Reaction Details |
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Target | BDNF/NT-3 growth factors receptor |
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Ligand | BDBM50457833 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1760792 (CHEMBL4195800) |
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IC50 | 2.6±n/a nM |
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Citation | Bagal, SK; Andrews, M; Bechle, BM; Bian, J; Bilsland, J; Blakemore, DC; Braganza, JF; Bungay, PJ; Corbett, MS; Cronin, CN; Cui, JJ; Dias, R; Flanagan, NJ; Greasley, SE; Grimley, R; James, K; Johnson, E; Kitching, L; Kraus, ML; McAlpine, I; Nagata, A; Ninkovic, S; Omoto, K; Scales, S; Skerratt, SE; Sun, J; Tran-Dubé, M; Waldron, GJ; Wang, F; Warmus, JS Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain. J Med Chem61:6779-6800 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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BDNF/NT-3 growth factors receptor |
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Name: | BDNF/NT-3 growth factors receptor |
Synonyms: | GP145-TrkB | NTRK1/NTRK2 | NTRK2 | NTRK2_HUMAN | Neurotrophic tyrosine kinase receptor type 2 | TRKB | Trk-B | TrkB tyrosine kinase | Tropomyosin-related kinase B | Tropomyosin-related kinase B (TRKB) | Tyrosine kinase receptor B (Trk-B) |
Type: | Enzyme |
Mol. Mass.: | 91996.87 |
Organism: | Homo sapiens (Human) |
Description: | Q16620 |
Residue: | 822 |
Sequence: | MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP
NSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHI
NFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNES
SKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHM
NETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH
WCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYT
LIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPST
DVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASP
LHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVL
KRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHI
VKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQI
AAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWM
PPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQ
EVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG
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BDBM50457833 |
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n/a |
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Name | BDBM50457833 |
Synonyms: | CHEMBL4210892 |
Type | Small organic molecule |
Emp. Form. | C24H23F4N5O4 |
Mol. Mass. | 521.4641 |
SMILES | Cn1cnc(c1)-c1cnc(O[C@H]2CCN(C[C@H]2F)C(=O)Cc2ccc(OC(F)(F)F)cc2)c(c1)C(N)=O |r| |
Structure |
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