14-6-9-16(23)10-7-14/h2-13H,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...				Bioorg Med Chem Lett 16: 4339-44 (2006) Article DOI: 10.1016/j.bmcl.2006.05.056 BindingDB Entry DOI: 10.7270/Q2251GFZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM16390 (4-(2,4-difluorophenyl)-5-[3-(1-methylcyclopropyl)-...) Show SMILES CC1(CC1)c1nnc2ccc(cn12)-c1ocnc1-c1ccc(F)cc1F Show InChI InChI=1S/C19H14F2N4O/c1-19(6-7-19)18-24-23-15-5-2-11(9-25(15)18)17-16(22-10-26-17)13-4-3-12(20)8-14(13)21/h2-5,8-10H,6-7H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...				Bioorg Med Chem Lett 16: 4339-44 (2006) Article DOI: 10.1016/j.bmcl.2006.05.056 BindingDB Entry DOI: 10.7270/Q2251GFZ
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50457826 (CHEMBL4216500) Show SMILES Cn1cnc(c1)-c1cnc(N)c(O[C@H]2CN(CC2(F)F)C(=O)Cc2ccc(OC(F)(F)F)cc2)c1 |r| Show InChI InChI=1S/C22H20F5N5O3/c1-31-9-16(30-12-31)14-7-17(20(28)29-8-14)34-18-10-32(11-21(18,23)24)19(33)6-13-2-4-15(5-3-13)35-22(25,26)27/h2-5,7-9,12,18H,6,10-11H2,1H3,(H2,28,29)/t18-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at prolink-tagged TrkA in human U2OS cells assessed as inhibition of beta-NGF-induced receptor phosphorylation by measuring reduc...				J Med Chem 61: 6779-6800 (2018) Article DOI: 10.1021/acs.jmedchem.8b00633 BindingDB Entry DOI: 10.7270/Q2K64MPW
					More data for this Ligand-Target Pair
NT-3 growth factor receptor (Homo sapiens (Human))	BDBM50457839 (CHEMBL4211921) Show SMILES Cn1cc(cn1)-c1ccc(O[C@@H]2CCN(C2)C(=O)Cc2ccc(OC(F)(F)F)cc2)c(n1)C(N)=O |r| Show InChI InChI=1S/C23H22F3N5O4/c1-30-12-15(11-28-30)18-6-7-19(21(29-18)22(27)33)34-17-8-9-31(13-17)20(32)10-14-2-4-16(5-3-14)35-23(24,25)26/h2-7,11-12,17H,8-10,13H2,1H3,(H2,27,33)/t17-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at prolink-tagged TrkC in human U2OS cells assessed as inhibition of NT3-induced receptor phosphorylation by measuring reduction ...				J Med Chem 61: 6779-6800 (2018) Article DOI: 10.1021/acs.jmedchem.8b00633 BindingDB Entry DOI: 10.7270/Q2K64MPW
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM16392 (4-(2,4-difluorophenyl)-5-[3-(1-methylcyclobutyl)-[...) Show SMILES CC1(CCC1)c1nnc2ccc(cn12)-c1ocnc1-c1ccc(F)cc1F Show InChI InChI=1S/C20H16F2N4O/c1-20(7-2-8-20)19-25-24-16-6-3-12(10-26(16)19)18-17(23-11-27-18)14-5-4-13(21)9-15(14)22/h3-6,9-11H,2,7-8H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...				Bioorg Med Chem Lett 16: 4339-44 (2006) Article DOI: 10.1016/j.bmcl.2006.05.056 BindingDB Entry DOI: 10.7270/Q2251GFZ
					More data for this Ligand-Target Pair
NT-3 growth factor receptor (Homo sapiens (Human))	BDBM50457833 (CHEMBL4210892) Show SMILES Cn1cnc(c1)-c1cnc(O[C@H]2CCN(C[C@H]2F)C(=O)Cc2ccc(OC(F)(F)F)cc2)c(c1)C(N)=O |r| Show InChI InChI=1S/C24H23F4N5O4/c1-32-12-19(31-13-32)15-9-17(22(29)35)23(30-10-15)36-20-6-7-33(11-18(20)25)21(34)8-14-2-4-16(5-3-14)37-24(26,27)28/h2-5,9-10,12-13,18,20H,6-8,11H2,1H3,(H2,29,35)/t18-,20+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at prolink-tagged TrkC in human U2OS cells assessed as inhibition of NT3-induced receptor phosphorylation by measuring reduction ...				J Med Chem 61: 6779-6800 (2018) Article DOI: 10.1021/acs.jmedchem.8b00633 BindingDB Entry DOI: 10.7270/Q2K64MPW
