| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelial lipase |
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| Ligand | BDBM50458642 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1764437 (CHEMBL4199684) |
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| IC50 | 19±n/a nM |
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| Citation |  Hangeland, JJ; Abell, LM; Adam, LP; Jiang, J; Friends, TJ; Haque, LE; Neels, J; Onorato, JM; Chen, AYA; Taylor, DS; Yin, X; Harrity, TW; Basso, MD; Yang, R; Sleph, PG; Gordon, DA; Huang, CS; Wexler, RR; Finlay, HJ; Lawrence, RM PK/PD Disconnect Observed with a Reversible Endothelial Lipase Inhibitor. ACS Med Chem Lett9:673-678 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelial lipase |
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| Name: | Endothelial lipase |
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| Synonyms: | EDL | EL | Endothelial cell-derived lipase | LIPE_HUMAN | LIPG |
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| Type: | Protein |
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| Mol. Mass.: | 56805.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9Y5X9 |
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| Residue: | 500 |
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| Sequence: | MSNSVPLLCFWSLCYCFAAGSPVPFGPEGRLEDKLHKPKATQTEVKPSVRFNLRTSKDPE
HEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTREKDANVVV
VDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGYAGN
FVKGTVGRITGLDPAGPMFEGADIHKRLSPDDADFVDVLHTYTRSFGLSIGIQMPVGHID
IYPNGGDFQPGCGLNDVLGSIAYGTITEVVKCEHERAVHLFVDSLVNQDKPSFAFQCTDS
NRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVYHYQMKIHVFSYKN
MGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLGDLLKIQLTWEGAS
QSWYNLWKEFRSYLSQPRNPGRELNIRRIRVKSGETQRKLTFCTEDPENTSISPGRELWF
RKCRDGWRMKNETSPTVELP
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| BDBM50458642 |
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| n/a |
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| Name | BDBM50458642 |
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| Synonyms: | CHEMBL4218352 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H29Cl2N3O3 |
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| Mol. Mass. | 442.379 |
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| SMILES | CCN1CC(C(=O)NCCCc2ccc(Cl)c(Cl)c2)=C(NCCOC(C)C)C1=O |t:19| |
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| Structure | 
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