| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H3 receptor |
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| Ligand | BDBM50459827 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1767247 (CHEMBL4219359) |
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| EC50 | 164±n/a nM |
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| Citation |  Kuder, KJ; ?a?ewska, D; Kaleta, M; Latacz, G; Kottke, T; Olejarz, A; Karcz, T; Fruzi?ski, A; Szczepa?ska, K; Karolak-Wojciechowska, J; Stark, H; Kie?-Kononowicz, K Synthesis and biological activity of novel tert-amylphenoxyalkyl (homo)piperidine derivatives as histamine H Bioorg Med Chem25:2701-2712 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H3 receptor |
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| Name: | Histamine H3 receptor |
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| Synonyms: | G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4) |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 48691.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Binding assays were using CHO cells stably expressing hH3R receptors. |
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| Residue: | 445 |
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| Sequence: | MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS
SAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAA
GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSV
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL
AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR
RAFTKLLCPQKLKIQPHSSLEHCWK
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| BDBM50459827 |
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| n/a |
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| Name | BDBM50459827 |
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| Synonyms: | CHEMBL4225644 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H39NO5 |
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| Mol. Mass. | 421.5702 |
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| SMILES | OC(=O)C(O)=O.CCC(C)(C)c1ccc(OCCCCCN2CCCC(C)C2)cc1 |
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| Structure | 
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