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM16393 (5-{3-tert-butyl-[1,2,4]triazolo[3,4-a]pyridin-6-yl...) Show SMILES CC(C)(C)c1nnc2ccc(cn12)-c1ocnc1-c1ccc(F)cc1F Show InChI InChI=1S/C19H16F2N4O/c1-19(2,3)18-24-23-15-7-4-11(9-25(15)18)17-16(22-10-26-17)13-6-5-12(20)8-14(13)21/h4-10H,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...				Bioorg Med Chem Lett 16: 4339-44 (2006) Article DOI: 10.1016/j.bmcl.2006.05.056 BindingDB Entry DOI: 10.7270/Q2251GFZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM16398 (4-(2,5-difluorophenyl)-5-[3-(1-methylcyclobutyl)-[...) Show SMILES CC1(CCC1)c1nnc2ccc(cn12)-c1ocnc1-c1cc(F)ccc1F Show InChI InChI=1S/C20H16F2N4O/c1-20(7-2-8-20)19-25-24-16-6-3-12(10-26(16)19)18-17(23-11-27-18)14-9-13(21)4-5-15(14)22/h3-6,9-11H,2,7-8H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...				Bioorg Med Chem Lett 16: 4339-44 (2006) Article DOI: 10.1016/j.bmcl.2006.05.056 BindingDB Entry DOI: 10.7270/Q2251GFZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM16404 (5-{3-tert-butyl-[1,2,4]triazolo[3,4-a]pyridin-6-yl...) Show SMILES CC(C)(C)c1nnc2ccc(cn12)-c1ocnc1-c1cc(F)c(F)cc1F Show InChI InChI=1S/C19H15F3N4O/c1-19(2,3)18-25-24-15-5-4-10(8-26(15)18)17-16(23-9-27-17)11-6-13(21)14(22)7-12(11)20/h4-9H,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...				Bioorg Med Chem Lett 16: 4339-44 (2006) Article DOI: 10.1016/j.bmcl.2006.05.056 BindingDB Entry DOI: 10.7270/Q2251GFZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM16346 (4-(4-chloro-2-fluorophenyl)-5-[3-(propan-2-yl)-[1,...) Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1ccc(Cl)cc1F Show InChI InChI=1S/C18H14ClFN4O/c1-10(2)18-23-22-15-6-3-11(8-24(15)18)17-16(21-9-25-17)13-5-4-12(19)7-14(13)20/h3-10H,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20	n/a	n/a	n/a	n/a	7.2	30
Pfizer					Assay Description The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...				Bioorg Med Chem Lett 16: 4339-44 (2006) Article DOI: 10.1016/j.bmcl.2006.05.056 BindingDB Entry DOI: 10.7270/Q2251GFZ
					More data for this Ligand-Target Pair
NT-3 growth factor receptor (Homo sapiens (Human))	BDBM50457825 (CHEMBL4207042) Show SMILES CNC(=O)c1cnc(N)c(O[C@H]2CN(CC2(F)F)C(=O)Cc2ccc(OC(F)(F)F)cc2)c1 |r| Show InChI InChI=1S/C20H19F5N4O4/c1-27-18(31)12-7-14(17(26)28-8-12)32-15-9-29(10-19(15,21)22)16(30)6-11-2-4-13(5-3-11)33-20(23,24)25/h2-5,7-8,15H,6,9-10H2,1H3,(H2,26,28)(H,27,31)/t15-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at prolink-tagged TrkC in human U2OS cells assessed as inhibition of NT3-induced receptor phosphorylation by measuring reduction ...				J Med Chem 61: 6779-6800 (2018) Article DOI: 10.1021/acs.jmedchem.8b00633 BindingDB Entry DOI: 10.7270/Q2K64MPW
					More data for this Ligand-Target Pair
NT-3 growth factor receptor (Homo sapiens (Human))	BDBM50457837 (CHEMBL4215846) Show SMILES Cn1cnc(c1)-c1ccc(OC2CCN(CC2)C(=O)Cc2ccc(OC(F)(F)F)cc2)c(c1)C(N)=O Show InChI InChI=1S/C25H25F3N4O4/c1-31-14-21(30-15-31)17-4-7-22(20(13-17)24(29)34)35-18-8-10-32(11-9-18)23(33)12-16-2-5-19(6-3-16)36-25(26,27)28/h2-7,13-15,18H,8-12H2,1H3,(H2,29,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at prolink-tagged TrkC in human U2OS cells assessed as inhibition of NT3-induced receptor phosphorylation by measuring reduction ...				J Med Chem 61: 6779-6800 (2018) Article DOI: 10.1021/acs.jmedchem.8b00633 BindingDB Entry DOI: 10.7270/Q2K64MPW
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM16401 (5-[3-(1-methylcyclopropyl)-[1,2,4]triazolo[3,4-a]p...) Show SMILES CC1(CC1)c1nnc2ccc(cn12)-c1ocnc1-c1cc(F)c(F)cc1F Show InChI InChI=1S/C19H13F3N4O/c1-19(4-5-19)18-25-24-15-3-2-10(8-26(15)18)17-16(23-9-27-17)11-6-13(21)14(22)7-12(11)20/h2-3,6-9H,4-5H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...				Bioorg Med Chem Lett 16: 4339-44 (2006) Article DOI: 10.1016/j.bmcl.2006.05.056 BindingDB Entry DOI: 10.7270/Q2251GFZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM16403 (5-[3-(1-methylcyclobutyl)-[1,2,4]triazolo[3,4-a]py...) Show SMILES CC1(CCC1)c1nnc2ccc(cn12)-c1ocnc1-c1cc(F)c(F)cc1F Show InChI InChI=1S/C20H15F3N4O/c1-20(5-2-6-20)19-26-25-16-4-3-11(9-27(16)19)18-17(24-10-28-18)12-7-14(22)15(23)8-13(12)21/h3-4,7-10H,2,5-6H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...				Bioorg Med Chem Lett 16: 4339-44 (2006) Article DOI: 10.1016/j.bmcl.2006.05.056 BindingDB Entry DOI: 10.7270/Q2251GFZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM16348 (4-(2-chloro-4-fluorophenyl)-5-[3-(propan-2-yl)-[1,...) Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1ccc(F)cc1Cl Show InChI InChI=1S/C18H14ClFN4O/c1-10(2)18-23-22-15-6-3-11(8-24(15)18)17-16(21-9-25-17)13-5-4-12(20)7-14(13)19/h3-10H,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...				Bioorg Med Chem Lett 16: 4339-44 (2006) Article DOI: 10.1016/j.bmcl.2006.05.056 BindingDB Entry DOI: 10.7270/Q2251GFZ
					More data for this Ligand-Target Pair
BDNF/NT-3 growth factors receptor (Homo sapiens (Human))	BDBM50457833 (CHEMBL4210892) Show SMILES Cn1cnc(c1)-c1cnc(O[C@H]2CCN(C[C@H]2F)C(=O)Cc2ccc(OC(F)(F)F)cc2)c(c1)C(N)=O |r| Show InChI InChI=1S/C24H23F4N5O4/c1-32-12-19(31-13-32)15-9-17(22(29)35)23(30-10-15)36-20-6-7-33(11-18(20)25)21(34)8-14-2-4-16(5-3-14)37-24(26,27)28/h2-5,9-10,12-13,18,20H,6-8,11H2,1H3,(H2,29,35)/t18-,20+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	2.60	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at prolink-tagged TrkB in human U2OS cells assessed as inhibition of BDNF-induced receptor phosphorylation by measuring reduction...				J Med Chem 61: 6779-6800 (2018) Article DOI: 10.1021/acs.jmedchem.8b00633 BindingDB Entry DOI: 10.7270/Q2K64MPW
					More data for this Ligand-Target Pair
BDNF/NT-3 growth factors receptor (Homo sapiens (Human))	BDBM50457839 (CHEMBL4211921) Show SMILES Cn1cc(cn1)-c1ccc(O[C@@H]2CCN(C2)C(=O)Cc2ccc(OC(F)(F)F)cc2)c(n1)C(N)=O |r| Show InChI InChI=1S/C23H22F3N5O4/c1-30-12-15(11-28-30)18-6-7-19(21(29-18)22(27)33)34-17-8-9-31(13-17)20(32)10-14-2-4-16(5-3-14)35-23(24,25)26/h2-7,11-12,17H,8-10,13H2,1H3,(H2,27,33)/t17-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.70	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at prolink-tagged TrkB in human U2OS cells assessed as inhibition of BDNF-induced receptor phosphorylation by measuring reduction...				J Med Chem 61: 6779-6800 (2018) Article DOI: 10.1021/acs.jmedchem.8b00633 BindingDB Entry DOI: 10.7270/Q2K64MPW
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM16405 (3-(2,5-difluorophenyl)-4-[3-(propan-2-yl)-[1,2,4]t...) Show SMILES CC(C)c1nnc2ccc(cn12)-c1c[nH]nc1-c1cc(F)ccc1F Show InChI InChI=1S/C18H15F2N5/c1-10(2)18-24-22-16-6-3-11(9-25(16)18)14-8-21-23-17(14)13-7-12(19)4-5-15(13)20/h3-10H,1-2H3,(H,21,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...				Bioorg Med Chem Lett 16: 4339-44 (2006) Article DOI: 10.1016/j.bmcl.2006.05.056 BindingDB Entry DOI: 10.7270/Q2251GFZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM16396 (4-(2,5-difluorophenyl)-5-[3-(1-methylcyclopropyl)-...) Show SMILES CC1(CC1)c1nnc2ccc(cn12)-c1ocnc1-c1cc(F)ccc1F Show InChI InChI=1S/C19H14F2N4O/c1-19(6-7-19)18-24-23-15-5-2-11(9-25(15)18)17-16(22-10-26-17)13-8-12(20)3-4-14(13)21/h2-5,8-10H,6-7H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...				Bioorg Med Chem Lett 16: 4339-44 (2006) Article DOI: 10.1016/j.bmcl.2006.05.056 BindingDB Entry DOI: 10.7270/Q2251GFZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM16340 (4-(2-chlorophenyl)-5-[3-(propan-2-yl)-[1,2,4]triaz...) Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1ccccc1Cl Show InChI InChI=1S/C18H15ClN4O/c1-11(2)18-22-21-15-8-7-12(9-23(15)18)17-16(20-10-24-17)13-5-3-4-6-14(13)19/h3-11H,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	7.2	30
Pfizer					Assay Description The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...				Bioorg Med Chem Lett 16: 4339-44 (2006) Article DOI: 10.1016/j.bmcl.2006.05.056 BindingDB Entry DOI: 10.7270/Q2251GFZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM16351 (5-[3-(propan-2-yl)-[1,2,4]triazolo[3,4-a]pyridin-6...) Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1cc(F)c(F)cc1F Show InChI InChI=1S/C18H13F3N4O/c1-9(2)18-24-23-15-4-3-10(7-25(15)18)17-16(22-8-26-17)11-5-13(20)14(21)6-12(11)19/h3-9H,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...				Bioorg Med Chem Lett 16: 4339-44 (2006) Article DOI: 10.1016/j.bmcl.2006.05.056 BindingDB Entry DOI: 10.7270/Q2251GFZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM16389 (5-{3-cyclopropyl-[1,2,4]triazolo[3,4-a]pyridin-6-y...) Show SMILES Fc1ccc(-c2ncoc2-c2ccc3nnc(C4CC4)n3c2)c(F)c1 Show InChI InChI=1S/C18H12F2N4O/c19-12-4-5-13(14(20)7-12)16-17(25-9-21-16)11-3-6-15-22-23-18(10-1-2-10)24(15)8-11/h3-10H,1-2H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...				Bioorg Med Chem Lett 16: 4339-44 (2006) Article DOI: 10.1016/j.bmcl.2006.05.056 BindingDB Entry DOI: 10.7270/Q2251GFZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM16386 (5-{3-tert-butyl-[1,2,4]triazolo[3,4-a]pyridin-6-yl...) Show SMILES CC(C)(C)c1nnc2ccc(cn12)-c1ocnc1-c1ccc(F)cc1 Show InChI InChI=1S/C19H17FN4O/c1-19(2,3)18-23-22-15-9-6-13(10-24(15)18)17-16(21-11-25-17)12-4-7-14(20)8-5-12/h4-11H,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...				Bioorg Med Chem Lett 16: 4339-44 (2006) Article DOI: 10.1016/j.bmcl.2006.05.056 BindingDB Entry DOI: 10.7270/Q2251GFZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM16391 (5-{3-cyclobutyl-[1,2,4]triazolo[3,4-a]pyridin-6-yl...) Show SMILES Fc1ccc(-c2ncoc2-c2ccc3nnc(C4CCC4)n3c2)c(F)c1 Show InChI InChI=1S/C19H14F2N4O/c20-13-5-6-14(15(21)8-13)17-18(26-10-22-17)12-4-7-16-23-24-19(25(16)9-12)11-2-1-3-11/h4-11H,1-3H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.75	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...				Bioorg Med Chem Lett 16: 4339-44 (2006) Article DOI: 10.1016/j.bmcl.2006.05.056 BindingDB Entry DOI: 10.7270/Q2251GFZ
					More data for this Ligand-Target Pair
NT-3 growth factor receptor (Homo sapiens (Human))	BDBM50457827 (CHEMBL4203759) Show SMILES CC(C)(O)COc1ccc(C(N)=O)c(O[C@H]2CCN(C[C@H]2F)C(=O)Cc2ccc(OC(F)(F)F)cc2)c1 |r| Show InChI InChI=1S/C25H28F4N2O6/c1-24(2,34)14-35-17-7-8-18(23(30)33)21(12-17)36-20-9-10-31(13-19(20)26)22(32)11-15-3-5-16(6-4-15)37-25(27,28)29/h3-8,12,19-20,34H,9-11,13-14H2,1-2H3,(H2,30,33)/t19-,20+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	3.90	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at prolink-tagged TrkC in human U2OS cells assessed as inhibition of NT3-induced receptor phosphorylation by measuring reduction ...				J Med Chem 61: 6779-6800 (2018) Article DOI: 10.1021/acs.jmedchem.8b00633 BindingDB Entry DOI: 10.7270/Q2K64MPW
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM16350 (5-[3-(propan-2-yl)-[1,2,4]triazolo[3,4-a]pyridin-6...) Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1cc(F)c(F)c(F)c1 Show InChI InChI=1S/C18H13F3N4O/c1-9(2)18-24-23-14-4-3-10(7-25(14)18)17-16(22-8-26-17)11-5-12(19)15(21)13(20)6-11/h3-9H,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.10	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...				Bioorg Med Chem Lett 16: 4339-44 (2006) Article DOI: 10.1016/j.bmcl.2006.05.056 BindingDB Entry DOI: 10.7270/Q2251GFZ
					More data for this Ligand-Target Pair
BDNF/NT-3 growth factors receptor (Homo sapiens (Human))	BDBM50457824 (CHEMBL4204174) Show SMILES Cn1cc(cn1)-c1ccc(OC2CCN(CC2)C(=O)Cc2ccc(OC(F)(F)F)cc2)c(c1)C(N)=O Show InChI InChI=1S/C25H25F3N4O4/c1-31-15-18(14-30-31)17-4-7-22(21(13-17)24(29)34)35-19-8-10-32(11-9-19)23(33)12-16-2-5-20(6-3-16)36-25(26,27)28/h2-7,13-15,19H,8-12H2,1H3,(H2,29,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at prolink-tagged TrkB in human U2OS cells assessed as inhibition of BDNF-induced receptor phosphorylation by measuring reduction...				J Med Chem 61: 6779-6800 (2018) Article DOI: 10.1021/acs.jmedchem.8b00633 BindingDB Entry DOI: 10.7270/Q2K64MPW
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM16337 (4-(2-fluoro-5-methylphenyl)-5-[3-(propan-2-yl)-[1,...) Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1cc(C)ccc1F Show InChI InChI=1S/C19H17FN4O/c1-11(2)19-23-22-16-7-5-13(9-24(16)19)18-17(21-10-25-18)14-8-12(3)4-6-15(14)20/h4-11H,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.30	n/a	n/a	n/a	n/a	7.2	30
Pfizer					Assay Description The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...				Bioorg Med Chem Lett 16: 4339-44 (2006) Article DOI: 10.1016/j.bmcl.2006.05.056 BindingDB Entry DOI: 10.7270/Q2251GFZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM16341 (4-(2,4-difluorophenyl)-5-[3-(propan-2-yl)-[1,2,4]t...) Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1ccc(F)cc1F Show InChI InChI=1S/C18H14F2N4O/c1-10(2)18-23-22-15-6-3-11(8-24(15)18)17-16(21-9-25-17)13-5-4-12(19)7-14(13)20/h3-10H,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.60	n/a	n/a	n/a	n/a	7.2	30
Pfizer					Assay Description The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...				Bioorg Med Chem Lett 16: 4339-44 (2006) Article DOI: 10.1016/j.bmcl.2006.05.056 BindingDB Entry DOI: 10.7270/Q2251GFZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM16379 (N-ethyl-6-[4-(4-fluorophenyl)-1,3-oxazol-5-yl]-N-m...) Show SMILES CCN(C)c1nnc2ccc(cn12)-c1ocnc1-c1ccc(F)cc1 Show InChI InChI=1S/C18H16FN5O/c1-3-23(2)18-22-21-15-9-6-13(10-24(15)18)17-16(20-11-25-17)12-4-7-14(19)8-5-12/h4-11H,3H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.70	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...				Bioorg Med Chem Lett 16: 4339-44 (2006) Article DOI: 10.1016/j.bmcl.2006.05.056 BindingDB Entry DOI: 10.7270/Q2251GFZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50305692 (3-tert-butyl-6-(2,4-difluorophenylthio)-[1,2,4]tri...) Show SMILES CC(C)(C)c1nnc2ccc(Sc3ccc(F)cc3F)cn12 Show InChI InChI=1S/C16H15F2N3S/c1-16(2,3)15-20-19-14-7-5-11(9-21(14)15)22-13-6-4-10(17)8-12(13)18/h4-9H,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.80	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of p38 alpha				Bioorg Med Chem Lett 20: 469-73 (2010) Article DOI: 10.1016/j.bmcl.2009.11.114 BindingDB Entry DOI: 10.7270/Q2G160XP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM15414 (4-(4-fluorophenyl)-5-[3-(propan-2-yl)-[1,2,4]triaz...) Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1ccc(F)cc1 Show InChI InChI=1S/C18H15FN4O/c1-11(2)18-22-21-15-8-5-13(9-23(15)18)17-16(20-10-24-17)12-3-6-14(19)7-4-12/h3-11H,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	7.2	30
Pfizer					Assay Description The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...				Bioorg Med Chem Lett 16: 4339-44 (2006) Article DOI: 10.1016/j.bmcl.2006.05.056 BindingDB Entry DOI: 10.7270/Q2251GFZ
					More data for this Ligand-Target Pair				3D Structure (crystal)
NT-3 growth factor receptor (Homo sapiens (Human))	BDBM50457828 (CHEMBL4218103) Show SMILES Cn1cc(cn1)-c1ccc(OC2CCN(CC2)C(=O)Nc2ccc(OC(F)(F)F)cc2)c(c1)C(N)=O Show InChI InChI=1S/C24H24F3N5O4/c1-31-14-16(13-29-31)15-2-7-21(20(12-15)22(28)33)35-18-8-10-32(11-9-18)23(34)30-17-3-5-19(6-4-17)36-24(25,26)27/h2-7,12-14,18H,8-11H2,1H3,(H2,28,33)(H,30,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at prolink-tagged TrkC in human U2OS cells assessed as inhibition of NT3-induced receptor phosphorylation by measuring reduction ...				J Med Chem 61: 6779-6800 (2018) Article DOI: 10.1021/acs.jmedchem.8b00633 BindingDB Entry DOI: 10.7270/Q2K64MPW
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM16347 (4-(5-chloro-2-fluorophenyl)-5-[3-(propan-2-yl)-[1,...) Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1cc(Cl)ccc1F Show InChI InChI=1S/C18H14ClFN4O/c1-10(2)18-23-22-15-6-3-11(8-24(15)18)17-16(21-9-25-17)13-7-12(19)4-5-14(13)20/h3-10H,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.10	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...				Bioorg Med Chem Lett 16: 4339-44 (2006) Article DOI: 10.1016/j.bmcl.2006.05.056 BindingDB Entry DOI: 10.7270/Q2251GFZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM16364 (N-ethyl-6-(4-phenyl-1,3-oxazol-5-yl)-[1,2,4]triazo...) Show SMILES CCNc1nnc2ccc(cn12)-c1ocnc1-c1ccccc1 Show InChI InChI=1S/C17H15N5O/c1-2-18-17-21-20-14-9-8-13(10-22(14)17)16-15(19-11-23-16)12-6-4-3-5-7-12/h3-11H,2H2,1H3,(H,18,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.40	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...				Bioorg Med Chem Lett 16: 4339-44 (2006) Article DOI: 10.1016/j.bmcl.2006.05.056 BindingDB Entry DOI: 10.7270/Q2251GFZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM16377 (6-[4-(4-fluorophenyl)-1,3-oxazol-5-yl]-N-(propan-2...) Show SMILES CC(C)Nc1nnc2ccc(cn12)-c1ocnc1-c1ccc(F)cc1 Show InChI InChI=1S/C18H16FN5O/c1-11(2)21-18-23-22-15-8-5-13(9-24(15)18)17-16(20-10-25-17)12-3-6-14(19)7-4-12/h3-11H,1-2H3,(H,21,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...				Bioorg Med Chem Lett 16: 4339-44 (2006) Article DOI: 10.1016/j.bmcl.2006.05.056 BindingDB Entry DOI: 10.7270/Q2251GFZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM16359 (4-(2-chloro-4,5-difluorophenyl)-5-[3-(propan-2-yl)...) Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1cc(F)c(F)cc1Cl Show InChI InChI=1S/C18H13ClF2N4O/c1-9(2)18-24-23-15-4-3-10(7-25(15)18)17-16(22-8-26-17)11-5-13(20)14(21)6-12(11)19/h3-9H,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.60	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...				Bioorg Med Chem Lett 16: 4339-44 (2006) Article DOI: 10.1016/j.bmcl.2006.05.056 BindingDB Entry DOI: 10.7270/Q2251GFZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM16342 (4-(2,5-difluorophenyl)-5-[3-(propan-2-yl)-[1,2,4]t...) Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1cc(F)ccc1F Show InChI InChI=1S/C18H14F2N4O/c1-10(2)18-23-22-15-6-3-11(8-24(15)18)17-16(21-9-25-17)13-7-12(19)4-5-14(13)20/h3-10H,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.80	n/a	n/a	n/a	n/a	7.2	30
Pfizer					Assay Description The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...				Bioorg Med Chem Lett 16: 4339-44 (2006) Article DOI: 10.1016/j.bmcl.2006.05.056 BindingDB Entry DOI: 10.7270/Q2251GFZ
					More data for this Ligand-Target Pair
BDNF/NT-3 growth factors receptor (Homo sapiens (Human))	BDBM50457837 (CHEMBL4215846) Show SMILES Cn1cnc(c1)-c1ccc(OC2CCN(CC2)C(=O)Cc2ccc(OC(F)(F)F)cc2)c(c1)C(N)=O Show InChI InChI=1S/C25H25F3N4O4/c1-31-14-21(30-15-31)17-4-7-22(20(13-17)24(29)34)35-18-8-10-32(11-9-18)23(33)12-16-2-5-19(6-3-16)36-25(26,27)28/h2-7,13-15,18H,8-12H2,1H3,(H2,29,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	6.10	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at prolink-tagged TrkB in human U2OS cells assessed as inhibition of BDNF-induced receptor phosphorylation by measuring reduction...				J Med Chem 61: 6779-6800 (2018) Article DOI: 10.1021/acs.jmedchem.8b00633 BindingDB Entry DOI: 10.7270/Q2K64MPW
					More data for this Ligand-Target Pair
BDNF/NT-3 growth factors receptor (Homo sapiens (Human))	BDBM50457825 (CHEMBL4207042) Show SMILES CNC(=O)c1cnc(N)c(O[C@H]2CN(CC2(F)F)C(=O)Cc2ccc(OC(F)(F)F)cc2)c1 |r| Show InChI InChI=1S/C20H19F5N4O4/c1-27-18(31)12-7-14(17(26)28-8-12)32-15-9-29(10-19(15,21)22)16(30)6-11-2-4-13(5-3-11)33-20(23,24)25/h2-5,7-8,15H,6,9-10H2,1H3,(H2,26,28)(H,27,31)/t15-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	6.20	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at prolink-tagged TrkB in human U2OS cells assessed as inhibition of BDNF-induced receptor phosphorylation by measuring reduction...				J Med Chem 61: 6779-6800 (2018) Article DOI: 10.1021/acs.jmedchem.8b00633 BindingDB Entry DOI: 10.7270/Q2K64MPW
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM16407 (4-(2,5-difluorophenyl)-5-[3-(propan-2-yl)-[1,2,4]t...) Show SMILES CC(C)c1nnc2ccc(cn12)-c1nc[nH]c1-c1cc(F)ccc1F Show InChI InChI=1S/C18H15F2N5/c1-10(2)18-24-23-15-6-3-11(8-25(15)18)16-17(22-9-21-16)13-7-12(19)4-5-14(13)20/h3-10H,1-2H3,(H,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.20	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...				Bioorg Med Chem Lett 16: 4339-44 (2006) Article DOI: 10.1016/j.bmcl.2006.05.056 BindingDB Entry DOI: 10.7270/Q2251GFZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM16336 (4-(4-fluoro-3-methylphenyl)-5-[3-(propan-2-yl)-[1,...) Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1ccc(F)c(C)c1 Show InChI InChI=1S/C19H17FN4O/c1-11(2)19-23-22-16-7-5-14(9-24(16)19)18-17(21-10-25-18)13-4-6-15(20)12(3)8-13/h4-11H,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.60	n/a	n/a	n/a	n/a	7.2	30
Pfizer					Assay Description The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...				Bioorg Med Chem Lett 16: 4339-44 (2006) Article DOI: 10.1016/j.bmcl.2006.05.056 BindingDB Entry DOI: 10.7270/Q2251GFZ
					More data for this Ligand-Target Pair
BDNF/NT-3 growth factors receptor (Homo sapiens (Human))	BDBM50457829 (CHEMBL4208510) Show SMILES Cn1cc(cn1)-c1ccc(OC2CCN(CC2)C(=O)Cc2ccc(OC(F)(F)F)cc2)c(n1)C(N)=O Show InChI InChI=1S/C24H24F3N5O4/c1-31-14-16(13-29-31)19-6-7-20(22(30-19)23(28)34)35-17-8-10-32(11-9-17)21(33)12-15-2-4-18(5-3-15)36-24(25,26)27/h2-7,13-14,17H,8-12H2,1H3,(H2,28,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.60	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at prolink-tagged TrkB in human U2OS cells assessed as inhibition of BDNF-induced receptor phosphorylation by measuring reduction...				J Med Chem 61: 6779-6800 (2018) Article DOI: 10.1021/acs.jmedchem.8b00633 BindingDB Entry DOI: 10.7270/Q2K64MPW
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50457837 (CHEMBL4215846) Show SMILES Cn1cnc(c1)-c1ccc(OC2CCN(CC2)C(=O)Cc2ccc(OC(F)(F)F)cc2)c(c1)C(N)=O Show InChI InChI=1S/C25H25F3N4O4/c1-31-14-21(30-15-31)17-4-7-22(20(13-17)24(29)34)35-18-8-10-32(11-9-18)23(33)12-16-2-5-19(6-3-16)36-25(26,27)28/h2-7,13-15,18H,8-12H2,1H3,(H2,29,34)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at prolink-tagged TrkA in human U2OS cells assessed as inhibition of beta-NGF-induced receptor phosphorylation by measuring reduc...				J Med Chem 61: 6779-6800 (2018) Article DOI: 10.1021/acs.jmedchem.8b00633 BindingDB Entry DOI: 10.7270/Q2K64MPW
					More data for this Ligand-Target Pair				3D Structure (crystal)
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50305696 (3-(2,4-difluorophenyl)-6-(2,4-difluorophenylthio)-...) Show SMILES Fc1ccc(Sc2ccc3nnc(-c4ccc(F)cc4F)n3c2)c(F)c1 Show InChI InChI=1S/C18H9F4N3S/c19-10-1-4-13(14(21)7-10)18-24-23-17-6-3-12(9-25(17)18)26-16-5-2-11(20)8-15(16)22/h1-9H	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.20	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of p38 alpha				Bioorg Med Chem Lett 20: 469-73 (2010) Article DOI: 10.1016/j.bmcl.2009.11.114 BindingDB Entry DOI: 10.7270/Q2G160XP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM16352 (5-[3-(propan-2-yl)-[1,2,4]triazolo[3,4-a]pyridin-6...) Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1c(F)cc(F)cc1F |(-5.34,-5.49,;-4.57,-4.15,;-3.03,-4.15,;-5.34,-2.82,;-6.87,-2.98,;-7.5,-1.57,;-6.35,-.54,;-6.35,1,;-5.02,1.77,;-3.69,1,;-3.69,-.54,;-5.02,-1.31,;-2.52,2,;-1.02,1.64,;-.22,2.96,;-1.22,4.13,;-2.64,3.53,;-3.97,4.3,;-3.97,5.85,;-2.64,6.62,;-5.31,6.62,;-6.64,5.85,;-7.98,6.62,;-6.64,4.3,;-5.31,3.53,;-5.31,1.99,)| Show InChI InChI=1S/C18H13F3N4O/c1-9(2)18-24-23-14-4-3-10(7-25(14)18)17-16(22-8-26-17)15-12(20)5-11(19)6-13(15)21/h3-9H,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7.20	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...				Bioorg Med Chem Lett 16: 4339-44 (2006) Article DOI: 10.1016/j.bmcl.2006.05.056 BindingDB Entry DOI: 10.7270/Q2251GFZ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM16372 (N-ethyl-6-[4-(4-fluorophenyl)-1,3-oxazol-5-yl]-[1,...) Show SMILES CCNc1nnc2ccc(cn12)-c1ocnc1-c1ccc(F)cc1 Show InChI InChI=1S/C17H14FN5O/c1-2-19-17-22-21-14-8-5-12(9-23(14)17)16-15(20-10-24-16)11-3-6-13(18)7-4-11/h3-10H,2H2,1H3,(H,19,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.60	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...				Bioorg Med Chem Lett 16: 4339-44 (2006) Article DOI: 10.1016/j.bmcl.2006.05.056 BindingDB Entry DOI: 10.7270/Q2251GFZ
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50457839 (CHEMBL4211921) Show SMILES Cn1cc(cn1)-c1ccc(O[C@@H]2CCN(C2)C(=O)Cc2ccc(OC(F)(F)F)cc2)c(n1)C(N)=O |r| Show InChI InChI=1S/C23H22F3N5O4/c1-30-12-15(11-28-30)18-6-7-19(21(29-18)22(27)33)34-17-8-9-31(13-17)20(32)10-14-2-4-16(5-3-14)35-23(24,25)26/h2-7,11-12,17H,8-10,13H2,1H3,(H2,27,33)/t17-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.70	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at prolink-tagged TrkA in human U2OS cells assessed as inhibition of beta-NGF-induced receptor phosphorylation by measuring reduc...				J Med Chem 61: 6779-6800 (2018) Article DOI: 10.1021/acs.jmedchem.8b00633 BindingDB Entry DOI: 10.7270/Q2K64MPW
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50305704 (CHEMBL595338 | methyl 3-(6-(2,4-difluorophenylthio...) Show SMILES COC(=O)c1ccc(C)c(c1)-c1nnc2ccc(Sc3ccc(F)cc3F)cn12 Show InChI InChI=1S/C21H15F2N3O2S/c1-12-3-4-13(21(27)28-2)9-16(12)20-25-24-19-8-6-15(11-26(19)20)29-18-7-5-14(22)10-17(18)23/h3-11H,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.80	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of p38 alpha				Bioorg Med Chem Lett 20: 469-73 (2010) Article DOI: 10.1016/j.bmcl.2009.11.114 BindingDB Entry DOI: 10.7270/Q2G160XP
					More data for this Ligand-Target Pair

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